Neuromuscular Function of the Knee Joint Following Knee Injuries: Does It Ever Get Back to Normal? A Systematic Review with Meta-Analyses

Beyza Tayfur, Chedsada Charuphongsa, Dylan Morrissey, Stuart Charles Miller, Beyza Tayfur, Chedsada Charuphongsa, Dylan Morrissey, Stuart Charles Miller

Abstract

Background: Neuromuscular deficits are common following knee injuries and may contribute to early-onset post-traumatic osteoarthritis, likely mediated through quadriceps dysfunction.

Objective: To identify how peri-articular neuromuscular function changes over time after knee injury and surgery.

Design: Systematic review with meta-analyses.

Data sources: PubMed, Web of Science, Embase, Scopus, CENTRAL (Trials).

Eligibility criteria for selecting studies: Moderate and high-quality studies comparing neuromuscular function of muscles crossing the knee joint between a knee-injured population (ligamentous, meniscal, osteochondral lesions) and healthy controls. Outcomes included normalized isokinetic strength, muscle size, voluntary activation, cortical and spinal-reflex excitability, and other torque related outcomes.

Results: A total of 46 studies of anterior cruciate ligament (ACL) and five of meniscal injury were included. For ACL injury, strength and voluntary activation deficits were evident (moderate to strong evidence). Cortical excitability was not affected at < 6 months (moderate evidence) but decreased at 24+ months (moderate evidence). Spinal-reflex excitability did not change at < 6 months (moderate evidence) but increased at 24+ months (strong evidence). We also found deficits in torque variability, rate of torque development, and electromechanical delay (very limited to moderate evidence). For meniscus injury, strength deficits were evident only in the short-term. No studies reported gastrocnemius, soleus or popliteus muscle outcomes for either injury. No studies were found for other ligamentous or chondral injuries.

Conclusions: Neuromuscular deficits persist for years post-injury/surgery, though the majority of evidence is from ACL injured populations. Muscle strength deficits are accompanied by neural alterations and changes in control and timing of muscle force, but more studies are needed to fill the evidence gaps we have identified. Better characterisation and therapeutic strategies addressing these deficits could improve rehabilitation outcomes, and potentially prevent PTOA.

Trial registration number: PROSPERO CRD42019141850.

Conflict of interest statement

Beyza Tayfur, Chedsada Charuphongsa, Dylan Morrissey and Stuart Miller declare that they have no conflicts of interest relevant to the content of this review.

Figures

Fig. 1
Fig. 1
Flow diagram of the study selection process
Fig. 2
Fig. 2
Findings and literature gap map for anterior cruciate ligament studies. Colours represent the evidence level as by van Tulder et al. [40] and directions represent injured group data when compared to control, with the effect size. SMD standardised mean difference, ST semitendinosus, BF biceps femoris, Ham:Quad hamstring:quadriceps
Fig. 3
Fig. 3
Findings and literature gap map for meniscus studies. Colours represent the evidence level as by van Tulder et al. [40] and directions represent injured group data when compared to control, with the effect size. SMD standardised mean difference, ST semitendinosus, BF biceps femoris, Ham:Quad hamstring:quadriceps
Fig. 4
Fig. 4
Forest plot of quadriceps active motor threshold from anterior cruciate ligament studies (increased active motor threshold meaning decreased cortical excitability)
Fig. 5
Fig. 5
Forest plot of quadriceps Hoffman reflex (spinal excitability) from anterior cruciate ligament studies
Fig. 6
Fig. 6
Forest plot of quadriceps voluntary activation from anterior cruciate ligament studies
Fig. 7
Fig. 7
Forest plot of quadriceps slow concentric strength from anterior cruciate ligament studies
Fig. 8
Fig. 8
Forest plot of hamstring slow concentric strength from anterior cruciate ligament studies

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