Tämä on tutkimus, jossa opitaan siitä, kuinka tutkimuslääkkeiden Sigvotatug Vedotin Plus pembrolitsumabi yhdistelmä toimii ihmisillä, joilla on ei-pienisoluinen keuhkosyöpä ja joilla on korkea PD-L1-taso.
tiistai 22. syyskuuta 2026 päivittänyt: Pfizer
AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
- Are confirmed to have NSCLC (Stage 3 or 4).
- Have PD-L1 levels in more than 50% of the cancer cells.
All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab.
Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.
Tutkimuksen yleiskatsaus
Tila
Rekrytointi
Ehdot
Interventio / Hoito
Opintotyyppi
Interventio
Ilmoittautuminen (Arvioitu)
714
Vaihe
- Vaihe 3
Yhteystiedot ja paikat
Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.
Opiskeluyhteys
- Nimi: Pfizer CT.gov Call Center
- Puhelinnumero: 1-800-718-1021
- Sähköposti: ClinicalTrials.gov_Inquiries@pfizer.com
Opiskelupaikat
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Utrecht, Alankomaat, 3543 AZ
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- St. Antonius Ziekenhuis, locatie Utrecht
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Gelderland
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Harderwijk, Gelderland, Alankomaat, 3844 DG
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- Ziekenhuis St. Jansdal
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North Brabant
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Breda, North Brabant, Alankomaat, 4818 CK
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Overijssel
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Zwolle, Overijssel, Alankomaat, 8025 AB
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Provincie Friesland
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Leeuwarden, Provincie Friesland, Alankomaat, 8934 AD
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Buenos Aires, Argentiina, 1426
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Buenos Aires, Argentiina, C1122AAL
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Córdoba, Argentiina, 5016
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Córdoba, Argentiina, 5000
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Córdoba, Argentiina, X5008AAC
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Córdoba, Argentiina, 5000
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San Juan, Argentiina, 5400
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Buenos Aires
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Berazategui, Buenos Aires, Argentiina, B1884BBF
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- Centro de Oncología e Investigación de Buenos Aires
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Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentiina, C1426ABP
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Florida, Buenos Aires, Argentiina, B1602DQD
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Mar del Plata, Buenos Aires, Argentiina, B7600FZD
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Pergamino, Buenos Aires, Argentiina, B2700CPM
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Cdad. Autónoma de Buenos Aires
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Buenos Aires, Cdad. Autónoma de Buenos Aires, Argentiina, C 1113
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Jujuy Province
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San Salvador de Jujuy, Jujuy Province, Argentiina, 4600
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Río Negro Province
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Cipolletti, Río Negro Province, Argentiina, 8324
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Santa Fe Province
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Rosario, Santa Fe Province, Argentiina, 2000
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Rosario, Santa Fe Province, Argentiina, S2000DSV
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Rosario, Santa Fe Province, Argentiina, S2002KDS
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Rosario, Santa Fe Province, Argentiina, S2000CVB
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New South Wales
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Coffs Harbour, New South Wales, Australia, 2450
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North Ryde, New South Wales, Australia, 2109
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Sydney, New South Wales, Australia, 2560
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Queensland
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Birtinya, Queensland, Australia, 4575
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Douglas, Queensland, Australia, 4814
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Gympie, Queensland, Australia, 4570
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Nambour, Queensland, Australia, 4560
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Woolloongabba, Queensland, Australia, 4102
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Western Australia
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Perth, Western Australia, Australia, 6009
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Brasschaat, Belgia, 2930
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Liège, Belgia, 4000
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Antwerpen
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Mechelen, Antwerpen, Belgia, 2800
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Bruxelles-capitale, Région de
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Brussels, Bruxelles-capitale, Région de, Belgia, 1090
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Hainaut
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Charleroi, Hainaut, Belgia, 6060
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Jaú, Brasilia, 17210-080
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Rio de Janeiro, Brasilia, 22281-100
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Rio de Janeiro, Brasilia, 22031-011
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Rio de Janeiro, Brasilia, 22271-110
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Rio de Janeiro, Brasilia, 22451-040
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São Paulo, Brasilia, 01246-000
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Ceará
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Fortaleza, Ceará, Brasilia, 60430235
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Fortaleza, Ceará, Brasilia, 60336232
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Espírito Santo
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Vitória, Espírito Santo, Brasilia, 29043-260
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Estado de Bahia
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Salvador, Estado de Bahia, Brasilia, 41950- 640
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Salvador, Estado de Bahia, Brasilia, 41253-190
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Federal District
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Brasília, Federal District, Brasilia, 70390-150
