Social support and resilience to stress: from neurobiology to clinical practice

Fatih Ozbay, Douglas C Johnson, Eleni Dimoulas, C A Morgan, Dennis Charney, Steven Southwick, Fatih Ozbay, Douglas C Johnson, Eleni Dimoulas, C A Morgan, Dennis Charney, Steven Southwick

Abstract

Numerous studies indicate social support is essential for maintaining physical and psychological health. The harmful consequences of poor social support and the protective effects of good social support in mental illness have been well documented. Social support may moderate genetic and environmental vulnerabilities and confer resilience to stress, possibly via its effects on the hypothalamic-pituitary-adrenocortical (HPA) system, the noradrenergic system, and central oxytocin pathways. There is a substantial need for additional research and development of specific interventions aiming to increase social support for psychiatrically ill and at-risk populations.

Keywords: cortisol; health; oxytocin; resilience; social support; stress.

References

    1. Southwick SM, Vythilingam M, Charney DS. The psychobiology of depression and resilience to stress: Implications for prevention and treatment. Annu Rev Clin Psychol. 2005;1:255–91.
    1. Charney DS. Psychobiological mechanism of resilience and vulnerability: Implications for successful adaptation to extreme stress. Am J Psychiatr. 2004;161:195–216.
    1. Geracioti TD, Jr, Baker DG, Ekhator NN, et al. CSF norepinephrine concentrations in posttraumatic stress disorder. Am J Psychiatry. 2001;158:1227–30.
    1. McFall ME, Murburg MM, Ko GN, Veith RC. Autonomic responses to stress in Vietnam combat veterans with posttraumatic stress disorder. Biol Psychiatry. 1990;27:1165–75.
    1. Southwick SM, Bremner JD, Rasmusson A, et al. Role of norepinephrine in the pathophysiology and treatment of posttraumatic stress disorder. Biol Psychiatry. 1999;46:1192–204.
    1. Morgan CA, III, Wang S, Southwick SM, et al. Plasma neuropeptide-Y concentrations in humans exposed to military survival training. Biol Psychiatry. 2000;47:902–9.
    1. Morgan CA, III, Rasmusson AM, Wang S, et al. Neuropeptide-Y, cortisol, and subjective distress in humans exposed to acute stress: Replication and extension of previous report. Biol Psychiatr. 2002;52:136–42.
    1. Rasmusson AM, Hauger RL, Morgan CA, et al. Low baseline and yohimbine-stimulated plasma neuropeptide Y (NPY) levels in combat- related PTSD. Biol Psychiatry. 2000;47:526–39.
    1. Yehuda R. Current status of cortisol findings in posttraumatic stress disorder. Psychiatr Clin N Am. 2002;25:341–68.
    1. Karlamangla AS, Singer BH, McEwen BS, et al. Allostatic load as a predictor of functional decline. MacArthur studies of successful aging. J Clin Epidemiol. 2002;55:696–710.
    1. Rasmusson AM, Vasek J, Lipschitz DS, et al. An increased capacity for adrenal DHEA release is associated with decreased avoidance and negative mood symptoms in women with PTSD. Neuropsychopharmacology. 2004;29:1546–57.
    1. Morgan CA, III, Southwick S, Hazlett G, et al. Relationships among plasma dehydroepiandrosterone sulfate and cortisol levels, symptoms of dissociation, and objective performance in humans exposed to acute stress. Arch Gen Psychiatry. 2004;61:819–25.
    1. Rasmusson AM, Pinna G, Paliwal P, et al. Decreased cerebrospinal fluid allopregnanolone levels in women with posttraumatic stress disorder. Biol Psychiatr. 2006;60:704–13.
    1. Lin N, Simeone RS, Ensel WM, Kuo W. Social support, stressful life events, and illness: A model and an empirical test. J Health Soc Behav. 1979;20:108–19.
    1. Stice E, Ragan J, Randall P. Prospective relations between social support and depression: Differential direction of effects for parent and peer support? J Abnorm Psychol. 2004;113:155–9.
    1. Lynch TR, Mendelson T, Robins CJ, et al. Perceived social support among depressed elderly, middle-aged, and young-adult samples: Cross-sectional and longitudinal analyses. J Affect Disord. 1999;55:159–70.
    1. Hyman SM, Gold SN, Cott MA. Forms of social support that moderate PTSD in childhood sexual abuse survivors. J Fam Violence. 2003;18:295–300. Srnger.
    1. Rozanski A, Blumenthal JA, Kaplan J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation. 1999;99:2192–217.
    1. Fontana AF, Kerns RD, Rosenberg RL, Colonese KL. Support, stress, and recovery from coronary heart disease: A longitudinal causal model. Health Psycho. 1989;8:175–93.
    1. Moos RH, Schaefer JA. Coping resources and processes: Current concepts and measures. In: Goldberger A, Breznitz S, editors. Handbook of Stress. Second. New York, NY: The Free Press; 1993. pp. 234–57.
    1. Shively CA, Clarkson TB, Kaplan JR. Social deprivation and coronary artery atherosclerosis in female cynomolgus monkeys. Atherosclerosis. 1989;77:69–76.
