An Official American Thoracic Society/European Respiratory Society Statement: Research questions in chronic obstructive pulmonary disease
Bartolome R Celli, Marc Decramer, Jadwiga A Wedzicha, Kevin C Wilson, Alvar Agustí, Gerard J Criner, William MacNee, Barry J Make, Stephen I Rennard, Robert A Stockley, Claus Vogelmeier, Antonio Anzueto, David H Au, Peter J Barnes, Pierre-Regis Burgel, Peter M Calverley, Ciro Casanova, Enrico M Clini, Christopher B Cooper, Harvey O Coxson, Daniel J Dusser, Leonardo M Fabbri, Bonnie Fahy, Gary T Ferguson, Andrew Fisher, Monica J Fletcher, Maurice Hayot, John R Hurst, Paul W Jones, Donald A Mahler, François Maltais, David M Mannino, Fernando J Martinez, Marc Miravitlles, Paula M Meek, Alberto Papi, Klaus F Rabe, Nicolas Roche, Frank C Sciurba, Sanjay Sethi, Nikos Siafakas, Don D Sin, Joan B Soriano, James K Stoller, Donald P Tashkin, Thierry Troosters, Geert M Verleden, Johny Verschakelen, Jorgen Vestbo, John W Walsh, George R Washko, Robert A Wise, Emiel F M Wouters, Richard L ZuWallack, ATS/ERS Task Force for COPD Research, Bartolome R Celli, Marc Decramer, Jadwiga A Wedzicha, Kevin C Wilson, Alvar Agust, Gerard J Criner, William MacNee, Barry J Make, Stephen I Rennard, Robert A Stockley, Claus Vogelmeier, Antonio Anzueto, David H Au, Peter J Barnes, Pierre-Regis Burgel, Peter M Calverley, Ciro Casanova, Enrico M Clini, Christopher B Cooper, Harvey O Coxson, Daniel J Dusser, Leonardo M Fabbri, Bonnie Fahy, Gary T Ferguson, Andrew Fisher, Monica J Fletcher, Maurice Hayot, John R Hurst, Paul W Jones, Donald A Mahler, François Maltais, David M Mannino, Fernando J Martinez, Marc Miravitlles, Paula M Meek, Alberto Papi, Klaus F Rabe, Nicolas Roche, Frank C Sciurba, Sanjay Sethi, Nikos Siafakas, Don D Sin, Joan B Soriano, James K Stoller, Donald P Tashkin, Thierry Troosters, Geert M Verleden, Johny Verschakelen, Jorgen Vestbo, John W Walsh, George R Washko, Robert A Wise, Emiel F M Wouters, Richard L Zuwallack, Bartolome R Celli, Marc Decramer, Jadwiga A Wedzicha, Kevin C Wilson, Alvar Agustí, Gerard J Criner, William MacNee, Barry J Make, Stephen I Rennard, Robert A Stockley, Claus Vogelmeier, Antonio Anzueto, David H Au, Peter J Barnes, Pierre-Regis Burgel, Peter M Calverley, Ciro Casanova, Enrico M Clini, Christopher B Cooper, Harvey O Coxson, Daniel J Dusser, Leonardo M Fabbri, Bonnie Fahy, Gary T Ferguson, Andrew Fisher, Monica J Fletcher, Maurice Hayot, John R Hurst, Paul W Jones, Donald A Mahler, François Maltais, David M Mannino, Fernando J Martinez, Marc Miravitlles, Paula M Meek, Alberto Papi, Klaus F Rabe, Nicolas Roche, Frank C Sciurba, Sanjay Sethi, Nikos Siafakas, Don D Sin, Joan B Soriano, James K Stoller, Donald P Tashkin, Thierry Troosters, Geert M Verleden, Johny Verschakelen, Jorgen Vestbo, John W Walsh, George R Washko, Robert A Wise, Emiel F M Wouters, Richard L ZuWallack, ATS/ERS Task Force for COPD Research, Bartolome R Celli, Marc Decramer, Jadwiga A Wedzicha, Kevin C Wilson, Alvar Agust, Gerard J Criner, William MacNee, Barry J Make, Stephen I Rennard, Robert A Stockley, Claus Vogelmeier, Antonio Anzueto, David H Au, Peter J Barnes, Pierre-Regis Burgel, Peter M Calverley, Ciro Casanova, Enrico M Clini, Christopher B Cooper, Harvey O Coxson, Daniel J Dusser, Leonardo M Fabbri, Bonnie Fahy, Gary T Ferguson, Andrew Fisher, Monica J Fletcher, Maurice Hayot, John R Hurst, Paul W Jones, Donald A Mahler, François Maltais, David M Mannino, Fernando J Martinez, Marc Miravitlles, Paula M Meek, Alberto Papi, Klaus F Rabe, Nicolas Roche, Frank C Sciurba, Sanjay Sethi, Nikos Siafakas, Don D Sin, Joan B Soriano, James K Stoller, Donald P Tashkin, Thierry Troosters, Geert M Verleden, Johny Verschakelen, Jorgen Vestbo, John W Walsh, George R Washko, Robert A Wise, Emiel F M Wouters, Richard L Zuwallack
Abstract
Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity, mortality, and resource use worldwide. The goal of this Official American Thoracic Society (ATS)/European Respiratory Society (ERS) Research Statement is to describe evidence related to diagnosis, assessment, and management; identify gaps in knowledge; and make recommendations for future research. It is not intended to provide clinical practice recommendations on COPD diagnosis and management.
Methods: Clinicians, researchers, and patient advocates with expertise in COPD were invited to participate. A literature search of Medline was performed, and studies deemed relevant were selected. The search was not a systematic review of the evidence. Existing evidence was appraised and summarized, and then salient knowledge gaps were identified.
Results: Recommendations for research that addresses important gaps in the evidence in all areas of COPD were formulated via discussion and consensus.
Conclusions: Great strides have been made in the diagnosis, assessment, and management of COPD as well as understanding its pathogenesis. Despite this, many important questions remain unanswered. This ATS/ERS Research Statement highlights the types of research that leading clinicians, researchers, and patient advocates believe will have the greatest impact on patient-centered outcomes.
Source: PubMed