Antacid effects of Chinese herbal prescriptions assessed by a modified artificial stomach model

Abstract

Aim: To assess the antacid effects of the tonic Chinese herbal prescriptions, si-jun-zi-tang (SJZT) and shen-ling-bai-zhu-san (SLBZS).

Methods: Decoctions of the tonic Chinese herbal prescriptions, SJZT and SLBZS, were prepared according to Chinese original documents. The pH of the prescription decoctions and their neutralizing effects on artificial gastric acids were determined and compared with water and the active controls, sodium bicarbonate and colloidal aluminum phosphate. A modified model of Vatier's artificial stomach was used to determine the duration of consistent neutralization effect on artificial gastric acids. The neutralization capacity in vitro was determined with the titration method of Fordtran's model.

Results: The results showed that both SJZT and SLBZS have antacid effects in vitro. Compared with the water group, SJZT and SLBZS were found to possess significant gastric acid neutralizing effects. The duration for consistent neutralization of SLBZS was significantly longer than that of water. Also, SLBZS and SJZT exhibited significant antacid capacities compared to water.

Conclusion: SJZT and SLBZS were consistently active in the artificial stomach model and are suggested to have antacid effects similar to the active control drugs.

Figures

Figure 1

pH values of test samples determined at temperatures from 25°C to 37°C. SJZT: Si-Jun-Zi-Tang; SLBZS: Shen-Ling-Bai-Zhu-San; CAP: Colloidal aluminum phosphate; SB: Sodium bicarbonate.

Figure 2

Duration of antacid effect for consistent neutralization of gastric acids. Ninety mililiters of test sample was added to 100 mL of artificial gastric juices at pH 1.2 in an artificial stomach. The duration was determined as the pH value was returned to 1.2. SJZT: Si-Jun-Zi-Tang; SLBZS: Shen-Ling-Bai-Zhu-San; CAP: Colloidal aluminum phosphate; SB: Sodium bicarbonate.