Comparing the effect of 0.06% -, 0.12% and 0.2% Chlorhexidine on plaque, bleeding and side effects in an experimental gingivitis model: a parallel group, double masked randomized clinical trial

Maliha Haydari, Ayse Gul Bardakci, Odd Carsten Koldsland, Anne Merete Aass, Leiv Sandvik, Hans R Preus, Maliha Haydari, Ayse Gul Bardakci, Odd Carsten Koldsland, Anne Merete Aass, Leiv Sandvik, Hans R Preus

Abstract

Background: Chlorhexidine is the gold standard of dental plaque prevention. The aim of the present study was to compare the plaque and gingivitis inhibiting effect of commercial products containing 0.2%, 0.12% and 0.06% chlorhexidine in a modified experimental gingivitis model.

Methods: In three groups of healthy volunteers, experimental gingivitis was induced and monitored over 21 days and simultaneously treated with the commercial solutions containing 0.2%, 0.12% and 0.06% chlorhexidine. The maxillary right quadrant of each individual received mouthwash only, whereas the maxillary left quadrant was subject to both rinsing and mechanical oral hygiene. Compliance and side effects were monitored at days 7, 14, and 21. Plaque and gingivitis scores were obtained at baseline and day 21.

Results: The commercial mouthwash containing 0.2% chlorhexidine resulted in statistically significantly lower plaque scores than the 0.12 and 0.06% mouthwashes after 21 days use, whereas no statistically significant difference was found between the effects of the two latter.

Conclusion: A commercially available mouthwash containing 0.2% chlorhexidine had statistically significant better effect in preventing dental plaque than the 0.12% and 0.06% solutions.

Trial registration: ClinicalTrials.gov NCT02911766 . Registration date: September 9th 2016.

Keywords: Anti-plaque agent; Chlorhexidine; Dental plaque; Gingivitis.

Conflict of interest statement

Ethics approval and consent to participate

The study was approved by the Regional Committee for Medical Research Ethics, South East Norway in 2016 (REK 2016/1748). Consent to participate was given by signing an informed consent approved by the Regional Committee for Medical Research Ethics, South East Norway in 2016.

Consent for publication

Not applicable.

Competing interests

The authors declare that there are no competing interests. The authors alone are responsible for the content and writing of the paper.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

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Fig. 1
Patient flow diagram

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