Cost-effectiveness analysis of empagliflozin compared with glimepiride in patients with Type 2 diabetes in China
Ahmed Salem, Peng Men, Mafalda Ramos, Yan-Jun Zhang, Anastasia Ustyugova, Mark Lamotte, Ahmed Salem, Peng Men, Mafalda Ramos, Yan-Jun Zhang, Anastasia Ustyugova, Mark Lamotte
Abstract
Aim: The study assesses the cost-effectiveness of empagliflozin versus glimepiride in patients with Type 2 diabetes and uncontrolled by metformin alone in China, based on the EMPA-REG H2H-SU trial. Materials & methods: A calibrated version of the IQVIA Core Diabetes Model was used. Cost of complications and utility were taken from literature. The Chinese healthcare system perspective and 5% discounting rates were applied. Results: Empagliflozin+metformin provides additional quality-adjusted life-years (0.317) driven by a reduction in the number of cardiovascular and renal events, for an additional cost of $1382 (CNY9703) compared with glimepiride+metformin. Conclusion: Empagliflozin is cost-effective treatment versus glimepiride applying a threshold of $30,290 (CNY212,676).
Trial registration: ClinicalTrials.gov NCT01167881.
Keywords: China; Type 2 diabetes mellitus; cardiovascular outcomes; cost–effectiveness; empagliflozin; glimepiride.
Source: PubMed