Association between iron status, iron deficiency anaemia, and severe early childhood caries: a case-control study

Robert J Schroth, Jeremy Levi, Eleonore Kliewer, James Friel, Michael E K Moffatt, Robert J Schroth, Jeremy Levi, Eleonore Kliewer, James Friel, Michael E K Moffatt

Abstract

Background: Severe tooth decay is known to affect the health and well-being of young children. However, little is known about the influence of Severe Early Childhood Caries (S-ECC) on childhood nutritional status. The purpose of this study was to contrast ferritin and haemoglobin levels between preschoolers with S-ECC and caries-free controls.

Methods: Children were recruited as part of a larger case-control study examining differences in nutritional status between those with and without S-ECC. Preschoolers with S-ECC were recruited on the day of their dental surgery, while caries-free controls were recruited from the community. Parents completed a questionnaire and the child underwent venipuncture. The study was approved by the University's Health Research Ethics Board. Statistics included descriptive, bivariate and logistic regression analyses. A p value ≤ .05 was significant. A total of 266 children were recruited; 144 with S-ECC and 122 caries-free.

Results: The mean age was 40.8 ± 14.1 months. The mean ferritin concentration for all children was 29.6 ± 17.9 μg/L while the mean haemoglobin level was 115.1 ± 10.1 g/L. Children with S-ECC were significantly more likely to have low ferritin (p=.033) and low haemoglobin levels (p>.001). Logistic regression analyses revealed that children with S-ECC were nearly twice as likely to have low ferritin levels and were over six times more likely to have iron deficiency anaemia than caries-free controls.

Conclusions: Children with S-ECC appear to be at significantly greater odds of having low ferritin status compared with caries-free children and also appear to have significantly lower haemoglobin levels than the caries-free control group. Children with S-ECC also appear to be at significantly greater odds for iron deficiency anaemia than cavity-free children.

Figures

Figure 1
Figure 1
Distribution of Ferritin, Haemoglobin, and MCV between Caries-Free and S-ECC Groups.
Figure 2
Figure 2
Distribution of Ferritin and Haemoglobin by other Published Thresholds [14].

References

    1. American Academy of Pediatric Dentistry. Definition of early childhood caries (ECC) Pediatr Dent. 2010;32:15.
    1. Schroth RJ, Harrison RL, Moffatt ME. Oral health of indigenous children and the influence of early childhood caries on childhood health and well-being. Pediatr Clin North Am. 2009;56:1481–1499. doi: 10.1016/j.pcl.2009.09.010.
    1. Dye BA, Tan S, Smith V. et al.Trends in oral health status: United States, 1988–1994 and 1999–2004. Vital Health Stat. 2007;11:1–92.
    1. Schroth RJ, Dahl PR, Haque M. et al.Early childhood caries among Hutterite preschool children in Manitoba,Canada. Rural Remote Health. 2010;10:1535.
    1. Schroth RJ, Moore P, Brothwell DJ. Prevalence of early childhood caries in 4 Manitoba communities. J Can Dent Assoc. 2005;71:567.
    1. Schroth RJ, Smith PJ, Whalen JC. et al.Prevalence of caries among preschool-aged children in a northern Manitoba community. J Can Dent Assoc. 2005;71:27.
    1. Harrison R, Lawrence H. et al.Oral health and the Aboriginal child: a forum for community members, researchers and policy-makers. J Can Dent Assoc. 2008;74:429–432.
    1. Schroth RJ, Cheba V. Determining the prevalence and risk factors for early childhood caries in a community dental health clinic. Pediatr Dent. 2007;29:387–396.
    1. Canadian Paediatric Decision Support Network. Canadian Paediatric Decision Support Network Annual Report April 2003-March 2004. Canadian Paediatric Decision Support Network. Ottawa: Canadian Association of Paediatric Health Centres; 2004. pp. 1–54.
    1. Schroth RJ, Morey B. Providing timely dental treatment for young children under general anesthesia in a government priority. J Can Dent Assoc. 2007;73:241–3.
    1. Acs G, Lodolini G, Kaminsky S. et al.Effect of nursing caries on body weight in a pediatric population. Pediatr Dent. 1992;14:302–305.
    1. Ayhan H, Suskan E, Yildirim S. The effect of nursing or rampant caries on height, body weight and head circumference. J Clin Pediatr Dent. 1996;20:209–212.
    1. Oliveira LB, Sheiham A, Bonecker M. Exploring the association of dental caries with social factors and nutritional status in Brazilian preschool children. Eur J Oral Sci. 2008;116:37–43. doi: 10.1111/j.1600-0722.2007.00507.x.
    1. Clarke M, Locker D, Berall G. et al.Malnourishment in a population of young children with severe early childhood caries. Pediatr Dent. 2006;28:254–259.
    1. Acs G, Shulman R, Ng MW. et al.The effect of dental rehabilitation on the body weight of children with early childhood caries. Pediatr Dent. 1999;21:109–113.
    1. Schroth R, Jeal N, Kliewer E. et al.The relationship between vitamin D and severe early childhood caries: a pilot study. Int J Vitam Nutr Res. 2012;82:53–62. doi: 10.1024/0300-9831/a000094.
    1. World Health Organization. Worldwide prevalence of anaemia 1993–2005. In: Benoist B, McLean E, Egli I, editor. WHO global database on anaemia. Geneva, Switzerland: World Health Organization; 2008.
    1. World Health Organization. Assessing the iron status of populations. Geneva, Switzerland: World Health Organization; 2007.
    1. Shaoul R, Gaitini L, Kharouba J. et al.The association of childhood iron deficiency anaemia with severe dental caries. Acta Paediatr. 2012;101(2):e76–79. doi: 10.1111/j.1651-2227.2011.02448.x.
    1. Gaur S, Nayak R. Underweight in low socioeconomic status preschool children with severe early childhood caries. J Indian Soc Pedod Prev Dent. 2011;29:305–309. doi: 10.4103/0970-4388.86375.
    1. Sinha N, Deshmukh PR, Garg BS. Epidemiological correlates of nutritional anemia among children (6–35 months) in rural Wardha, Central India. Indian J Med Sci. 2008;62:45–54. doi: 10.4103/0019-5359.39366.
    1. Fretham SJ, Carlson ES, Georgieff MK. The role of iron in learning and memory. Adv Nutr. 2011;2:112–121. doi: 10.3945/an.110.000190.

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