- ICH GCP
- 미국 임상 시험 레지스트리
- 임상시험 NCT00002976
Estrogen Replacement Therapy in Treating Women With Early-Stage Endometrial Cancer
A Randomized Double-Blinded Trial of Estrogen Replacement Therapy Versus Placebo in Women With Stage I or II Endometrial Adenocarcinoma
RATIONALE: Estrogen replacement therapy may improve quality-of-life in postmenopausal women with endometrial cancer. It is not yet known whether estrogen replacement therapy will affect cancer recurrence.
PURPOSE: Randomized double-blinded phase III trial to determine the effectiveness of estrogen replacement therapy in treating women who have stage I or stage II endometrial cancer.
연구 개요
상세 설명
OBJECTIVES:
- Determine the effect of estrogen replacement therapy on recurrence free and overall survival in women with a history of stage I or II endometrial adenocarcinoma.
OUTLINE: This is a randomized, double blind study. Patients are stratified according to stage of endometrial cancer (IA vs IB/IC vs II). Patients are randomized to one of two treatment arms:
- Arm I: Patients receive oral conjugated estrogens (Premarin) daily for 3 years.
- Arm II: Patients receive oral placebo daily for 3 years. Patients are followed every 6 months for 3 years and then annually for 2 years.
PROJECTED ACCRUAL: Approximately 2,108 patients will be accrued for this study.
연구 유형
등록 (예상)
단계
- 3단계
연락처 및 위치
연구 장소
-
-
Alabama
-
Birmingham, Alabama, 미국, 35294-3300
- University of Alabama at Birmingham Comprehensive Cancer Center
-
Mobile, Alabama, 미국, 36688
- MBCCOP - Gulf Coast
-
-
Arizona
-
Phoenix, Arizona, 미국, 85006-2726
- CCOP - Greater Phoenix
-
Phoenix, Arizona, 미국, 85012
- Veterans Affairs Medical Center - Phoenix (Carl T. Hayden)
-
Tucson, Arizona, 미국, 85724
- Arizona Cancer Center
-
Tucson, Arizona, 미국, 85723
- Veterans Affairs Medical Center - Tucson
-
-
Arkansas
-
Little Rock, Arkansas, 미국, 72205
- University of Arkansas for Medical Sciences
-
Little Rock, Arkansas, 미국, 72205
- Veterans Affairs Medical Center - Little Rock (McClellan)
-
-
California
-
Duarte, California, 미국, 91010
- City of Hope Comprehensive Cancer Center
-
Los Angeles, California, 미국, 90095-1781
- Jonsson Comprehensive Cancer Center, UCLA
-
Los Angeles, California, 미국, 90033-0804
- USC/Norris Comprehensive Cancer Center and Hospital
-
Los Angeles, California, 미국, 90073
- Veterans Affairs Medical Center - West Los Angeles
-
Los Gatos, California, 미국, 95032
- Community Hospital of Los Gatos
-
Martinez, California, 미국, 94553
- Veterans Affairs Outpatient Clinic - Martinez
-
Oakland, California, 미국, 94609-3305
- CCOP - Bay Area Tumor Institute
-
Orange, California, 미국, 92868
- Chao Family Comprehensive Cancer Center
-
Sacramento, California, 미국, 95817
- University of California Davis Medical Center
-
Santa Rosa, California, 미국, 95403
- CCOP - Santa Rosa Memorial Hospital
-
Travis Air Force Base, California, 미국, 94535
- David Grant Medical Center
-
-
Colorado
-
Denver, Colorado, 미국, 80220
- Veterans Affairs Medical Center - Denver
-
Denver, Colorado, 미국, 80010
- University of Colorado Cancer Center
-
-
Connecticut
-
New Britain, Connecticut, 미국, 06052
-
-
District of Columbia
-
Washington, District of Columbia, 미국, 20307-5001
- Walter Reed Army Medical Center
-
Washington, District of Columbia, 미국, 20060
- MBCCOP-Howard University Cancer Center
-
-
Florida
-
