Ex Vivo Test of New Stroke Treatment Using Magnetic Nanorobots
Steered t-PA Delivery for Thrombolysis Test Using Magnetic Swarming Nanorobots on Human Placenta as an ex Vivo Model of Human Cerebral Vascular System
Tissue plasminogen activator (tPA) is the FDA approved thrombolytic drug for patients with acute ischemic stroke. While transcatheter endovascular therapy is widely accepted as an effective method for targeted blood vessels via a catheter to elicit ischemic necrosis.
To improve targeting accuracy administrated tPA and avoiding collateral tissue damage, we developed a magnetic nanorobotic system to active system to active intravenous delivery of tPA for targeted thrombus removal. Here human placenta will be used as an ex vivo model for human cerebral vascular system in our ex vivo thrombolysis study. Our magnetic nanorobotic system encapsulated with tPA overcomes the limitations of passive thrombolytic therapy with tPA alone and will be a promising approach for the treatment of ischemic stroke and other thrombotic diseases
연구 개요
상태
정황
연구 유형
등록 (예상)
연락처 및 위치
연구 장소
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New Territories
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Shatin, New Territories, 홍콩
- 모집하지 않고 적극적으로
- Advanced Nanomaterials & Microrobotics Laboratory, Room 202, William M.W Mong Engineering Building, CUHK and Room 508, Li Ka Shing Medical Sciences Building, Prince of Wales Hospital
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Shatin, New Territories, 홍콩
- 모병
- Department of Obstetrics and Gynaecology, Prince of Wales Hospital
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연락하다:
- Pui Wah Chung, Doctor
- 전화번호: (852) 35051537
- 이메일: jacquelinechung@cuhk.edu.hk
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수석 연구원:
- Pui Wah Chung, Doctor
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참여기준
자격 기준
공부할 수 있는 나이
건강한 자원 봉사자를 받아들입니다
연구 대상 성별
샘플링 방법
연구 인구
- Healthy pregnant women at 20-45 years of age of any ethic origin, giving childbirth with natural delivery or caesarean sections after 37-42 weeks of gestation.
- Healthy singleton pregnancy.
- Participant able to give voluntary, written, informed consent to participate in the study.
설명
Inclusion Criteria:
- Healthy pregnant women at 20-45 years of age of any ethic origin, giving childbirth with natural delivery or caesarean sections after 37-42 weeks of gestation.
- Healthy singleton pregnancy.
- Participant able to give voluntary, written, informed consent to participate in the study.
Exclusion Criteria:
- Abnormal prenatal development (e.g intrauterine growth restriction)
- Early preterm birth < 37 weeks
- Verbal Confirmation of hypercholesterolemia
- Family history of stroke or vascular disease
- Type I or Type II diabetes and gestational diabetes
- Cancer, except skin cancers completely excised with no chemotherapy or radiation with a follow up that is negative.
- Clinically significant abnormal laboratory results at screening.
- Any other active or unstable medical condition.
- History of liver disease.
- History of hypertension (including pre-eclampsia)
공부 계획
연구는 어떻게 설계됩니까?
디자인 세부사항
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Thrombolysis performance
기간: 1 -2 hours
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Size of thrombus by angiography, mm
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1 -2 hours
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Time for recanalization
기간: 1 -2 hours
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Time for recanalization of occluded vessels, mins
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1 -2 hours
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Damage to vessels
기간: 1 -2 hours
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Histological damage evaluation.
The vessels are sectioned and stained with H&E stain
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1 -2 hours
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
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Stability of magnetic nanorobots
기간: 1 - 2 hours
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Controllability of the magnetic nanorobots.
The loss in mass of nanorobots after magetic navigation in blood vessels is measured.
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1 - 2 hours
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Dosage requirement
기간: 1 - 2 hours
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Dosage requirement of nanorobots and thus t-PA, mg
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1 - 2 hours
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Distribution of administrated nanorobots
기간: 1 - 2 hours
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The distribution of administrated nanorobots.
The position of nanorobots is tracked by MRI.
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1 - 2 hours
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공동 작업자 및 조사자
연구 기록 날짜
연구 주요 날짜
연구 시작 (실제)
기본 완료 (예상)
연구 완료 (예상)
연구 등록 날짜
최초 제출
QC 기준을 충족하는 최초 제출
처음 게시됨 (실제)
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
QC 기준을 충족하는 마지막 업데이트 제출
마지막으로 확인됨
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .