Impact of online patient reminders to improve asthma care: A randomized controlled trial

Andrew C Pool, Jennifer L Kraschnewski, Jennifer M Poger, Joshua Smyth, Heather L Stuckey, Timothy J Craig, Erik B Lehman, Chengwu Yang, Christopher N Sciamanna, Andrew C Pool, Jennifer L Kraschnewski, Jennifer M Poger, Joshua Smyth, Heather L Stuckey, Timothy J Craig, Erik B Lehman, Chengwu Yang, Christopher N Sciamanna

Abstract

Importance: Asthma is one of the most burdensome chronic illnesses in the US. Despite widespread dissemination of evidence-based guidelines, more than half of the adults with asthma have uncontrolled symptoms.

Objective: To examine the efficacy of an online tool designed to improve asthma control.

Design: 12-month single blind randomized controlled trial of the online tool (Intervention condition, IC) versus an active control tool (CC).

Setting: Patients enrolled in an insurance plan.

Participants: Participants were 408 adults (21-60 years of age) with persistent asthma.

Intervention: At least once each month and before provider visits, participants in the IC answered questions online about their asthma symptoms, asthma medications and asthma care received from providers, such as an asthma management plan. The tool then provided tailored feedback to remind patients 1) to ask health care providers specific questions that may improve asthma control (e.g., additional controller medications) and 2) to consistently perform specific self-care behaviors (e.g., proper inhaler technique). Participants in the CC received similar questions and feedback, yet focused instead on preventive services unrelated to asthma control (e.g., cancer screening).

Main outcome measures: The main outcome measure was asthma control, as assessed by the 5-question Asthma Control Test (ACT). Secondary outcomes included quality of life, medication use and healthcare utilization (e.g., emergency department visits).

Results: After 12 months, 323 participants completed follow-up measures (79.2%). Participants in the IC reported a greater mean improvement in the ACT score than participants in the CC (2.3 vs. 1.2; p = 0.02) and 9 of 11 individual asthma control survey items showed non-significant improvements favoring the IC. No differences were observed in medication adherence, number of asthma controller medications or health care utilization.

Conclusion and relevance: Simple and brief online patient reminders improved asthma control among insured patients. Although future studies are needed to understand the mechanism of the improvement, the magnitude of the effect on asthma control was similar to the addition of an additional controller medication. Given the widespread use of the Internet, simple tools such as this may be useful for improving the control of other chronic diseases as well.

Trial registration: This study is registered at clinicaltrials.gov, NCT00921401, "Improving the Quality of Asthma Care Using the Internet".

Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1. CONSORT.
Fig 1. CONSORT.
Fig 2. Fidelity: Percentage of participants using…
Fig 2. Fidelity: Percentage of participants using intervention at least once in each month.