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Curitiba, Paraná, Brasilia, 81520-060
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Pernambuco
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Recife, Pernambuco, Brasilia, 52010-902
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Piauí
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Teresina, Piauí, Brasilia, 64049-200
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Rio Grande do Norte
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Natal, Rio Grande do Norte, Brasilia, 59062-000
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- Liga Norte Riograndense Contra o Câncer
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Rio Grande do Sul
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Ijuí, Rio Grande do Sul, Brasilia, 98700-000
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Porto Alegre, Rio Grande do Sul, Brasilia, 90560032
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Porto Alegre, Rio Grande do Sul, Brasilia, 90610-000
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Santa Catarina
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Lages, Santa Catarina, Brasilia, 88501-001
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- ANIMI - Unidade de Tratamento Oncologico
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São Paulo
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Barretos, São Paulo, Brasilia, 14784400
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- Fundação Pio XII - Hospital de Câncer de Barretos
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Bragança Paulista, São Paulo, Brasilia, 12916-542
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- Hospital Universitário São Francisco na Providência de Deus
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Ribeirão Preto, São Paulo, Brasilia, 14051-140
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- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
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Santo André, São Paulo, Brasilia, 09060-650
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- Faculdade de Medicina do ABC
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São José do Rio Preto, São Paulo, Brasilia, 15090000
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- Fundação Faculdade Regional de Medicina de São José do Rio Preto
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São Paulo, São Paulo, Brasilia, 01327-001
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- Hospital Alemao Oswaldo Cruz
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Burgas, Bulgaria, 8000
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- Complex Oncology Center - Burgas
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Plovdiv, Bulgaria, 4000
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- Medical Center Futuremeds
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Sofia, Bulgaria, 1407
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Sofia, Bulgaria, 1330
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- MHAT for Women's Health Nadezhda
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Sofia, Bulgaria, 1756
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- University Specialized Hospital for Active Treatment of Oncology EAD
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Pazardzhik
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Panagyurishte, Pazardzhik, Bulgaria, 4500
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- MBAL Uni Hospital
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Los Ríos Region
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Valdivia, Los Ríos Region, Chile, 5090000
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- Clínica Alemana Valdivia
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Valdivia, Los Ríos Region, Chile, 5690000
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- Oncocentro Valdivia
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Santiago Metropolitan
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La Florida, Santiago Metropolitan, Chile, 8241479
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- Iceg Clinic
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Providencia, Santiago Metropolitan, Chile, 7500966
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- Fundacion Arturo Lopez Perez
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Providencia, Santiago Metropolitan, Chile, 7501010
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- Profar
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Providencia, Santiago Metropolitan, Chile, 7500836
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- FALP
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Providencia, Santiago Metropolitan, Chile, 750000
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- Fundación Arturo Lopéz Pérez
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Santiago, Santiago Metropolitan, Chile, 8241479
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- Clínica Vespucio
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Santiago, Santiago Metropolitan, Chile, 8380455
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- Instituto Nacional del Cancer
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Santiago, Santiago Metropolitan, Chile, 8380456
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- Sociedad Oncovida SA
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Santiago, RM
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Providencia, Santiago, RM, Chile, 7500921
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- FALP
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Valparaiso
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Viña del Mar, Valparaiso, Chile, 2520598
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- Oncocentro Apys
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Barcelona, Espanja, 08035
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- Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR")
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Barcelona, Espanja, 08035
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- Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO"
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Las Palmas de Gran Canaria, Espanja, 35016
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- Complejo Hospitalario Universitario Insular Materno-Infantil
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Madrid, Espanja, 28040
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- Hospital Universitario Fundación Jiménez Díaz
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Madrid, Espanja, 28003
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- FutureMeds - Madrid
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Madrid, Espanja, 28007
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- Hospital General Universitario Gregorio Marañon
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Málaga, Espanja, 29004
