이것은 PD-L1 수치가 높은 비소세포폐암 환자에게 연구 약물인 Sigvotatug Vedotin과 Pembrolizumab의 병용 요법이 어떻게 작용하는지 알아보기 위한 연구입니다.
2026년 9월 22일 업데이트: Pfizer
AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
- Are confirmed to have NSCLC (Stage 3 or 4).
- Have PD-L1 levels in more than 50% of the cancer cells.
All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab.
Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.
연구 개요
연구 유형
중재적
등록 (추정된)
714
단계
- 3단계
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 연락처
- 이름: Pfizer CT.gov Call Center
- 전화번호: 1-800-718-1021
- 이메일: ClinicalTrials.gov_Inquiries@pfizer.com
연구 장소
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Athens, 그리스, 115 26
- 모병
- Errikos Dunant Hospital Center
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Larissa, 그리스, 41110
- 모병
- University General Hospital of Larissa, Urology Department
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Thessaloniki, 그리스, 552 36
- 모병
- Agios Loukas Clinic
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Attikí
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Athens, Attikí, 그리스, 115 27
- 모병
- Thoracic General Hospital of Athens "I Sotiria"
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Athens, Attikí, 그리스, 155 62
- 모병
- Metropolitan General Hospital
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Athens, Attikí, 그리스, 185 47
- 모병
- Metropolitan Hospital
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Marousi, Attikí, 그리스, 151 23
- 모병
- Hygeia Hospital
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Thessaloníki
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Thessaloniki, Thessaloníki, 그리스, 570 01
- 모병
- European Interbalkan Medical Center
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-
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Utrecht, 네덜란드, 3543 AZ
- 모병
- St. Antonius Ziekenhuis, locatie Utrecht
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Gelderland
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Harderwijk, Gelderland, 네덜란드, 3844 DG
- 모병
- Ziekenhuis St. Jansdal
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North Brabant
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Breda, North Brabant, 네덜란드, 4818 CK
- 아직 모집하지 않음
- Amphia Ziekenhuis, locatie Breda Molengracht
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Overijssel
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Zwolle, Overijssel, 네덜란드, 8025 AB
- 모병
- Isala, locatie Zwolle
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Provincie Friesland
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Leeuwarden, Provincie Friesland, 네덜란드, 8934 AD
- 아직 모집하지 않음
- Frisius Medisch Centrum
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Kaohsiung City, 대만, 807
- 아직 모집하지 않음
- Kaohsiung Medical University Chung-Ho Memorial Hospital
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Kaohsiung City, 대만, 833401
- 모병
- Chang Gung Memorial Hospital at Kaohsiung
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Taichung, 대만, 407
- 아직 모집하지 않음
- Taichung Veterans General Hospital
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Tainan, 대만, 704
- 모병
- National Cheng Kung University Hospital
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Taipei, 대만, 11217
- 모병
- Taipei Veterans General Hospital
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Taipei, 대만, 10002
- 아직 모집하지 않음
- National Taiwan University Hospital
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Tainan
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Tainan, Tainan, 대만, 73657
- 아직 모집하지 않음
- Chi Mei Hospital - Liouying Branch
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Taipei
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Taipei City, Taipei, 대만, 106
- 아직 모집하지 않음
- National Taiwan University Cancer Center (NTUCC)
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-
-
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Jeonranamdo
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Hwasun-gun, Jeonranamdo, 대한민국, 58128
- 모병
- Chonnam National University Hwasun Hospital
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Kyǒnggi-do
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Seongnam, Kyǒnggi-do, 대한민국, 13620
- 모병
- Seoul National University Bundang Hospital
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Suwon, Kyǒnggi-do, 대한민국, 16499
- 모병
- Ajou University Hospital
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Suwon, Kyǒnggi-do, 대한민국, 16247
- 모병
- The Catholic University Of Korea St. Vincent's Hospital
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Pusan-kwangyǒkshi
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Busan, Pusan-kwangyǒkshi, 대한민국, 49241
- 모병
- Pusan National University Hospital
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Haeundae-gu, Pusan-kwangyǒkshi, 대한민국, 48108
- 모병
- Inje University Haeundae Paik Hospital
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Seoul-teukbyeolsi [seoul]
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Seoul, Seoul-teukbyeolsi [seoul], 대한민국, 03722
- 모병
- Severance Hospital, Yonsei University Health System
-
Seoul, Seoul-teukbyeolsi [seoul], 대한민국, 07061
- 모병
- Boramae Medical Center
-
Seoul, Seoul-teukbyeolsi [seoul], 대한민국, 08308
- 모병
- Korea University Guro Hospital
-
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Taegu-kwangyǒkshi
-
Deagu, Taegu-kwangyǒkshi, 대한민국, 41404
- 모병
- Kyungpook National University Chilgok Hospital
-
-
-
-
-
Bad Berka, 독일, 99437
- 모병
- Zentralklinik Bad Berka GmbH
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Berlin, 독일, 10117
- 모병
- Charité - Universitätsmedizin Berlin
-
Berlin, 독일, 13353
- 모병
- Charité Campus Virchow-Klinikum
-
Berlin, 독일, 13353
- 모병
- Labor Berlin
-
Berlin, 독일, 13509
- 모병
- Vivantes Humboldt Klinikum Apotheke Nord
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Berlin, 독일, 13585
- 모병
- Vivantes Hospital Spandau
-
Gauting, 독일, 82131
- 모병
- Asklepios Klinik Gauting GmbH
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Großhansdorf, 독일, 22927
- 모병
- LungenClinic Grosshansdorf
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München, 독일, 81377
- 모병
- Radiologie München
-
-
Baden-Wurttemberg
-
Ulm, Baden-Wurttemberg, 독일, 89081
- 모병
- Universitaetsklinikum Ulm
-
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Bavaria
-
Gröbenzell, Bavaria, 독일, 82194
- 모병
- Johannes Apotheke Gröbenzell
-
Traunstein, Bavaria, 독일, 83278
- 모병
- Klinikum Traunstein
-
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Hesse
-
Giessen, Hesse, 독일, 35392
- 모병
- UKGM Gießen/Marburg
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Kassel, Hesse, 독일, 34125
- 모병
- Klinikum Kassel
-
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Rhineland-Palatinate
-
Koblenz, Rhineland-Palatinate, 독일, 56068
- 모병
- InVO Institut für Versorgungsforschung in der Onkologie
-
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Saxony
-
Chemnitz, Saxony, 독일, 09116
- 모병
- Klinikum Chemnitz - Flemmingstraße
-
Chemnitz, Saxony, 독일, 09113
- 모병
- Klinikum Chemnitz gGmbH
-
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Saxony-Anhalt
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Halle, Saxony-Anhalt, 독일, 06120
- 모병
- Krankenhaus Martha-Maria Halle-Dölau
-
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Schleswig-Holstein
-
Lübeck, Schleswig-Holstein, 독일, 23538
- 모병
- Universitätsklinikum Schleswig-Holstein
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Oldenburg in Holstein, Schleswig-Holstein, 독일, 23758
- 모병
- ohO Research GmbH
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-
-
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Bucharest
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Bucharest, Bucharest, 루마니아, 013812
- 모병
- SC Memorial Healthcare International SRL
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Bucharest, Bucharest, 루마니아, 022338
- 모병
- Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
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Bucharest, Bucharest, 루마니아, 077190
- 아직 모집하지 않음
- Sc Mnt Healthcare Europe Srl
-
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Cluj
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Cluj-Napoca, Cluj, 루마니아, 400641
- 모병
- SC Medisprof SRL
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Florești, Cluj, 루마니아, 407280
- 모병
- SC Radiotherapy Center Cluj SRL
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Constanța County
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Ovidiu, Constanța County, 루마니아, 905900
- 모병
- Ovidius Clinical Hospital OCH
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Dolj
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Craiova, Dolj, 루마니아, 200542
- 아직 모집하지 않음
- Centrul de Oncologie "Sfântul Nectarie"
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Craiova, Dolj, 루마니아, 200385
- 모병
- SC Oncolab SRL
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Timiș County
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Timișoara, Timiș County, 루마니아, 300166
- 아직 모집하지 않음
- S C Oncocenter Oncologie Clinica S R L
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-
-
-
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Mexico City, 멕시코, 14080
- 아직 모집하지 않음
- Instituto Nacional de Cancerologia
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Puebla City, 멕시코, 72530
- 모병
- Clinica Integral Internacional de Oncología
-
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Jalisco
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Guadalajara, Jalisco, 멕시코, 44340
- 모병
- Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
-
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Veracruz
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Veracruz de Ignacio de LA Llave, Veracruz, 멕시코, 91900
- 아직 모집하지 않음
- Instituto Veracruzano en Investigación Clínica S.C.
