Indications for haematopoietic cell transplantation for haematological diseases, solid tumours and immune disorders: current practice in Europe, 2022

John A Snowden, Isabel Sánchez-Ortega, Selim Corbacioglu, Grzegorz W Basak, Christian Chabannon, Rafael de la Camara, Harry Dolstra, Rafael F Duarte, Bertram Glass, Raffaella Greco, Arjan C Lankester, Mohamad Mohty, Bénédicte Neven, Régis Peffault de Latour, Paolo Pedrazzoli, Zinaida Peric, Ibrahim Yakoub-Agha, Anna Sureda, Nicolaus Kröger, European Society for Blood and Marrow Transplantation (EBMT), John A Snowden, Isabel Sánchez-Ortega, Selim Corbacioglu, Grzegorz W Basak, Christian Chabannon, Rafael de la Camara, Harry Dolstra, Rafael F Duarte, Bertram Glass, Raffaella Greco, Arjan C Lankester, Mohamad Mohty, Bénédicte Neven, Régis Peffault de Latour, Paolo Pedrazzoli, Zinaida Peric, Ibrahim Yakoub-Agha, Anna Sureda, Nicolaus Kröger, European Society for Blood and Marrow Transplantation (EBMT)

Abstract

For over two decades, the EBMT has updated recommendations on indications for haematopoietic cell transplantation (HCT) practice based on clinical and scientific developments in the field. This is the eighth special EBMT report on the indications for HCT for haematological diseases, solid tumours and immune disorders. Our aim is to provide general guidance on HCT indications according to prevailing clinical practice in EBMT countries and centres. In order to inform patient decisions, these recommendations must be considered in conjunction with the risk of the disease, risk of HCT procedure and non-transplant strategies, including evolving cellular therapies. HCT techniques are constantly evolving and we make no specific recommendations, but encourage harmonisation of practice, where possible, to ensure experience across indications can be meaningfully aggregated via registry outputs. We also recommend working according to JACIE accreditation standards to maintain quality in clinical and laboratory components of practice, including benchmarking of survival outcomes. Since the last edition, the COVID-19 pandemic has affected clinical decision making and activity across indications. Although the full impact of the pandemic is yet to be determined, we recommend that decision making across indications is delivered with ongoing reference to EBMT and national COVID-19 guidance, in accordance with current local conditions.

Conflict of interest statement

BG discloses employment and management position by Helios; advisory/expert activity by Roche, Celgene, BMS, Gilead, Janssen, Novartis, Riemser, MSD and Jazz; honoraria by BMS, Celgene, Novartis, Roche, Riemser, Janssen, MSD, Jazz and funding scientific research by Roche, Celgene and Amgen. RG discloses speaking honoraria from educational events supported by Biotest, Pfizer, Medac and Magenta. ACL discloses consultancy and research support by Neovii Biotec. MM discloses honoraria by Adaptive Biotechnologies, Amgen, Astellas, Celgene-BMS, GSK, Gilead, Janssen, Jazz Pharmaceuticals, Novartis, Oncopeptides, Pfizer, Sanofi, Takeda and research funding by Janssen and Sanofi. RPL discloses expert consultant/speaker’s fees by Alexion, Amgen, Gilead, Jazz, Keocyte, MSD, Novartis, Pfizer, Roche, Samsung and Sobi and research grant by Alexion, Amgen, Jazz pharmaceutical, Novartis and Pfizer. AS discloses honoraria by Takeda, BMS/Celgene, MSD, Janssen, Amgen, Novartis, Gilead Kite, Sanofi, Roche and Alexion; consultancy by Takeda, BMS/Celgene, Novartis, Janssen, Gilead and Sanofi; speaker’s bureau by Takeda and research support by Takeda and BMS/Celgene. JAS declares honoraria for educational events from Jazz, Gilead, Janssen, for advisory board membership from Medac, and for trial IDMC membership from Kiadis Pharma. The following authors declare that they have no conflict of interest in this manuscript: IS-O, SC, GWB, CC, RC, HD, RFD, BN, PP, ZP, IY-A and NK.

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Source: PubMed

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薬物療法

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