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- Hospital Quirón Málaga
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Seville, Espanja, 41013
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- Hospital Universitario Virgen Del Rocio
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A Coruña [LA Coruña]
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A Coruña, A Coruña [LA Coruña], Espanja, 15006
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Alicante
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Elche, Alicante, Espanja, 03203
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- Hospital General Universitario de Elche
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Barcelona [barcelona]
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Barcelona, Barcelona [barcelona], Espanja, 08028
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Barcelona/spain
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Barcelona, Barcelona/spain, Espanja, 08035
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- Hospital Universitari Vall D Hebron
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Catalunya [cataluña]
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Barcelona, Catalunya [cataluña], Espanja, 08041
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- Hospital de la Santa Creu i Sant Pau
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L'Hospitalet de Llobregat, Catalunya [cataluña], Espanja, 08908
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- Institut Català d'Oncologia - L'Hospitalet
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Cádiz
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Jerez de la Frontera, Cádiz, Espanja, 11407
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Illes Balears [islas Baleares]
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Palma, Illes Balears [islas Baleares], Espanja, 07198
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Madrid, Comunidad de
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Madrid, Madrid, Comunidad de, Espanja, 28041
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Valenciana, Comunitat
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Valencia, Valenciana, Comunitat, Espanja, 46010
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Jeonranamdo
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Hwasun-gun, Jeonranamdo, Etelä -Korea, 58128
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Kyǒnggi-do
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Seongnam, Kyǒnggi-do, Etelä -Korea, 13620
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Suwon, Kyǒnggi-do, Etelä -Korea, 16499
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Suwon, Kyǒnggi-do, Etelä -Korea, 16247
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Pusan-kwangyǒkshi
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Busan, Pusan-kwangyǒkshi, Etelä -Korea, 49241
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Haeundae-gu, Pusan-kwangyǒkshi, Etelä -Korea, 48108
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Seoul-teukbyeolsi [seoul]
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Seoul, Seoul-teukbyeolsi [seoul], Etelä -Korea, 03722
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Seoul, Seoul-teukbyeolsi [seoul], Etelä -Korea, 07061
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Seoul, Seoul-teukbyeolsi [seoul], Etelä -Korea, 08308
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- Korea University Guro Hospital
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Taegu-kwangyǒkshi
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Deagu, Taegu-kwangyǒkshi, Etelä -Korea, 41404
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Karnataka
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Bengaluru, Karnataka, Intia, 560069
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Maharashtra
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Mumbai, Maharashtra, Intia, 400012
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Pune, Maharashtra, Intia, 411004
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Thane, Maharashtra, Intia, 401107
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National Capital Territory of Delhi
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New Delhi, National Capital Territory of Delhi, Intia, 110088
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New Delhi, National Capital Territory of Delhi, Intia, 110005
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New Delhi, National Capital Territory of Delhi, Intia, 110075
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Telangana
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Hyderabad, Telangana, Intia, 500032
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Petah Tikva, Israel, 4941492
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Jerusalem
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Jerusalem, Jerusalem, Israel, 9013102
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Avellino, Italia, 83100
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Milan, Italia, 20132
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Milan, Italia, 20141
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Padova, Italia, 35128
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Campania
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Naples, Campania, Italia, 80131
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Catania
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Misterbianco, Catania, Italia, 95045
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Emilia-Romagna
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Meldola, Emilia-Romagna, Italia, 47014
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- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
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Pesaro AND Urbino
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Pesaro (PU), Pesaro AND Urbino, Italia, 61121
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Piedmont
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Orbassano, Piedmont, Italia, 10043
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ROMA
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Rome, ROMA, Italia, 00186
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- Ospedale Isola Tiberina - Gemelli Isola
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ROME
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Roma, ROME, Italia, 00144
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- IRCCS Istituto Nazionale dei Tumori Regina Elena
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Sicily
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Catania, Sicily, Italia, 95123
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- Policlinico "G. Rodolico"
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Graz, Itävalta, 8036
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- Medizinische Universität Graz