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-
-
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California
-
Fullerton, California, 미국, 92835
- 모병
- Providence Medical Foundation
-
Fullerton, California, 미국, 92835
- 모병
- Providence St. Jude Medical Center
-
Fullerton, California, 미국, 92835
- 모병
- Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center
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Fullerton, California, 미국, 92835
- 모병
- St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)
-
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Colorado
-
Golden, Colorado, 미국, 80401
- 모병
- Intermountain Health Cancer Center Lutheran Hospital
-
Grand Junction, Colorado, 미국, 81501
- 모병
- Cancer Centers of Colorado St. Mary's Regional Hospital
-
Grand Junction, Colorado, 미국, 81505
- 모병
- Intermountain Health
-
Grand Junction, Colorado, 미국, 81501
- 모병
- Intermountain Health St. Mary's Regional Hospital
-
Wheat Ridge, Colorado, 미국, 80401
- 모병
- Intermountain Health Lutheran Hospital
-
-
District of Columbia
-
Washington D.C., District of Columbia, 미국, 20422
- 모병
- Washington DC Veterans Affairs Medical Center
-
-
Florida
-
Orange City, Florida, 미국, 32763
- 모병
- Mid Florida Hematology and Oncology Center
-
Plantation, Florida, 미국, 33322
- 모병
- BRCR Global
-
-
Illinois
-
Elmhurst, Illinois, 미국, 60126
- 모병
- Endeavor Health
-
Hinsdale, Illinois, 미국, 60521
- 모병
- Hope and Healing Cancer Services
-
Libertyville, Illinois, 미국, 60048
- 모병
- Advocate Medical Group - Libertyville Oncology
-
Naperville, Illinois, 미국, 60540
- 모병
- Endeavor Health
-
New Lenox, Illinois, 미국, 60451
- 모병
- Hope and Healing Cancer Services
-
Oak Lawn, Illinois, 미국, 60453
- 모병
- Advocate Christ Medical Center
-
Park Ridge, Illinois, 미국, 60068
- 모병
- Advocate Lutheran General Hospital
-
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Kansas
-
Overland Park, Kansas, 미국, 66213
- 모병
- Saint Luke's South Hospital
-
-
Maine
-
Portland, Maine, 미국, 04102
- 모병
- Maine Medical Center
-
Scarborough, Maine, 미국, 04074
- 모병
- MaineHealth Cancer Care and Blood Disorders Scarborough
-
South Portland, Maine, 미국, 04106
- 모병
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Massachusetts
-
Fairhaven, Massachusetts, 미국, 02719
- 모병
- Southcoast Centers for Cancer Care
-
Fall River, Massachusetts, 미국, 02720
- 모병
- Southcoast Centers for Cancer Care
-
-
Michigan
-
Grand Rapids, Michigan, 미국, 49503
- 모병
- Corewell Health
-
Grand Rapids, Michigan, 미국, 49503
- 모병
- Corewell Health - Butterworth Hospital
-
Grand Rapids, Michigan, 미국, 49503
- 모병
- Corewell Health - Lemmen Holton Cancer Pavilion
-
Grand Rapids, Michigan, 미국, 49503
- 모병
- Corewell Health - Research Specimen Processing Area
-
Grand Rapids, Michigan, 미국, 49503
- 모병
- Corewell Health Investigational Drug Services
-
-
Minnesota
-
Burnsville, Minnesota, 미국, 55337
- 모병
- Minnesota Oncology Hematology, PA
-
Coon Rapids, Minnesota, 미국, 55433
- 모병
- Minnesota Oncology Hematology PA
-
Edina, Minnesota, 미국, 55435
- 모병
- M Health Fairview Cancer Clinic-Edina
-
Edina, Minnesota, 미국, 55435
- 모병
- Minnesota Oncology Hematology PA
-
Maple Grove, Minnesota, 미국, 55369
- 모병
- Minnesota Oncology Hematology PA
-
Maplewood, Minnesota, 미국, 55109
- 모병
- M Health Fairview St. John's Hospital
-
Maplewood, Minnesota, 미국, 55109
- 모병
- Minnesota Oncology Hematology PA
-
Minneapolis, Minnesota, 미국, 55415
- 모병
- Hennepin County Medical Center
-
Robbinsdale, Minnesota, 미국, 55422
- 모병
- North Memorial Health Cancer Center
-
Saint Louis Park, Minnesota, 미국, 55426
- 모병
- Park Nicollet Frauenshuh Cancer Center
-
Saint Louis Park, Minnesota, 미국, 55426
- 모병
- Metro Minnesota Community Oncology Research Consortium (MMCORC)
-
Saint Paul, Minnesota, 미국, 55101
- 모병
- Regions Hospital
-
Woodbury, Minnesota, 미국, 55125
- 모병
- Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center
-
-
Mississippi
-
Jackson, Mississippi, 미국, 39202
- 모병
- Jackson Oncology Associates, PLLC
-
Jackson, Mississippi, 미국, 39216
- 모병
- Jackson Oncology Associates, PLLC
-
-
Missouri
-
Kansas City, Missouri, 미국, 64111
- 모병
- Saint Luke's Hospital of Kansas City
-
Lee's Summit, Missouri, 미국, 64086
- 모병
- Saint Luke's East Hospital
-
-
Montana
-
Billings, Montana, 미국, 59101
- 모병
- SCL Health - Montana
-
Billings, Montana, 미국, 59102
- 모병
- SCL Health - Montana
-
-
Nebraska
-
Fremont, Nebraska, 미국, 68025
- 모병
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont
