Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference

K Ezzedine, H W Lim, T Suzuki, I Katayama, I Hamzavi, C C E Lan, B K Goh, T Anbar, C Silva de Castro, A Y Lee, D Parsad, N van Geel, I C Le Poole, N Oiso, L Benzekri, R Spritz, Y Gauthier, S K Hann, M Picardo, A Taieb, Vitiligo Global Issue Consensus Conference Panelists, K Ezzedine, H W Lim, T Suzuki, I Katayama, I Hamzavi, C C E Lan, B K Goh, T Anbar, C Silva de Castro, A Y Lee, D Parsad, N van Geel, I C Le Poole, N Oiso, L Benzekri, R Spritz, Y Gauthier, S K Hann, M Picardo, A Taieb, Vitiligo Global Issue Consensus Conference Panelists

Abstract

During the 2011 International Pigment Cell Conference (IPCC), the Vitiligo European Taskforce (VETF) convened a consensus conference on issues of global importance for vitiligo clinical research. As suggested by an international panel of experts, the conference focused on four topics: classification and nomenclature; definition of stable disease; definition of Koebner's phenomenon (KP); and 'autoimmune vitiligo'. These topics were discussed in seven working groups representing different geographical regions. A consensus emerged that segmental vitiligo be classified separately from all other forms of vitiligo and that the term 'vitiligo' be used as an umbrella term for all non-segmental forms of vitiligo, including 'mixed vitiligo' in which segmental and non-segmental vitiligo are combined and which is considered a subgroup of vitiligo. Further, the conference recommends that disease stability be best assessed based on the stability of individual lesions rather than the overall stability of the disease as the latter is difficult to define precisely and reliably. The conference also endorsed the classification of KP for vitiligo as proposed by the VETF (history based, clinical observation based, or experimentally induced). Lastly, the conference agreed that 'autoimmune vitiligo' should not be used as a separate classification as published evidence indicates that the pathophysiology of all forms of vitiligo likely involves autoimmune or inflammatory mechanisms.

© 2012 John Wiley & Sons A/S.

Figures

Figure 1
Figure 1
Mixed vitiligo in a 9-yr-old patient with patient (A) segmental and (B) non-segmental involvement.
Figure 2
Figure 2
Vitiligo punctata, patient with multiple pea-sized depigmented macules of the trunk, punctate vitiligo.
Figure 3
Figure 3
Vitiligo minor, multiple hypopigmented macules in a 27-yr-old dark-skinned woman.
Figure 4
Figure 4
Follicular vitiligo, complete whitening of the body hair (A) associated with depigmented macules of the face and eyelashes whitening (B) in a 12-yr-old boy.
Figure 5
Figure 5
Monosegmental vitiligo, depigmented macules unilaterally distributed with sharp midline demarcation.
Figure 6
Figure 6
Bisegmental vitiligo, bilaterally distributed, depigmented macules of each lesion do not cross the midline.

Source: PubMed

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