Prevalence, risk factors, and glycaemic control of type 2 diabetes mellitus in eastern Sudan: a community-based study

Saeed M Omar, Imad R Musa, Amir ElSouli, Ishag Adam, Saeed M Omar, Imad R Musa, Amir ElSouli, Ishag Adam

Abstract

Background: Diabetes mellitus (DM) constitutes a global health threat and burden, especially in developing countries. We conducted a cross-sectional study in Gadarif in eastern Sudan to evaluate the prevalence and glycaemic control of patients with type 2 diabetes mellitus (T2DM).

Methods: We performed a cross-sectional community-based study. Data on blood glucose levels, and anthropometric, demographic and clinical history data were obtained.

Results: Six hundred Sudanese adults with a mean (SD) age of 44.9 (16.5) years were enrolled. More than two-thirds (70.3%) of the study participants were women. The prevalence of T2DM, newly diagnosed T2DM and uncontrolled T2DM was 20.8%, 10.0% and 80.0%, respectively. Logistic regression analysis showed no significant association between education, marital status, body mass index, waist circumference and DM. However older age (AOR = 4.88, 95% CI = 3.09-7.70) and a family history of DM (AOR = 2.58, 95% CI = 1.59-4.20) were associated with T2DM.

Conclusion: The prevalence of T2DM is high among the Sudanese population, especially in older people and those with a family history of DM. The high prevalence of uncontrolled DM in this setting is another hidden burden.

Keywords: Sudan; diabetes; glycaemic control; prevalence.

Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

References

    1. WHO. Global health estimates, (2018, accessed 14 January 2019).
    1. International Diabetes Federation. IDF diabetes atlas. 8th ed. Brussels: International Diabetes Federation, 2017.
    1. Boutayeb A, Lamlili MEN, Boutayeb W, et al. The rise of diabetes prevalence in the Arab region. Open J Epidemiol 2012; 2: 55–60.
    1. Holman N, Young B, Gadsby R. Current prevalence of type 1 and type 2 diabetes in adults and children in the UK. Diabet Med 2015; 32: 1119–1120.
    1. Wang S, Ma W, Yuan Z, et al. Association between obesity indices and type 2 diabetes mellitus among middle-aged and elderly people in Jinan, China: a cross-sectional study. BMJ Open 2016; 6: e012742.
    1. Nayak SB, Rahming V, Raghunanan Y, et al. Prevalence of diabetes, obesity and dyslipidaemia in persons within high and low income groups living in North and South Trinidad. J Clin Diagn Res 2016; 10: IC08–IC13.
    1. Al-Quwaidhi A, Critchley J, O’Flaherty M, et al. Obesity and type 2 diabetes mellitus: a complex association. Saudi J Obes 2013; 1: 49–56.
    1. Babu GR, Murthy G, Ana Y, et al. Association of obesity with hypertension and type 2 diabetes mellitus in India: a meta-analysis of observational studies. World J Diabetes 2018; 9: 40–52.
    1. Chang SA, Kim HS, Yoon KH, et al. Body mass index is the most important determining factor for the degree of insulin resistance in non-obese type 2 diabetic patients in Korea. Metabolism 2004; 53: 142–146.
    1. Youssef G, Nagy S, El-Gengehe A, et al. Masked uncontrolled hypertension: prevalence and predictors. Egypt Hear J 2018; 70: 369–373.
    1. Ramaswamy G, Chinnakali P, Selvaraju S, et al. High prevalence of prediabetes among the family members of individuals with diabetes: findings from targeted screening program from south India. Diabetes Metab Syndr Clin Res Rev 2019; 13: 866–872.
    1. Volaco A, Cavalcanti AM, Filho RP, et al. Socioeconomic status: the missing link between obesity and diabetes mellitus? Curr Diabetes Rev 2018; 14: 321–326.
    1. Elmadhoun WM, Noor SK, Ibrahim AA, et al. Prevalence of diabetes mellitus and its risk factors in urban communities of Sudan: population-based study. J Diabetes 2016; 8: 839–846.
    1. Forouhi NG, Wareham NJ. Epidemiology of diabetes. Medicine (Baltimore) 2014; 42: 698–702.
    1. Ploth DW, Mbwambo JK, Fonner VA, et al. Prevalence of CKD, diabetes, and hypertension in rural Tanzania. Kidney Int Reports 2018; 3: 905–915.
    1. Isara AR, Okundia PO. The burden of hypertension and diabetes mellitus in rural communities in Southern Nigeria. Pan Afr Med J 2015; 20: 1–7.
    1. Bello-Ovosi BO, Asuke S, Abdulrahman SO, et al. Prevalence and correlates of hypertension and diabetes mellitus in an urban community in north-western Nigeria. Pan Afr Med J 2018; 29: 1–7.
    1. Worede A, Alemu S, Gelaw YA, et al. The prevalence of impaired fasting glucose and undiagnosed diabetes mellitus and associated risk factors among adults living in a rural Koladiba town, northwest Ethiopia. BMC Res Notes 2017; 10: 1–7.
    1. Noor SK, Elmadhoun WM, Bushara SO, et al. Glycaemic control in Sudanese individuals with type 2 diabetes: population based study. Diabetes Metab Syndr Clin Res Rev 2017; 11: S147–S151.
    1. Bushara SO, Noor SK, Elmadhoun WM, et al. Undiagnosed hypertension in a rural community in Sudan and association with some features of the metabolic syndrome: how serious is the situation? Ren Fail 2015; 37: 1022–1026.
    1. Modawi HF, Ibrahim MEA, Hassan MMA. Use of MODIS imagery to generate ahistorical background of wildland fire regime in Southern part of Gedaref State-Sudan, (2015, accessed 19 April 2019).
    1. Riley L, Guthold R, Cowan M, et al. The World Health Organization STEPwise approach to noncommunicable disease risk-factor surveillance: methods, challenges, and opportunities. Am J Public Health 2016; 106: 74–78.
    1. Omar SM, Musa IR, Osman OE, et al. Assessment of glycemic control in type 2 diabetes in the Eastern Sudan. BMC Res Notes 2018; 11: 373.
    1. American Diabetes Association. Glycemic targets: standards of medical care in diabetes – 2018. Diabetes Care 2018; 41: S55–S64.
    1. Eltom MA, Babiker Mohamed AH, Elrayah-Eliadarous H, et al. Increasing prevalence of type 2 diabetes mellitus and impact of ethnicity in North Sudan. Diabetes Res Clin Pract 2017; 136: 93–99.
