The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor- β in Pregnancy Complicated by Placental Insufficiency

Dorota Darmochwal-Kolarz, Magdalena Michalak, Bogdan Kolarz, Monika Przegalinska-Kalamucka, Agnieszka Bojarska-Junak, Dariusz Sliwa, Jan Oleszczuk, Dorota Darmochwal-Kolarz, Magdalena Michalak, Bogdan Kolarz, Monika Przegalinska-Kalamucka, Agnieszka Bojarska-Junak, Dariusz Sliwa, Jan Oleszczuk

Abstract

Aim: The aim of the study was to evaluate the role of Interleukin-17 (IL-17), Interleukin-23 (IL-23), and transforming growth factor-β (TGF-β) in pregnancy complicated by placental insufficiency and in normal pregnancy.

Material and methods: The study comprised 34 patients with pregnancy complicated by fetal growth restriction (FGR) associated with preeclampsia (PE), as well as 35 healthy pregnant women. The concentrations of IL-17, IL-23, and TGF-β in sera from maternal peripheral blood were determined by an immunoenzymatic assay.

Results: There were higher concentrations of IL-17 in the study group when compared to the controls. In the group of patients with placental insufficiency, the levels of IL-17 positively correlated with systolic blood pressure (R = 0.42, p < 0.01). The study obtained comparable concentrations of IL-23 in both studied groups. The concentrations of TGF-β were significantly lower in pregnancy complicated by the insufficiency of placenta when compared to the controls.

Conclusions: It seems possible that the increased concentrations of IL-17 and the deficiency of TGF-β in pregnancy complicated by FGR and PE can be responsible for the activation of inflammatory response observed in PE cases.

Figures

Figure 1
Figure 1
The comparison of (a) IL-17, (b) IL-23, and (c) TGF-β concentrations in sera of patients with pregnancy complicated by placental insufficiency (n = 34) and healthy women with uncomplicated pregnancy (n = 35).

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Source: PubMed

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