Improved Health-Related Quality of Life in Older Kidney Recipients 1 Year After Transplantation

Kjersti Lønning, Kristian Heldal, Tomm Bernklev, Cathrine Brunborg, Marit Helen Andersen, Nanna von der Lippe, Anna Varberg Reisæter, Pål-Dag Line, Anders Hartmann, Karsten Midtvedt, Kjersti Lønning, Kristian Heldal, Tomm Bernklev, Cathrine Brunborg, Marit Helen Andersen, Nanna von der Lippe, Anna Varberg Reisæter, Pål-Dag Line, Anders Hartmann, Karsten Midtvedt

Abstract

Background: We aimed to evaluate changes in health-related quality of life (HRQoL) in patients 65 years or older from time of kidney transplantation (KTx) until 1 year postengraftment.

Methods: A single-center prospective study was conducted. HRQoL was measured pre-KTx and at 2, 6, and 12 months postengraftment using self-reported Kidney Disease and Quality of Life short-form version 1.3. Intraindividual scores before and after KTx were evaluated. Liu Comorbidity Index was registered at enlisting. short-form-36 scores were additionally compared with scores from an age-matched population.

Results: From January 1, 2013, until November 30, 2016, a total of 289 waitlisted patients were included. By September 1, 2017, 134 had reached 1 year postengraftment, and valid questionnaires were available in 120 (90%) patients. Mean age at KTx was 71.6 years (±4.3 years), 71% were male. Living donor was used in 21%, and preemptive KTx was performed in 30% of the recipients. Median waiting time for KTx from deceased donor was 16 months (range, 0.6-50.5 months). A total of 79 (66%) recipients had a Liu Comorbidity Index score of 3 or less.All HRQoL scores except the domain social function improved at 2 months postengraftment and remained stable or continued to improve at 1 year.HRQoL scores 12 months postengraftment were similar to those described in an age-matched general population except for the domain social function which remained at a significantly lower level. Time in dialysis was the most important variable associated with impaired HRQoL postengraftment.

Conclusions: HRQoL scores showed clinically significant improvement in older KTx recipients 1 year posttransplant.

Conflict of interest statement

The authors declare no conflict of interests.

Figures

FIGURE 1
FIGURE 1
Study flowchart.
FIGURE 2
FIGURE 2
Changes in HRQoL from KTx to 1 year postengraftment.
FIGURE 3
FIGURE 3
Changes in HRQoL scores at 2, 6, and 12 months after KTx compared to pretransplantation.
FIGURE 4
FIGURE 4
HRQoL scores at 12 months after KTx compared with the age-matched general Norwegian population, presented as z scores.

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