Gut Resistome After Oral Antibiotics in Preschool Children in Burkina Faso: A Randomized, Controlled Trial

Catherine E Oldenburg, Armin Hinterwirth, Ali Sié, Boubacar Coulibaly, Lucienne Ouermi, Clarisse Dah, Charlemagne Tapsoba, Susie L Cummings, Lina Zhong, Cindi Chen, Samarpita Sarkar, Till Bärnighausen, Thomas M Lietman, Jeremy D Keenan, Thuy Doan, Catherine E Oldenburg, Armin Hinterwirth, Ali Sié, Boubacar Coulibaly, Lucienne Ouermi, Clarisse Dah, Charlemagne Tapsoba, Susie L Cummings, Lina Zhong, Cindi Chen, Samarpita Sarkar, Till Bärnighausen, Thomas M Lietman, Jeremy D Keenan, Thuy Doan

Abstract

We evaluated the effect of systemic antibiotics (azithromycin, amoxicillin, cotrimoxazole, or placebo) on the gut resistome in children aged 6 to 59 months. Azithromycin and cotrimoxazole led to an increase in macrolide and sulfonamide resistance determinants. Resistome expansion can be induced with a single course of antibiotics.

Keywords: antimicrobial resistance; randomized controlled trial; resistome.

© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

Figures

Figure 1.
Figure 1.
Box plot of Chao1 richness of resistance genes by antibiotic arm. Individual points represent individual samples.

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Source: PubMed

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