Olive pomace oil can improve blood lipid profile: a randomized, blind, crossover, controlled clinical trial in healthy and at-risk volunteers

Susana González-Rámila, Beatriz Sarriá, Miguel A Seguido, Joaquín García-Cordero, Raquel Mateos, Laura Bravo, Susana González-Rámila, Beatriz Sarriá, Miguel A Seguido, Joaquín García-Cordero, Raquel Mateos, Laura Bravo

Abstract

Purpose: This study aimed to assess the effect of dietary consumption of olive pomace oil (OPO) on blood lipids (primary outcome) and other cardiovascular disease (CVD) risk factors (blood pressure, inflammation and endothelial function as secondary outcomes).

Methods: A randomized, controlled, blind, crossover intervention was carried out in healthy and at-risk (hypercholesterolemic) subjects. Participants consumed daily 45 g of OPO or high-oleic acid sunflower oil (HOSO) as control oil during 4 weeks.

Results: OPO significantly reduced low-density lipoprotein cholesterol (LDL-C; P = 0.003) and apolipoprotein B (Apo B; P = 0.022) serum concentrations, and LDL/HDL ratio (P = 0.027) in healthy and at-risk volunteers. These effects were not observed with HOSO. Blood pressure, peripheral artery tonometry (PAT), endothelial function and inflammation biomarkers were not affected.

Conclusions: Regular consumption of OPO in the diet could have hypolipidemic actions in subjects at cardiovascular risk as well as in healthy consumers, contributing to CVD prevention.

Clinical trial registry: NCT04997122, August 8, 2021, retrospectively registered.

Keywords: Cardiovascular health; Endothelial function; Lipid profile; Oleic acid-rich sunflower oil; Olive pomace oil.

Conflict of interest statement

Interprofesional del Aceite de Orujo de Oliva (ORIVA) financed the study and the predoctoral contract of SG-R. Community of Madrid partly financed the predoctoral contracts of MAS (PEJD-2018-PRE/SAL-9104) and JG-C (PEJD-2017-PRE/BIO-4225). No other conflicts of interests are declared. ORIVA had no part on the design, conductance, analysis or interpretation of results.

© 2022. The Author(s).

Figures

Fig. 1
Fig. 1
Study flowchart according to CONSORT (Consolidated Standards of Reporting Trials)

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