Muscle fatigue: general understanding and treatment

Jing-Jing Wan, Zhen Qin, Peng-Yuan Wang, Yang Sun, Xia Liu, Jing-Jing Wan, Zhen Qin, Peng-Yuan Wang, Yang Sun, Xia Liu

Abstract

Muscle fatigue is a common complaint in clinical practice. In humans, muscle fatigue can be defined as exercise-induced decrease in the ability to produce force. Here, to provide a general understanding and describe potential therapies for muscle fatigue, we summarize studies on muscle fatigue, including topics such as the sequence of events observed during force production, in vivo fatigue-site evaluation techniques, diagnostic markers and non-specific but effective treatments.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Gruet M, Temesi J, Rupp T, Levy P, Millet GY, Verges S. Stimulation of the motor cortex and corticospinal tract to assess human muscle fatigue. Neuroscience 2013; 231: 384–399.
    1. Norheim KB, Jonsson G, Omdal R. Biological mechanisms of chronic fatigue. Rheumatology(Oxford) 2011; 50: 1009–1018.
    1. Silverman MN, Heim CM, Nater UM, Marques AH, Sternberg EM. Neuroendocrine and immune contributors to fatigue. PM R 2010; 2: 338–346.
    1. Kroenke K, Wood DR, Mangelsdorff AD, Meier NJ, Powell JB. Chronic fatigue in primary care. Prevalence, patient characteristics, and outcome. JAMA 1988; 260: 929–934.
    1. Gandevia SC. Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 2001; 81: 1725–1789.
    1. Bigland-Ritchie B, Jones DA, Hosking GP, Edwards RH. Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle. Clin Sci Mol Med 1978; 54: 609–614.
    1. Kent-Braun JA, Fitts RH, Christie A. Skeletal muscle fatigue. Compr Physiol 2012; 2: 997–1044.
    1. Swart J, Lamberts RP, Lambert MI, Lambert EV, Woolrich RW, Johnston S et al. Exercising with reserve: exercise regulation by perceived exertion in relation to duration of exercise and knowledge of endpoint. Br J Sports Med 2009; 43: 775–781.
    1. Klass M, Roelands B, Lévénez M, Fontenelle V, Pattyn N, Meeusen R et al. Effects of noradrenaline and dopamine on supraspinal fatigue in well-trained men. Med Sci Sports Exerc 2012; 44: 2299–2308.
    1. Roelands B, Goekint M, Heyman E, Piacentini MF, Watson P, Hasegawa H et al. Acute norepinephrine reuptake inhibition decreases performance in normal and high ambient temperature. J Appl Physiol 2008; 105: 206–212.
    1. Piacentini MF, Meeusen R, Buyse L, De SG, Kempenaers F, Van NJ et al. No effect of a noradrenergic reuptake inhibitor on performance in trained cyclists. Med Sci Sports Exerc 2002; 34: 1189–1193.
    1. Enoka RM, Fuglevand AJ. Motor unit physiology: some unresolved issues. Muscle nerve 2001; 24: 4–17.
    1. Heckman CJ, Enoka RM. Motor unit. Compr Physiol 2012; 2: 2629–2682.
    1. Taylor JL, Amann M, Duchateau J, Meeusen R, Rice CL. Neural contributions to muscle fatigue: from the brain to the muscle and back again. Med Sci Sports Exerc 2016; 48: 2294–2306.
    1. Darques JL, Decherchi P, Jammes Y. Mechanisms of fatigue-induced activation of group IV muscle afferents: the roles played by lactic acid and inflammatory mediators. Neurosci Lett 1998; 257: 109–112.
    1. Darques JL, Jammes Y. Fatigue-induced changes in group IV muscle afferent activity: differences between high- and low-frequency electrically induced fatigues. Brain Res 1997; 750: 147–154.
