Hyperglycemia as a Prognostic Factor In Acute Ischemic Stroke Patients
Background: Hyperglycemia is encountered in 20% to 40% of acute stroke patients, with or without a pre-morbid diagnosis of diabetes mellitus. Hyperglycemia is a risk factor for infarct expansion and poor outcome through the first 72 hours of onset in both diabetics and non-diabetics patients. This study was done to evaluate the glycemic status after acute ischemic stroke and assess its rule in influencing stroke outcome as regards the duration of hospital stay, motor deficit and mortality.
Methods: This retrospective study was conducted in Elzaiton specialized hospital from June 2016 to June 2017on 80 patients after approval of local medical ethical committee. Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms were included and divided into two groups, controlled group (Random blood suger not more than 150 mg/dl) and uncontrolled group ( Random blood suger more than 150 mg/dl). All patients were evaluated for GCS as a primary outcome and for hemorrhagic transformation, hospital stay duration, mechanical ventilation, need for vasopressors,hospital stay and mortality as secondary outcomes.
연구 개요
상세 설명
Patients and Methods This study was prospective study conducted in Elzaiton specialized hospital and Ain Shams University from june2016 to June 2017on 80 patients after approval of local medical ethical committee
All patients was subjected to the following
- Full clinical history …age, sex, weight and medical history
- GCS and motor deficit
- Random blood glucose level at admission and 4-6 times daily during hospital stay
- HbA1c on admission
- Hemodynamic monitoring
- Duration of hospital stay
- Thirty day mortality
- Other laboratory investigation to rule out other similar cause
- Follow up hemorrhagic transformation Study tools: Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms will be evaluated.
On ICU admission the random blood sugar was recorded and categorized to less than 150mg/dl (accepted) and more than 150mg/dl(not controlled). Also serial Random blood sugar daily was recorded and categorized to accepted or good control if less than 150mg/dl and not controlled if more than 150mg/dl.
Patients were divided into 2 groups Patients with accepted random blood sugar at admission and controlled blood sugar during hospital stay.
Patients with increased random blood sugar at admission and poor blood sugar control during hospital stay.
These data were collected and patients were observed as regards duration of hospital stay,hemorrhagic transformation, hospital stay duration and 30-days mortality
연구 유형
등록 (실제)
연락처 및 위치
연구 장소
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Ain Shams University Specialized Hospital
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Cairo, Ain Shams University Specialized Hospital, 이집트
- Hanaa El Gendy
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms will be evaluated.
At ICU admission the random blood sugar was recorded and categorized to less than 150mg/dl (accepted) and more than 150mg/dl(not controlled). Also serial Random blood sugar daily was recorded and categorized to accepted or good control if less than 150mg/dl and not controlled if more than 150mg/dl.
Patients were divided into 2 groups Patients with accepted random blood sugar at admission and controlled blood sugar during hospital stay (B) Patients with increased random blood sugar at admission and poor blood sugar control during hospital stay These data were collected and patients were observed as regards duration of hospital stay, motor deficit improvement or worsening using Rating scale for muscle strength
설명
Inclusion criteria
- Age: 40-70years
- Sex: Any sex
- Patients with acute ischemic stroke without other major comorbidities within 24 hours of onset of symptoms were evaluated.
Exclusion criteria
- Subdural heamatoma, metabolic causes or transient ischemic attack
- Sub arachnoid heamorrage
- Heamorragic stroke
- Patients with major comorbidities at admission as end stage liver disease, end stage renal disease and malignant hypertension
- Patients with hyperglycemia at admission and controlled blood sugar during hospital stay
- Patients with DKA or hypoglycemia (RBS less than 70 mg dl)
공부 계획
공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (실제)
연구 완료 (실제)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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