Cardiovascular Biomarker Profile on Antiretroviral Therapy Is Not Influenced by History of an IRIS Event in People With HIV and Suppressed Viremia
Aurelie Gouel-Cheron, Martha Nason, Adam Rupert, Virginia Sheikh, Greg Robby, Gary A Fahle, Irini Sereti, Aurelie Gouel-Cheron, Martha Nason, Adam Rupert, Virginia Sheikh, Greg Robby, Gary A Fahle, Irini Sereti
Abstract
Immune reconstitution inflammatory syndrome (IRIS) is characterized by release of proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy (ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people with HIV is currently unclear. In this retrospective analysis of 143 participants who maintained suppression of HIV viremia, we compared biomarkers related to inflammation, coagulation, and cardiovascular risk after 3 years on ART in participants with and without a history of IRIS. There was no evidence of higher levels of persistent chronic inflammation in people with HIV who had a history of an IRIS event. ClinicalTrials.gov Identifier . NCT00286767.
Keywords: AIDS; HIV infection; biomarkers; cytomegalovirus; immune reconstitution inflammatory syndrome (IRIS); inflammation.
Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020.
Source: PubMed