    1. Vie B, Gomez N, Brerro-Saby C, Weber JP, Jammes Y. Changes in stationary upright standing and proprioceptive reflex control of foot muscles after fatiguing static foot inversion. J Biomech 2013; 46: 1676–1682.
    1. Brerro-Saby C, Delliaux S, Steinberg JG, Jammes Y. Fatigue-induced changes in tonic vibration response (TVR) in humans: relationships between electromyographic and biochemical events. Muscle Nerve 2008; 38: 1481–1489.
    1. Fichna J, Poole DP, Veldhuis N, MacEachern SJ, Saur D, Zakrzewski PK et al. Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. J Mol Med(Berl) 2015; 93: 1297–1309.
    1. MacIntosh BR, Holash RJ, Renaud JM. Skeletal muscle fatigue—regulation of excitation-contraction coupling to avoid metabolic catastrophe. J Cell Sci 2012; 125: 2105–2114.
    1. Allen DG, Lamb GD, Westerblad H. Impaired calcium release during fatigue. J Appl Physiol 2008; 104: 296–305.
    1. Wright JR, McCloskey DI, Fitzpatrick RC. Effect of muscle perfusion on fatigue andsystemic arterial pressure i human subjects. J Appl Physiol 1999; 86: 845–851.
    1. Degens H, Salmons S, Jarvis JC. Intramuscular pressure, force and blood flow in rabbit tibialis anterior muscles during single and repetitive contractions. Eur J Appl Physiol Occup Physiol 1998; 78: 13–19.
    1. Pitcher JB, Miles TS. Influence of muscle blood flow on fatigue during intermittent human hand-grip exercise and recovery. Clin Exp Pharmacol Physiol 1997; 24: 471–476.
    1. Tachi M, Kouzaki M, Kanehisa H, Fukunaga T. The influence of circulatory difference on muscle oxygenation and fatigue during intermittent static dorsiflexion. Eur J Appl Physiol 2004; 91: 682–688.
    1. Degens H, Sanchez Horneros JM, Hopman MT. Acute hypoxia limits endurance but does not affect muscle contractile properties. Muscle Nerve 2006; 33: 532–537.
    1. Cole MA, Brown MD. Response of the human triceps surae muscle to electrical stimulation during varying levels of blood flow restriction. Eur J Appl Physiol 2000; 82: 39–44.
    1. Lanza IR, Wigmore DM, Befroy DE, Kent-Braun JA. In vivo ATP production during free-flow and ischaemic muscle contractions in humans. J Physiol 2006; 577: 353–367.
    1. Wigmore DM, Propert K, Kentbraun JA. Blood flow does not limit skeletal muscle force production during incremental isometric contractions. Eur J Appl Physiol 2006; 96: 370–378.
    1. Amann M, Romer LM, Subudhi AW, Pegelow DF, Dempsey JA. Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol 2007; 581: 389–403.
    1. Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF, Dempsey JA. Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 2006; 575: 937–952.
    1. Grassi B, Rossiter HB, Hogan MC, Howlett RA, Harris JE, Goodwin ML et al. Faster O(2) uptake kinetics in canine skeletal muscle in situ after acute creatine kinase inhibition. J Physiol 2011; 589: 221–233.
    1. Kent JA, Ortenblad N, Hogan MC, Poole DC, Musch TI. No Muscle Is an Island: Integrative Perspectives on Muscle Fatigue. Med Sci Sports Exerc 2016; 48: 2281–2293.
    1. Homsher E. Muscle enthalpy production and its relationship to actomyosin ATPase. Annu Rev Physiol 1987; 49: 673–690.
    1. Ashar FN, Moes A, Moore AZ, Grove ML, Chaves PHM, Coresh J et al. Association of mitochondrial DNA levels with frailty and all-cause mortality. J Mol Med(Berl) 2015; 93: 177–186.
    1. Nielsen J, Ortenblad N. Physiological aspects of the subcellular localization of glycogen in skeletal muscle. Appl Physiol Nutr Metab 2013; 38: 91–99.