Jacksonville, Florida, 미국, 32224
- Mayo Clinic
-
Pensacola, Florida, 미국, 32504
- Sacred Heart Hospital of Pensacola
-
Saint Petersburg, Florida, 미국, 33701
- Tampa Bay Cancer Consortium
-
Tampa, Florida, 미국, 33612-9497
- H. Lee Moffitt Cancer Center and Research Institute
-
-
Georgia
-
Atlanta, Georgia, 미국, 30342-1701
- CCOP - Atlanta Regional
-
Fort Gordon, Georgia, 미국, 30905-5650
- Dwight David Eisenhower Army Medical Center
-
Savannah, Georgia, 미국, 31403-3089
- Medical College of Georgia Comprehensive Cancer Center
-
-
Hawaii
-
Honolulu, Hawaii, 미국, 96859-5000
- Tripler Army Medical Center
-
Honolulu, Hawaii, 미국, 96813-2424
- Cancer Research Center of Hawaii
-
-
Illinois
-
Chicago, Illinois, 미국, 60612-7323
- MBCCOP - University of Illinois at Chicago
-
Chicago, Illinois, 미국, 60612
- Veterans Affairs Medical Center - Chicago (Westside Hospital)
-
Chicago, Illinois, 미국, 60637-1470
- University of Chicago Cancer Research Center
-
Chicago, Illinois, 미국, 60611-3013
- Robert H. Lurie Comprehensive Cancer Center, Northwestern University
-
Decatur, Illinois, 미국, 62526
- CCOP - Central Illinois
-
Hines, Illinois, 미국, 60141
- Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital)
-
Maywood, Illinois, 미국, 60153
- Loyola University Medical Center
-
Urbana, Illinois, 미국, 61801
- CCOP - Carle Cancer Center
-
-
Indiana
-
Indianapolis, Indiana, 미국, 46202-5289
- Indiana University Cancer Center
-
-
Iowa
-
Des Moines, Iowa, 미국, 50309-1016
- CCOP - Iowa Oncology Research Association
-
Iowa City, Iowa, 미국, 52242-1009
- Holden Comprehensive Cancer Center
-
-
Kansas
-
Kansas City, Kansas, 미국, 66160-7390
- University of Kansas Medical Center
-
Wichita, Kansas, 미국, 67214-3882
- CCOP - Wichita
-
Wichita, Kansas, 미국, 67218
- Veterans Affairs Medical Center - Wichita
-
-
Kentucky
-
Lexington, Kentucky, 미국, 40536-0084
- Albert B. Chandler Medical Center, University of Kentucky
-
Lexington, Kentucky, 미국, 40502-2236
- Veterans Affairs Medical Center - Lexington
-
-
Louisiana
-
Baton Rouge, Louisiana, 미국, 70805
- Earl K. Long Medical Center
-
New Orleans, Louisiana, 미국, 70112
- Tulane University School of Medicine
-
New Orleans, Louisiana, 미국, 70121
- Ochsner Clinic
-
New Orleans, Louisiana, 미국, 70112
- MBCCOP - LSU Health Sciences Center
-
Shreveport, Louisiana, 미국, 71130-3932
- Louisiana State University Health Sciences Center - Shreveport
-
Shreveport, Louisiana, 미국, 71130
- Veterans Affairs Medical Center - Shreveport
-
-
Massachusetts
-
Boston, Massachusetts, 미국, 02118
- Boston Medical Center
-
Jamaica Plain, Massachusetts, 미국, 02130
- Veterans Affairs Medical Center - Boston (Jamaica Plain)
-
-
Michigan
-
Ann Arbor, Michigan, 미국, 48105
- Veterans Affairs Medical Center - Ann Arbor
-
Ann Arbor, Michigan, 미국, 48106
- CCOP - Ann Arbor Regional
-
Ann Arbor, Michigan, 미국, 48109-0912
- University of Michigan Comprehensive Cancer Center
-
Detroit, Michigan, 미국, 48202
- Henry Ford Hospital
-
Detroit, Michigan, 미국, 48201-1932
- Veterans Affairs Medical Center - Detroit
-
Grand Rapids, Michigan, 미국, 49503
- CCOP - Grand Rapids Clinical Oncology Program
-
Grand Rapids, Michigan, 미국, 49503
- Butterworth Hospital
-
Kalamazoo, Michigan, 미국, 49007-3731
- CCOP - Kalamazoo
-
Royal Oak, Michigan, 미국, 48073-6769
- CCOP - Beaumont
-
Southfield, Michigan, 미국, 48075-9975
- Providence Hospital - Southfield
-
-