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Vienna, Itävalta, 1090
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- Medizinische Universität Wien
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Vienna, Itävalta, 1210
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- Klinik Floridsdorf
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Upper Austria
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Linz, Upper Austria, Itävalta, 4020
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Fukuoka, Japani, 810-8563
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- National Hospital Organization Kyushu Medical Center
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Fukuoka, Japani, 811-1395
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Kyoto, Japani, 612-8555
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Okayama, Japani, 701-1154
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- National Hospital Organization Okayama Medical Center
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Osaka, Japani, 541-8567
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- Osaka International Cancer Institute
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Ehime
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Tōon, Ehime, Japani, 791-0295
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Fukuoka
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Kurume, Fukuoka, Japani, 830-0011
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Gunma
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Otashi, Gunma, Japani, 373-8550
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Hokkaido
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Asahikawa, Hokkaido, Japani, 0708644
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- National Hospital Organization Asahikawa Medical Center
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Hyōgo
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Kobe, Hyōgo, Japani, 650-0047
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Kanagawa
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Yokohama, Kanagawa, Japani, 2418515
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Mie-ken
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Tsu, Mie-ken, Japani, 514-1101
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Miyagi
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Sendai, Miyagi, Japani, 9810914
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Osaka
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Sakai, Osaka, Japani, 591-8555
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- NHO Kinki Chuo Chest Medical Center
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Suita, Osaka, Japani, 565-0871
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- The University of Osaka Hospital
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Tokyo
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Bunkyo-ku, Tokyo, Japani, 113-8603
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- Nippon Medical School Hospital
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Chuo-ku, Tokyo, Japani, 104-0045
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- National Cancer Center Hospital
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Koto, Tokyo, Japani, 135-8550
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- The Cancer Institute Hospital of JFCR
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Meguro-Ku, Tokyo, Japani, 152-8902
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- National Hospital Organization Tokyo Medical Center
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Yamagata
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Yamagata, Yamagata, Japani, 990-9585
- Rekrytointi
- Yamagata University Hospital
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British Columbia
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Abbotsford British Columbia, British Columbia, Kanada, V2S 0C2
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- BC Cancer Abbotsford
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Quebec
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Montreal, Quebec, Kanada, H1T 2M4
- Rekrytointi
- CIUSSS de l'Est-de-l'Île-de-Montréal
-
Saint-Jérôme, Quebec, Kanada, J7Y 0L1
- Rekrytointi
- Centre de Services Ambulatoire de St-Jerome
-
Saint-Jérôme, Quebec, Kanada, J7Z 2V4
- Rekrytointi
- Unité de Recherche Clinique du CISSS des Laurentides
-
-
-
-
Anhui
-
Hefei, Anhui, Kiina, 230031
- Rekrytointi
- Anhui Provincial Cancer Hospital
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, Kiina, 101149
- Rekrytointi
- Beijing Chest Hospital,Capital Medical University
-
Beijing, Beijing Municipality, Kiina, 100142
- Rekrytointi
- Beijing Cancer hospital
-
-
Fujian
-
Fuzhou, Fujian, Kiina, 350014
- Rekrytointi
- Fujian Cancer Hospital
-
-
Guangdong
-
Guangzhou, Guangdong, Kiina, 510515
- Rekrytointi
- Nanfang Hospital of Southern Medical University
-
Huizhou, Guangdong, Kiina, 516001
- Rekrytointi
- Huizhou Central People's Hospital
-
-
Guangxi
-
Nanning, Guangxi, Kiina
- Rekrytointi
- Guangxi Medical University Affiliated Tumor Hospital
-
-
Heilongjiang
-
Harbin, Heilongjiang, Kiina, 150081
- Rekrytointi
- Harbin Medical University Cancer Hospital
-
-
Henan
-
Luoyang, Henan, Kiina, 471003
- Rekrytointi
- The First Affiliated Hospital of Henan University of Science &Technology
-
Zhengzhou, Henan, Kiina, 450008
- Rekrytointi
- Henan Cancer Hospital
-
-
Hubei
-
Wuhan, Hubei, Kiina, 430079
- Rekrytointi
- Hubei Cancer Hospital
-
Wuhan, Hubei, Kiina, 430048
- Rekrytointi
- Wuhan Union Hospital Cancer Center
-
-
Hunan
-
Changsha, Hunan, Kiina, 410013
- Rekrytointi
- Hunan Cancer Hospital
-
-
Jiangsu
-
Changzhou, Jiangsu, Kiina, 213003
- Rekrytointi
- The First People's Hospital of Changzhou
-
Nanjing, Jiangsu, Kiina, 210029
- Rekrytointi
- Jiangsu Province Hospital
-
Xuzhou, Jiangsu, Kiina, 221006
- Rekrytointi
- The Affiliated Hospital of Xuzhou Medical College
-
-
Jiangxi
-
Nanchang, Jiangxi, Kiina, 330209
- Rekrytointi
- The First Affiliated Hospital of Nanchang University
-
-
Jilin
-
Changchun, Jilin, Kiina, 130000
- Rekrytointi
- Jilin Province Tumor Hospital
-
-
Shaanxi
-
Xi'an, Shaanxi, Kiina, 710061
- Rekrytointi
- The First Affiliated Hospital of Xi'an Jiaotong University
-
-
Shandong
-
Jinan, Shandong, Kiina, 250117
- Rekrytointi
- Shandong Cancer Hospital
-
Jinan, Shandong, Kiina, 250013
- Rekrytointi
- Jinan Central Hospital
-
Linyi, Shandong, Kiina, 276001
- Rekrytointi
- LinYi Cancer Hospital
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, Kiina, 200032
- Rekrytointi
- Fudan University Shanghai Cancer Center
-
Shanghai, Shanghai Municipality, Kiina, 200030
- Rekrytointi
- Shanghai Chest Hospital
-
-
Sichuan
-
Chengdu, Sichuan, Kiina, 610041
- Rekrytointi
- West China Hospital, Sichuan University
-
Chengdu, Sichuan, Kiina, 610041
- Rekrytointi
- Sichuan Cancer hospital
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, Kiina, 300052
- Rekrytointi
- Tianjin Medical University General Hospital
-
-
