Personality dimensions of patients can change during the course of parkinson's disease

Mathilde Boussac, Christophe Arbus, Julia Dupouy, Estelle Harroch, Vanessa Rousseau, Aurélie Croiset, Fabienne Ory-Magne, Olivier Rascol, Caroline Moreau, Anne-Sophie Rolland, David Maltête, Tiphaine Rouaud, Mylène Meyer, Sophie Drapier, Bruno Giordana, Mathieu Anheim, Elodie Hainque, Béchir Jarraya, Isabelle Benatru, Nicolas Auzou, Lhaouas Belamri, Mélissa Tir, Ana-Raquel Marques, Stephane Thobois, Alexandre Eusebio, Jean Christophe Corvol, David Devos, Christine Brefel-Courbon, PREDI-STIM study group, Mathilde Boussac, Christophe Arbus, Julia Dupouy, Estelle Harroch, Vanessa Rousseau, Aurélie Croiset, Fabienne Ory-Magne, Olivier Rascol, Caroline Moreau, Anne-Sophie Rolland, David Maltête, Tiphaine Rouaud, Mylène Meyer, Sophie Drapier, Bruno Giordana, Mathieu Anheim, Elodie Hainque, Béchir Jarraya, Isabelle Benatru, Nicolas Auzou, Lhaouas Belamri, Mélissa Tir, Ana-Raquel Marques, Stephane Thobois, Alexandre Eusebio, Jean Christophe Corvol, David Devos, Christine Brefel-Courbon, PREDI-STIM study group

Abstract

Background: Studies assessing personality dimensions by the "Temperament and Character Inventory" (TCI) have previously found an association between Parkinson's disease (PD) and lower Novelty Seeking and higher Harm Avoidance scores. Here, we aimed to describe personality dimensions of PD patients with motor fluctuations and compare them to a normative population and other PD populations.

Methods: All PD patients awaiting Deep Brain Stimulation (DBS) answered the TCI before neurosurgery. Their results were compared to those of historical cohorts (a French normative population, a de novo PD population, and a PD population with motor fluctuations).

Results: Most personality dimensions of our 333 included PD patients with motor fluctuations who are candidates for DBS were different from those of the normative population and some were also different from those of the De Novo PD population, whereas they were similar to those of another population of PD patients with motor fluctuations.

Conclusions: During the course of PD, personality dimensions can change in parallel with the development of motor fluctuations, either due to the evolution of the disease and/or dopaminergic treatments.

Trial registration: ClinicalTrials.gov NCT02360683.

Conflict of interest statement

The authors have declared that no competing interests exist.

