Prediabetes Phenotype Influences Improvements in Glucose Homeostasis with Resistance Training

Joshua D Eikenberg, Jyoti Savla, Elaina L Marinik, Kevin P Davy, John Pownall, Mary E Baugh, Kyle D Flack, Soheir Boshra, Richard A Winett, Brenda M Davy, Joshua D Eikenberg, Jyoti Savla, Elaina L Marinik, Kevin P Davy, John Pownall, Mary E Baugh, Kyle D Flack, Soheir Boshra, Richard A Winett, Brenda M Davy

Abstract

Purpose: To determine if prediabetes phenotype influences improvements in glucose homeostasis with resistance training (RT).

Methods: Older, overweight individuals with prediabetes (n = 159; aged 60±5 yrs; BMI 33±4 kg/m2) completed a supervised RT program twice per week for 12 weeks. Body weight and composition, strength, fasting plasma glucose, 2-hr oral glucose tolerance, and Matsuda-Defronza estimated insulin sensitivity index (ISI) were assessed before and after the intervention. Participants were categorized according to their baseline prediabetes phenotype as impaired fasting glucose only (IFG) (n = 73), impaired glucose tolerance only (IGT) (n = 21), or combined IFG and IGT (IFG/IGT) (n = 65).

Results: Chest press and leg press strength increased 27% and 18%, respectively, following the 12-week RT program (both p<0.05). Waist circumference (-1.0%; pre 109.3±10.3 cm, post 108.2±10.6 cm) and body fat (-0.6%; pre 43.7±6.8%, post 43.1±6.8%) declined, and lean body mass (+1.3%; pre 52.0±10.4 kg, post 52.7±10.7 kg) increased following the intervention. Fasting glucose concentrations did not change (p>0.05) following the intervention. However, 2-hr oral glucose tolerance improved in those with IGT (pre 8.94±0.72 mmol/l, post 7.83±1.11 mmol/l, p<0.05) and IFG/IGT (pre 9.66±1.11mmol/l, post 8.60±2.00 mmol/l) but not in those with IFG (pre 6.27±1.28mmol/l, post 6.33± 1.55 mmol/l). There were no significant changes in ISI or glucose area under the curve following the RT program.

Conclusions: RT without dietary intervention improves 2-hr oral glucose tolerance in individuals with prediabetes. However, the improvements in glucose homeostasis with RT appear limited to those with IGT or combined IFG and IGT.

Trial registration: ClinicalTrials.gov: NCT01112709.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. Flow diagram.
Fig 1. Flow diagram.
Fig 2
Fig 2
(a) Changes in 2-hour oral glucose tolerance from baseline after 12-weeks of resistance training in the pooled sample (All), participants with impaired fasting glucose (IFG), participants with impaired glucose tolerance (IGT), and participants with IFG/IGT. * p<0.001 vs. baseline. (b) Change in fasting glucose from baseline after 12-weeks of resistance training for the pooled sample. Error bars show standard error.

