Different responses of the oral, nasal and lung microbiomes to cigarette smoke
Stefan Pfeiffer, Christian Herzmann, Karoline I Gaede, Draginja Kovacevic, Susanne Krauss-Etschmann, Michael Schloter, Stefan Pfeiffer, Christian Herzmann, Karoline I Gaede, Draginja Kovacevic, Susanne Krauss-Etschmann, Michael Schloter
Abstract
To examine the role of smoking on the bacterial community composition of the upper and the lower respiratory tract, a monocentric, controlled prospective study was performed, including healthy smokers, ex-smokers and never-smokers. Smokers were further grouped according to their smoking history. Bacterial diversity was analysed using a molecular barcoding approach based on directly extracted DNA. Our study shows for the first time distinct bacterial response patterns in the upper and lower respiratory tract to cigarette smoking leading to a higher abundance of opportunistic pathogens. The clinical significance of these dysbioses for health needs to be further explored.
Trial registration: ClinicalTrials.gov NCT03562442.
Keywords: tobacco and the lung.
Conflict of interest statement
Competing interests: None declared.
© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
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Source: PubMed