Microbiota transplantation: concept, methodology and strategy for its modernization

Faming Zhang, Bota Cui, Xingxiang He, Yuqiang Nie, Kaichun Wu, Daiming Fan, FMT-standardization Study Group, Baisui Feng, Dongfeng Chen, Jianlin Ren, Mingming Deng, Ning Li, Pengyuan Zheng, Qing Cao, Shaoqi Yang, Xingxiang He, Yu Liu, Yuqiang Nie, Yongjian Zhou, Daiming Fan, Kaichun Wu, Yongzhan Nie, Guozhong Ji, Pan Li, Bota Cui, Faming Zhang, Faming Zhang, Bota Cui, Xingxiang He, Yuqiang Nie, Kaichun Wu, Daiming Fan, FMT-standardization Study Group, Baisui Feng, Dongfeng Chen, Jianlin Ren, Mingming Deng, Ning Li, Pengyuan Zheng, Qing Cao, Shaoqi Yang, Xingxiang He, Yu Liu, Yuqiang Nie, Yongjian Zhou, Daiming Fan, Kaichun Wu, Yongzhan Nie, Guozhong Ji, Pan Li, Bota Cui, Faming Zhang

Abstract

Fecal microbiota transplantation (FMT) has become a research focus of biomedicine and clinical medicine in recent years. The clinical response from FMT for different diseases provided evidence for microbiota-host interactions associated with various disorders, including Clostridium difficile infection, inflammatory bowel disease, diabetes mellitus, cancer, liver cirrhosis, gut-brain disease and others. To discuss the experiences of using microbes to treat human diseases from ancient China to current era should be important in moving standardized FMT forward and achieving a better future. Here, we review the changing concept of microbiota transplantation from FMT to selective microbiota transplantation, methodology development of FMT and step-up FMT strategy based on literature and state experts' perspectives.

Keywords: Clostridium difficile; bacteria; inflammatory bowel disease; microbiome; perspectives; selective microbiota transplantation; step-up fecal microbiota transplantation.

Figures

Figure 1
Figure 1
The changing of using microbial cells to treat human diseases
Figure 2
Figure 2
The delivering ways of microbiota transplantation in gastrointestinal tract
Figure 3
Figure 3
The step-up FMT strategy
Figure 4
Figure 4
The GMP laboratory for preparation of fecal microbiota

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