    1. Ortenblad N, Westerblad H, Nielsen J. Muscle glycogen stores and fatigue. J Physiol 2013; 591: 4405–4413.
    1. Bergstrom J, Hermansen L, Hultman E, Saltin B. Diet, muscle glycogen and physical performance. Acta Physiol Scand 1967; 71: 140–150.
    1. Hermansen L, Hultman E, Saltin B. Muscle glycogen during prolonged severe exercise. Acta Physiol Scand 1967; 71: 129–139.
    1. Hargreaves M, McConell G, Proietto J. Influence of muscle glycogen on glycogenolysis and glucose uptake during exercise in humans. J Appl Physiol 1995; 78: 288–292.
    1. Sahlin K, Tonkonogi M, Soderlund K. Energy supply and muscle fatigue in humans. Acta Physiol Scand 1998; 162: 261–266.
    1. Chin ER, Allen DG. Effects of reduced muscle glycogen concentration on force, Ca2+ release and contractile protein function in intact mouse skeletal muscle. J Physiol 1997; 498: 17–29.
    1. Nielsen J, Schroder HD, Rix CG, Ortenblad N. Distinct effects of subcellular glycogen localization on tetanic relaxation time and endurance in mechanically skinned rat skeletal muscle fibres. J Physiol 2009; 587: 3679–3690.
    1. Ortenblad N, Nielsen J, Saltin B, Holmberg HC. Role of glycogen availability in sarcoplasmic reticulum Ca2+ kinetics in human skeletal muscle. J Physiol 2011; 589: 711–725.
    1. Metzger JM, Moss RL. Effects of tension and stiffness due to reduced pH in mammalian fast- and slow-twitch skinned skeletal muscle fibres. J Physiol 1990; 428: 737–750.
    1. Pate E, Bhimani M, Franks-Skiba K, Cooke R. Reduced effect of pH on skinned rabbit psoas muscle mechanics at high temperatures: implications for fatigue. J Physiol 1995; 486: 689–694.
    1. Stackhouse SK, Reisman DS, Binder-Macleod SA. Challenging the role of pH in skeletal muscle fatigue. Phys Ther 2001; 81: 1897–1903.
    1. Westerblad H, Allen DG, Lannergren J. Muscle fatigue: lactic acid or inorganic phosphate the major cause? News Physiol Sci 2002; 17: 17–21.
    1. Allen DG, Trajanovska S. The multiple roles of phosphate in muscle fatigue. Front Physiol 2012; 3: 463.
    1. Debold EP. Potential molecular mechanisms underlying muscle fatigue mediated by reactive oxygen and nitrogen species. Front Physiol 2015; 6: 239.
    1. Delliaux S, Brerro-Saby C, Steinberg JG, Jammes Y. Reactive oxygen species activate the group IV muscle afferents in resting and exercising muscle in rats. Pflugers Arch 2009; 459: 143–150.
    1. Allen DG, Lamb GD, Westerblad H. Skeletal muscle fatigue: cellular mechanisms. Physiol Rev 2008; 88: 287–332.
    1. Macdonald WA, Stephenson DG. Effects of ADP on sarcoplasmic reticulum function in mechanically skinned skeletal muscle fibres of the rat. J Physiol 2001; 532: 499–508.
    1. Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol 2009; 4: 198–219.
    1. Huey KA, Meador BM. Contribution of IL-6 to the Hsp72, Hsp25, and alphaB-crystallin [corrected] responses to inflammation and exercise training in mouse skeletal and cardiac muscle. J Appl Physiol 2008; 105: 1830–1836.
    1. Jammes Y, Steinberg JG, Olivier M, Brerro-Saby C, Condo J, Ravailhe S et al. The mechanisms of the widespread production of phosphorylated HSP25 after fatiguing muscle stimulation. J Exp Biol 2013; 216: 3620–3626.