References

    1. Santangelo G, Garramone F, Baiano C, D’Iorio A, Piscopo F, Raimo S, et al. Personality and Parkinson’s disease: A meta-analysis. Parkinsonism. 2018.
    1. Boussac M, Arbus C, Dupouy J, Harroch E, Rousseau V, Ory-Magne F, et al. Personality Dimensions Are Associated with Quality of Life in Fluctuating Parkinson’s Disease Patients (PSYCHO-STIM). J Park Dis. 2020. Jan 1;10(3):1057–66. 10.3233/JPD-191903
    1. Pélissolo A, Lépine JP. Normative data and factor structure of the Temperament and Character Inventory (TCI) in the French version. Psychiatry Res. 2000. Apr 24;94(1):67–76. 10.1016/s0165-1781(00)00127-x
    1. Dupouy J. Personnalité Et Maladie De Parkinson Idiopathique: À Propos D’Une Revue De La Littérature Et De Deux Études Expérimentales. Toulouse; 2014.
    1. Kaasinen V, Nurmi E, Bergman J, Eskola O, Solin O, Sonninen P, et al. Personality traits and brain dopaminergic function in Parkinson’s disease. In: Proceedings of the National Academy of Sciences of the United States of America. 2001. p. 13272–13277. 10.1073/pnas.231313198
    1. Hansenne M. Le modèle biosocial de la personnalité de Cloninger. Année Psychol. 2001;101(1):155–81.
    1. Bodi N, Keri S, Nagy H, Moustafa A, Myers CE, Daw N, et al. Reward-learning and the novelty-seeking personality: a between-and within-subjects study of the effects of dopamine agonists on young Parkinson’s patients. Brain. 2009;132(9):2385–2395. 10.1093/brain/awp094
    1. Chae H, Park SH, Garcia D, Lee SJ. Cloninger’s TCI associations with adaptive and maladaptive emotion regulation strategies. PeerJ [Internet]. 2019. Oct 24 [cited 2019 Dec 13];7 Available from: 10.7717/peerj.7958
    1. Braak H, Del Tredici K, Rüb U, de Vos RAI, Jansen Steur ENH, Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003. April;24(2):197–211. 10.1016/s0197-4580(02)00065-9
    1. Castrioto A, Thobois S, Carnicella S, Maillet A, Krack P. Emotional manifestations of PD: Neurobiological basis. Mov Disord. 2016;31(8):1103–13. 10.1002/mds.26587
    1. Ebstein RP, Novick O, Umansky R, Priel B, Osher Y, Blaine D, et al. Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of Novelty Seeking. Nat Genet. 1996. January;12(1):78 10.1038/ng0196-78
    1. Benjamin J, Li L, Patterson C, Greenberg BD, Murphy DL, Hamer DH. Population and familial association between the D4 dopamine receptor gene and measures of Novelty Seeking. Nat Genet. 1996. January;12(1):81 10.1038/ng0196-81
    1. Noble EP, Ozkaragoz TZ, Ritchie TL, Zhang X, Belin TR, Sparkes RS. D2 and D4 dopamine receptor polymorphisms and personality. Am J Med Genet. 1998. May 8;81(3):257–67.
    1. Hansenne M, Ansseau M. Harm avoidance and serotonin. Biol Psychol. 1999. Oct;51(1):77–81. 10.1016/s0301-0511(99)00018-6
    1. Ricketts MH, Hamer RM, Sage JI, Manowitz P, Feng F, Menza MA. Association of a serotonin transporter gene promoter polymorphism with harm avoidance behaviour in an elderly population. Psychiatr Genet. 1998;8(2):41–4. 10.1097/00041444-199800820-00001
    1. Curtin F, Walker JP, Peyrin L, Soulier V, Badan M, Schulz P. Reward dependence is positively related to urinary monoamines in normal men. Biol Psychiatry. 1997. Aug 15;42(4):275–81. 10.1016/S0006-3223(96)00364-2
    1. Garvey MJ, Noyes R, Cook B, Blum N. Preliminary confirmation of the proposed link between reward-dependence traits and norepinephrine. Psychiatry Res. 1996. Nov 1;65(1):61–4. 10.1016/0165-1781(96)02954-x
    1. Ham B-J, Choi M-J, Lee H-J, Kang R-H, Lee M-S. Reward dependence is related to norepinephrine transporter T-182C gene polymorphism in a Korean population. Psychiatr Genet. 2005. June;15(2):145–7. 10.1097/00041444-200506000-00012
    1. Ishii T, Sawamoto N, Tabu H, Kawashima H, Okada T, Togashi K, et al. Altered striatal circuits underlie characteristic personality traits in Parkinson’s disease. J Neurol. 2016;263(9):1828–1839. 10.1007/s00415-016-8206-0
    1. Cloninger CR, Svrakic DM, Przybeck TR. A psychobiological model of temperament and character. Arch Gen Psychiatry. 1993. Dec;50(12):975–90. 10.1001/archpsyc.1993.01820240059008
    1. Heiden P, Heinz A, Romanczuk‐Seiferth N. Pathological gambling in Parkinson’s disease: what are the risk factors and what is the role of impulsivity? Eur J Neurosci. 2017;45(1):67–72. 10.1111/ejn.13396
    1. Ceravolo R, Frosini D, Rossi C, Bonuccelli U. Spectrum of addictions in Parkinson’s disease: from dopamine dysregulation syndrome to impulse control disorders. J Neurol. 2010. November 1;257(2):276–83. 10.1007/s00415-010-5715-0
    1. Weintraub D, Siderowf AD, Potenza MN, Goveas J, Morales KH, Duda JE, et al. Association of dopamine agonist use with impulse control disorders in Parkinson disease. Arch Neurol. 2006;63(7):969–973. 10.1001/archneur.63.7.969
    1. Olanow CW, Stern MB, Sethi K. The scientific and clinical basis for the treatment of Parkinson disease (2009). Neurology. 2009. May 26;72(Issue 21, Supplement 4):S1–136. 10.1212/WNL.0b013e3181a1d44c
    1. Warren N, O’Gorman C, Lehn A, Siskind D. Dopamine dysregulation syndrome in Parkinson’s disease: a systematic review of published cases. J Neurol Neurosurg Psychiatry. 2017;88(12):1060–4. 10.1136/jnnp-2017-315985
    1. Evans AH, Strafella AP, Weintraub D, Stacy M. Impulsive and compulsive behaviors in Parkinson’s disease. Mov Disord. 2009;24(11):1561–70. 10.1002/mds.22505
    1. Wood SK, Bhatnagar S. Resilience to the effects of social stress: Evidence from clinical and preclinical studies on the role of coping strategies. Neurobiol Stress. 2015. Jan 1;1:164–73. 10.1016/j.ynstr.2014.11.002
    1. Garcia-Romeu A. Self-transcendence as a measurable transpersonal construct. J Transpers Psychol. 2010;42(1):26–47.

Source: PubMed

3
購読する