-
Grand Island, Nebraska, 미국, 68803
- 모병
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
-
Grand Island, Nebraska, 미국, 68803
- 모병
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional
-
Kearney, Nebraska, 미국, 68845
- 모병
- Kearney Cancer Center
-
Lincoln, Nebraska, 미국, 68516
- 모병
- Cancer Partners of Nebraska
-
Omaha, Nebraska, 미국, 68130
- 모병
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists
-
Omaha, Nebraska, 미국, 68114
- 모병
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist
-
Omaha, Nebraska, 미국, 68124
- 모병
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan
-
-
New York
-
Nyack, New York, 미국, 10960
- 모병
- Hematology Oncology Associates of Rockland
-
-
North Carolina
-
Greenville, North Carolina, 미국, 27834
- 모병
- Brody School of Medicine at East Carolina University
-
Greenville, North Carolina, 미국, 27834
- 모병
- ECU Health Medical Center
-
Wilson, North Carolina, 미국, 27893
- 모병
- Carolina Cancer Research Center
-
-
Ohio
-
Avon, Ohio, 미국, 44011
- 모병
- University Hospitals Seidman Cancer Center at UH Avon Health Center
-
Canton, Ohio, 미국, 44718
- 종료됨
- Gabrail Cancer Center Research
-
Cleveland, Ohio, 미국, 44106
- 모병
- University Hospitals Cleveland Medical Center
-
Mentor, Ohio, 미국, 44060
- 모병
- University Hospitals Seidman Cancer Center at UH Mentor Health Center
-
Orange, Ohio, 미국, 44122
- 모병
- UH Minoff Health Center at Chagrin Highlands
-
-
Texas
-
Conroe, Texas, 미국, 77384
- 모병
- The University of Texas, MD Anderson Cancer Center - Woodlands
-
El Paso, Texas, 미국, 79915
- 모병
- Renovatio Clinical - El Paso
-
Houston, Texas, 미국, 77030
- 모병
- University of Texas MD Anderson Cancer Center
-
Houston, Texas, 미국, 77030
- 모병
- The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
-
Houston, Texas, 미국, 77030
- 모병
- The University of Texas MD Anderson Cancer Center Diagnostic Imaging
-
Houston, Texas, 미국, 77030
- 모병
- The University of Texas, MD Anderson Cancer Center- Interventional Radiology
-
Houston, Texas, 미국, 77054
- 모병
- The University of Texas MD Anderson Cancer Center Clinical Research Imaging
-
Houston, Texas, 미국, 77079
- 모병
- The University of Texas, MD Anderson Cancer Center - West Houston
-
Kingwood, Texas, 미국, 77339
- 모병
- Community Clinical Trials
-
League City, Texas, 미국, 77573
- 모병
- The University of Texas, MD Anderson Cancer Center - League City
-
Sugar Land, Texas, 미국, 77478
- 모병
- The University of Texas, MD Anderson Cancer Center - Sugar Land
-
The Woodlands, Texas, 미국, 77380
- 모병
- Renovatio Clinical
-
The Woodlands, Texas, 미국, 77381
- 모병
- Woodlands Radiology
-
-
Washington
-
Olympia, Washington, 미국, 98502
- 모병
- American Oncology Network Vista Oncology Division-West office
-
Olympia, Washington, 미국, 98506
- 모병
- American Oncology Network Vista Oncology Division-East office
-
-
Wisconsin
-
Grafton, Wisconsin, 미국, 53024
- 모병
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, 미국, 54311
- 모병
- Aurora BayCare Medical Center
-
Milwaukee, Wisconsin, 미국, 53215
- 모병
- Aurora St. Luke's Medical Center
-
-
-
-
-
Brasschaat, 벨기에, 2930
- 모병
- Algemeen Ziekenhuis klina
-
Liège, 벨기에, 4000
- 모병
- Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
-
-
Antwerpen
-
Mechelen, Antwerpen, 벨기에, 2800
- 모병
- AZ Sint-Maarten
-
-
Bruxelles-capitale, Région de
-
Brussels, Bruxelles-capitale, Région de, 벨기에, 1090
- 모병
- UZ Brussel
-
-
Hainaut
-
Charleroi, Hainaut, 벨기에, 6060
- 모병
- Grand Hôpital de Charleroi
-
-
-
-
-
Burgas, 불가리아, 8000
- 모병
- Complex Oncology Center - Burgas
-
Plovdiv, 불가리아, 4000
- 아직 모집하지 않음
- Medical Center Futuremeds
-
Sofia, 불가리아, 1407
- 모병
- Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
-
Sofia, 불가리아, 1330
- 모병
- MHAT for Women's Health Nadezhda
-
Sofia, 불가리아, 1756
- 모병
- University Specialized Hospital for Active Treatment of Oncology EAD
-
-
Pazardzhik
-
Panagyurishte, Pazardzhik, 불가리아, 4500
- 모병
- MBAL Uni Hospital
-
-
-
-
-
Jaú, 브라질, 17210-080
- 아직 모집하지 않음
- Fundação Doutor Amaral Carvalho
-
Rio de Janeiro, 브라질, 22281-100
- 모병
- Instituto D'Or de Pesquisa e Ensino
-
Rio de Janeiro, 브라질, 22031-011
- 모병
- Instituto D'Or de Pesquisa e Ensino
-
Rio de Janeiro, 브라질, 22271-110
- 모병
- Instituto D'Or de Pesquisa e Ensino
-
Rio de Janeiro, 브라질, 22451-040
- 모병
- Instituto D'Or de Pesquisa e Ensino
-
São Paulo, 브라질, 01246-000
- 아직 모집하지 않음
- Icesp - Instituto Do Câncer Do Estado de São Paulo
-
-
Ceará
-
Fortaleza, Ceará, 브라질, 60430235
- 모병
- Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
-
Fortaleza, Ceará, 브라질, 60336232
- 모병
- Crio - Centro Regional Integrado de Oncologia
-
-
Espírito Santo
-
Vitória, Espírito Santo, 브라질, 29043-260
- 모병
- Afecc Associacao Feminina Educacao Combate Cancer
-
-
Estado de Bahia
-
Salvador, Estado de Bahia, 브라질, 41950- 640
- 모병
- Clinica Amo - Rio Vermelho
-
Salvador, Estado de Bahia, 브라질, 41253-190
- 모병
- Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael
-
-
Federal District
-
Brasília, Federal District, 브라질, 70390-150
- 아직 모집하지 않음
- Onco-Vida - Instituto Especializado De Oncologia
-
-
Paraná
-
Curitiba, Paraná, 브라질, 81520-060
- 모병
- Hospital Erasto Gaertner
-
-
Pernambuco
-
Recife, Pernambuco, 브라질, 52010-902
- 모병
- Real Hospital de Beneficência Portuguesa de Pernambuco
-
-
Piauí
-
Teresina, Piauí, 브라질, 64049-200
- 모병
- Vencer Centro de Pesquisa LTDA
-
-
Rio Grande do Norte
-
Natal, Rio Grande do Norte, 브라질, 59062-000
- 모병
- Liga Norte Riograndense Contra o Câncer
-
-
Rio Grande do Sul
-
Ijuí, Rio Grande do Sul, 브라질, 98700-000
- 모병
- ONCOSITE - Centro de Pesquisa Clinica em Oncologia
-
Porto Alegre, Rio Grande do Sul, 브라질, 90560032
- 아직 모집하지 않음
- Hospital Moinhos de Vento
-
Porto Alegre, Rio Grande do Sul, 브라질, 90610-000
- 모병
- Hospital São Lucas da PUCRS
-
-
Santa Catarina
-
Lages, Santa Catarina, 브라질, 88501-001
- 모병
- ANIMI - Unidade de Tratamento Oncologico
-
-
São Paulo
-
Barretos, São Paulo, 브라질, 14784400
- 모병
- Fundação Pio XII - Hospital de Câncer de Barretos
-
Bragança Paulista, São Paulo, 브라질, 12916-542
- 모병
- Hospital Universitário São Francisco na Providência de Deus
-
Ribeirão Preto, São Paulo, 브라질, 14051-140
- 모병
- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
-
Santo André, São Paulo, 브라질, 09060-650
- 모병
- Faculdade de Medicina do ABC
-
São José do Rio Preto, São Paulo, 브라질, 15090000
- 모병
- Fundação Faculdade Regional de Medicina de São José do Rio Preto
-
São Paulo, São Paulo, 브라질, 01327-001
- 모병
- Hospital Alemao Oswaldo Cruz
-
-
-
-
-
Riyadh, 사우디 아라비아, 11211
- 아직 모집하지 않음
- King Faisal Specialist Hospital and Research Center
-
-
Riyadh Region
-
Riyadh, Riyadh Region, 사우디 아라비아, 11472
- 아직 모집하지 않음
- King Saud University Medical City
-
-
-
-
-
Zurich, 스위스, 8091
- 모병
- UniversitätsSpital Zürich
-
-
Canton of Bern
-
Bern, Canton of Bern, 스위스, 3010
- 모병
- Inselspital Bern
-
-
-
-
-
Barcelona, 스페인, 08035
- 모병
- Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR")
-
Barcelona, 스페인, 08035
- 모병
- Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO"
-
Las Palmas de Gran Canaria, 스페인, 35016
- 모병
- Complejo Hospitalario Universitario Insular Materno-Infantil
-
Madrid, 스페인, 28040
- 모병
- Hospital Universitario Fundación Jiménez Díaz
-
Madrid, 스페인, 28003
- 모병
- FutureMeds - Madrid
-
Madrid, 스페인, 28007
- 모병
- Hospital General Universitario Gregorio Marañon
-
Málaga, 스페인, 29004
- 모병
- Hospital Quirón Málaga
-
Seville, 스페인, 41013
- 모병
- Hospital Universitario Virgen Del Rocio
-
-
A Coruña [LA Coruña]
-
A Coruña, A Coruña [LA Coruña], 스페인, 15006
- 모병
- CHUAC-Complejo Hospitalario Universitario A Coruña
-
-
Alicante
-
Elche, Alicante, 스페인, 03203
- 모병
- Hospital General Universitario de Elche
-
-
Barcelona [barcelona]
-
Barcelona, Barcelona [barcelona], 스페인, 08028
- 모병
- Hospital Universitari Dexeus
-
-
Barcelona/spain
-
Barcelona, Barcelona/spain, 스페인, 08035
- 모병
- Hospital Universitari Vall D Hebron
-
-
Catalunya [cataluña]
-
Barcelona, Catalunya [cataluña], 스페인, 08041
- 모병
- Hospital de la Santa Creu i Sant Pau
-
L'Hospitalet de Llobregat, Catalunya [cataluña], 스페인, 08908
- 모병
- Institut Català d'Oncologia - L'Hospitalet
-
-
Cádiz
-
Jerez de la Frontera, Cádiz, 스페인, 11407
- 모병
- Hospital Jerez de la Frontera
-
-
Illes Balears [islas Baleares]
-
Palma, Illes Balears [islas Baleares], 스페인, 07198
- 모병
- Hospital Son Llàtzer
-
-
Madrid, Comunidad de
-
Madrid, Madrid, Comunidad de, 스페인, 28041
- 모병
- Hospital Universitario 12 de Octubre
-
-
Valenciana, Comunitat
-
Valencia, Valenciana, Comunitat, 스페인, 46010
- 모병
- Hospital Clinico de Valencia
-
-
-
-
-
Nové Zámky, 슬로바키아, 94034
- 모병
- Fakultna nemocnica s poliklinikou Nove Zamky
-
Poprad, 슬로바키아, 058 01
- 모병
- POKO Poprad s.r.o.
-
-
Bratislava Region
-
Bratislava, Bratislava Region, 슬로바키아, 821 01
- 모병
- Univerzitná nemocnica Bratislava - Nemocnica Ružinov
-
-
Košice Region
-
Košice, Košice Region, 슬로바키아, 040 01
- 모병
- Vychodoslovensky Onkologicky Ustav a.s.