References

    1. Akinbami LJ, Moorman JE, Bailey C, Zahran HS, King M, Johnson CA, et al. Trends in asthma prevalence, health care use, and mortality in the United States, 2001–2010. NCHS Data Brief. May 2012(94):1–8.
    1. Sullivan PW, Ghushchyan VH, Slejko JF, Belozeroff V, Globe DR, Lin SL. The burden of adult asthma in the United States: evidence from the Medical Expenditure Panel Survey. J Allergy Clin Immunol. 2011;127(2):363–369. e1–e3. 10.1016/j.jaci.2010.10.042
    1. Centers for Disease Control and Prevention. Asthma’s Impact on the Nation: Data from the CDC National Asthma Control Program. 2012. . Accessed September 25, 2015.
    1. Schatz M, Mosen DM, Kosinski M, Vollmer WM, Magid DJ, O’Connor E, et al. Predictors of asthma control in a random sample of asthmatic patients. J Asthma. May 2007;44(4):341–5. 10.1080/02770900701344421
    1. Vollmer WM, Markson LE, O'Connor E, Frazier EA, Berger M, Buist AS. Association of asthma control with health care utilization: a prospective evaluation. Am J Respir Crit Care Med. 2002;165(2):195–199. 10.1164/ajrccm.165.2.2102127
    1. Carlton BG, Lucas DO, Ellis EF, Conboy-Ellis K, Shoheiber O, Stempel DA. The status of asthma control and asthma prescribing practices in the United States: results of a large prospective asthma control survey of primary care practices. J Asthma. 2005;42(7):529–535.
    1. National Heart, Lung and Blood Institute. Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Bethesda: 2007. . Accessed August 5, 2015.
    1. Liou A, Grubb JR, Schechtman KB, Hamilos DL. Causative and contributive factors to asthma severity and patterns of medication use in patients seeking specialized asthma care. Chest. 2003;124(5):1781–1788.
    1. Mularski RA, Asch SM, Shrank WH, Kerr EA, Setodji CM, Adams JL, et al. The quality of obstructive lung disease care for adults in the United States as measured by adherence to recommended processes. Chest. 2006;130(6):1844–1850. 10.1378/chest.130.6.1844
    1. Schonlau M, Mangione-Smith R, Chan KS, Keesey J, Rosen M, Louis TA, et al. Evaluation of a quality improvement collaborative in asthma care: does it improve processes and outcomes of care? Ann Fam Med. 2005;3(3):200–208. 10.1370/afm.269
    1. Slejko JF, Ghushchyan VH, Sucher B, Globe DR, Lin SL, Globe G, et al. Asthma control in the United States, 2008–2010: Indicators of poor asthma control. J Allergy Clin Immunol. 2014;133(6):1579–1587. 10.1016/j.jaci.2013.10.028
    1. Yong PL, Werner RM. Process quality measures and asthma exacerbations in the medicaid population. J Allergy Clin Immunol. 2009;124(5):961–966. 10.1016/j.jaci.2009.07.027
    1. Stone EG, Morton SC, Hulscher ME, Maglione MA, Roth EA, Grimshaw JM, et al. Interventions that increase use of adult immunization and cancer screening services: a meta-analysis. Ann Intern Med. 2002;136(9):641–651.
    1. Ornstein SM, Garr DR, Jenkins RG, Rust PF, Arnon A. Computer-generated physician and patient reminders. Tools to improve population adherence to selected preventive services. J Fam Pract. 1991;32(1):82–90.
    1. Smith SK, Trevena L, Simpson JM, Barratt A, Nutbeam D, McCaffery KJ. A decision aid to support informed choices about bowel cancer screening among adults with low education: randomised controlled trial. BMJ. 2010;341:c5370 10.1136/bmj.c5370
    1. Kravitz RL, Epstein RM, Feldman MD, et al. Influence of Patients' Requests for Direct-to-Consumer Advertised Antidepressants: A Randomized Controlled Trial. JAMA. 2005;293(16):1995–2002. 10.1001/jama.293.16.1995
    1. Kravitz RL, Bell RA, Azari R, Kelly-Reif S, Krupat E, Thom DH. Direct observation of requests for clinical services in office practice: what do patients want and do they get it? Arch Intern Med. 2003;163(14):1673–1681. 10.1001/archinte.163.14.1673
