Evaluation of teriparatide treatment in adults with osteogenesis imperfecta

Abstract

Background: Adults with osteogenesis imperfecta (OI) have a high risk of fracture. Currently, few treatment options are available, and bone anabolic therapies have not been tested in clinical trials for OI treatment.

Methods: 79 adults with OI were randomized to receive 20 μg recombinant human parathyroid hormone (teriparatide) or placebo for 18 months in a double-blind, placebo-controlled trial. The primary endpoint was the percent change in areal bone mineral density (aBMD) of the lumbar spine (LS), as determined by dual-energy X-ray absorptiometry. Secondary endpoints included percent change in bone remodeling markers and vertebral volumetric BMD (vBMD) by quantitative computed tomography, estimated vertebral strength by finite element analysis, and self-reported fractures.

Results: Compared with the placebo group, the teriparatide group showed increased LS aBMD (6.1% ± 1.0% vs. 2.8% ± 1.0% change from baseline; P < 0.05) and total hip aBMD (2.6% ± 1.0% vs. -2.4% ± 1.0% change; P < 0.001). Vertebral vBMD and strength improved with teriparatide therapy (18% ± 6% and 15% ± 3% change, respectively), but declined with placebo (-5.0% ± 6% and -2.0% ± 3% change; P < 0.05 for both comparisons). Serum procollagen type 1 N-terminal propeptide (P1NP) and urine collagen N-telopeptide (NTx) levels increased with teriparatide therapy (135% ± 14% and 64% ± 10% change, respectively). Teriparatide-induced elevation of P1NP levels was less pronounced in severe forms of OI (type III/IV) compared with the milder form (type I). Type I OI patients exhibited robust BMD increases with teriparatide; however, there was no observed benefit for those with type III/IV OI. There was no difference in self-reported fractures between the 2 groups.

Conclusions: Adults with OI, particularly those with less severe disease (type I), displayed a teriparatide-induced anabolic response, as well as increased hip and spine aBMD, vertebral vBMD, and estimated vertebral strength. Trial registration. Clinicaltrials.gov NCT00131469. Funding. The Osteoporosis Imperfecta Foundation, Eli Lilly and Co., the National Center for Advancing Translational Science (NCATS) at the NIH (grant no. UL1RR024140), and the Baylor College of Medicine General Clinical Research Center (grant no. RR00188).

Figures

Figure 1. Enrollment, randomization, and study populations.

Figure 2. Bone density and vertebral strength.

(A–D) Percent change from baseline in LS aBMD (g/cm2; A), TH aBMD (g/cm2; B), FN aBMD (g/cm2; C), and radial aBMD (g/cm2; D) in teriparatide- and placebo-treated patients (mITT population). Error bars denote SEM. Values shown are estimated least-squares mean of percent change. The number of patients with nonmissing percent change data at each time point is shown in parentheses. *P < 0.05, **P < 0.001 between treatment groups.

Figure 3. Spine QCT measures and FEA.

Percent change from baseline in spinal trabecular vBMD (mg/cm3), vertebral strength (N), and Φ (vertebral load/vertebral strength ratio) in teriparatide-and placebo-treated patients (mITT population) at 18 months. Error bars denote SEM. *P < 0.05 between treatment groups.

Figure 4. Bone remodeling markers.

(A and B) Percent change from baseline in serum P1NP (μg/l; A) and urinary NTx (nM BCE/mM; B) in teriparatide and placebo-treated patients (mITT population) at baseline and at 6, 12, and 18 months. Error bars denote SEM. Values shown are estimated least-squares mean of percent change. The number of patients with nonmissing percent change data at each time point is shown in parentheses. *P < 0.05, **P < 0.001 between treatment groups.