    1. Khedr EM, Fawi G, Allah Abbas MA, et al. Prevalence of diabetes and diabetic neuropathy in Qena Governorate: population-based survey. Neuroepidemiology 2016; 46: 173–181.
    1. Arugu GM, Maduka O. Risk factors for diabetes mellitus among adult residents of a rural district in Southern Nigeria: implications for prevention and control. Niger J Clin Pract 2017; 20: 1544–1549.
    1. Noor SK, Bushara SO, Sulaiman AA, et al. Undiagnosed diabetes mellitus in rural communities in Sudan: prevalence and risk factors. East Mediterr Health J 2015; 21: 164–170.
    1. Aynalem SB, Zeleke AJ. Prevalence of diabetes mellitus and its risk factors among individuals aged 15 years and above in Mizan-Aman Town, Southwest Ethiopia, 2016: a cross sectional study. Int J Endocrinol 2018; 2018: 1–7.
    1. Suvarna P, Shruti K, Maruti D, et al. Diabetes in the Kokan region of India. World J Diabetes 2019; 10: 37–46.
    1. Vijayakumar G, Manghat S, Vijayakumar R, et al. Incidence of type 2 diabetes mellitus and prediabetes in Kerala, India: results from a 10-year prospective cohort. BMC Public Health 2019; 19: 140.
    1. Cheung BM, Wat NM, Tso AW, et al. Association between raised blood pressure and dysglycemia in Hong Kong Chinese. Diabetes Care 2008; 31: 1889–1891.
    1. Song X, Qiu M, Zhang X, et al. Gender-related affecting factors of prediabetes on its 10-year outcome. BMJ Open Diabetes Res Care 2016; 4: e000169.
    1. Sattar N. Gender aspects in type 2 diabetes mellitus and cardiometabolic risk. Best Pract Res Clin Endocrinol Metab 2013; 27: 501–507.
    1. Wikner C, Gigante B, Hellénius ML, et al. The risk of type 2 diabetes in men is synergistically affected by parental history of diabetes and overweight. PLoS One 2013; 8: e61763.
    1. Cornelis MC, Glymour M, Kawachi I, et al. Abstract P213: marital status and risk of type 2 diabetes in the health professionals follow-up study. Circulation 2012; 125: 213.
    1. Cornelis MC, Chiuve SE, Glymour MM, et al. Bachelors, divorcees, and widowers: does marriage protect men from type 2 diabetes? PLoS One 2014; 9: e106720.
    1. Chang SA. Smoking and type 2 diabetes mellitus. Diabetes Metab J 2012; 36: 399–403.
    1. Ailhaud G, Reach G. Does obesity protect against diabetes? A new controversy. Ann Endocrinol (Paris) 2001; 62: S43–S54.
    1. Ji Y, Yiorkas AM, Frau F, et al. Genome-wide and abdominal MRI data provide evidence that a genetically determined favorable adiposity phenotype is characterized by lower ectopic liver fat and lower risk of type 2 diabetes, heart disease, and hypertension. Diabetes 2019; 68: 207–219.
    1. InterAct Consortium, Spijkerman AM, van der A DL, et al. Smoking and long-term risk of type 2 diabetes: the EPIC-interact study in European populations. Diabetes Care 2014; 37: 3164–3171.
    1. White WB, Cain LR, Benjamin EJ, et al. High-intensity cigarette smoking is associated with incident diabetes mellitus in black adults: the Jackson heart study. J Am Heart Assoc 2018; 7: pii: e007413.
    1. Akter S, Goto A, Mizoue T. Smoking and the risk of type 2 diabetes in Japan: a systematic review and meta-analysis. J Epidemiol 2017; 27: 553–561.
    1. Gatimu SM, Milimo BW, Sebastian MS. Prevalence and determinants of diabetes among older adults in Ghana. BMC Public Health 2016; 16: 1174.
    1. Metcalf PA, Scragg RK, Jackson R. Light to moderate alcohol consumption is protective for type 2 diabetes mellitus in normal weight and overweight individuals but not the obese. J Obes 2014; 2014: 634587.
    1. Awadalla H, Noor SK, Elmadhoun WM, et al. Diabetes complications in Sudanese individuals with type 2 diabetes: overlooked problems in sub-Saharan Africa? Diabetes Metab Syndr 2017; 11(Suppl. 2): S1047–S1051.
    1. Ashur ST, Shah SA, Bosseri S, et al. Glycaemic control status among type 2 diabetic patients and the role of their diabetes coping behaviours: a clinic-based study in Tripoli, Libya. Libyan J Med 2016; 11: 1–9.
    1. Adeniyi OV, Yogeswaran P, Longo-Mbenza B, et al. Cross-sectional study of patients with type 2 diabetes in OR Tambo district, South Africa. BMJ Open 2016; 6: 10875.
    1. Fiagbe J, Bosoka S, Opong J, et al. Prevalence of controlled and uncontrolled diabetes mellitus and associated factors of controlled diabetes among diabetic adults in the Hohoe municipality of Ghana. Diabetes Manag 2017; 7: 343–354.

Source: PubMed

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