    1. Koh TJ. Do small heat shock proteins protect skeletal muscle from injury? Exerc Sport Sci Rev 2002; 30: 117–121.
    1. Jiang B, Xiao W, Shi Y, Liu M, Xiao X. Heat shock pretreatment inhibited the release of Smac/DIABLO from mitochondria and apoptosis induced by hydrogen peroxide in cardiomyocytes and C2C12 myogenic cells. Cell Stress Chaperones 2005; 10: 252–262.
    1. Luo Z, Lei H, Sun Y, Liu X, Su DF. Orosomucoid, an acute response protein with multiple modulating activities. J Physiol Biochem 2015; 71: 329–340.
    1. Lei H, Sun Y, Luo Z, Yourek G, Gui H, Yang Y et al. Fatigue-induced Orosomucoid 1 acts on C-C chemokine receptor type 5 to enhance muscle endurance. Sci Rep 2016; 6: 18839.
    1. Qin Z, Wan JJ, Sun Y, Wang PY, Su DF, Lei H et al. ORM promotes skeletal muscle glycogen accumulation via CCR5-activated AMPK pathway in mice. Front Pharmacol 2016; 7: 302.
    1. Hoffman BW, Oya T, Carroll TJ, Cresswell AG. Increases in corticospinal responsiveness during a sustained submaximal plantar flexion. J Appl Physiol 2009; 107: 112–120.
    1. McNeil CJ, Martin PG, Gandevia SC, Taylor JL. The response to paired motor cortical stimuli is abolished at a spinal level during human muscle fatigue. J Physiol-London 2009; 58: 5601–5612.
    1. Levenez M, Garland SJ, Klass M, Duchateau J. Cortical and spinal modulation of antagonist coactivation during a submaximal fatiguing contraction in humans. J Neurophysiol 2008; 99: 554–563.
    1. Patikas DA, Bassa H, Kotzamanidis C. Changes in the reflex excitability during and after a sustained, low-intensity muscle contraction. Int J Sports Med 2006; 27: 124–130.
    1. Papaiordanidou M, Guiraud D, Varray A. Kinetics of neuromuscular changes during low-frequency electrical stimulation. Muscle Nerve 2010; 41: 54–62.
    1. Hwang IS, Huang CY, Wu PS, Chen YC, Wang CH. Assessment of H reflex sensitivity with M wave alternation consequent to fatiguing contractions. Int J Neurosci 2008; 118: 1317–1330.
    1. Kalmar JM, Del BC, Cafarelli E. Increased spinal excitability does not offset central activation failure. Exp Brain Res 2006; 173: 446–457.
    1. Behm DG, St-Pierre DM. Effects of fatigue duration and muscle type on voluntary and evoked contractile properties. J Appl Physiol 1997; 82: 1654–1661.
    1. Kent-Braun JA. Central and peripheral contributions to muscle fatigue in humans during sustained maximal effort. Eur J Appl Physiol Occup Physiol 1999; 80: 57–63.
    1. Finsterer J. Biomarkers of peripheral muscle fatigue during exercise. BMC Musculoskelet Disord 2012; 13: 218.
    1. Korzeniewski B. AMP deamination delays muscle acidification during heavy exercise and hypoxia. J Biol Chem 2006; 281: 3057–3066.
    1. Gosker HR, Schols AMWJ. Fatigued muscles in COPD but no finishing line in sight. Eur Respir J 2008; 31: 693–694.
    1. Malenfant S, Potus F, Fournier F, Breuils-Bonnet S, Pflieger A, Bourassa S et al. Skeletal muscle proteomic signature and metabolic impairment in pulmonary hypertension. J Mol Med 2015; 93: 573–584.
    1. Ding Y, Fang HQ, Shang W, Xiao Y, Sun T, Hou N et al. Mitoflash altered by metabolic stress in insulin-resistant skeletal muscle. J Mol Med 2015; 93: 1119–1130.
