Design and methodology of the Swiss Transplant Cohort Study (STCS): a comprehensive prospective nationwide long-term follow-up cohort

Michael T Koller, Christian van Delden, Nicolas J Müller, Philippe Baumann, Christian Lovis, Hans-Peter Marti, Thomas Fehr, Isabelle Binet, Sabina De Geest, Heiner C Bucher, Pascal Meylan, Manuel Pascual, Jürg Steiger, Michael T Koller, Christian van Delden, Nicolas J Müller, Philippe Baumann, Christian Lovis, Hans-Peter Marti, Thomas Fehr, Isabelle Binet, Sabina De Geest, Heiner C Bucher, Pascal Meylan, Manuel Pascual, Jürg Steiger

Abstract

In Switzerland, organ procurement is well organized at the national-level but transplant outcomes have not been systematically monitored so far. Therefore, a novel project, the Swiss Transplant Cohort Study (STCS), was established. The STCS is a prospective multicentre study, designed as a dynamic cohort, which enrolls all solid organ recipients at the national level. The features of the STCS are a flexible patient-case system that allows capturing all transplant scenarios and collection of patient-specific and allograft-specific data. Beyond comprehensive clinical data, specific focus is directed at psychosocial and behavioral factors, infectious disease development, and bio-banking. Between May 2008 and end of 2011, the six Swiss transplant centers recruited 1,677 patients involving 1,721 transplantations, and a total of 1,800 organs implanted in 15 different transplantation scenarios. 10 % of all patients underwent re-transplantation and 3% had a second transplantation, either in the past or during follow-up. 34% of all kidney allografts originated from living donation. Until the end of 2011 we observed 4,385 infection episodes in our patient population. The STCS showed operative capabilities to collect high-quality data and to adequately reflect the complexity of the post-transplantation process. The STCS represents a promising novel project for comparative effectiveness research in transplantation medicine.

Figures

Fig. 1
Fig. 1
Organization of the Swiss Transplant Cohort Study patient-case system based on a hypothetical complex transplantation scenario
Fig. 2
Fig. 2
Overall patient survival by first transplantation in the Swiss Transplant Cohort Study (1.5.2008 until 30.09.2011)
Fig. 3
Fig. 3
Rate of proven infectious diseases by type of transplantation and pathogen in the Swiss Transplant Cohort Study (1.5.2008 until 31.12.2011)

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Source: PubMed

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