Testing the effects of gentle vibrotactile stimulation on symptom relief in fibromyalgia

Jesus Pujol, Daniel Ramos-López, Laura Blanco-Hinojo, Guillem Pujol, Héctor Ortiz, Gerard Martínez-Vilavella, Josep Blanch, Jordi Monfort, Joan Deus, Jesus Pujol, Daniel Ramos-López, Laura Blanco-Hinojo, Guillem Pujol, Héctor Ortiz, Gerard Martínez-Vilavella, Josep Blanch, Jordi Monfort, Joan Deus

Abstract

Background: Sensory disturbances in fibromyalgia extend beyond nociception. It has been proposed that imbalance in the mutual competition between painful input and non-painful sensory activity may, to a significant extent, account for the augmented subjective perception of pain. In this context, non-nociceptive somatosensory stimulation could arguably attenuate fibromyalgia symptoms by restoring the sensory balance. We specifically tested the effect of vibrotactile stimulation on symptom relief in fibromyalgia patients with a randomized, double-blind, sham-controlled, crossover clinical trial.

Methods: Seventy-seven female patients were randomized and data from 63 valid cases were analyzed. Active intervention involved extensive body stimulation with gentle mechanical vibrations administered during 3 h at night for 3 weeks, and the placebo effect was controlled using identical instruments to simulate an alternative treatment option. The primary outcome measure combined pain, fatigue, and complaints of poor cognition.

Results: Vibrotactile stimulation was significantly superior to sham in alleviating fibromyalgia symptoms globally. However, univariate analyses showed that the effect was not universal. Benefits were perceived on unpleasant somatic sensations such as generalized pain and fatigue, but not on poor cognition, anxiety, and depression. Vibrotactile stimulation was notably well tolerated and sleep quality significantly improved despite the fact that vibrations were administered at night.

Conclusions: Results thus provide new evidence that non-nociceptive somatosensory stimulation may favorably act upon altered somatosensory balance in fibromyalgia. From a clinical perspective, both the degree of improvement and the easy application of our proposal would seem to support a potential role for vibrotactile stimulation in the symptomatic treatment of fibromyalgia.

Trial registration: ClinicalTrials.gov registration number NCT03227952 . Registered 24 July, 2017.

Keywords: Fibromyalgia; Pain; Sensory balance; Somatosensory system; Vibrotactile stimulation.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Instruments used to administer vibrotactile stimulation (above) and sham (bottom). An electronic engine controlled stimuli delivery. Mechanical vibrotactile stimuli were generated using 6 vibration motors fitted into a standard mattress. Sham treatment was applied using identical instruments, with an electrical signal turning on a pilot light to indicate that the (simulated) treatment was operative
Fig. 2
Fig. 2
CONSORT flow diagram
Fig. 3
Fig. 3
Bar graphs showing NRS score reduction for the three fibromyalgia key symptoms
Fig. 4
Fig. 4
Bar graphs showing NRS score reduction for fatigue separately for each allocation group to illustrate the intervention order effect

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