Yunnan
-
Kunming, Yunnan, Kiina, 650118
- Rekrytointi
- Yunnan Province Cancer Hospital
-
-
Zhejiang
-
Hangzhou, Zhejiang, Kiina, 310016
- Rekrytointi
- Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
-
Taizhou, Zhejiang, Kiina, 317000
- Rekrytointi
- Taizhou Hospital of Zhejiang Province
-
Wenzhou, Zhejiang, Kiina, 325000
- Rekrytointi
- The First Affiliated Hospital of Wenzhou Medical University
-
-
-
-
-
Athens, Kreikka, 115 26
- Rekrytointi
- Errikos Dunant Hospital Center
-
Larissa, Kreikka, 41110
- Rekrytointi
- University General Hospital of Larissa, Urology Department
-
Thessaloniki, Kreikka, 552 36
- Rekrytointi
- Agios Loukas Clinic
-
-
Attikí
-
Athens, Attikí, Kreikka, 115 27
- Rekrytointi
- Thoracic General Hospital of Athens "I Sotiria"
-
Athens, Attikí, Kreikka, 155 62
- Rekrytointi
- Metropolitan General Hospital
-
Athens, Attikí, Kreikka, 185 47
- Rekrytointi
- Metropolitan Hospital
-
Marousi, Attikí, Kreikka, 151 23
- Rekrytointi
- Hygeia Hospital
-
-
Thessaloníki
-
Thessaloniki, Thessaloníki, Kreikka, 570 01
- Rekrytointi
- European Interbalkan Medical Center
-
-
-
-
-
Mexico City, Meksiko, 14080
- Ei vielä rekrytointia
- Instituto Nacional de Cancerologia
-
Puebla City, Meksiko, 72530
- Rekrytointi
- Clinica Integral Internacional de Oncología
-
-
Jalisco
-
Guadalajara, Jalisco, Meksiko, 44340
- Rekrytointi
- Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
-
-
Veracruz
-
Veracruz de Ignacio de LA Llave, Veracruz, Meksiko, 91900
- Ei vielä rekrytointia
- Instituto Veracruzano en Investigación Clínica S.C.
-
-
-
-
-
Gdansk, Puola, 80-214
- Rekrytointi
- Uniwersyteckie Centrum Kliniczne
-
Gliwice, Puola, 44-102
- Rekrytointi
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
-
Poznan, Puola, 60-569
- Rekrytointi
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
-
-
Greater Poland Voivodeship
-
Poznan, Greater Poland Voivodeship, Puola, 60-693
- Rekrytointi
- Med-Polonia Sp. z o. o.
-
-
Lublin Voivodeship
-
Lublin, Lublin Voivodeship, Puola, 20-609
- Rekrytointi
- Instytut Genetyki i Immunologii GENIM
-
-
Masovian Voivodeship
-
Warsaw, Masovian Voivodeship, Puola, 02-781
- Rekrytointi
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
-
-
Łódź Voivodeship
-
Lodz, Łódź Voivodeship, Puola, 90-302
- Rekrytointi
- Instytut MSF Sp zoo
-
-
-
-
-
Marseille, Ranska, 13915
- Rekrytointi
- Assistance Publique Hôpitaux de Marseille - Hôpital Nord
-
Nice, Ranska, 06189
- Rekrytointi
- Centre Antoine Lacassagne
-
Paris, Ranska, 75248
- Rekrytointi
- Institut Curie
-
Paris, Ranska, 75014
- Rekrytointi
- Hopitaux Universitaires Paris Centre-Hopital Cochin
-
-
Aquitaine
-
Pessac, Aquitaine, Ranska, 33604
- Rekrytointi
- CHU Bordeaux Haut-Leveque
-
-
Brittany Region
-
Quimper, Brittany Region, Ranska, 1757 - 29107
- Rekrytointi
- Centre Hospitalier de Cornouaille Quimper - Concarneau
-
-
Haute-garonne
-
Toulouse, Haute-garonne, Ranska, 31059
- Rekrytointi
- CHU de Toulouse - Hopital Larrey
-
-
Ille-et-vilaine
-
Rennes, Ille-et-vilaine, Ranska, 35033
- Rekrytointi
- Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
-
-
Languedoc-roussillon
-
Montpellier, Languedoc-roussillon, Ranska, 34070
- Rekrytointi
- Centre de Cancérologie du Grand Montpellier
-
-
Loire-atlantique
-
Saint-Herblain, Loire-atlantique, Ranska, 44805
- Rekrytointi
- Institut de Cancérologie de l'Ouest
-
Saint-Herblain, Loire-atlantique, Ranska, 44800
- Rekrytointi
- Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
-
-
PAYS de Loire
-
Cholet, PAYS de Loire, Ranska, 49300
- Rekrytointi
- Centre Hospitalier de Cholet
-
-
Provence-Alpes-Côte d'Azur Region
-
Toulon, Provence-Alpes-Côte d'Azur Region, Ranska, 83056
- Rekrytointi
- Centre Hospitalier intercommunal de Toulon La Seyne sur Hospital Sainte-Musse health establishment
-
-
Val-de-marne
-
Créteil, Val-de-marne, Ranska, 94010
- Rekrytointi
- Centre Hospitalier Intercommunal de Créteil
-
-
-
-
Bucharest
-
Bucharest, Bucharest, Romania, 013812
- Rekrytointi
- SC Memorial Healthcare International SRL
-
Bucharest, Bucharest, Romania, 022338
- Rekrytointi
- Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
-
Bucharest, Bucharest, Romania, 077190
- Ei vielä rekrytointia
- Sc Mnt Healthcare Europe Srl
-
-
Cluj
-
Cluj-Napoca, Cluj, Romania, 400641
- Rekrytointi
- SC Medisprof SRL
-
Florești, Cluj, Romania, 407280
- Rekrytointi
- SC Radiotherapy Center Cluj SRL
-
-
Constanța County
-
Ovidiu, Constanța County, Romania, 905900
- Rekrytointi
- Ovidius Clinical Hospital OCH
-
-
Dolj
-
Craiova, Dolj, Romania, 200542
- Ei vielä rekrytointia
- Centrul de Oncologie "Sfântul Nectarie"
-
Craiova, Dolj, Romania, 200385
- Rekrytointi
- SC Oncolab SRL
-
-
Timiș County
-
Timișoara, Timiș County, Romania, 300166
- Ei vielä rekrytointia
- S C Oncocenter Oncologie Clinica S R L
-
-
-
-
-
Bad Berka, Saksa, 99437
- Rekrytointi
- Zentralklinik Bad Berka GmbH
-
Berlin, Saksa, 10117
- Rekrytointi
- Charité - Universitätsmedizin Berlin
-
Berlin, Saksa, 13353
- Rekrytointi
- Charité Campus Virchow-Klinikum
-
Berlin, Saksa, 13353
- Rekrytointi
- Labor Berlin
-
Berlin, Saksa, 13509
- Rekrytointi
- Vivantes Humboldt Klinikum Apotheke Nord
-
Berlin, Saksa, 13585
- Rekrytointi
- Vivantes Hospital Spandau
-
Gauting, Saksa, 82131
- Rekrytointi
- Asklepios Klinik Gauting GmbH
-
Großhansdorf, Saksa, 22927
- Rekrytointi
- LungenClinic Grosshansdorf
-
München, Saksa, 81377
- Rekrytointi
- Radiologie München
-
-
Baden-Wurttemberg
-
Ulm, Baden-Wurttemberg, Saksa, 89081
- Rekrytointi
- Universitaetsklinikum Ulm
-
-
Bavaria
-
Gröbenzell, Bavaria, Saksa, 82194
- Rekrytointi
- Johannes Apotheke Gröbenzell
-
Traunstein, Bavaria, Saksa, 83278
- Rekrytointi
- Klinikum Traunstein
-
-
Hesse
-
Giessen, Hesse, Saksa, 35392
- Rekrytointi
- UKGM Gießen/Marburg
-
Kassel, Hesse, Saksa, 34125
- Rekrytointi
- Klinikum Kassel
-
-
Rhineland-Palatinate
-
Koblenz, Rhineland-Palatinate, Saksa, 56068
- Rekrytointi
- InVO Institut für Versorgungsforschung in der Onkologie
-
-
Saxony
-
Chemnitz, Saxony, Saksa, 09116
- Rekrytointi
- Klinikum Chemnitz - Flemmingstraße
-
Chemnitz, Saxony, Saksa, 09113
- Rekrytointi
- Klinikum Chemnitz gGmbH
-
-
Saxony-Anhalt
-
Halle, Saxony-Anhalt, Saksa, 06120
- Rekrytointi
- Krankenhaus Martha-Maria Halle-Dölau
-
-
Schleswig-Holstein
-
Lübeck, Schleswig-Holstein, Saksa, 23538
- Rekrytointi
- Universitätsklinikum Schleswig-Holstein
-
Oldenburg in Holstein, Schleswig-Holstein, Saksa, 23758
- Rekrytointi
- ohO Research GmbH
-
-
-
-
-
Riyadh, Saudi-Arabia, 11211
- Ei vielä rekrytointia
- King Faisal Specialist Hospital and Research Center
-
-
Riyadh Region
-
Riyadh, Riyadh Region, Saudi-Arabia, 11472
- Ei vielä rekrytointia
- King Saud University Medical City
-
-
-
-
-
Nové Zámky, Slovakia, 94034
- Rekrytointi
- Fakultna nemocnica s poliklinikou Nove Zamky
-
Poprad, Slovakia, 058 01
- Rekrytointi
- POKO Poprad s.r.o.
-
-
Bratislava Region
-
Bratislava, Bratislava Region, Slovakia, 821 01
- Rekrytointi
- Univerzitná nemocnica Bratislava - Nemocnica Ružinov
-
-
Košice Region
-
Košice, Košice Region, Slovakia, 040 01
- Rekrytointi
- Vychodoslovensky Onkologicky Ustav a.s.
