n3 PUFA and Muscle-disuse Atrophy in Young Women
Effects of n3 PUFA Supplementation on the Attenuation of Muscle Disuse Atrophy in Young Women
연구 개요
상세 설명
Biological aging is associated with the loss of skeletal muscle mass and strength resulting in compromised metabolic function and mobility. Throughout life, individuals will also experience periods of reduced physical activity/muscle disuse that independently lower muscle mass and strength accelerating the aging process. The losses in muscle mass with aging and disuse are underpinned by feeding-induced declines in rates of muscle protein synthesis. Thus, strategies to enhance muscle protein synthesis could have clinical implications for those who wish to maintain metabolic health and function during times of muscle disuse.
Supplementation with n3 PUFA-enriched fish oil has been shown to potentiate rates of muscle protein synthesis in response to simulated feeding in both younger and older adults. Fish oil supplementation also has been efficacious in enhancing skeletal muscle strength during a period of resistance exercise training. However, no study has examined the impact of fish oil supplementation to enhance muscle protein synthesis and offset declines in muscle mass/strength during a period of immobilization.
연구 유형
등록 (실제)
단계
- 해당 없음
연락처 및 위치
연구 장소
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Ontario
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Hamilton, Ontario, 캐나다, L8S 4K1
- Exercise Metabolism Research Laboratory, McMaster Univeristy
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
설명
Inclusion Criteria:
- Female
- Aged 18-30 years
Exclusion Criteria:
- Take any analgesic or anti-inflammatory drugs(s), prescription or non-prescription, chronically will be excluded
- A history of neuromuscular problems or muscle and/or bone wasting diseases
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- Use medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
- Fish allergy
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 더블
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: n3 PUFA
Intervention: n3 PUFA (3000mg of Eicosapentaenoic acid per day and 1800mg of Docosahexaenoic acid per day)
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하루 에이코사펜타엔산 3000mg 및 하루 도코사헥사엔산 1800mg
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위약 비교기: Placebo
Intervention: Organic Sunflower Oil 5000mg per day
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유기농 해바라기 오일 하루 5000mg
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Muscle Volume
기간: Baseline (0 days), After (14 days) of unilateral limb immobilization and at 14 days post immobilization
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Change in Muscle Volume Measured by Magnetic Resonance Imaging
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Baseline (0 days), After (14 days) of unilateral limb immobilization and at 14 days post immobilization
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Integrated Rates of Muscle Protein Synthesis
기간: Before (0 days), During (0-14 days inclusive), and After (14-28 days inclusive) of unilateral limb immobilization
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Change in Muscle Protein Synthesis
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Before (0 days), During (0-14 days inclusive), and After (14-28 days inclusive) of unilateral limb immobilization
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Skeletal Muscle Strength
기간: Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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Change in Skeletal Muscle Strength
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Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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Muscle Lipid Composition
기간: Baseline (-28 days), and at Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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Change in Muscle Lipid Composition
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Baseline (-28 days), and at Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
근육 위축에 대한 임상 시험
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Istanbul University모병Masticatory Muscle Pain | 근시 통증 증후군 (MP)칠면조
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Istanbul University모병이갈이 | 근막 통증 증후군 | Masticatory Muscle Pain | 현지 근육통터키 (Türkiye)
n3 PUFA 강화 어유에 대한 임상 시험
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National Heart, Lung, and Blood Institute (NHLBI)완전한
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Mario Negri Institute for Pharmacological Research모병염증 | 지질 | 심혈관 질환 | n-3 다중불포화 지방산 (n-3 PUFA)이탈리아
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Mayo ClinicNational Institute on Aging (NIA); National Center for Research Resources (NCRR)완전한