    1. Sciamanna CN, Nicholson RA, Lofland JH, Manocchia M, Mui S, Hartmann CW. Effects of a website designed to improve the management of migraines. Headache. 2006;46:92–100. 10.1111/j.1526-4610.2006.00312.x
    1. Sciamanna CN, Harrold LR, Manocchia M, Walker NJ, Mui S. The effect of web-based, personalized, osteoarthritis quality improvement feedback on patient satisfaction with osteoarthritis care. Am J Med Qual. 2005;20(3):127–137. 10.1177/1062860605274518
    1. Thiboutot J, Stuckey H, Binette A, Kephart D, Curry W, Falkner B, et al. A web-based patient activation intervention to improve hypertension care: study design and baseline characteristics in the web hypertension study. Contemp Clin Trials. 2010;31(6):634–646. 10.1016/j.cct.2010.08.012
    1. Hartmann CW, Sciamanna CN, Blanch DC, Mui S, Lawless HK, Manocchia M, et al. A Website to Improve Asthma Care by Suggesting Patient Questions for Physicians: Qualitative Analysis of User Experiences. J Med Internet Res. 2007;9(1):e3 10.2196/jmir.9.1.e3
    1. Nathan RA, Sorkness CA, Kosinski M, Schatz M, Li JT, Marcus P, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol. 2004;113(1):59–65. 10.1016/j.jaci.2003.09.008
    1. Schatz M, Sorkness CA, Li JT, Marcus P, Murray JJ, Nathan RA, et al. Asthma Control Test: reliability, validity, and responsiveness in patients not previously followed by asthma specialists. J Allergy Clin Immunol. 2006;117(3):549–556. 10.1016/j.jaci.2006.01.011
    1. Schatz M, Zeiger RS, Yang SJ, Chen W, Crawford WW, Sajjan SG, et al. Persistent asthma defined using HEDIS versus survey criteria. Am J Manag Care. November 2010;16(11):e281–e288.
    1. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. September 15 2007;176(6):532–555. 10.1164/rccm.200703-456SO
    1. Gibson JT, Barker KN. Quality and comprehensiveness of the National Drug Code Directory on magnetic tape. Am J Hosp Pharm. 1988;45(2):337–340.
    1. Fontana SA, Baumann LC, Helberg C, Love RR. The delivery of preventive services in primary care practices according to chronic disease status. Am J Public Health. 1997;87(7):1190–1196.
    1. Beckman TJ, Cuddihy RM, Scheitel SM, Naessens JM, Killian JM, Pankratz VS. Screening mammogram utilization in women with diabetes. Diabetes Care. Dec 2001;24(12):2049–2053.
    1. Bell RA, Shelton BJ, Paskett ED. Colorectal cancer screening in North Carolina: associations with diabetes mellitus and demographic and health characteristics. Prev Med. 2001;32(2):163–167.
    1. Thiboutot J, Sciamanna CN, Falkner B, Kephart DK, Stuckey HL, Adelman AM, et al. Effects of a web-based patient activation intervention to overcome clinical inertia on blood pressure control: cluster randomized controlled trial. J Med Internet Res. 2013;15(9):e158 10.2196/jmir.2298
    1. Van Sickle D, Magzamen S, Truelove S, Morrison T. Remote monitoring of inhaled bronchodilator use and weekly feedback about asthma management: an open-group, short-term pilot study of the impact on asthma control. PLoS ONE. 2013;8(2):e55335 10.1371/journal.pone.0055335
    1. Halterman JS, Auinger P, Conn KM, Lynch K, Yoos HL, Szilagyi PG. Inadequate therapy and poor symptom control among children with asthma: findings from a multistate sample. Ambul Pediatr. 2007;7(2):153–159.
    1. Talreja N, Baptist AP. Effect of age on asthma control: results from the National Asthma Survey. Ann Allergy Asthma Immunol. January 2011;106(1):24–29. 10.1016/j.anai.2010.10.017
    1. Hess LM, Raebel MA, Conner DA, Malone DC. Measurement of adherence in pharmacy administrative databases: a proposal for standard definitions and preferred measures. Ann Pharmacother. Jul-Aug 2006;40(7–8):1280–1288. 10.1345/aph.1H018