    1. Siegel AJ, Januzzi J, Sluss P, Lee-Lewandrowski E, Wood M, Shirey T et al. Cardiac biomarkers, electrolytes, and other analytes in collapsed marathon runners: implications for the evaluation of runners following competition. Am J Clin Pathol 2008; 129: 948–951.
    1. Galal NM, Fouad HM, Saied A, Dabnon M. Hyperammonemia in the pediatric emergency care setting. Pediatr Emerg Care 2010; 26: 888–891.
    1. Esbjornsson M, Norman B, Suchdev S, Viru M, Lindhgren A, Jansson E. Greater growth hormone and insulin response in women than in men during repeated bouts of sprint exercise. Acta Physiol Scand 2009; 197: 107–115.
    1. Speranza L, Grilli A, Patruno A, Franceschelli S, Felzani G, Pesce M et al. Plasmatic markers of muscular stress in isokinetic exercise. J Biol Reg Homeos Ag 2007; 21: 23–31.
    1. Puig JG, Mateos FA, Miranda ME, Torres RJ, de Miguel E, Perez de Ayala C et al. Purine metabolism in women with primary gout. Am J Med 1994; 97: 332–338.
    1. Bloomer RJ, Goldfarb AH, Wideman L, Mckenzie MJ, Consitt LA. Effects of acute aerobic and anaerobic exercise on blood markers of oxidative stress. J Strength Cond Res 2005; 19: 276–285.
    1. Margonis K, Fatouros IG, Jamurtas AZ, Nikolaidis MG, Douroudos L, Chatzinikolaou A et al. Oxidative stress biomarkers responses to physical overtraining: Implications for diagnosis. Free Radical Bio Med 2007; 43: 901–910.
    1. Karsikas S, Myllymäki M, Heikkilä M, Sormunen R, Kivirikko KI, Myllyharju J et al. HIF-P4H-2 deficiency protects against skeletal muscle ischemia-reperfusion injury. J Mol Med(Berl) 2016; 94: 301–310.
    1. Robertson JD, Maughan RJ, Duthie GG, Morrice PC. Increased blood antioxidant systems of runners in response to training load. Clin Sci (Lond) 1991; 80: 611–618.
    1. Ward WF, Qi W, Remmen HV, Zackert WE, Roberts LJ, Richardson A. Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels. J Gerontol A Biol Sci Med Sci 2005; 60: 847–851.
    1. Kawamoto EM, Vasconcelos AR, Degaspari S, Bohmer AE, Scavone C, Marcourakis T. Age-related changes in nitric oxide activity, cyclic GMP, and TBARS levels in platelets and erythrocytes reflect the oxidative status in central nervous system. Age(Dordr) 2013; 35: 331–342.
    1. Pandey KB, Mehdi MM, Maurya PK, Rizvi SI. Plasma protein oxidation and its correlation with antioxidant potential during human aging. Dis Markers 2010; 29: 31–36.
    1. Mendoza-Nunez VM, Ruiz-Ramos M, Sanchez-Rodriguez MA, Retana-Ugalde R, Munoz-Sanchez JL. Aging-related oxidative stress in healthy humans. Tohoku J Exp Med 2007; 213: 261–268.
    1. Cavalca V, Veglia F, Squellerio I, Marenzi G, Minardi F, De Metrio M et al. Glutathione, vitamin E and oxidative stress in coronary artery disease: relevance of age and gender. Eur J Clin Invest 2009; 39: 267–272.
    1. Vitai M, Goth L. Reference ranges of normal blood catalase activity and levels in familial hypocatalasemia in Hungary. Clin Chim Acta 1997; 261: 35–42.
    1. Jha R, Rizvi SI. Carbonyl formation in erythrocyte membrane proteins during aging in humans. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2011; 155: 39–42.
    1. Li G, Liu L, Hu H, Zhao Q, Xie F, Chen K et al. Age-related carbonyl stress and erythrocyte membrane protein carbonylation. Clin Hemorheol Microcirc 2010; 46: 305–311.
