In vitro myometrial contractility profiles of different pharmacological agents used for induction of labor

Abstract

Objective: To investigate the effects of different pharmacological induction agents on myometrial contractility.

Study design: Myometrial biopsies were obtained from 13 term nonlaboring women undergoing scheduled cesarean delivery. Tissue strips were suspended in organ chambers for isometric tension recording. The effects of cumulative doses (10-10 mol/L to 10-5 mol/L) of prostaglandin E1 (PGE1), E2 (PGE2), and oxytocin on spontaneous uterine contractility were determined. Areas under the contraction curve were compared using one-way analysis of variance on ranks with Dunn post hoc test.

Results: Oxytocin-induced myometrial contractility was superior to PGE1, PGE2, and time controls (CTR) at all the concentrations tested. When only prostaglandins were compared with CTR, PGE1 10-5 mol/L increased myometrial contractility, and PGE2 had no effects.

Conclusion: Oxytocin and prostaglandins have different effects on myometrial contractility accounting for different mechanisms of action and side effects. The increased uterine contractility observed with PGE1 as compared with PGE2 can contribute to explain the higher success of vaginal delivery.

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Figures

Figure1. Baseline contractility

Kruskal-Wallis One Way Analysis of Variance on Ranks p = 0.3.Oxy: oxytocin.

Figure 2. Effect of cumulative concentrations of oxytocin, PGE1 and PGE2 on uterine contractility

Kruskal-Wallis One Way Analysis of Variance on Ranks followed by Dunn’s post hoc test * p

Figure 3. Effect of cumulative concentrations of PGE1 and PGE2 on uterine contractility

Kruskal-Wallis One Way Analysis of Variance on Ranks followed by Dunn’s post hoc test * p