Meditation experience is associated with increased cortical thickness

Abstract

Previous research indicates that long-term meditation practice is associated with altered resting electroencephalogram patterns, suggestive of long lasting changes in brain activity. We hypothesized that meditation practice might also be associated with changes in the brain's physical structure. Magnetic resonance imaging was used to assess cortical thickness in 20 participants with extensive Insight meditation experience, which involves focused attention to internal experiences. Brain regions associated with attention, interoception and sensory processing were thicker in meditation participants than matched controls, including the prefrontal cortex and right anterior insula. Between-group differences in prefrontal cortical thickness were most pronounced in older participants, suggesting that meditation might offset age-related cortical thinning. Finally, the thickness of two regions correlated with meditation experience. These data provide the first structural evidence for experience-dependent cortical plasticity associated with meditation practice.

Figures

Fig. 1

Cortical regions thicker in meditators than in controls. (a and b) Statistical map depicting between-group differences in thickness at each point on the cortical surface overlaid on the inflated average brain. All points meeting a P < 0.01 threshold (uncorrected) are displayed to better illustrate the anatomic extent of the areas and the relative specificity of the findings. Numbered regions: (1) insula, (2) Brodmann area (BA) 9/10, (3) somatosensory cortex, (4) auditory cortex. (c and d) Scatter plot of mean cortical thickness of each participant in the subregion above threshold within each circled region of (c) insula and (d) BA 9/10, plotted versus age. Meditation participants: blue circles; control participants: red squares.

Fig. 2

Visual area correlated with meditation experience. (a) Statistical map depicting cortical thickness correlated with change in respiration rate. (b) Scatter plot of mean cortical thickness of each participant from the circled region within the inferior occipitotemporal lobe plotted versus change in respiration rate. Note: negative change in breathing rate (left side) is associated with more hours of meditation experience and a thicker cortex.