    1. Palasuwan A, Suksom D, Margaritis I, Soogarun S, Rousseau AS. Effects of tai chi training on antioxidant capacity in pre- and postmenopausal women. J Aging Res 2011; 2011: 234696.
    1. Rosety-Rodriguez M, Rosety M, Ordonez FJ. [Influence of regular exercise on erythrocyte catalase activity in adolescents with Down syndrome]. Med Clin (Barc) 2006; 127: 533–534.
    1. Tan TY, Lu CH, Lin TK, Liou CW, Chuang YC, Schminke U. Factors associated with gender difference in the intima-media thickness of the common carotid artery. Clin Radiol 2009; 64: 1097–1103.
    1. Basu S, Helmersson J, Jarosinska D, Sallsten G, Mazzolai B, Barregard L. Regulatory factors of basal F(2)-isoprostane formation: population, age, gender and smoking habits in humans. Free Radic Res 2009; 43: 85–91.
    1. Nanda N, Bobby Z, Hamide A. Oxidative stress and protein glycation in primary hypothyroidism. Male/female difference. Clin Exp Med 2008; 8: 101–108.
    1. Kamper EF, Chatzigeorgiou A, Tsimpoukidi O, Kamper M, Dalla C, Pitychoutis PM et al. Sex differences in oxidant/antioxidant balance under a chronic mild stress regime. Physiol Behav 2009; 98: 215–222.
    1. Simpson RJ, Florida-James GD, Whyte GP, Guy K. The effects of intensive, moderate and downhill treadmill running on human blood lymphocytes expressing the adhesion/activation molecules CD54 (ICAM-1), CD18 (beta2 integrin) and CD53. Eur J Appl Physiol 2006; 97: 109–121.
    1. Speranza L, Grilli A, Patruno A, Franceschelli S, Felzani G, Pesce M et al. Plasmatic markers of muscular stress in isokinetic exercise. J Biol Regul Homeost Agents 2007; 21: 21–29.
    1. Brandt C, Pedersen BK. The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases. J Biomed Biotechnol 2010; 2010: 520258.
    1. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K et al. Gender specificity of altered human immune cytokine profiles in aging. FASEB J 2010; 24: 3580–3589.
    1. Stulnig T, Maczek C, Böck G, Majdic O, Wick G. Reference intervals for human peripheral blood lymphocyte subpopulations from 'healthy' young and aged subjects. Int Arch Allergy Immunol 1995; 108: 205–210.
    1. Foster AD, Soloviova K, Puliaeva I, Puliaiev M, Puliaev R, Finkelman F et al. Donor CD8 T cells and IFN-gamma are critical for sex-based differences in donor CD4 T cell engraftment and lupus-like phenotype in short-term chronic graft-versus-host disease mice. J Immunol 2011; 186: 6238–6254.
    1. Nijs J, Van Oosterwijck J, Meeus M, Lambrecht L, Metzger K, Fremont M et al. Unravelling the nature of postexertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: the role of elastase, complement C4a and interleukin-1beta. J Intern Med 2010; 267: 418–435.
    1. Nielsen AR, Mounier R, Plomgaard P, Mortensen OH, Penkowa M, Speerschneider T et al. Expression of interleukin-15 in human skeletal muscle effect of exercise and muscle fibre type composition. The J Physioly 2007; 584: 305–312.
    1. Finsterer J, Milvay E. Stress lactate in mitochondrial myopathy under constant, unadjusted workload. Eur J Neurol 2004; 11: 811–816.
    1. Weiss B, Laties VG. Enhancement of human performance by caffeine and the amphetamines. Pharmacol Rev 1962; 14: 1–36.
    1. Wyndham CH, Rogers GG, Benade AJ, Strydom NB. Physiological effects of the amphetamines during exercise. S Afr Med J 1971; 45: 247–252.