References

    1. Menke A, Casagrande S, Geiss L, Cowie CC. Prevalence of and Trends in Diabetes Among Adults in the United States, 1988–2012. JAMA. 2015;314(10):1021–9. 10.1001/jama.2015.10029 .
    1. Nathan DM, Davidson MB, DeFronzo RA, Heine RJ, Henry RR, Pratley R, et al. Impaired fasting glucose and impaired glucose tolerance: implications for care. Diabetes care. 2007;30(3):753–9. 10.2337/dc07-9920 .
    1. Gerstein HC, Santaguida P, Raina P, Morrison KM, Balion C, Hunt D, et al. Annual incidence and relative risk of diabetes in people with various categories of dysglycemia: a systematic overview and meta-analysis of prospective studies. Diabetes Res Clin Pract. 2007;78(3):305–12. 10.1016/j.diabres.2007.05.004 .
    1. Abdul-Ghani MA, DeFronzo RA. Pathophysiology of prediabetes. Curr Diab Rep. 2009;9(3):193–9. Epub 2009/06/06. .
    1. Kanat M, Norton L, Winnier D, Jenkinson C, DeFronzo RA, Abdul-Ghani MA. Impaired early- but not late-phase insulin secretion in subjects with impaired fasting glucose. Acta Diabetol. 2011;48(3):209–17. Epub 2011/05/10. 10.1007/s00592-011-0285-x .
    1. Basu R, Barosa C, Jones J, Dube S, Carter R, Basu A, et al. Pathogenesis of prediabetes: role of the liver in isolated fasting hyperglycemia and combined fasting and postprandial hyperglycemia. J Clin Endocrinol Metab. 2013;98(3):E409–17. 10.1210/jc.2012-3056
    1. Abdul-Ghani MA, Tripathy D, DeFronzo RA. Contributions of beta-cell dysfunction and insulin resistance to the pathogenesis of impaired glucose tolerance and impaired fasting glucose. Diabetes Care. 2006;29(5):1130–9. 10.2337/diacare.2951130 .
    1. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hamalainen H, Ilanne-Parikka P, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. New Engl J Med. 2001;344(18):1343–50. Epub 2001/05/03. 10.1056/NEJM200105033441801 .
    1. Eriksson KF, Lindgarde F. Prevention of type 2 (non-insulin-dependent) diabetes mellitus by diet and physical exercise. The 6-year Malmo feasibility study. Diabetologia. 1991;34(12):891–8. Epub 1991/12/01. .
    1. Mensink M, Blaak EE, Corpeleijn E, Saris WH, de Bruin TW, Feskens EJ. Lifestyle intervention according to general recommendations improves glucose tolerance. Obes Res. 2003;11(12):1588–96. Epub 2003/12/25. 10.1038/oby.2003.211 .
    1. Lindahl B, Nilsson TK, Jansson JH, Asplund K, Hallmans G. Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. J Intern Med. 1999;246(1):105–12. Epub 1999/08/14. .
    1. Pan XR, Li GW, Hu YH, Wang JX, Yang WY, An ZX, et al. Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care. 1997;20(4):537–44. Epub 1997/04/01. .
    1. Oldroyd JC, Unwin NC, White M, Mathers JC, Alberti KG. Randomised controlled trial evaluating lifestyle interventions in people with impaired glucose tolerance. Diabetes Res Clin Pr 2006;72(2):117–27. Epub 2005/11/22. 10.1016/j.diabres.2005.09.018 .
    1. Lau C, Toft U, Tetens I, Carstensen B, Jorgensen T, Pedersen O, et al. Dietary patterns predict changes in two-hour post-oral glucose tolerance test plasma glucose concentrations in middle-aged adults. The Journal of nutrition. 2009;139(3):588–93. Epub 2009/01/23. 10.3945/jn.108.100339 .
    1. Buford TW, Pahor M. Making preventive medicine more personalized: implications for exercise-related research. Preventive medicine. 2012;55(1):34–6. 10.1016/j.ypmed.2012.05.001
    1. Smutok MA, Reece C, Kokkinos PF, Farmer CM, Dawson PK, DeVane J, et al. Effects of exercise training modality on glucose tolerance in men with abnormal glucose regulation. Int J Sports Med. 1994;15(6):283–9. 10.1055/s-2007-1021061 .
    1. Cauza E, Hanusch-Enserer U, Strasser B, Ludvik B, Metz-Schimmerl S, Pacini G, et al. The relative benefits of endurance and strength training on the metabolic factors and muscle function of people with type 2 diabetes mellitus. Arch Phys Med Rehab. 2005;86(8):1527–33. 10.1016/j.apmr.2005.01.007 .
    1. Baldi JC, Snowling N. Resistance training improves glycaemic control in obese type 2 diabetic men. Int J Sports Med. 2003;24(6):419–23. 10.1055/s-2003-41173 .
    1. Dunstan DW, Daly RM, Owen N, Jolley D, De Courten M, Shaw J, et al. High-intensity resistance training improves glycemic control in older patients with type 2 diabetes. Diabetes Care. 2002;25(10):1729–36. .
    1. Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care. 2002;25(12):2335–41. .
    1. American Diabetes A. Standards of medical care in diabetes—2012. Diabetes Care. 2012;35 Suppl 1:S11–63. 10.2337/dc12-s011
    1. Grontved A, Rimm EB, Willett WC, Andersen LB, Hu FB. A Prospective Study of Weight Training and Risk of Type 2 Diabetes Mellitus in Men. Arch Intern Med. 2012:1–7. Epub 2012/08/08. 10.1001/archinternmed.2012.3138 .
    1. Iglay HB, Thyfault JP, Apolzan JW, Campbell WW. Resistance training and dietary protein: effects on glucose tolerance and contents of skeletal muscle insulin signaling proteins in older persons. Am J Clin Nutr. 2007;85(4):1005–13. Epub 2007/04/07. doi: 85/4/1005 [pii]. .
