Comparison of flow characteristics and vascular reactivity of radial artery and long saphenous vein grafts [NCT00139399]

William C F Chong, Peter Collins, Carolyn M Webb, Anthony C De Souza, John R Pepper, Christopher S Hayward, Neil E Moat, William C F Chong, Peter Collins, Carolyn M Webb, Anthony C De Souza, John R Pepper, Christopher S Hayward, Neil E Moat

Abstract

Background: The morphological and functional differences between arteries and veins may have implications on coronary artery bypass graft (CABG) survival. Although subjective differences have been observed between radial artery (RA) and long saphenous venous (LSV) grafts, these have not been quantified. This study assessed and compared the flow characteristics and in-vivo graft flow responses of RA and LSV aorto-coronary grafts.

Methods: Angiograms from 52 males taken 3.7 +/- 1.0 months after CABG surgery were analyzed using adjusted Thrombolysis in Myocardial Infarction (TIMI) frame count. Graft and target coronary artery dimensions were measured using quantitative coronary angiography. Estimated TIMI velocity (V(E)) and volume flow (F(E)) were then calculated. A further 7 patients underwent in-vivo graft flow responses assessments to adenosine, acetylcholine and isosorbide dinitrate (ISDN) using intravascular Doppler.

Results: The V(E) for RA grafts was significantly greater than LSV grafts (P = 0.002), however there was no difference in volume F(E) (P = 0.20). RA grafts showed positive endothelium-dependent and -independent vasodilatation, and LSV grafts showed no statistically significant response to adenosine and acetylcholine. There was no difference in flow velocity or volume responses. Seven RA grafts (11%) had compromised patency (4 (6%) > or = 50% stenosis in the proximal/distal anastomoses, and 3 (5%) diffuse narrowing). Thirty-seven (95%) LSV grafts achieved perfect patency and 2 (5%) were occluded.

Conclusion: The flow characteristics and flow responses of the RA graft suggest that it is a more physiological conduit than the LSV graft. The clinical relevance of the balance between imperfect patency versus the more physiological vascular function in the RA graft may be revealed by the 5-year angiographic follow-up of this trial.

Trial registration: ClinicalTrials.gov NCT00139399.

Figures

Figure 1
Figure 1
Cross-sectional areas of target coronary artery versus respective radial artery graft (top) or long saphenous vein graft (bottom).
Figure 2
Figure 2
Graft vasodilatation to pharmacologic stimulation in RA (dark bars) and LSV (hatched bars) grafts after correction for native coronary artery territory.

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