    1. Gerald MC. Effects of (+)-amphetamine on the treadmill endurance performance of rats. Neuropharmacology 1978; 17: 703–704.
    1. Morozova E, Yoo Y, Behrouzvaziri A, Zaretskaia M, Rusyniak D, Zaretsky D et al. Amphetamine enhances endurance by increasing heat dissipation. Physiol Rep 2016; 4: e12955.
    1. Graham TE, Spriet LL. Performance and metabolic responses to a high caffeine dose during prolonged exercise. J Appl Physiol 1991; 71: 2292–2298.
    1. Spriet LL, MacLean DA, Dyck DJ, Hultman E, Cederblad G, Graham TE. Caffeine ingestion and muscle metabolism during prolonged exercise in humans. Am J Physiol 1992; 262: E891–E898.
    1. Paluska SA. Caffeine and exercise. Curr Sports Med Rep 2003; 2: 213–219.
    1. Magkos F, Kavouras SA. Caffeine use in sports, pharmacokinetics in man, and cellular mechanisms of action. Crit Rev Food Sci Nutr 2005; 45: 535–562.
    1. Jones G. Caffeine and other sympathomimetic stimulants: modes of action and effects on sports performance. Essays Biochem 2008; 44: 109–123.
    1. Young R, Glennon RA. Stimulus effects of phenylpropanolamine optical isomers in (+)amphetamine-trained rats. Pharmacol BiochemBehav 2000; 66: 489–494.
    1. Blinks JR, Olson CB, Jewell BR, Bravený P. Influence of caffeine and other methylxanthines on mechanical properties of isolated mammalian heart muscle. Evidence for a dual mechanism of action. Circ Res 1972; 30: 367–392.
    1. Bell DG, Mclellan TM, Sabiston CM. Effect of ingesting caffeine and ephedrine on 10-km run performance. Med Sci Sports Exerc 2002; 34: 344.
    1. Asai H, Asahi T, Yamamura M, Yamauchi-Kohno R, Saito A. Lack of behavioral tolerance by repeated treatment with taltirelin hydrate, a thyrotropin-releasing hormone analog, in rats. Pharmacol Biochem Behav 2005; 82: 646–651.
    1. Braiden RW, Fellingham GW, Conlee RK. Effects of cocaine on glycogen metabolism and endurance during high intensity exercise. Med Sci Sports Exerc 1994; 26: 695–700.
    1. Kim D. Practical use and risk of modafinil, a novel waking drug. Environ Health Toxicol 2012; 27: e2012007.
    1. Jacobs I, Bell DG. Effects of acute modafinil ingestion on exercise time to exhaustion. Med Sci Sports Exerc 2004; 36: 1078–1082.
    1. Wu X, Fan W, Pan Y, Zhai Y, Niu Y, Li C et al. Synthesis, crystal structure and anti-fatigue effects of some benzamide derivatives. Molecules 2014; 19: 1034–1046.
    1. Qi B, Liu L, Zhang H, Zhou GX, Wang S, Duan XZ et al. Anti-fatigue effects of proteins isolated from Panax quinquefolium. J Ethnopharmacol 2014; 153: 430–434.
    1. Bao L, Cai X, Wang J, Zhang Y, Sun B, Li Y. Anti-fatigue effects of small molecule oligopeptides isolated from Panax ginseng C. A. Meyer in mice. Nutrients 2016; 8: 807.
    1. Qi B, Zhang L, Zhang Z, Ouyang J, Huang H. Effects of ginsenosides-Rb1 on exercise-induced oxidative stress in forced swimming mice. Pharmacogn Mag 2014; 10: 458–463.
    1. Wang J, Li S, Fan Y, Chen Y, Liu D, Cheng H et al. Anti-fatigue activity of the water-soluble polysaccharides isolated from Panax ginseng CA Meyer. J Ethnopharmacol 2010; 130: 421–423.