-
-
Nitra Region
-
Komárno, Nitra Region, 슬로바키아, 945 05
- 모병
- Nemocnica AGEL Komarno
-
-
Trnava Region
-
Trnava, Trnava Region, 슬로바키아, 917 02
- 모병
- Fakultna nemocnica Trnava
-
-
-
-
-
Buenos Aires, 아르헨티나, 1426
- 모병
- Centro Oncologico Korben
-
Buenos Aires, 아르헨티나, C1122AAL
- 모병
- Instituto Argentino de Diagnóstico y Tratamiento (IADT)
-
Córdoba, 아르헨티나, 5016
- 모병
- Hospital Privado Universitario de Córdoba
-
Córdoba, 아르헨티나, 5000
- 모병
- Sanatorio Privado de la Cañada
-
Córdoba, 아르헨티나, X5008AAC
- 모병
- Centro Medico Privado CEMAIC
-
Córdoba, 아르헨티나, 5000
- 아직 모집하지 않음
- Centro Urológico Profesor Bengió
-
San Juan, 아르헨티나, 5400
- 모병
- Instituto San Marcos
-
-
Buenos Aires
-
Berazategui, Buenos Aires, 아르헨티나, B1884BBF
- 모병
- Centro de Oncología e Investigación de Buenos Aires
-
Ciudad Autónoma de Buenos Aires, Buenos Aires, 아르헨티나, C1426ABP
- 모병
- Fundación Respirar
-
Florida, Buenos Aires, 아르헨티나, B1602DQD
- 모병
- Centro Medico de Enfermedades Respiratorias -CEMER
-
Mar del Plata, Buenos Aires, 아르헨티나, B7600FZD
- 모병
- Investigaciones Oncológicas C. Colón S.A
-
Pergamino, Buenos Aires, 아르헨티나, B2700CPM
- 아직 모집하지 않음
- Centro de Investigación Pergamino
-
-
Cdad. Autónoma de Buenos Aires
-
Buenos Aires, Cdad. Autónoma de Buenos Aires, 아르헨티나, C 1113
- 모병
- Centro de Investigaciones Medicas y Desarrollo LC
-
-
Jujuy Province
-
San Salvador de Jujuy, Jujuy Province, 아르헨티나, 4600
- 모병
- Fundacion Ars Medica
-
-
Río Negro Province
-
Cipolletti, Río Negro Province, 아르헨티나, 8324
- 모병
- Fundacion Medica de Rio Negro y Neuquen
-
-
Santa Fe Province
-
Rosario, Santa Fe Province, 아르헨티나, 2000
- 모병
- Fundacion Estudios Clinicos
-
Rosario, Santa Fe Province, 아르헨티나, S2000DSV
- 모병
- Sanatorio Parque
-
Rosario, Santa Fe Province, 아르헨티나, S2002KDS
- 모병
- Hospital Provincial del Centenario
-
Rosario, Santa Fe Province, 아르헨티나, S2000CVB
- 모병
- Sanatorio Británico
-
-
-
-
-
Manchester, 영국, M20 4BX
- 모병
- The Christie NHS Foundation Trust
-
Reading, 영국, RG1 5AN
- 아직 모집하지 않음
- Royal Berkshire Hospital
-
-
Carnwall
-
Truro, Carnwall, 영국, TR1 3LJ
- 모병
- Royal Cornwall Hospitals NHS Trust
-
-
England
-
Sheffield, England, 영국, S10 2SJ
- 아직 모집하지 않음
- Weston Park Hospital
-
-
Hampshire
-
Southampton, Hampshire, 영국, SO16 6YD
- 모병
- University Hospital Southampton NHS Foundation Trust
-
-
Hillingdon
-
Northwood, Hillingdon, 영국, HA6 2RN
- 아직 모집하지 않음
- Mount Vernon Hospital
-
-
London, CITY of
-
London, London, CITY of, 영국, EC1A 7BE
- 모병
- St Bartholomew's Hospital
-
-
Somerset
-
Taunton, Somerset, 영국, TA1 5DA
- 아직 모집하지 않음
- Musgrove Park Hospital
-
-
Suffolk
-
Ipswich, Suffolk, 영국, IP4 5PD
- 아직 모집하지 않음
- Ipswich Hospital
-
-
-
-
-
Graz, 오스트리아, 8036
- 모병
- Medizinische Universität Graz
-
Vienna, 오스트리아, 1090
- 모병
- Medizinische Universität Wien
-
Vienna, 오스트리아, 1210
- 모병
- Klinik Floridsdorf
-
-
Upper Austria
-
Linz, Upper Austria, 오스트리아, 4020
- 모병
- Ordensklinikum Linz GmbH Elisabethinen
-
-
-
-
-
Petah Tikva, 이스라엘, 4941492
- 모병
- Clalit Health Services through Rabin Medical Center
-
-
Jerusalem
-
Jerusalem, Jerusalem, 이스라엘, 9013102
- 모병
- Shaare Zedek Medical Center
-
-
-
-
-
Avellino, 이탈리아, 83100
- 모병
- Azienda Ospedaliera San Giuseppe Moscati
-
Milan, 이탈리아, 20132
- 모병
- Ospedale San Raffaele
-
Milan, 이탈리아, 20141
- 모병
- Istituto Europeo di Oncologia IRCCS
-
Padova, 이탈리아, 35128
- 모병
- Istituto Oncologico Veneto IRCCS
-
-
Campania
-
Naples, Campania, 이탈리아, 80131
- 모병
- Istituto Nazionale Tumori IRCCS Fondazione Pascale
-
-
Catania
-
Misterbianco, Catania, 이탈리아, 95045
- 모병
- Humanitas Istituto Clinico Catanese
-
-
Emilia-Romagna
-
Meldola, Emilia-Romagna, 이탈리아, 47014
- 모병
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
-
-
Pesaro AND Urbino
-
Pesaro (PU), Pesaro AND Urbino, 이탈리아, 61121
- 모병
- Azienda Sanitaria Territoriale Pesaro e Urbino (AST PU)
-
-
Piedmont
-
Orbassano, Piedmont, 이탈리아, 10043
- 모병
- Azienda Ospedaliero-Universitaria San Luigi Gonzaga
-
-
ROMA
-
Rome, ROMA, 이탈리아, 00186
- 모병
- Ospedale Isola Tiberina - Gemelli Isola
-
-
ROME
-
Roma, ROME, 이탈리아, 00144
- 모병
- IRCCS Istituto Nazionale dei Tumori Regina Elena
-
-
Sicily
-
Catania, Sicily, 이탈리아, 95123
- 모병
- Policlinico "G. Rodolico"
-
-
-
-
Karnataka
-
Bengaluru, Karnataka, 인도, 560069
- 모병
- Spandana Oncology Centre (SOC)
-
-
Maharashtra
-
Mumbai, Maharashtra, 인도, 400012
- 모병
- Tata Memorial Hospital
-
Pune, Maharashtra, 인도, 411004
- 모병
- Sahyadri Super Speciality Hospital
-
Thane, Maharashtra, 인도, 401107
- 모병
- Bhakti Vedanta Hospital and Research Institute
-
-
National Capital Territory of Delhi
-
New Delhi, National Capital Territory of Delhi, 인도, 110088
- 모병
- Fortis Hospital
-
New Delhi, National Capital Territory of Delhi, 인도, 110005
