Cellular senescence impact on immune cell fate and function

Rita Vicente, Anne-Laure Mausset-Bonnefont, Christian Jorgensen, Pascale Louis-Plence, Jean-Marc Brondello, Rita Vicente, Anne-Laure Mausset-Bonnefont, Christian Jorgensen, Pascale Louis-Plence, Jean-Marc Brondello

Abstract

Cellular senescence occurs not only in cultured fibroblasts, but also in undifferentiated and specialized cells from various tissues of all ages, in vitro and in vivo. Here, we review recent findings on the role of cellular senescence in immune cell fate decisions in macrophage polarization, natural killer cell phenotype, and following T-lymphocyte activation. We also introduce the involvement of the onset of cellular senescence in some immune responses including T-helper lymphocyte-dependent tissue homeostatic functions and T-regulatory cell-dependent suppressive mechanisms. Altogether, these data propose that cellular senescence plays a wide-reaching role as a homeostatic orchestrator.

Keywords: cellular senescence; chronic and autoimmune diseases; immune cells; tissue homeostasis.

© 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

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