    1. Kim S, Kim J, Lee Y, Seo MK, Sung DJ. Anti-fatigue effects of acute red ginseng intake in recovery from repetitive anaerobic exercise. Iran J Public Health 2016; 45: 387–389.
    1. Liang MT, Podolka TD, Chuang WJ. Panax notoginseng supplementation enhances physical performance during endurance exercise. J Strength Cond Res 2005; 19: 108–114.
    1. Yong-xin X, Jian-jun Z. Evaluation of anti-fatigue activity of total saponins of Radix notoginseng. Indian J Med Res 2013; 137: 151–155.
    1. De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab 2004; 14: 298–307.
    1. Kang DZ, Hong HD, Kim KI, Choi SY. Anti-fatigue effects of fermented rhodiola rosea extract in mice. Prev Nutr Food Sci 2015; 20: 38–42.
    1. Morihara N, Nishihama T, Ushijima M, Ide N, Takeda H, Hayama M. Garlic as an anti-fatigue agent. Mol Nutr Food Res 2007; 51: 1329–1334.
    1. Morihara N, Ushijima M, Kashimoto N, Sumioka I, Nishihama T, Hayama M et al. Aged garlic extract ameliorates physical fatigue. Biol Pharm Bull 2006; 29: 962–966.
    1. Ushijima M, Sumioka I, Kakimoto M, Yokoyama K, Uda N, Matsuura H et al. Effect of garlic and garlic preparations on physiological and psychological stress in mice. Phytother Res 1997; 11: 226–230.
    1. Verma SK, Rajeevan V, Jain P, Bordia A. Effect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery disease. Indian J Physiol Pharmacol 2005; 49: 115–118.
    1. Lu YL, Chia CY, Liu YW, Hou WC. Biological activities and applications of dioscorins, the major tuber storage proteins of yam. J Tradit Complement Med 2012; 2: 41–46.
    1. Wu Z, Zhang S, Li P, Lu X, Wang J, Zhao L et al. Effect of aurantii fructus immaturus flavonoid on the contraction of isolated gastric smooth muscle strips in rats. Evid Based Complement Alternat Med 2016; 2016: 5616905.
    1. Levic DS, Minkel JR, Wang WD, Rybski WM, Melville DB, Knapik EW. Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease. J Mol Med (Berl) 2015; 93: 165–176.
    1. Tian HH, Ong WS, Tan CL. Nutritional supplement use among university athletes in Singapore. Singapore Med J 2009; 50: 165–172.
    1. Lukaski HC. Vitamin and mineral status: effects on physical performance. Nutrition 2004; 20: 632–644.
    1. Brutsaert TD, Hernandez-Cordero S, Rivera J, Viola T, Hughes G, Haas JD. Iron supplementation improves progressive fatigue resistance during dynamic knee extensor exercise in iron-depleted, nonanemic women. Am J Clin Nutr 2003; 77: 441–448.
    1. Telford RD, Catchpole EA, Deakin V, Hahn AG, Plank AW. The effect of 7 to 8 months of vitamin/mineral supplementation on athletic performance. Int J Sport Nutr 1992; 2: 135–153.
    1. Lai YA, Lin YA, Chang WH. Long-term effects of fish oil supplementation on exercise performance and anti-fatigue in college students: 266 Board #103 June 1, 11: 00 AM–12: 30 PM. Med Sci Sport Exer 2016; 48: 62–63.
    1. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000; 80: 1107–1213.
    1. Anderson O. Creatine propels British athletes to Olympic gold medals: Is creatine the one true ergogenic aid. Running Res News 1993; 9: 1–5.
    1. Alford C, Cox H, Wescott R. The effects of red bull energy drink on human performance and mood. Amino acids 2001; 21: 139–150.
    1. Maughan RJ. Nutritional ergogenic aids and exercise performance. Nutr Res Rev 1999; 12: 255–280.

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