Minnesota
-
Duluth, Minnesota, 미국, 55805
- CCOP - Duluth
-
Minneapolis, Minnesota, 미국, 55455
- University of Minnesota Cancer Center
-
-
Mississippi
-
Biloxi, Mississippi, 미국, 39531-2410
- Veterans Affairs Medical Center - Biloxi
-
Jackson, Mississippi, 미국, 39216-4505
- University of Mississippi Medical Center
-
Jackson, Mississippi, 미국, 39216
- Veterans Affairs Medical Center - Jackson
-
Keesler AFB, Mississippi, 미국, 39534-2576
- Keesler Medical Center - Keesler AFB
-
-
Missouri
-
Columbia, Missouri, 미국, 65203
- Ellis Fischel Cancer Center - Columbia
-
Kansas City, Missouri, 미국, 64128
- Veterans Affairs Medical Center - Kansas City
-
Kansas City, Missouri, 미국, 64131
- CCOP - Kansas City
-
Saint Louis, Missouri, 미국, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, 미국, 63141
- CCOP - St. Louis-Cape Girardeau
-
Saint Louis, Missouri, 미국, 63110
- St. Louis University Health Sciences Center
-
Saint Louis, Missouri, 미국, 63117
- Department of OB-GYN
-
Springfield, Missouri, 미국, 65807
- CCOP - Cancer Research for the Ozarks
-
-
Montana
-
Billings, Montana, 미국, 59101
- CCOP - Montana Cancer Consortium
-
-
Nebraska
-
Omaha, Nebraska, 미국, 68114
- Methodist Cancer Center - Omaha
-
Omaha, Nebraska, 미국, 68106
- CCOP - Missouri Valley Cancer Consortium
-
-
New Jersey
-
Camden, New Jersey, 미국, 08103-1489
- Cooper Hospital/University Medical Center
-
Morristown, New Jersey, 미국, 07962-1956
- Morristown Memorial Hospital
-
-
New Mexico
-
Albuquerque, New Mexico, 미국, 87108-5138
- Veterans Affairs Medical Center - Albuquerque
-
Albuquerque, New Mexico, 미국, 87131
- MBCCOP - University of New Mexico HSC
-
-
New York
-
Albany, New York, 미국, 12208
- Cancer Center of Albany Medical Center
-
Brooklyn, New York, 미국, 11203
- State University of New York Health Science Center at Brooklyn
-
New York, New York, 미국, 10021
- Memorial Sloan-Kettering Cancer Center
-
New York, New York, 미국, 10032
- Herbert Irving Comprehensive Cancer Center
-
Rochester, New York, 미국, 14642
- University of Rochester Medical Center
-
Stony Brook, New York, 미국, 11794-8091
- State University of New York Health Sciences Center - Stony Brook
-
Syracuse, New York, 미국, 13210
- Crouse Hospital
-
-
North Carolina
-
Chapel Hill, North Carolina, 미국, 27599-7295
- Lineberger Comprehensive Cancer Center, UNC
-
Durham, North Carolina, 미국, 27710
- Duke Comprehensive Cancer Center
-
Southern Pines, North Carolina, 미국, 28388-0749
- Southern Pines Women's Health Center
-
Winston-Salem, North Carolina, 미국, 27104-4241
- CCOP - Southeast Cancer Control Consortium
-
Winston-Salem, North Carolina, 미국, 27157-1065
- Comprehensive Cancer Center at Wake Forest University
-
Winston-Salem, North Carolina, 미국, 27157-1065
- University of Tennessee Cancer Institute
-
-
Ohio
-
Cincinnati, Ohio, 미국, 45220-2288
- Veterans Affairs Medical Center - Cincinnati
-
Cincinnati, Ohio, 미국, 45267-0501
- Barrett Cancer Center
-
Cleveland, Ohio, 미국, 44106
- Ireland Cancer Center
-
Cleveland, Ohio, 미국, 44195-9001
- Cleveland Clinic Taussig Cancer Center
-
Columbus, Ohio, 미국, 43210-1240
- Arthur G. James Cancer Hospital - Ohio State University
-
Columbus, Ohio, 미국, 43206
- CCOP - Columbus
-
Dayton, Ohio, 미국, 45428
- Veterans Affairs Medical Center - Dayton
-
Kettering, Ohio, 미국, 45429
- CCOP - Dayton
-
-
Oklahoma
-
Oklahoma City, Oklahoma, 미국, 73104