    1. Elliott WJ, Plauschinat CA, Skrepnek GH, Gause D. Persistence, adherence, and risk of discontinuation associated with commonly prescribed antihypertensive drug monotherapies. J Am Board Fam Med. 2007;20(1):72–80. 10.3122/jabfm.2007.01.060094
    1. Balkrishnan R, Rajagopalan R, Camacho FT, Huston SA, Murray FT, Anderson RT. Predictors of medication adherence and associated health care costs in an older population with type 2 diabetes mellitus: a longitudinal cohort study. Clin Ther. 2003;25(11):2958–2971.
    1. Kim C, Beckles GL. Cardiovascular disease risk reduction in the Behavioral Risk Factor Surveillance System. Am J Prev Med. 2004;27(1):1–7.
    1. Greenlund KJ, Denny CH, Mokdad AH, Watkins N, Croft JB, Mensah GA. Using behavioral risk factor surveillance data for heart disease and stroke prevention programs. Am J Prev Med. 2005;29(5 Suppl 1):81–87. 10.1016/j.amepre.2005.07.007
    1. Halm EA, Wisnivesky JP, Leventhal H. Quality and access to care among a cohort of inner-city adults with asthma: who gets guideline concordant care? Chest. 2005;128(4):1943–1950. 10.1378/chest.128.4.1943
    1. Apter AJ, Boston RC, George M, Norfleet AL, Tenhave T, Coyne JC, et al. Modifiable barriers to adherence to inhaled steroids among adults with asthma: it's not just black and white. J Allergy Clin Immunol. 2003;111(6):1219–1226.
    1. Adams RJ, Fuhlbrigge A, Guilbert T, Lozano P, Martinez F. Inadequate use of asthma medication in the United States: results of the asthma in America national population survey. J Allergy Clin Immunol. 2002;110(1):58–64.
    1. Little R, Yau L. Intent-to-treat analysis for longitudinal studies with drop-outs. Biometrics. 1996;52(4):1324–1333.
    1. Yasui H, Fujisawa T, Inui N, Kato M, Hashimoto D, Enomoto N, Nakamura Y, et al. Impact of add-on pranlukast in stable asthma; the additive effect on peripheral airway inflammation. Respir Med. 2012;106(4):508–514. 10.1016/j.rmed.2011.12.014
    1. van der Meer V, Bakker MJ, van den Hout WB, Rabe KF, Sterk PJ, Kievit J, et al. Internet-based self-management plus education compared with usual care in asthma: a randomized trial. Ann Intern Med. 2009;151(2):110–120.
    1. Rasmussen LM, Phanareth K, Nolte H, Backer V. Internet-based monitoring of asthma: a long-term, randomized clinical study of 300 asthmatic subjects. J Allergy Clin Immunol. 2005;115(6):1137–1142. 10.1016/j.jaci.2005.03.030
    1. Fox S, Duggan M. Health Online 2013 [updated January 15, 2013; cited 2013 June 25]. .
    1. Broderick JE, Stone AA, Smyth JM, Kaell AT. The feasibility and effectiveness of an expressive writing intervention for rheumatoid arthritis via home-based videotaped instructions. Ann Behav Med. 2004;27(1):50–59. 10.1207/s15324796abm2701_7
    1. Flay BR, Graumlich S, Segawa E, Burns JL, Holliday MY. Effects of 2 prevention programs on high-risk behaviors among African American youth: a randomized trial. Arch Pediatr Adolesc Med. 2004;158(4):377–384. 10.1001/archpedi.158.4.377
    1. Krishna S, Francisco BD, Balas EA, Konig P, Graff GR, Madsen RW. Internet-enabled interactive multimedia asthma education program: a randomized trial. Pediatrics. 2003;11(3):503–510.
    1. Chan DS, Callahan CW, Hatch-Pigott VB, Lawless A, Proffitt HL, Manning NE, et al. Internet-based home monitoring and education of children with asthma is comparable to ideal office-based care: results of a 1-year asthma in-home monitoring trial. Pediatrics. 2007;119(3):569–578. 10.1542/peds.2006-1884
    1. Fox S. Digital Divisions. Washington: Pew Internet and American Life Project;2005.
    1. Ward BW, Schiller JS, Goodman RA. Multiple chronic conditions among US adults: a 2012 update. Prev Chronic Dis. 2014;11:E62 10.5888/pcd11.130389

Source: PubMed

3
購読する