Pulmonary and extrapulmonary features in bronchopulmonary dysplasia: a comparison with healthy children

Naciye Vardar-Yagli, Deniz Inal-Ince, Melda Saglam, Hulya Arikan, Sema Savci, Ebru Calik-Kutukcu, Ugur Ozcelik, Naciye Vardar-Yagli, Deniz Inal-Ince, Melda Saglam, Hulya Arikan, Sema Savci, Ebru Calik-Kutukcu, Ugur Ozcelik

Abstract

[Purpose] The aim of this study was to compare functional capacity and peripheral muscle strength in preterm children with bronchopulmonary dysplasia (BPD) with those of age-matched full-term healthy controls. [Subjects and Methods] Eighteen BPD subjects and 20 healthy subjects were enrolled in the study. Pulmonary function testing was performed. Body composition was determined using the skinfold method. An analysis of posture was scored. Muscle strength was evaluated using a dynamometer. Functional capacity was assessed using the six-minute walking test (6MWT). [Results] Pulmonary function testing parameters, 6MWT distance, and quadriceps strength of the children with BPD were significantly lower than those of healthy peers. The scores of posture analysis of the children with BPD were significantly higher than those of healthy subjects. Exercise heart rate was significantly higher in the children with BPD compared to healthy children. The 6MWT distance correlated with height, fat-free mass, exercise dyspnea perception, and hand grip strength in BPD children. [Conclusion] The study showed that preterm children with BPD had disturbed pulmonary and extrapulmonary characteristics. BPD had lower fat free mass, reduced lung function, worsen postural function, a shorter 6MWT distance, and lower quadriceps strength than healthy children. These features may provide insights into the choice of outcome measures for pulmonary rehabilitation for BPD.

Keywords: Bronhopulmonary dysplasia; Functional capacity; Lung function.

References

    1. Popova AP: Mechanisms of bronchopulmonary dysplasia. J Cell Commun Signal, 2013, 7: 119–127.
    1. Bhandari A, McGrath-Morrow S: Long-term pulmonary outcomes of patients with bronchopulmonary dysplasia. Semin Perinatol, 2013, 37: 132–137
    1. Robin B, Kim YJ, Huth J, et al. : Pulmonary function in bronchopulmonary dysplasia. Pediatr Pulmonol, 2004, 37: 236–242.
    1. Sanchez-Solis M, Garcia-Marcos L, Bosch-Gimenez V, et al. : Lung function among infants born preterm, with or without bronchopulmonary dysplasia. Pediatr Pulmonol, 2012, 47: 674–681PubMed.
    1. Carlo WA: Long-term respiratory morbidities after bronchopulmonary dysplasia despite current therapies. J Pediatr, 2014, 164: 12–13
    1. Indra N, Al-Naimi A: Preterm birth and long-term pulmonary function, preterm birth -mother and child, InTech, Available from: function, 2012.
    1. Tsopanoglou SP, Davidson J, Goulart AL, et al. : Functional capacity during exercise in very-low-birth-weight premature children. Pediatr Pulmonol, 2014, 49: 91–98
    1. Vrijlandt EJ, Gerritsen J, Boezen HM, et al. : Lung function and exercise capacity in young adults born prematurely. Am J Respir Crit Care Med, 2006, 173: 890–896.
    1. Bott L, Béghin L, Gondon E, et al. : Body composition in children with bronchopulmonary dysplasia predicted from bioelectric impedance and anthropometric variables: comparison with a reference dual X-ray absorptiometry. Clin Nutr, 2006, 25: 810–815.
    1. Lee E, Roh H: Developmental characteristics of infants according to their gestational age and birth weight. J Phys Ther Sci, 2012, 24: 535–540.
    1. Lee E, Kak H, Oh T,, et al. : Comparison of motor development of preterm and full term infants. J Phys Ther Sci, 2011, 23: 745–748.
    1. Vogt H, Lindström K, Bråbäck L, et al. : Preterm birth and inhaled corticosteroid use in 6- to 19-year-olds: a Swedish national cohort study. Pediatrics, 2011, 127: 1052–1059.
    1. Bhandari A, Bhandari V: ‘‘New’’ bronchopulmonary dysplasia: a clinical review. Clin Pulm Med, 2011, 18: 137–143.
    1. Slaughter MH, Lohman TG, Boileau RA, et al. : Skinfold equations for estimation of body fatness in children and youth. Hum Biol, 1988, 60: 709–723.
    1. Rupper GL: Manual of pulmonary function testing. St Louis: Mosby, 1998.
    1. Adams GM: Exercise physiology laboratory manual. Dubuque (IA), USA: Wm C Brown, 1990.
    1. Beenakker EA, van der Hoeven JH, Fock JM, et al. : Reference values of maximum isometric muscle force obtained in 270 children aged 4–16 years by hand-held dynamometry. Neuromuscul Disord, 2001, 11: 441–446.
    1. ATS Committee on Proficiency Standards for Clinical Pulmonary Function Laboratories: ATS statement: guidelines for the six-minute walk test. Am J Respir Crit Care Med, 2002, 166: 111–117.
    1. Borg GA: Psychophysical bases of perceived exertion. Med Sci Sports Exerc, 1982, 14: 377–381.
    1. Geiger R, Strasak A, Treml B, et al. : Six-minute walk test in children and adolescents. J Pediatr, 2007, 150: 395–399, 399.e1–399.e2.
    1. Corbin CB, Welk GJ, Corbin WR, et al. : Concepts of fitness and wellness: a comprehensive lifestyle approach. Boston: McGraw Hill, 2006.
    1. Huysman WA, de Ridder M, de Bruin NC, et al. : Growth and body composition in preterm infants with bronchopulmonary dysplasia. Arch Dis Child Fetal Neonatal Ed, 2003, 88: F46–F51.
    1. Kurzner SI, Garg M, Bautista DB, et al. : Growth failure in infants with bronchopulmonary dysplasia: nutrition and elevated resting metabolic expenditure. Pediatrics, 1988, 81: 379–384.
    1. Sindel BD, Maisels MJ, Ballantine TV: Gastroesophageal reflux to the proximal esophagus in infants with bronchopulmonary dysplasia. Am J Dis Child, 1989, 143: 1103–1106.
    1. Weinstein MR, Oh W: Oxygen consumption in infants with bronchopulmonary dysplasia. J Pediatr, 1981, 99: 958–961.
    1. de Meer K, Westerterp KR, Houwen RH, et al. : Total energy expenditure in infants with bronchopulmonary dysplasia is associated with respiratory status. Eur J Pediatr, 1997, 156: 299–304.
    1. Doyle LW, Faber B, Callanan C, et al. : Bronchopulmonary dysplasia in very low birth weight subjects and lung function in late adolescence. Pediatrics, 2006, 118: 108–113.
    1. Rogers M, Fay TB, Whitfield MF, et al. : Aerobic capacity, strength, flexibility, and activity level in unimpaired extremely low birth weight (<or=800 g) survivors at 17 years of age compared with term-born control subjects. Pediatrics, 2005, 116: e58–e65.
    1. Vrijlandt EJ, Boezen HM, Gerritsen J, et al. : Respiratory health in prematurely born preschool children with and without bronchopulmonary dysplasia. J Pediatr, 2007, 150: 256–261.
    1. Tattersall R, Walshaw MJ: Posture and cystic fibrosis. J R Soc Med, 2003, 96: 18–22.

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