    1. Stanton ME, Patterson JM, Levine S. Social influences on conditioned cortisol secretion in the squirrel monkey. Psychoneuroendocrinology. 1985;10:125–34.
    1. Sapolsky RM, Alberts SC, Altmann J. Hypercortisolism associated with social subordinance or social isolation among wild baboons. Arch Gen Psychiatr. 1997;54:1137–43.
    1. Ratcliffe HL, Luginbuhl H, Schnarr WR, Chacko K. Coronary arteriosclerosis in swine: Evidence of a relation to behavior. J Comp Physiol Psychol. 1969;68:385-92.
    1. Sapolsky RM. In: Why Zebras Don't Get Ulcers. Third. Sapolsky RM, editor. New York: Times Books; 2004.
    1. Stansfeld SA, Fuhrer R, Head J, et al. Work and psychiatric disorder in the whitehall II study. J Psychosom Res. 1997;43:73–81.
    1. Uchino BN, Cacioppo JT, Kiecolt-Glaser JK. The relationship between social support and physiological processes: A review with emphasis on underlying mechanisms and implications for health. Psychol Bul. 1996;119:488–531.
    1. Kamarck TW, Annunziato B, Amateau LM. Affiliation moderates the effects of social threat on stress-related cardiovascular responses: Boundary conditions for a laboratory model of social support. Psychosom Med. 1995;57:183–194.
    1. Kirschbaum C, Klauer T, Filipp SH, Hellhammer DH. Sex-specific effects of social support on cortisol and subjective responses to acute psychological stress. Psychosom Med. 1995;57:23–31.
    1. Lepore SJ, Allen KA, Evans GW. Social support lowers cardiovascular reactivity to an acute stressor. Psychosom Med. 1993;55:518–24.
    1. Steptoe A, Owen N, Kunz-Ebrecht SR, Brydon L. Loneliness and neuroendocrine, cardiovascular, and inflammatory stress responses in middle-aged men and women. Psychoneuroendocrinology. 2004;29:593–611.
    1. Bartz JA, Hollander E. The neuroscience of affiliation: Forging links between basic and clinical research on neuropeptides and social behavior. Horm Beha. 2006;50:518–528.
    1. Francis DD, Champagne FC, Meaney MJ. Variations in maternal behaviour are associated with differences in oxytocin receptor levels in the rat. J Neuroendocrinol. 2000;12:1145–8.
    1. Insel TR, Shapiro LE. Oxytocin receptor distribution reflects social organization in monogamous and polygamous voles. Proc Natl Acad Sci U S A. 1992;89:5981–5.
    1. Neumann ID, Torner L, Wigger A. Brain oxytocin: Differential inhibition of neuroendocrine stress responses and anxiety-related behaviour in virgin, pregnant and lactating rats. Neuroscience. 2000;95:567–75.
    1. Heinrichs M, Baumgartner T, Kirschbaum C, Ehlert U. Social support and oxytocin interact to suppress cortisol and subjective responses to psychosocial stress. Biol Psychiatry. 2003;54:1389–98.
    1. Berkman LF. The role of social relations in health promotion. Psychosom Med. 1995;57:245–54.
    1. Paykel ES. Life events, social support and depression. Acta Psychiatr Scand Suppl. 1994;377:50–8.
    1. Oxman TE, Hull JG. Social support and treatment response in older depressed primary care patients. J Gerontol B Psychol Sci Soc Sci. 2001;56:P35–45.
    1. Michalak EE, Wilkinson C, Hood K, et al. Seasonality, negative life events, and social support in a community sample. Br J Psychiatry. 2003;182:434–8.
    1. Mohr DC, Classen C. Barrera Jr. M. The relationship between social support, depression, and treatment for depression in people with multiple sclerosis. Psychol Med. 2004;34:533–541.
    1. Manne SL, Pape SJ, Taylor KL, Dougherty J. Spouse support, coping, and mood among individuals with cancer. Ann Behav Med. 1999;21:111–21.
    1. Revenson TA, Schiaffino KM, Majerovitz SD, Gibofsky A. Social support as a double-edged sword: The relation of positive and problematic support to depression among rheumatoid arthritis patients. Soc Sci Med. 1991;33:807–13.
    1. Johnson DR, Lubin H, Rosenheck R, et al. The impact of the homecoming reception on the development of posttraumatic stress disorder. the west haven homecoming stress scale (WHHSS) J Trauma Stress. 1997;10:259–77.
    1. Resick PA. Stress and Trauma. New York, NY: Psychology Press; 2001.
    1. Travis LA, Lyness JM, Shields CG, et al. Social support, depression, and functional disability in older adult primary-care patients. Am J Geriatr Psychiatry. 2004;12:265–71.
    1. Sayal K, Checkley S, Rees M, et al. Effects of social support during weekend leave on cortisol and depression ratings: A pilot study. J Affect Dis. 2002;71:153–7.
    1. Boscarino JA. Post-traumatic stress and associated disorders among vietnam veterans: The significance of combat exposure and social support. J Trauma Stress. 1995;8:317–36.
    1. Kaufman J, Yang BZ, Douglas-Palumberi H, et al. Brain-derived neurotrophic factor-5-HTTLPR gene interactions and environmental modifiers of depression in children. Biol Psychiatry. 2006;59:673–80.
    1. Weaver IC, Cervoni N, Champagne FA, et al. Epigenetic programming by maternal behavior. Nat Neurosci. 2004;7:847–54.

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