- 모병
- Dr B. L. Kapur Memorial Hospital
-
New Delhi, National Capital Territory of Delhi, 인도, 110075
- 모병
- Venkateshwar Hospital
-
-
Telangana
-
Hyderabad, Telangana, 인도, 500032
- 아직 모집하지 않음
- AIG Hospitals
-
-
-
-
-
Fukuoka, 일본, 810-8563
- 모병
- National Hospital Organization Kyushu Medical Center
-
Fukuoka, 일본, 811-1395
- 모병
- National Hospital Organization Kyushu Cancer Center
-
Kyoto, 일본, 612-8555
- 모병
- National Hospital Organization Kyoto Medical Center
-
Okayama, 일본, 701-1154
- 모병
- National Hospital Organization Okayama Medical Center
-
Osaka, 일본, 541-8567
- 모병
- Osaka International Cancer Institute
-
-
Ehime
-
Tōon, Ehime, 일본, 791-0295
- 아직 모집하지 않음
- Ehime University Hospital
-
-
Fukuoka
-
Kurume, Fukuoka, 일본, 830-0011
- 모병
- Kurume University Hospital
-
-
Gunma
-
Otashi, Gunma, 일본, 373-8550
- 모병
- Gunma Prefectural Cancer Center
-
-
Hokkaido
-
Asahikawa, Hokkaido, 일본, 0708644
- 모병
- National Hospital Organization Asahikawa Medical Center
-
-
Hyōgo
-
Kobe, Hyōgo, 일본, 650-0047
- 모병
- Kobe City Medical Center General Hospital
-
-
Kanagawa
-
Yokohama, Kanagawa, 일본, 2418515
- 아직 모집하지 않음
- Kanagawa cancer center
-
-
Mie-ken
-
Tsu, Mie-ken, 일본, 514-1101
- 모병
- Mie Chuo Medical Center
-
-
Miyagi
-
Sendai, Miyagi, 일본, 9810914
- 모병
- Sendai Kousei Hospital
-
-
Osaka
-
Sakai, Osaka, 일본, 591-8555
- 모병
- NHO Kinki Chuo Chest Medical Center
-
Suita, Osaka, 일본, 565-0871
- 모병
- The University of Osaka Hospital
-
-
Tokyo
-
Bunkyo-ku, Tokyo, 일본, 113-8603
- 아직 모집하지 않음
- Nippon Medical School Hospital
-
Chuo-ku, Tokyo, 일본, 104-0045
- 모병
- National Cancer Center Hospital
-
Koto, Tokyo, 일본, 135-8550
- 모병
- The Cancer Institute Hospital of JFCR
-
Meguro-Ku, Tokyo, 일본, 152-8902
- 모병
- National Hospital Organization Tokyo Medical Center
-
-
Yamagata
-
Yamagata, Yamagata, 일본, 990-9585
- 모병
- Yamagata University Hospital
-
-
-
-
Anhui
-
Hefei, Anhui, 중국, 230031
- 모병
- Anhui Provincial Cancer Hospital
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, 중국, 101149
- 모병
- Beijing Chest Hospital,Capital Medical University
-
Beijing, Beijing Municipality, 중국, 100142
- 모병
- Beijing Cancer hospital
-
-
Fujian
-
Fuzhou, Fujian, 중국, 350014
- 모병
- Fujian Cancer Hospital
-
-
Guangdong
-
Guangzhou, Guangdong, 중국, 510515
- 모병
- Nanfang Hospital of Southern Medical University
-
Huizhou, Guangdong, 중국, 516001
- 모병
- Huizhou Central People's Hospital
-
-
Guangxi
-
Nanning, Guangxi, 중국
- 모병
- Guangxi Medical University Affiliated Tumor Hospital
-
-
Heilongjiang
-
Harbin, Heilongjiang, 중국, 150081
- 모병
- Harbin Medical University Cancer Hospital
-
-
Henan
-
Luoyang, Henan, 중국, 471003
- 모병
- The First Affiliated Hospital of Henan University of Science &Technology
-
Zhengzhou, Henan, 중국, 450008
- 모병
- Henan Cancer Hospital
-
-
Hubei
-
Wuhan, Hubei, 중국, 430079
- 모병
- Hubei Cancer Hospital
-
Wuhan, Hubei, 중국, 430048
- 모병
- Wuhan Union Hospital Cancer Center
-
-
Hunan
-
Changsha, Hunan, 중국, 410013
- 모병
- Hunan Cancer Hospital
-
-
Jiangsu
-
Changzhou, Jiangsu, 중국, 213003
- 모병
- The First People's Hospital of Changzhou
-
Nanjing, Jiangsu, 중국, 210029
- 모병
- Jiangsu Province Hospital
-
Xuzhou, Jiangsu, 중국, 221006
- 모병
- The Affiliated Hospital of Xuzhou Medical College
-
-
Jiangxi
-
Nanchang, Jiangxi, 중국, 330209
- 모병
- The First Affiliated Hospital of Nanchang University
-
-
Jilin
-
Changchun, Jilin, 중국, 130000
- 모병
- Jilin Province Tumor Hospital
-
-
Shaanxi
-
Xi'an, Shaanxi, 중국, 710061
- 모병
- The First Affiliated Hospital of Xi'an Jiaotong University
-
-
Shandong
-
Jinan, Shandong, 중국, 250117
- 모병
- Shandong Cancer Hospital
-
Jinan, Shandong, 중국, 250013
- 모병
- Jinan Central Hospital
-
Linyi, Shandong, 중국, 276001
- 모병
- LinYi Cancer Hospital
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, 중국, 200032
- 모병
- Fudan University Shanghai Cancer Center
-
Shanghai, Shanghai Municipality, 중국, 200030
- 모병
- Shanghai Chest Hospital
-
-
Sichuan
-
Chengdu, Sichuan, 중국, 610041
- 모병
- West China Hospital, Sichuan University
-
Chengdu, Sichuan, 중국, 610041
- 모병
- Sichuan Cancer hospital
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, 중국, 300052
- 모병
- Tianjin Medical University General Hospital
-
-
Yunnan
-
Kunming, Yunnan, 중국, 650118
- 모병
- Yunnan Province Cancer Hospital
-
-
Zhejiang
-
Hangzhou, Zhejiang, 중국, 310016
- 모병
- Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
-
Taizhou, Zhejiang, 중국, 317000
- 모병
- Taizhou Hospital of Zhejiang Province
-
Wenzhou, Zhejiang, 중국, 325000
- 모병
- The First Affiliated Hospital of Wenzhou Medical University
-
-
-
-
-
Liberec1, 체코, 460 01
- 모병
- Krajska nemocnice Liberec, a.s.
-
Nový Jičín, 체코, 741 01
- 모병
- Nemocnice AGEL Novy Jicin a.s.
