Safety and Immunogenicity of a Single Low Dose or High Dose of Clade 2 Influenza A(H5N1) Inactivated Vaccine in Adults Previously Primed With Clade 1 Influenza A(H5N1) Vaccine
Patricia L Winokur, Shital M Patel, Rebecca Brady, Wilbur H Chen, Samer S El-Kamary, Kathryn Edwards, C Buddy Creech, Sharon Frey, Wendy A Keitel, Robert Belshe, Emmanuel Walter, Abbie Bellamy, Heather Hill, Patricia L Winokur, Shital M Patel, Rebecca Brady, Wilbur H Chen, Samer S El-Kamary, Kathryn Edwards, C Buddy Creech, Sharon Frey, Wendy A Keitel, Robert Belshe, Emmanuel Walter, Abbie Bellamy, Heather Hill
Abstract
Influenza A(H5N1) vaccination strategies that improve the speed of the immunological response and cross-clade protection are desired. We compared the immunogenicity of a single 15-μg or 90-μg dose of A/H5N1/Indonesia/05/05 (clade 2) vaccine in adults who were previously primed with A/H5N1/Vietnam/1203/2004 (clade 1) vaccine. High-dose vaccine resulted in significantly higher titers to both clade 1 and 2 antigens. Clade 2 titers were unaffected by the previous dose of clade 1 vaccine. Low-dose priming with a mismatched pandemic influenza A(H5N1) vaccine would improve the rapidity, magnitude, and cross-reactivity of the immunological response following a single high-dose, unadjuvanted, pandemic vaccine.
Keywords: H5N1; influenza; prime-boost; vaccine.
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Source: PubMed