n3 PUFA and Muscle-disuse Atrophy in Young Women
Effects of n3 PUFA Supplementation on the Attenuation of Muscle Disuse Atrophy in Young Women
研究概览
详细说明
Biological aging is associated with the loss of skeletal muscle mass and strength resulting in compromised metabolic function and mobility. Throughout life, individuals will also experience periods of reduced physical activity/muscle disuse that independently lower muscle mass and strength accelerating the aging process. The losses in muscle mass with aging and disuse are underpinned by feeding-induced declines in rates of muscle protein synthesis. Thus, strategies to enhance muscle protein synthesis could have clinical implications for those who wish to maintain metabolic health and function during times of muscle disuse.
Supplementation with n3 PUFA-enriched fish oil has been shown to potentiate rates of muscle protein synthesis in response to simulated feeding in both younger and older adults. Fish oil supplementation also has been efficacious in enhancing skeletal muscle strength during a period of resistance exercise training. However, no study has examined the impact of fish oil supplementation to enhance muscle protein synthesis and offset declines in muscle mass/strength during a period of immobilization.
研究类型
注册 (实际的)
阶段
- 不适用
联系人和位置
学习地点
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Ontario
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Hamilton、Ontario、加拿大、L8S 4K1
- Exercise Metabolism Research Laboratory, McMaster Univeristy
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参与标准
资格标准
适合学习的年龄
接受健康志愿者
有资格学习的性别
描述
Inclusion Criteria:
- Female
- Aged 18-30 years
Exclusion Criteria:
- Take any analgesic or anti-inflammatory drugs(s), prescription or non-prescription, chronically will be excluded
- A history of neuromuscular problems or muscle and/or bone wasting diseases
- Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
- Use medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications)
- Fish allergy
学习计划
研究是如何设计的?
设计细节
- 主要用途:基础科学
- 分配:随机化
- 介入模型:并行分配
- 屏蔽:双倍的
武器和干预
参与者组/臂 |
干预/治疗 |
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实验性的:n3 PUFA
Intervention: n3 PUFA (3000mg of Eicosapentaenoic acid per day and 1800mg of Docosahexaenoic acid per day)
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每天 3000 毫克二十碳五烯酸和 1800 毫克二十二碳六烯酸
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安慰剂比较:Placebo
Intervention: Organic Sunflower Oil 5000mg per day
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有机葵花籽油 5000 毫克/天
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研究衡量的是什么?
主要结果指标
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Muscle Volume
大体时间:Baseline (0 days), After (14 days) of unilateral limb immobilization and at 14 days post immobilization
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Change in Muscle Volume Measured by Magnetic Resonance Imaging
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Baseline (0 days), After (14 days) of unilateral limb immobilization and at 14 days post immobilization
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次要结果测量
结果测量 |
措施说明 |
大体时间 |
---|---|---|
Integrated Rates of Muscle Protein Synthesis
大体时间:Before (0 days), During (0-14 days inclusive), and After (14-28 days inclusive) of unilateral limb immobilization
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Change in Muscle Protein Synthesis
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Before (0 days), During (0-14 days inclusive), and After (14-28 days inclusive) of unilateral limb immobilization
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Skeletal Muscle Strength
大体时间:Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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Change in Skeletal Muscle Strength
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Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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Muscle Lipid Composition
大体时间:Baseline (-28 days), and at Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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Change in Muscle Lipid Composition
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Baseline (-28 days), and at Before (0 days), After (14 days) of unilateral limb immobilization and at 14 days Post immobilization
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合作者和调查者
研究记录日期
研究主要日期
学习开始 (实际的)
初级完成 (实际的)
研究完成 (实际的)
研究注册日期
首次提交
首先提交符合 QC 标准的
首次发布 (实际的)
研究记录更新
最后更新发布 (实际的)
上次提交的符合 QC 标准的更新
最后验证
更多信息
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肌肉萎缩的临床试验
n3 富含多不饱和脂肪酸的鱼油的临床试验
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Mayo ClinicNational Institute on Aging (NIA); National Center for Research Resources (NCRR)完全的
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National Heart, Lung, and Blood Institute (NHLBI)完全的