Autologous Platelet-Rich Plasma Treatment Enables Pregnancy for a Woman in Premature Menopause

Konstantinos Sfakianoudis, Mara Simopoulou, Nikolaos Nitsos, Anna Rapani, Athanasios Pappas, Agni Pantou, Margarita Chronopoulou, Efthymios Deligeoroglou, Michael Koutsilieris, Konstantinos Pantos, Konstantinos Sfakianoudis, Mara Simopoulou, Nikolaos Nitsos, Anna Rapani, Athanasios Pappas, Agni Pantou, Margarita Chronopoulou, Efthymios Deligeoroglou, Michael Koutsilieris, Konstantinos Pantos

Abstract

This report presents the case of a woman aged 40 who has experienced premature menopause from the age of 35. Having rejected oocyte donation, she opted for intraovarian injection of autologous platelet-rich plasma with the aim to rejuvenate the ovarian tissue and enable the employment of her own gametes through in-vitro fertilization. Six weeks following the autologous platelet-rich plasma treatment, a significant reduction in the patient's follicle-stimulating hormone (FSH) levels were noted. A natural in-vitro fertilization cycle led to a biochemical pregnancy, resulting in a spontaneous abortion at the 5th week of pregnancy. This is the first report of a successful autologous platelet-rich plasma application leading to pregnancy in menopause. This report uniquely contributes to the medical knowledge and challenges current practice in the context of infertility. The efficiency and safety of this treatment with regard to the reproductive system merits further investigation.

Keywords: autologous platelet rich plasma; menstrual restoration; pregnancy; premature menopause; rejuvenation.

Conflict of interest statement

The authors declare no conflict of interest.

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