Faecal calprotectin indicates intestinal inflammation in COVID-19

Maria Effenberger, Felix Grabherr, Lisa Mayr, Julian Schwaerzler, Manfred Nairz, Markus Seifert, Richard Hilbe, Stefanie Seiwald, Sabine Scholl-Buergi, Gernot Fritsche, Rosa Bellmann-Weiler, Günter Weiss, Thomas Müller, Timon Erik Adolph, Herbert Tilg, Maria Effenberger, Felix Grabherr, Lisa Mayr, Julian Schwaerzler, Manfred Nairz, Markus Seifert, Richard Hilbe, Stefanie Seiwald, Sabine Scholl-Buergi, Gernot Fritsche, Rosa Bellmann-Weiler, Günter Weiss, Thomas Müller, Timon Erik Adolph, Herbert Tilg

No abstract available

Keywords: gut inflammation; infectious diarrhoea.

Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Increased FC and serum IL-6 feature acute diarrhoea in COVID-19. (A) FC concentration determined by ELISA. Group A (n=18): COVID-19 patients without diarrhoea. Group B (n=13): COVID-19 patients who reported diarrhoea which ceased 48 hours before stool collection. Group C (n=9): COVID-19 patients with acute diarrhoea (onset

References

    1. Liang W, Feng Z, Rao S, et al. . Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus. Gut 2020. 10.1136/gutjnl-2020-320832. [Epub ahead of print: 26 Feb 2020].
    1. Wang D, Hu B, Hu C, et al. . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA 2020. 10.1001/jama.2020.1585. [Epub ahead of print: 07 Feb 2020].
    1. Xiao F, Tang M, Zheng X, et al. . Evidence for gastrointestinal infection of SARS-CoV-2. Gastroenterology 2020. 10.1053/j.gastro.2020.02.055
    1. Jin X, Lian J-S, Hu J-H, et al. . Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms. Gut 2020. 10.1136/gutjnl-2020-320926. [Epub ahead of print: 24 Mar 2020].
    1. Lin L, Jiang X, Zhang Z, et al. . Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection. Gut 2020. 10.1136/gutjnl-2020-321013. [Epub ahead of print: 02 Apr 2020].
    1. Pan Y, Zhang D, Yang P, et al. . Viral load of SARS-CoV-2 in clinical samples. Lancet Infect Dis 2020;20:411–2. 10.1016/S1473-3099(20)30113-4
    1. Magro F, Lopes J, Borralho P, et al. . Comparison of different histological indexes in the assessment of UC activity and their accuracy regarding endoscopic outcomes and faecal calprotectin levels. Gut 2019;68:594–603. 10.1136/gutjnl-2017-315545
    1. Hoffmann M, Kleine-Weber H, Schroeder S, et al. . SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor. Cell 2020. 10.1016/j.cell.2020.02.052. [Epub ahead of print: 04 Mar 2020].
    1. Zhang H, Kang Z, Gong H, et al. . Digestive system is a potential route of COVID-19: an analysis of single-cell coexpression pattern of key proteins in viral entry process. Gut 2020:gutjnl-2020-320953 10.1136/gutjnl-2020-320953
    1. Mazza S, Sorce A, Peyvandi F, et al. . A fatal case of COVID-19 pneumonia occurring in a patient with severe acute ulcerative colitis. Gut 2020. 10.1136/gutjnl-2020-321183. [Epub ahead of print: 03 Apr 2020].

Source: PubMed

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