-
-
Nitra Region
-
Komárno, Nitra Region, Slovakia, 945 05
- Rekrytointi
- Nemocnica AGEL Komarno
-
-
Trnava Region
-
Trnava, Trnava Region, Slovakia, 917 02
- Rekrytointi
- Fakultna nemocnica Trnava
-
-
-
-
-
Zurich, Sveitsi, 8091
- Rekrytointi
- UniversitätsSpital Zürich
-
-
Canton of Bern
-
Bern, Canton of Bern, Sveitsi, 3010
- Rekrytointi
- Inselspital Bern
-
-
-
-
-
Kaohsiung City, Taiwan, 807
- Ei vielä rekrytointia
- Kaohsiung Medical University Chung-Ho Memorial Hospital
-
Kaohsiung City, Taiwan, 833401
- Rekrytointi
- Chang Gung Memorial Hospital at Kaohsiung
-
Taichung, Taiwan, 407
- Ei vielä rekrytointia
- Taichung Veterans General Hospital
-
Tainan, Taiwan, 704
- Rekrytointi
- National Cheng Kung University Hospital
-
Taipei, Taiwan, 11217
- Rekrytointi
- Taipei Veterans General Hospital
-
Taipei, Taiwan, 10002
- Ei vielä rekrytointia
- National Taiwan University Hospital
-
-
Tainan
-
Tainan, Tainan, Taiwan, 73657
- Ei vielä rekrytointia
- Chi Mei Hospital - Liouying Branch
-
-
Taipei
-
Taipei City, Taipei, Taiwan, 106
- Ei vielä rekrytointia
- National Taiwan University Cancer Center (NTUCC)
-
-
-
-
-
Adana, Turkki (Türkiye), 01140
- Rekrytointi
- Adana Medical Park Seyhan Hastanesi
-
Ankara, Turkki (Türkiye), 06680
- Rekrytointi
- Liv Hospital Ankara
-
Ankara, Turkki (Türkiye), 06520
- Rekrytointi
- Memorial Ankara Hastanesi
-
Ankara, Turkki (Türkiye), 06230
- Rekrytointi
- Hacettepe Universite Hastaneleri
-
Ankara, Turkki (Türkiye), 06560
- Rekrytointi
- Gazi University Health Research and Application Center Gazi Hospital
-
Ankara, Turkki (Türkiye), 06010
- Rekrytointi
- Gulhane Egitim Arastirma Hastanesi
-
Ankara, Turkki (Türkiye), 06800
- Rekrytointi
- Ankara Bilkent Şehir Hastanesi
-
Antalya, Turkki (Türkiye), 07100
- Rekrytointi
- Antalya Egitim ve Arastırma Hastanesi
-
Diyarbakır, Turkki (Türkiye), 21200
- Rekrytointi
- Dicle Üniversitesi
-
İstanbul - Fatih, Turkki (Türkiye), 34098
- Rekrytointi
- Istanbul Universitesi Cerrahpasa
-
-
Turkey
-
Ankara, Turkey, Turkki (Türkiye), 06230
- Rekrytointi
- Ankara University Health Practice and Research Hospitals
-
-
İ̇stanbul
-
Istanbul, İ̇stanbul, Turkki (Türkiye), 34722
- Rekrytointi
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
-
Istanbul, İ̇stanbul, Turkki (Türkiye), 34214
- Rekrytointi
- Medipol Mega Universite Hastanesi
-
Istanbul, İ̇stanbul, Turkki (Türkiye), 34295
- Rekrytointi
- İ.A.Ü VM Medical Park Florya Hastanesi
-
-
İ̇zmir
-
Izmir, İ̇zmir, Turkki (Türkiye), 35100
- Rekrytointi
- Ege Universitesi Hastanesi
-
Izmir, İ̇zmir, Turkki (Türkiye), 35110
- Rekrytointi
- İzmir Suat Seren Chest Disease Training & Research Hospital
-
-
-
-
-
Liberec1, Tšekki, 460 01
- Rekrytointi
- Krajska nemocnice Liberec, a.s.
-
Nový Jičín, Tšekki, 741 01
- Rekrytointi
- Nemocnice AGEL Novy Jicin a.s.
-
Olomouc, Tšekki, 779 00
- Rekrytointi
- Fakultni nemocnice Olomouc
-
Prague, Tšekki, 150 00
- Rekrytointi
- Fakultni Nemocnice Motol a Homolka
-
-
Praha 4
-
Prague, Praha 4, Tšekki, 140 59
- Rekrytointi
- Fakultni Thomayerova nemocnice
-
-
-
-
-
Székesfehérvár, Unkari, 8000
- Ei vielä rekrytointia
- Fejér Vármegyei Szent György Egyetemi Oktató Kórház
-
Tatabánya, Unkari, 2800
- Ei vielä rekrytointia
- Komárom-Esztergom Vármegyei Szent Borbála Kórház
-
-
Bekes County
-
Gyula, Bekes County, Unkari, 5700
- Rekrytointi
- Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház
-
-
Veszprém megye
-
Farkasgyepű, Veszprém megye, Unkari, 8582
- Ei vielä rekrytointia
- Farkasgyepui Tudogyogyintezet
-
-
-
-
-
Manchester, Yhdistynyt kuningaskunta, M20 4BX
- Rekrytointi
- The Christie NHS Foundation Trust
-
Reading, Yhdistynyt kuningaskunta, RG1 5AN
- Ei vielä rekrytointia
- Royal Berkshire Hospital
-
-
Carnwall
-
Truro, Carnwall, Yhdistynyt kuningaskunta, TR1 3LJ
- Rekrytointi
- Royal Cornwall Hospitals NHS Trust
-
-
England
-
Sheffield, England, Yhdistynyt kuningaskunta, S10 2SJ
- Ei vielä rekrytointia
- Weston Park Hospital
-
-
Hampshire
-
Southampton, Hampshire, Yhdistynyt kuningaskunta, SO16 6YD
- Rekrytointi
- University Hospital Southampton NHS Foundation Trust
-
-
Hillingdon
-
Northwood, Hillingdon, Yhdistynyt kuningaskunta, HA6 2RN
- Ei vielä rekrytointia
- Mount Vernon Hospital
-
-
London, CITY of
-
London, London, CITY of, Yhdistynyt kuningaskunta, EC1A 7BE
- Rekrytointi
- St Bartholomew's Hospital
-
-
Somerset
-
Taunton, Somerset, Yhdistynyt kuningaskunta, TA1 5DA
- Ei vielä rekrytointia
- Musgrove Park Hospital
-
-
Suffolk
-
