Premedication practices for tracheal intubation in neonates transported by French medical transport teams: a prospective observational study
Ricardo Carbajal, Noella Lode, Azzedine Ayachi, Ourida Chouakri, Véronique Henry-Larzul, Katia Kessous, Audrey Normand, Emilie Courtois, Jessica Rousseau, Patricia Cimerman, Jean-Louis Chabernaud, Ricardo Carbajal, Noella Lode, Azzedine Ayachi, Ourida Chouakri, Véronique Henry-Larzul, Katia Kessous, Audrey Normand, Emilie Courtois, Jessica Rousseau, Patricia Cimerman, Jean-Louis Chabernaud
Abstract
Objectives: Premedication practices for neonatal tracheal intubations have not yet been described for neonatal transport teams. Our objective is to describe the use of sedation/analgesia (SA) for tracheal intubations and to assess its tolerance in neonates transported by medical transport teams in France.
Setting: This prospective observational study was part of the EPIPPAIN 2 project and collected around-the-clock data on SA practices in neonates intubated by all five paediatric medical transport teams of the Paris region during a 2-month period. Intubations were classified as emergent, semiemergent and non-emergent. Sedation level and conditions of intubation were assessed with the Tonus, Reactivity, Awareness and Conditions of intubation to Help in Endotracheal intubation Assessment (TRACHEA score). The scores range from 0 to 10 representing an increasing ladder from adequate to inadequate sedation, and from excellent to very poor conditions of intubation.
Participants: 40 neonates intubated in 28 different centres.
Results: The mean (SD) age was 34.9 (3.9) weeks, and 62.5% were intubated in the delivery room. 30/40 (75%) of intubations were performed with the use of SA. In 18/30 (60.0%) intubations performed with SA, the drug regimen was the association of sufentanil and midazolam. Atropine was given in 19/40 intubations. From the 16, 21 and 3 intubations classified as emergent, semiemergent and non-emergent, respectively, 8 (50%), 19 (90.5%) and 3 (100%) were performed with SA premedication. 79.3% of intubations performed with SA had TRACHEA scores of 3 or less. 22/40 (55%) infants had at least one of the following adverse events: muscle rigidity, bradycardia below 100/min, desaturation below 80% and nose or pharynx-larynx bleeding. 7/24 (29.2%) of those who had only one attempt presented at least one of these adverse events compared with 15/16 (93.8%) of those who needed two or more attempts (p<0.001).
Conclusion: SA premedication is largely feasible for tracheal intubations performed in neonates transported by medical transport teams including intubations judged as emergent or semiemergent.
Trial registration number: NCT01346813; Results.
Keywords: epidemiology; intubation; neonatal intensive & critical care; neonatology; pain management.
Conflict of interest statement
Competing interests: None declared.
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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