Development of a Model to Predict Progression-Free Survival After Erlotinib in Patients With Non-Small Cell Lung Cancer
Development of a Model to Predict Progression Free Survival After Treatment With Erlotinib in E3503
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer. It may also help doctors predict how patients respond to treatment with erlotinib.
PURPOSE: This laboratory study is developing a model to predict progression-free survival after erlotinib in patients with non-small cell lung cancer.
연구 개요
상세 설명
OBJECTIVES:
- Assess mesenchymal and epithelial markers in tissues from patients with non-small cell lung cancer treated with erlotinib hydrochloride on clinical trial ECOG-E3503.
- Determine the loss of epithelial markers (E-cadherin) and gain of mesenchymal markers (vimentin/cytokeratin co-expression) in these patients.
- Assess whether mesenchymal and epithelial markers are predictive of progression-free survival (PFS) of these patients.
- Identify a single nucleotide polymorphism profile via whole genome mapping and other known biomarkers to predict PFS of these patients.
OUTLINE: Tissue samples are analyzed by whole genome mapping for single nucleotide polymorphism (SNP) rate and by signal detection rate and by quantitative immunohistochemistry for mesenchymal (vimentin/cytokeratin) and epithelial (E-cadherin) marker transitions. After biomarker identification and gene mapping are complete, a model to predict progression-free survival in these patients is developed.
PROJECTED ACCRUAL: A total of 137 samples will be accrued for this study.
연구 유형
등록 (실제)
참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
설명
DISEASE CHARACTERISTICS:
Diagnosis of non-small cell lung cancer, including any of the following subtypes:
- Adenocarcinoma
- Squamous cell carcinoma
- Bronchoalveolar carcinoma
- Carcinoid
- Stage IIIB or IV or recurrent disease
- Must have received treatment with erlotinib hydrochloride on clinical trial ECOG-E3503
PATIENT CHARACTERISTICS:
- Not specified
PRIOR CONCURRENT THERAPY:
- See Disease Characteristics
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Mesenchymal and epithelial markers
기간: 1 month
|
Mesenchymal and epithelial markers
|
1 month
|
|
Loss of epithelial markers (E-cadherin) and gain of mesenchymal markers (vimentin/cytokeratin co-expression)
기간: 1 month
|
Loss of epithelial markers (E-cadherin) and gain of mesenchymal markers
|
1 month
|
|
Correlation of progression-free survival (PFS) by mesenchymal and epithelial markers
기간: 1 month
|
Correlation of progression-free survival (PFS) by mesenchymal and epithelial markers
|
1 month
|
|
Identification of a single nucleotide polymorphism profile via whole genome mapping and other known biomarkers to predict PFS
기간: 1 month
|
Identification of a single nucleotide polymorphism profile via whole genome mapping and other known biomarkers to predict PFS
|
1 month
|
공동 작업자 및 조사자
수사관
- 연구 의자: Jill Kolesar, PharmD, University of Wisconsin, Madison
간행물 및 유용한 링크
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (추정)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 연구와 관련된 용어
기타 연구 ID 번호
- CDR0000543981
- ECOG-E3503T1
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