Do corticosteroids play a role in the management of traumatic brain injury?

Reid Hoshide, Vincent Cheung, Lawrence Marshall, Ekkehard Kasper, Clark C Chen, Reid Hoshide, Vincent Cheung, Lawrence Marshall, Ekkehard Kasper, Clark C Chen

Abstract

Neuroprotective strategies for the medical management of traumatic brain injury (TBI) have been elusive. While laboratory studies provide a conceptual framework for the potential efficacy of corticosteroids in this context, clinical trials testing this hypothesis have yielded no convincing evidence of clinical benefit. Here, we review the five key randomized control trials (RCTs) that have examined this issue. Based on the proposed primary endpoints of these RCTs, the five RCTs consistently showed that corticosteroids do not confer significant benefit in the TBI population.

Keywords: Outcomes; TBI; randomized controlled trials; steroids; traumatic brain injury.

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Source: PubMed

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