- Oklahoma Medical Research Foundation
-
Oklahoma City, Oklahoma, 미국, 73104
- Veterans Affairs Medical Center - Oklahoma City
-
Oklahoma City, Oklahoma, 미국, 73190
- University of Oklahoma College of Medicine
-
-
Oregon
-
Portland, Oregon, 미국, 97207
- Veterans Affairs Medical Center - Portland
-
Portland, Oregon, 미국, 97225
- CCOP - Columbia River Program
-
Portland, Oregon, 미국, 97239
- OHSU Cancer Institute
-
Portland, Oregon, 미국, 97210
- Good Samaritan Hospital Comprehensive Cancer Center
-
-
Pennsylvania
-
Abington, Pennsylvania, 미국, 19001-3788
- Abington Memorial Hospital
-
Philadelphia, Pennsylvania, 미국, 19111
- Fox Chase Cancer Center
-
Wynnewood, Pennsylvania, 미국, 19096
- CCOP - MainLine Health
-
-
South Carolina
-
Charleston, South Carolina, 미국, 29425-0721
- Medical University of South Carolina
-
Charleston, South Carolina, 미국, 29401-5799
- Veterans Affairs Medical Center - Charleston
-
Greenville, South Carolina, 미국, 29615
- CCOP - Greenville
-
Spartanburg, South Carolina, 미국, 29303
- CCOP - Upstate Carolina
-
-
South Dakota
-
Sioux Falls, South Dakota, 미국, 57104
- CCOP - Sioux Community Cancer Consortium
-
-
Tennessee
-
Knoxville, Tennessee, 미국, 37901
- Baptist Regional Cancer Center - Knoxville
-
Knoxville, Tennessee, 미국, 37920
- University of Tennessee Medical Center at Knoxville
-
Nashville, Tennessee, 미국, 37203
- Brookview Research, Inc.
-
-
Texas
-
Fort Sam Houston, Texas, 미국, 78234-6200
- Brooke Army Medical Center
-
Galveston, Texas, 미국, 77555-0587
- University of Texas Medical Branch
-
Houston, Texas, 미국, 77030-4009
- CCOP - M.D. Anderson Research Base
-
Lubbock, Texas, 미국, 79410
- Covenant Health System
-
San Antonio, Texas, 미국, 78284
- Veterans Affairs Medical Center - San Antonio (Murphy)
-
San Antonio, Texas, 미국, 78284-7845
- University of Texas Health Science Center at San Antonio
-
Temple, Texas, 미국, 76504
- Veterans Affairs Medical Center - Temple
-
Temple, Texas, 미국, 76508
- CCOP - Scott and White Hospital
-
-
Utah
-
Salt Lake City, Utah, 미국, 84148
- Veterans Affairs Medical Center - Salt Lake City
-
Salt Lake City, Utah, 미국, 84112-5550
- Huntsman Cancer Institute
-
-
Vermont
-
Burlington, Vermont, 미국, 05401
- Fletcher Allen Health Care - Medical Center Campus
-
-
Virginia
-
Charlottesville, Virginia, 미국, 22908
- Cancer Center at the University of Virginia
-
Norfolk, Virginia, 미국, 23510-1115
- Eastern Virginia Medical School
-
Richmond, Virginia, 미국, 23298-0037
- Massey Cancer Center
-
Roanoke, Virginia, 미국, 24013
- University of Virginia at Roanoke
-
-
Washington
-
Seattle, Washington, 미국, 98101
- CCOP - Virginia Mason Research Center
-
Seattle, Washington, 미국, 98104
- Swedish Cancer Institute
-
Seattle, Washington, 미국, 98108
- Veterans Affairs Medical Center - Seattle
-
Seattle, Washington, 미국, 98109-1024
- Fred Hutchinson Cancer Research Center
-
Tacoma, Washington, 미국, 98431-5000
- Madigan Army Medical Center
-
Tacoma, Washington, 미국, 98405-0986
- CCOP - Northwest
-
-
Wisconsin
-
Green Bay, Wisconsin, 미국, 54301
- CCOP - St. Vincent Hospital Cancer Center, Green Bay
-
-
참여기준
자격 기준
공부할 수 있는 나이
- 어린이
- 성인
- 고령자
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
DISEASE CHARACTERISTICS:
- Histologically confirmed grade I, II or III endometrial adenocarcinoma (endometrioid, villoglandular, mucinous, adenosquamous, papillary serous, clear cell, or not otherwise specified)