-
Olomouc, 체코, 779 00
- 모병
- Fakultni nemocnice Olomouc
-
Prague, 체코, 150 00
- 모병
- Fakultni Nemocnice Motol a Homolka
-
-
Praha 4
-
Prague, Praha 4, 체코, 140 59
- 모병
- Fakultni Thomayerova nemocnice
-
-
-
-
Los Ríos Region
-
Valdivia, Los Ríos Region, 칠레, 5090000
- 모병
- Clínica Alemana Valdivia
-
Valdivia, Los Ríos Region, 칠레, 5690000
- 모병
- Oncocentro Valdivia
-
-
Santiago Metropolitan
-
La Florida, Santiago Metropolitan, 칠레, 8241479
- 모병
- Iceg Clinic
-
Providencia, Santiago Metropolitan, 칠레, 7500966
- 모병
- Fundacion Arturo Lopez Perez
-
Providencia, Santiago Metropolitan, 칠레, 7501010
- 모병
- Profar
-
Providencia, Santiago Metropolitan, 칠레, 7500836
- 모병
- FALP
-
Providencia, Santiago Metropolitan, 칠레, 750000
- 모병
- Fundación Arturo Lopéz Pérez
-
Santiago, Santiago Metropolitan, 칠레, 8241479
- 모병
- Clínica Vespucio
-
Santiago, Santiago Metropolitan, 칠레, 8380455
- 모병
- Instituto Nacional del Cancer
-
Santiago, Santiago Metropolitan, 칠레, 8380456
- 모병
- Sociedad Oncovida SA
-
-
Santiago, RM
-
Providencia, Santiago, RM, 칠레, 7500921
- 모병
- FALP
-
-
Valparaiso
-
Viña del Mar, Valparaiso, 칠레, 2520598
- 모병
- Oncocentro Apys
-
-
-
-
British Columbia
-
Abbotsford British Columbia, British Columbia, 캐나다, V2S 0C2
- 모병
- BC Cancer Abbotsford
-
-
Quebec
-
Montreal, Quebec, 캐나다, H1T 2M4
- 모병
- CIUSSS de l'Est-de-l'Île-de-Montréal
-
Saint-Jérôme, Quebec, 캐나다, J7Y 0L1
- 모병
- Centre de Services Ambulatoire de St-Jerome
-
Saint-Jérôme, Quebec, 캐나다, J7Z 2V4
- 모병
- Unité de Recherche Clinique du CISSS des Laurentides
-
-
-
-
-
Adana, 터키 (Türkiye), 01140
- 모병
- Adana Medical Park Seyhan Hastanesi
-
Ankara, 터키 (Türkiye), 06680
- 모병
- Liv Hospital Ankara
-
Ankara, 터키 (Türkiye), 06520
- 모병
- Memorial Ankara Hastanesi
-
Ankara, 터키 (Türkiye), 06230
- 모병
- Hacettepe Universite Hastaneleri
-
Ankara, 터키 (Türkiye), 06560
- 모병
- Gazi University Health Research and Application Center Gazi Hospital
-
Ankara, 터키 (Türkiye), 06010
- 모병
- Gulhane Egitim Arastirma Hastanesi
-
Ankara, 터키 (Türkiye), 06800
- 모병
- Ankara Bilkent Şehir Hastanesi
-
Antalya, 터키 (Türkiye), 07100
- 모병
- Antalya Egitim ve Arastırma Hastanesi
-
Diyarbakır, 터키 (Türkiye), 21200
- 모병
- Dicle Üniversitesi
-
İstanbul - Fatih, 터키 (Türkiye), 34098
- 모병
- Istanbul Universitesi Cerrahpasa
-
-
Turkey
-
Ankara, Turkey, 터키 (Türkiye), 06230
- 모병
- Ankara University Health Practice and Research Hospitals
-
-
İ̇stanbul
-
Istanbul, İ̇stanbul, 터키 (Türkiye), 34722
- 모병
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
-
Istanbul, İ̇stanbul, 터키 (Türkiye), 34214
- 모병
- Medipol Mega Universite Hastanesi
-
Istanbul, İ̇stanbul, 터키 (Türkiye), 34295
- 모병
- İ.A.Ü VM Medical Park Florya Hastanesi
-
-
İ̇zmir
-
Izmir, İ̇zmir, 터키 (Türkiye), 35100
- 모병
- Ege Universitesi Hastanesi
-
Izmir, İ̇zmir, 터키 (Türkiye), 35110
- 모병
- İzmir Suat Seren Chest Disease Training & Research Hospital
-
-
-
-
-
Gdansk, 폴란드, 80-214
- 모병
- Uniwersyteckie Centrum Kliniczne
-
Gliwice, 폴란드, 44-102
- 모병
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
-
Poznan, 폴란드, 60-569
- 모병
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
-
-
Greater Poland Voivodeship
-
Poznan, Greater Poland Voivodeship, 폴란드, 60-693
- 모병
- Med-Polonia Sp. z o. o.
-
-
Lublin Voivodeship
-
Lublin, Lublin Voivodeship, 폴란드, 20-609
- 모병
- Instytut Genetyki i Immunologii GENIM
-
-
Masovian Voivodeship
-
Warsaw, Masovian Voivodeship, 폴란드, 02-781
- 모병
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
-
-
Łódź Voivodeship
-
Lodz, Łódź Voivodeship, 폴란드, 90-302
- 모병
- Instytut MSF Sp zoo
-
-
-
-
-
Marseille, 프랑스, 13915
- 모병
- Assistance Publique Hôpitaux de Marseille - Hôpital Nord
-
Nice, 프랑스, 06189
- 모병
- Centre Antoine Lacassagne
-
Paris, 프랑스, 75248
- 모병
- Institut Curie
-
Paris, 프랑스, 75014
- 모병
- Hopitaux Universitaires Paris Centre-Hopital Cochin
-
-
Aquitaine
-
Pessac, Aquitaine, 프랑스, 33604
- 모병
- CHU Bordeaux Haut-Leveque
-
-
Brittany Region
-
Quimper, Brittany Region, 프랑스, 1757 - 29107
- 모병
- Centre Hospitalier de Cornouaille Quimper - Concarneau
-
-
Haute-garonne
-
Toulouse, Haute-garonne, 프랑스, 31059
- 모병
- CHU de Toulouse - Hopital Larrey
-
-
Ille-et-vilaine
-
Rennes, Ille-et-vilaine, 프랑스, 35033
- 모병
- Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
-
-
Languedoc-roussillon
-
Montpellier, Languedoc-roussillon, 프랑스, 34070
- 모병
- Centre de Cancérologie du Grand Montpellier
-
-
Loire-atlantique
-
Saint-Herblain, Loire-atlantique, 프랑스, 44805
- 모병
- Institut de Cancérologie de l'Ouest
-
Saint-Herblain, Loire-atlantique, 프랑스, 44800
- 모병
- Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
-
-
PAYS de Loire
-
Cholet, PAYS de Loire, 프랑스, 49300
- 모병
- Centre Hospitalier de Cholet
-
-
Provence-Alpes-Côte d'Azur Region
-
Toulon, Provence-Alpes-Côte d'Azur Region, 프랑스, 83056
- 모병
- Centre Hospitalier intercommunal de Toulon La Seyne sur Hospital Sainte-Musse health establishment
-
-
Val-de-marne
-
Créteil, Val-de-marne, 프랑스, 94010
- 모병
- Centre Hospitalier Intercommunal de Créteil
-
-
-
-
-
Székesfehérvár, 헝가리, 8000
- 아직 모집하지 않음
- Fejér Vármegyei Szent György Egyetemi Oktató Kórház
-
Tatabánya, 헝가리, 2800
- 아직 모집하지 않음
- Komárom-Esztergom Vármegyei Szent Borbála Kórház
-
-
Bekes County
-
Gyula, Bekes County, 헝가리, 5700
- 모병
- Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház
-
-
Veszprém megye
-
Farkasgyepű, Veszprém megye, 헝가리, 8582
- 아직 모집하지 않음
- Farkasgyepui Tudogyogyintezet
-
-
-
-
New South Wales
-
Coffs Harbour, New South Wales, 호주, 2450
- 모병
- Coffs Harbour Health Campus
-
North Ryde, New South Wales, 호주, 2109
- 모병
- Macquarie University
-
Sydney, New South Wales, 호주, 2560
- 모병
- Campbelltown Hospital
-
-
Queensland
-
Birtinya, Queensland, 호주, 4575
- 모병
- Sunshine Coast University Hospital
-
Douglas, Queensland, 호주, 4814
- 모병
- Townsville University Hospital
-
Gympie, Queensland, 호주, 4570
- 모병
- Gympie Hospital
-
Nambour, Queensland, 호주, 4560
- 모병
- Nambour General Hospital
-
Woolloongabba, Queensland, 호주, 4102
- 모병
- Princess Alexandra Hospital
-
-
Western Australia
-
Perth, Western Australia, 호주, 6009
- 모병
- Sir Charles Gairdner Hospital
-
-
참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
18년 이상 (성인, 고령자)
건강한 자원 봉사자를 받아들입니다
아니
연구 대상 성별
모두
설명
Inclusion Criteria:
-
Participants must meet the following criteria:
- Have pathologically confirmed Stage IIIB or IIIC NSCLC and not be a candidate for surgical resection or definitive chemoradiation, or Stage IV NSCLC per the AJCC Staging Manual (Version 8.0) and the UICC Staging System (Eighth edition).