    1. Joseph LJ, Trappe TA, Farrell PA, Campbell WW, Yarasheski KE, Lambert CP, et al. Short-term moderate weight loss and resistance training do not affect insulin-stimulated glucose disposal in postmenopausal women. Diabetes Care. 2001;24(11):1863–9. .
    1. Geirsdottir OG, Arnarson A, Briem K, Ramel A, Jonsson PV, Thorsdottir I. Effect of 12-week resistance exercise program on body composition, muscle strength, physical function, and glucose metabolism in healthy, insulin-resistant, and diabetic elderly Icelanders. J Gerontol A Biol Sci Med Sci. 2012;67(11):1259–65. 10.1093/gerona/gls096 .
    1. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New Engl J Med. 2002;346(6):393–403. Epub 2002/02/08. 10.1056/NEJMoa012512
    1. Marinik EL, Kelleher S, Savla J, Winett RA, Davy BM. The resist diabetes trial: Rationale, design, and methods of a hybrid efficacy/effectiveness intervention trial for resistance training maintenance to improve glucose homeostasis in older prediabetic adults. Contemp Clin Trials. 2014;37(1):19–32. 10.1016/j.cct.2013.11.006
    1. Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22(9):1462–70. .
    1. Pickering TG, Hall JE, Appel LJ, Falkner BE, Graves J, Hill MN, et al. Recommendations for blood pressure measurement in humans and experimental animals: Part 1: blood pressure measurement in humans: a statement for professionals from the Subcommittee of Professional and Public Education of the American Heart Association Council on High Blood Pressure Research. Hypertension. 2005;45(1):142–61. 10.1161/01.HYP.0000150859.47929.8e .
    1. Whaley MH, Brubaker PH, Otto RM, Armstrong LE. ACSM's guidelines for exercise testing and prescription 7th ed. Philadelphia, Pa.: Lippincott Williams & Wilkins; 2006. xxi, 366 p. p.
    1. Kohl HW, Blair SN, Paffenbarger RS Jr, Macera CA, Kronenfeld JJ. A mail survey of physical activity habits as related to measured physical fitness. Am J Epidemiol. 1988;127(6):1228–39. .
    1. Muthén LK, Muthén BO. How to Use a Monte Carlo Study to Decide on Sample Size and Determine Power. Struct Equ Modeling: A Multidisciplinary Journal. 2002;9(4):599–620. 10.1207/S15328007SEM0904_8
    1. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, et al. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. New Engl J Med. 2002;346(6):393–403. 10.1056/NEJMoa012512
    1. Ishii T, Yamakita T, Sato T, Tanaka S, Fujii S. Resistance Training Improves Insulin Sensitivity in NIDDM Subjects Without Altering Maximal Oxygen Uptake. Diabetes Care. 1998;21(8):1353–5. 10.2337/diacare.21.8.1353
    1. Ibanez J, Izquierdo M, Arguelles I, Forga L, Larrion JL, Garcia-Unciti M, et al. Twice-weekly progressive resistance training decreases abdominal fat and improves insulin sensitivity in older men with type 2 diabetes. Diabetes Care. 2005;28(3):662–7. .
    1. Dunstan DW, Vulikh E, Owen N, Jolley D, Shaw J, Zimmet P. Community center-based resistance training for the maintenance of glycemic control in adults with type 2 diabetes. Diabetes Care. 2006;29(12):2586–91. 10.2337/dc06-1310 .
    1. Dunstan DW, Puddey IB, Beilin LJ, Burke V, Morton AR, Stanton KG. Effects of a short-term circuit weight training program on glycaemic control in NIDDM. Diabetes Res Clin Pr. 1998;40(1):53–61. .
    1. Fenicchia LM, Kanaley JA, Azevedo JL Jr, Miller CS, Weinstock RS, Carhart RL, et al. Influence of resistance exercise training on glucose control in women with type 2 diabetes. Metabolis. 2004;53(3):284–9. .
    1. Kraemer WJ, Adams K, Cafarelli E, Dudley GA, Dooly C, Feigenbaum MS, et al. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sport Exer. 2002;34(2):364–80. .
    1. MacCallum RC, Browne MW, Sugawara HM. Power analysis and determination of sample size for covariance structure modeling. Psychol Methods. 1996;1(2):130–49. 10.1037/1082-989X.1.2.130
    1. Satorra A, Saris W. Power of the likelihood ratio test in covariance structure analysis. Psychometrika. 1985;50(1):83–90. 10.1007/BF02294150
    1. Barnett AG, van der Pols JC, Dobson AJ. Regression to the mean: what it is and how to deal with it. Int J Epidemiol. 2005;34(1):215–20. 10.1093/ije/dyh299 .
    1. Pruessner JC, Kirschbaum C, Meinlschmid G, Hellhammer DH. Two formulas for computation of the area under the curve represent measures of total hormone concentration versus time-dependent change. Psychoneuroendocrino. 2003;28(7):916–31. .
    1. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA. Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes. 2006;55(5):1430–5. .
    1. Weyer C, Bogardus C, Pratley RE. Metabolic characteristics of individuals with impaired fasting glucose and/or impaired glucose tolerance. Diabetes. 1999;48(11):2197–203. .
    1. Wasada T, Kuroki H, Katsumori K, Arii H, Sato A, Aoki K. Who are more insulin resistant, people with IFG or people with IGT? Diabetologia. 2004;47(4):758–9. .
    1. Holten MK, Zacho M, Gaster M, Juel C, Wojtaszewski JF, Dela F. Strength training increases insulin-mediated glucose uptake, GLUT4 content, and insulin signaling in skeletal muscle in patients with type 2 diabetes. Diabetes. 2004;53(2):294–305. .

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