Must have had total hysterectomy and bilateral salpingo-oophorectomy within past 20 weeks
- Surgical stage IA, IB, IC, IIA (occult), or IIB (occult) disease
- Must have had normal mammogram, or a negative breast biopsy after an abnormal mammogram, within past year
PATIENT CHARACTERISTICS:
Age:
- Not specified
Performance status:
- Not specified
Life expectancy:
- Not specified
Hematopoietic:
- Not specified
Hepatic:
- Bilirubin no greater than 1.5 times normal
- SGOT no greater than 3 times normal
- No acute liver disease
Renal:
- Not specified
Cardiovascular:
- No prior thromboembolic disease
Other:
- No prior or current carcinoma of the breast
- No other prior invasive malignancy within the past 5 years except nonmelanoma skin cancer
PRIOR CONCURRENT THERAPY:
Biologic therapy:
- Not specified
Chemotherapy:
- Not specified
Endocrine therapy:
- No concurrent hormonal therapy
Radiotherapy:
- Not specified
Surgery:
- See Disease Characteristics
- Recovered from prior surgery
Other:
- No prior cancer treatment that would preclude study therapy
- Concurrent participation on GOG Lap-1 or GOG Lap-2 allowed
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
공동 작업자 및 조사자
수사관
- 연구 의자: Richard R. Barakat, MD, Memorial Sloan Kettering Cancer Center
- 연구 의자: David S. Alberts, MD, University of Arizona
간행물 및 유용한 링크
연구 기록 날짜
연구 주요 날짜
연구 시작
기본 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (추정)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- CDR0000065498
- GOG-137A
- E-G0137
- SWOG-G0137
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
자궁내막암에 대한 임상 시험
-
Georgetown UniversityNational Cancer Institute (NCI); American Cancer Society, Inc.; Susan G. Komen Breast Cancer...완전한
-
University of UtahNational Cancer Institute (NCI)모병피로 | 좌식 생활 | 전이성 전립선암 | IV기 전립선암 AJCC(American Joint Committee on Cancer) v8 | IVA기 전립선암 AJCC(American Joint Committee on Cancer) v8 | IVB기 전립선암 AJCC(American Joint Committee on Cancer) v8미국
-
Jonsson Comprehensive Cancer Center아직 모집하지 않음전립선암 | IVB기 전립선암 American Joint Committee on Cancer(AJCC) v8미국
-
Rashmi Verma, MDNational Cancer Institute (NCI)모병거세저항성 전립선암 | 전이성 전립선 선암종 | IVB기 전립선암 American Joint Committee on Cancer(AJCC) v8미국
-
Jonsson Comprehensive Cancer Center빼는전립선 선암종 | 2기 전립선암 AJCC v8 | IIC기 전립선암 AJCC v8 | IIA기 전립선암 AJCC v8 | IIB기 전립선암 AJCC v8 | 1기 전립선암 American Joint Committee on Cancer(AJCC) v8미국
-
Jonsson Comprehensive Cancer CenterMiraDX모집하지 않고 적극적으로전립선 선암종 | 2기 전립선암 AJCC v8 | IIC기 전립선암 AJCC v8 | IIA기 전립선암 AJCC v8 | IIB기 전립선암 AJCC v8 | 1기 전립선암 American Joint Committee on Cancer(AJCC) v8미국
-
Jonsson Comprehensive Cancer Center종료됨거세저항성 전립선암 | 전이성 전립선암 | IVA기 전립선암 AJCC v8 | IVB기 전립선암 AJCC v8 | IV기 전립선암 American Joint Committee on Cancer(AJCC) v8미국
-
Jonsson Comprehensive Cancer CenterProgenics Pharmaceuticals, Inc.종료됨2기 전립선암 AJCC v8 | IIIA기 전립선암 AJCC v8 | IIIB기 전립선암 AJCC v8 | IIC기 전립선암 AJCC v8 | 3기 전립선암 AJCC v8 | IIIC기 전립선암 AJCC v8 | IIA기 전립선암 AJCC v8 | IIB기 전립선암 AJCC v8 | 1기 전립선암 American Joint Committee on Cancer(AJCC) v8미국
-
Assiut University아직 모집하지 않음South Egypt Cancer Institute(SECI)에서 소아 악성종양 환자에 대한 KDIGO 기준을 사용하여 AKI의 누적 발병률을 확인하기 위해
-
Jonsson Comprehensive Cancer CenterNational Cancer Institute (NCI)모집하지 않고 적극적으로III기 전립선 선암종 AJCC v7 | II기 전립선 선암종 AJCC v7 | 1기 전립선 선암종 American Joint Committee on Cancer(AJCC) v7미국