Perinatal systemic inflammatory response syndrome and retinopathy of prematurity
Beena G Sood, Ashima Madan, Shampa Saha, Diana Schendel, Poul Thorsen, Kristin Skogstrand, David Hougaard, Seetha Shankaran, Wally Carlo, NICHD neonatal research network, Alan Jobe, William Oh, Abbot R Laptook, Lewis P Rubin, Angelita M Hensman, Avroy A Fanaroff, Michele C Walsh, Nancy S Newman, Bonnie S Siner, Diana E Schendel, Edward F Donovan, Vivek Narendran, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Ronald N Goldberg, C Michael Cotten, Kathy J Auten, Barbara J Stoll, Ira Adams-Chapman, Ellen C Hale, Linda L Wright, Rosemary D Higgins, Sumner J Yaffe, Elizabeth M McClure, James A Lemons, Brenda B Poindexter, Diana D Appel, Dianne E Herron, Leslie D Wilson, W Kenneth Poole, Abhik Das, Scott A McDonald, Betty Hastings, Kristin Zaterka-Baxter, Jeanette O'Donnell Auman, David K Stevenson, Krisa P Van Meurs, M Bethany Ball, Kristin Skogstrand, David M Hougaard, Poul Thorsen, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Neil N Finer, Maynard R Rasmussen, David Kaegi, Kathy Arnell, Clarence Demetrio, Wade Rich, Charles R Bauer, Shahnaz Duara, Ruth Everett-Thomas, Lu-Ann Papile, Conra Backstrom Lacy, Sheldon B Korones, Henrietta S Bada, Tina Hudson, Abbot R Laptook, Walid A Salhab, R Sue Broyles, Susie Madison, Jackie F Hickman, Sally S Adams, Linda A Madden, Elizabeth Heyne, Cristin Dooley, Jon E Tyson, Kathleen Kennedy, Brenda H Morris, Esther G Akpa, Patty A Cluff, Claudia Y Franco, Anna E Lis, Georgia E McDavid, Patti L Tate, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Barbara G Jackson, Nancy J Peters, G Ganesh Konduri, Geraldine Muran, Rebecca Bara, Richard A Ehrenkranz, Patricia Gettner, Monica Konstantino, Elaine Romano, Beena G Sood, Ashima Madan, Shampa Saha, Diana Schendel, Poul Thorsen, Kristin Skogstrand, David Hougaard, Seetha Shankaran, Wally Carlo, NICHD neonatal research network, Alan Jobe, William Oh, Abbot R Laptook, Lewis P Rubin, Angelita M Hensman, Avroy A Fanaroff, Michele C Walsh, Nancy S Newman, Bonnie S Siner, Diana E Schendel, Edward F Donovan, Vivek Narendran, Barbara Alexander, Cathy Grisby, Marcia Worley Mersmann, Holly L Mincey, Jody Hessling, Ronald N Goldberg, C Michael Cotten, Kathy J Auten, Barbara J Stoll, Ira Adams-Chapman, Ellen C Hale, Linda L Wright, Rosemary D Higgins, Sumner J Yaffe, Elizabeth M McClure, James A Lemons, Brenda B Poindexter, Diana D Appel, Dianne E Herron, Leslie D Wilson, W Kenneth Poole, Abhik Das, Scott A McDonald, Betty Hastings, Kristin Zaterka-Baxter, Jeanette O'Donnell Auman, David K Stevenson, Krisa P Van Meurs, M Bethany Ball, Kristin Skogstrand, David M Hougaard, Poul Thorsen, Namasivayam Ambalavanan, Monica V Collins, Shirley S Cosby, Neil N Finer, Maynard R Rasmussen, David Kaegi, Kathy Arnell, Clarence Demetrio, Wade Rich, Charles R Bauer, Shahnaz Duara, Ruth Everett-Thomas, Lu-Ann Papile, Conra Backstrom Lacy, Sheldon B Korones, Henrietta S Bada, Tina Hudson, Abbot R Laptook, Walid A Salhab, R Sue Broyles, Susie Madison, Jackie F Hickman, Sally S Adams, Linda A Madden, Elizabeth Heyne, Cristin Dooley, Jon E Tyson, Kathleen Kennedy, Brenda H Morris, Esther G Akpa, Patty A Cluff, Claudia Y Franco, Anna E Lis, Georgia E McDavid, Patti L Tate, T Michael O'Shea, Robert G Dillard, Lisa K Washburn, Barbara G Jackson, Nancy J Peters, G Ganesh Konduri, Geraldine Muran, Rebecca Bara, Richard A Ehrenkranz, Patricia Gettner, Monica Konstantino, Elaine Romano
Abstract
Fetal and neonatal inflammation is associated with several morbidities of prematurity. Its relationship to retinopathy of prematurity (ROP) has not been investigated. Our objective was to determine the relationship between cytokine levels and ROP in the first 3 postnatal wks. Data for this study were derived from the NICHD Cytokine Study. Dried blood spots (DBS) were obtained from infants <1000 g on days 0-1, 3 +/- 1, 7 +/- 2, 14 +/- 3, and 21 +/- 3. Infants were classified into three groups-no, mild, and severe ROP. Multiplex Luminex assay was used to quantify 20 cytokines. Temporal profiles of cytokines were evaluated using mixed-effects models after controlling for covariates. Of 1074 infants enrolled, 890 were examined for ROP and 877 included in the analysis. ROP was associated with several clinical characteristics on unadjusted analyses. Eight cytokines remained significantly different across ROP groups in adjusted analyses. IL-6 and IL-17 showed significant effects in early time periods (D0-3); TGF-beta, brain-derived neurotrophic factor (BDNF), and regulated on activation, normal T cell expressed and secreted (RANTES) in later time periods (D7-21) and IL-18, C-reactive protein (CRP), and neurotrophin-4 (NT-4) in both early and later time periods. We conclude that perinatal inflammation may be involved in the pathogenesis of ROP.
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Source: PubMed