Intracerebral haemorrhage: mechanisms of injury and therapeutic targets
Richard F Keep, Ya Hua, Guohua Xi, Richard F Keep, Ya Hua, Guohua Xi
Abstract
Intracerebral haemorrhage accounts for about 10-15% of all strokes and is associated with high mortality and morbidity. No successful phase 3 clinical trials for this disorder have been completed. In the past 6 years, the number of preclinical and clinical studies focused on intracerebral haemorrhage has risen. Important advances have been made in animal models of this disorder and in our understanding of mechanisms underlying brain injury after haemorrhage. Several therapeutic targets have subsequently been identified that are now being pursued in clinical trials. Many clinical trials have been based on limited preclinical data, and guidelines to justify taking preclinical results to the clinic are needed.
Conflict of interest statement
Conflicts of interest
We have no conflicts of interest.
Copyright © 2012 Elsevier Ltd. All rights reserved.
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Source: PubMed