- Participants with known AGAs including EGFR, ALK, ROS1, NTRK, BRAF, RET, and MET, for which there are approved and available first-line therapies per local SOC are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology.
- Participants with large cell neuroendocrine carcinoma are excluded.
- Must be an appropriate candidate for treatment with pembrolizumab monotherapy per local guidelines.
-
Tumor has PD-L1 expression in ≥50% of tumor cells (TPS ≥50%) as determined by local testing.
-
Measurable disease based on RECIST v1.1 per investigator.
-
Resolution of acute effects of any prior therapy to either baseline severity or NCI CTCAE Grade 1 or less (except for AEs not constituting a safety risk in the investigator's judgment), unless otherwise excluded.
Exclusion Criteria:
-
Life expectancy of <3 months in the opinion of the investigator.
-
Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.
-
Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.
-
Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab.
-
Participants with any of the following respiratory conditions:
- Evidence of noninfectious or drug-induced ILD or pneumonitis
- Known DLCO (adjusted for hemoglobin) <50% predicted.
- Grade ≥3 pulmonary disease unrelated to underlying malignancy
-
Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Up to 5 clinically asymptomatic brain metastases of longest diameter <1.0 cm are permitted without definitive surgery and/or radiotherapy.
-
Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery (excluding peripherally inserted central catheter placement and implantable central venous port placement) within 3 days prior to first dose of study intervention.
-
Receipt of a live vaccine within 30 days prior to first dose of study intervention.
-
Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0.
-
Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.
-
Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for >2 weeks, or required treatment with systemic immunosuppressive therapy.
-
History of autoimmune disease that has required systemic treatment in the past 2 years
-
Participants with prior solid organ or bone marrow transplantation.
-
Currently receiving a high-dose steroid (>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant.
-
Prior and concomitant therapy:
-
Any prior treatment with MMAE-derived drugs or IB6 targeting agents.
-
Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.
- (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose.
- Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose.
-
Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received. This includes both curative and palliative radiotherapy.
-
Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy.
-
Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor
-
-
History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV.
-
Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 치료
- 할당: 무작위
- 중재 모델: 병렬 할당
- 마스킹: 하나의
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
|---|---|
|
실험적: Sigvotatug Vedotin with Pembrolizumab
Participants will receive Sigvotatug Vedotin, administered as an IV infusion and pembrolizumab, administered as an IV infusion. |
MMAE-Antibody Drug Conjugate targeting Integrin Beta-6 Anti-PD-(L)1 |
|
활성 비교기: Pembrolizumab Monotherapy
Participants will receive pembrolizumab, administered as an IV infusion. |
Anti-PD-(L)1 |
연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Overall Survival
기간: Baseline to date of death from any cause (Approximately 2 years).
|
Overall survival defined as the duration from enrollment to death. |
Baseline to date of death from any cause (Approximately 2 years).
|
|
Progression Free Survival (PFS) assessed by blinded independent central review (BICR)
기간: From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first. |
From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
|---|---|---|
|
Progression Free Survival as assessed by Investigator
기간: From Baseline to date of first progression or death (Approximately 4 years).
|
Progression Free Survival (PFS) is defined as the time from the date of first dose of study interventions to the date of first documentation of PD or death due to any cause, whichever occurs first. |
From Baseline to date of first progression or death (Approximately 4 years).
|
|
Objective Response Rate as assessed by BICR
기간: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Objective Response Rate as assessed by Investigator
기간: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Defined as the proportion of participants who achieve a best response of complete response (CR) or partial response (PR) using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria as assessed by Investigator. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Duration of Response as assessed by BICR
기간: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Duration of Response as assessed by Investigator
기간: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Defined time from the initial response (CR or PR) until documented tumor progression or death from any cause and based on Investigator assessment. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Number of participants with adverse events (AEs)
기간: From Baseline to end of treatment (up to 4 years).
|
Counts of participants who had treatment-emergent adverse events (TEAEs), defined as newly occurring or worsening after first dose. Relatedness to [study drug] was assessed by the investigator (Yes/No). Participants with multiple occurrences of an AE within a category were counted once within the category. |
From Baseline to end of treatment (up to 4 years).
|
|
Pharmacokinetics (PK) of antibody-conjugated monomethyl auristatin E (ac-MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
기간: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of ac-MMAE in plasma: Plasma predose concentration (Cpredose)
기간: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of unconjugated monomethyl auristatin E (MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
기간: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of MMAE in plasma: Plasma predose concentration (Cpredose)
기간: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Number of participants with antidrug antibodies (ADAs)
기간: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the immunogenicity of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Time to response (TTR) using RECIST v1.1 as assessed by BICR
기간: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by BICR. |
The time from the date of randomization to the date of first documentation of objective response.
|
|
TTR using RECIST v1.1 as assessed by investigator
기간: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by investigator assessment. |
The time from the date of randomization to the date of first documentation of objective response.
|
공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
스폰서
수사관
- 연구 책임자: Pfizer CT.gov Call Center, Pfizer
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (실제)
2025년 7월 23일
기본 완료 (추정된)
2028년 9월 5일
연구 완료 (추정된)
2029년 3월 1일
연구 등록 날짜
최초 제출
2024년 12월 26일
QC 기준을 충족하는 최초 제출
2024년 12월 26일
처음 게시됨 (실제)
2025년 1월 3일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2026년 9월 25일
QC 기준을 충족하는 마지막 업데이트 제출
2026년 9월 22일
마지막으로 확인됨
2026년 9월 1일
추가 정보
이 연구와 관련된 용어
추가 관련 MeSH 약관
기타 연구 ID 번호
- C5751003
- 2024-517968-36-00 (레지스트리 식별자: CTIS (EU))
개별 참가자 데이터(IPD) 계획
개별 참가자 데이터(IPD)를 공유할 계획입니까?
예
IPD 계획 설명
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
약물 및 장치 정보, 연구 문서
미국 FDA 규제 의약품 연구
예
미국 FDA 규제 기기 제품 연구
아니
미국에서 제조되어 미국에서 수출되는 제품
예
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .