Chromosomal Instability in Tumor Initiation and Development
Duc-Hiep Bach, Wei Zhang, Anil K Sood, Duc-Hiep Bach, Wei Zhang, Anil K Sood
Abstract
Chromosomal instability (CIN) is one of the major forms of genomic instability in various human cancers and is recognized as a common hallmark of tumorigenesis and heterogeneity. However, some malignant tumors show a paucity of chromosomal alterations, suggesting that tumor progression and evolution can occur in the absence of CIN. It is unclear whether CIN is stable between precursor lesions, primary tumor, and metastases or if it evolves during these steps. In this review, we describe the influence of CIN on the various steps in tumor initiation and development. Given the recognized significant effects of CIN in cancer, CIN-targeted therapeutics could have a major impact on improving clinical outcomes.
Conflict of interest statement
Disclosure of Potential Conflicts of Interest
A.K. Sood reports receiving commercial research grant from M-Trap; has an ownership interest (including stock, patents, etc.) in BioPath; and is a consultant/advisory board member for Kiyatec and Merck. No potential conflicts of interest were disclosed by the other authors.
©2019 American Association for Cancer Research.
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Source: PubMed