Approaches and Challenges in SARS-CoV-2 Vaccine Development

Gabriel Dagotto, Jingyou Yu, Dan H Barouch, Gabriel Dagotto, Jingyou Yu, Dan H Barouch

Abstract

The explosive spread of SARS-CoV-2 suggests that a vaccine will be required to end this global pandemic. Progress in SARS-CoV-2 vaccine development to date has been faster than for any other pathogen in history. Multiple SARS-CoV-2 vaccine candidates have been evaluated in preclinical models and are currently in clinical trials. In this Perspective, we discuss three topics that are critical for SARS-CoV-2 vaccine development: antigen selection and engineering, preclinical challenge studies in non-human primate models, and immune correlates of protection.

Keywords: COVID-19; SARS-CoV-2; vaccine.

Conflict of interest statement

Declaration of Interests Correspondence and requests for materials should be addressed to D.H.B. (dbarouch@bidmc.harvard.edu). D.H.B. is a co-inventor on provisional vaccine patents (62/969,008; 62/994,630) that have been licensed.

Copyright © 2020 Elsevier Inc. All rights reserved.

Figures

Figure 1
Figure 1
SARS-CoV-2 Spike Graphical representation of the SARS-CoV-2 S protein sequence and crystal structure of SARS-CoV-2 S protein ectodomain (PDB: 6VSB) (Wrapp et al., 2020) created by using PyMol software. The transmembrane domain and cytoplasmic tail were not crystallized. TM, transmembrane domain; CT, cytoplasmic tail.

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