Ipswich, Suffolk, Yhdistynyt kuningaskunta, IP4 5PD
- Ei vielä rekrytointia
- Ipswich Hospital
-
-
-
-
California
-
Fullerton, California, Yhdysvallat, 92835
- Rekrytointi
- Providence Medical Foundation
-
Fullerton, California, Yhdysvallat, 92835
- Rekrytointi
- Providence St. Jude Medical Center
-
Fullerton, California, Yhdysvallat, 92835
- Rekrytointi
- Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center
-
Fullerton, California, Yhdysvallat, 92835
- Rekrytointi
- St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)
-
-
Colorado
-
Golden, Colorado, Yhdysvallat, 80401
- Rekrytointi
- Intermountain Health Cancer Center Lutheran Hospital
-
Grand Junction, Colorado, Yhdysvallat, 81501
- Rekrytointi
- Cancer Centers of Colorado St. Mary's Regional Hospital
-
Grand Junction, Colorado, Yhdysvallat, 81505
- Rekrytointi
- Intermountain Health
-
Grand Junction, Colorado, Yhdysvallat, 81501
- Rekrytointi
- Intermountain Health St. Mary's Regional Hospital
-
Wheat Ridge, Colorado, Yhdysvallat, 80401
- Rekrytointi
- Intermountain Health Lutheran Hospital
-
-
District of Columbia
-
Washington D.C., District of Columbia, Yhdysvallat, 20422
- Rekrytointi
- Washington DC Veterans Affairs Medical Center
-
-
Florida
-
Orange City, Florida, Yhdysvallat, 32763
- Rekrytointi
- Mid Florida Hematology and Oncology Center
-
Plantation, Florida, Yhdysvallat, 33322
- Rekrytointi
- BRCR Global
-
-
Illinois
-
Elmhurst, Illinois, Yhdysvallat, 60126
- Rekrytointi
- Endeavor Health
-
Hinsdale, Illinois, Yhdysvallat, 60521
- Rekrytointi
- Hope and Healing Cancer Services
-
Libertyville, Illinois, Yhdysvallat, 60048
- Rekrytointi
- Advocate Medical Group - Libertyville Oncology
-
Naperville, Illinois, Yhdysvallat, 60540
- Rekrytointi
- Endeavor Health
-
New Lenox, Illinois, Yhdysvallat, 60451
- Rekrytointi
- Hope and Healing Cancer Services
-
Oak Lawn, Illinois, Yhdysvallat, 60453
- Rekrytointi
- Advocate Christ Medical Center
-
Park Ridge, Illinois, Yhdysvallat, 60068
- Rekrytointi
- Advocate Lutheran General Hospital
-
-
Kansas
-
Overland Park, Kansas, Yhdysvallat, 66213
- Rekrytointi
- Saint Luke's South Hospital
-
-
Maine
-
Portland, Maine, Yhdysvallat, 04102
- Rekrytointi
- Maine Medical Center
-
Scarborough, Maine, Yhdysvallat, 04074
- Rekrytointi
- MaineHealth Cancer Care and Blood Disorders Scarborough
-
South Portland, Maine, Yhdysvallat, 04106
- Rekrytointi
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Massachusetts
-
Fairhaven, Massachusetts, Yhdysvallat, 02719
- Rekrytointi
- Southcoast Centers for Cancer Care
-
Fall River, Massachusetts, Yhdysvallat, 02720
- Rekrytointi
- Southcoast Centers for Cancer Care
-
-
Michigan
-
Grand Rapids, Michigan, Yhdysvallat, 49503
- Rekrytointi
- Corewell Health
-
Grand Rapids, Michigan, Yhdysvallat, 49503
- Rekrytointi
- Corewell Health - Butterworth Hospital
-
Grand Rapids, Michigan, Yhdysvallat, 49503
- Rekrytointi
- Corewell Health - Lemmen Holton Cancer Pavilion
-
Grand Rapids, Michigan, Yhdysvallat, 49503
- Rekrytointi
- Corewell Health - Research Specimen Processing Area
-
Grand Rapids, Michigan, Yhdysvallat, 49503
- Rekrytointi
- Corewell Health Investigational Drug Services
-
-
Minnesota
-
Burnsville, Minnesota, Yhdysvallat, 55337
- Rekrytointi
- Minnesota Oncology Hematology, PA
-
Coon Rapids, Minnesota, Yhdysvallat, 55433
- Rekrytointi
- Minnesota Oncology Hematology PA
-
Edina, Minnesota, Yhdysvallat, 55435
- Rekrytointi
- M Health Fairview Cancer Clinic-Edina
-
Edina, Minnesota, Yhdysvallat, 55435
- Rekrytointi
- Minnesota Oncology Hematology PA
-
Maple Grove, Minnesota, Yhdysvallat, 55369
- Rekrytointi
- Minnesota Oncology Hematology PA
-
Maplewood, Minnesota, Yhdysvallat, 55109
- Rekrytointi
- M Health Fairview St. John's Hospital
-
Maplewood, Minnesota, Yhdysvallat, 55109
- Rekrytointi
- Minnesota Oncology Hematology PA
-
Minneapolis, Minnesota, Yhdysvallat, 55415
- Rekrytointi
- Hennepin County Medical Center
-
Robbinsdale, Minnesota, Yhdysvallat, 55422
- Rekrytointi
- North Memorial Health Cancer Center
-
Saint Louis Park, Minnesota, Yhdysvallat, 55426
- Rekrytointi
- Park Nicollet Frauenshuh Cancer Center
-
Saint Louis Park, Minnesota, Yhdysvallat, 55426
- Rekrytointi
- Metro Minnesota Community Oncology Research Consortium (MMCORC)
-
Saint Paul, Minnesota, Yhdysvallat, 55101
- Rekrytointi
- Regions Hospital
-
Woodbury, Minnesota, Yhdysvallat, 55125
- Rekrytointi
- Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center
-
-
Mississippi
-
Jackson, Mississippi, Yhdysvallat, 39202
- Rekrytointi
- Jackson Oncology Associates, PLLC
-
Jackson, Mississippi, Yhdysvallat, 39216
- Rekrytointi
- Jackson Oncology Associates, PLLC
-
-
Missouri
-
Kansas City, Missouri, Yhdysvallat, 64111
- Rekrytointi
- Saint Luke's Hospital of Kansas City
-
Lee's Summit, Missouri, Yhdysvallat, 64086
- Rekrytointi
- Saint Luke's East Hospital
-
-
Montana
-
Billings, Montana, Yhdysvallat, 59101
- Rekrytointi
- SCL Health - Montana
-
Billings, Montana, Yhdysvallat, 59102
- Rekrytointi
- SCL Health - Montana
-
-
Nebraska
-
Fremont, Nebraska, Yhdysvallat, 68025
- Rekrytointi
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont
-
Grand Island, Nebraska, Yhdysvallat, 68803
- Rekrytointi
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
-
Grand Island, Nebraska, Yhdysvallat, 68803
- Rekrytointi
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional
-
Kearney, Nebraska, Yhdysvallat, 68845
- Rekrytointi
- Kearney Cancer Center
-
Lincoln, Nebraska, Yhdysvallat, 68516
- Rekrytointi
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Yhdysvallat, 68130
- Rekrytointi
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists
-
Omaha, Nebraska, Yhdysvallat, 68114
- Rekrytointi
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist
-
Omaha, Nebraska, Yhdysvallat, 68124
- Rekrytointi
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan
-
-
New York
-
Nyack, New York, Yhdysvallat, 10960
- Rekrytointi
- Hematology Oncology Associates of Rockland
-
-
North Carolina
-
Greenville, North Carolina, Yhdysvallat, 27834
- Rekrytointi
- Brody School of Medicine at East Carolina University
-
Greenville, North Carolina, Yhdysvallat, 27834
- Rekrytointi
- ECU Health Medical Center
-
Wilson, North Carolina, Yhdysvallat, 27893
- Rekrytointi
- Carolina Cancer Research Center
-
-
Ohio
-
Avon, Ohio, Yhdysvallat, 44011
- Rekrytointi
- University Hospitals Seidman Cancer Center at UH Avon Health Center
-
Canton, Ohio, Yhdysvallat, 44718
- Lopetettu
- Gabrail Cancer Center Research
-
Cleveland, Ohio, Yhdysvallat, 44106
- Rekrytointi
- University Hospitals Cleveland Medical Center
-
Mentor, Ohio, Yhdysvallat, 44060
- Rekrytointi
- University Hospitals Seidman Cancer Center at UH Mentor Health Center
-
Orange, Ohio, Yhdysvallat, 44122
- Rekrytointi
- UH Minoff Health Center at Chagrin Highlands
-
-
Texas
-
Conroe, Texas, Yhdysvallat, 77384
- Rekrytointi
- The University of Texas, MD Anderson Cancer Center - Woodlands
-
El Paso, Texas, Yhdysvallat, 79915
- Rekrytointi
- Renovatio Clinical - El Paso
-
Houston, Texas, Yhdysvallat, 77030
- Rekrytointi
- University of Texas MD Anderson Cancer Center
-
Houston, Texas, Yhdysvallat, 77030
- Rekrytointi
- The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
-
Houston, Texas, Yhdysvallat, 77030
- Rekrytointi
- The University of Texas MD Anderson Cancer Center Diagnostic Imaging
-
Houston, Texas, Yhdysvallat, 77030
- Rekrytointi
- The University of Texas, MD Anderson Cancer Center- Interventional Radiology
-
Houston, Texas, Yhdysvallat, 77054
- Rekrytointi
- The University of Texas MD Anderson Cancer Center Clinical Research Imaging
-
Houston, Texas, Yhdysvallat, 77079
- Rekrytointi
- The University of Texas, MD Anderson Cancer Center - West Houston
-
Kingwood, Texas, Yhdysvallat, 77339
- Rekrytointi
- Community Clinical Trials
-
League City, Texas, Yhdysvallat, 77573
- Rekrytointi
- The University of Texas, MD Anderson Cancer Center - League City
-
Sugar Land, Texas, Yhdysvallat, 77478
- Rekrytointi
- The University of Texas, MD Anderson Cancer Center - Sugar Land
-
The Woodlands, Texas, Yhdysvallat, 77380
- Rekrytointi
- Renovatio Clinical
-
The Woodlands, Texas, Yhdysvallat, 77381
- Rekrytointi
- Woodlands Radiology
-
-
Washington
-
Olympia, Washington, Yhdysvallat, 98502
- Rekrytointi
- American Oncology Network Vista Oncology Division-West office
-
Olympia, Washington, Yhdysvallat, 98506
- Rekrytointi
- American Oncology Network Vista Oncology Division-East office
-
-
Wisconsin
-
Grafton, Wisconsin, Yhdysvallat, 53024
- Rekrytointi
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Yhdysvallat, 54311
- Rekrytointi
- Aurora BayCare Medical Center
-
Milwaukee, Wisconsin, Yhdysvallat, 53215
- Rekrytointi
- Aurora St. Luke's Medical Center
-
-
Osallistumiskriteerit
Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.
Kelpoisuusvaatimukset
Opintokelpoiset iät
18 vuotta ja vanhemmat (Aikuinen, Vanhempi Aikuinen)
Hyväksyy terveitä vapaaehtoisia
Ei
Sukupuolet, jotka voivat opiskella
Kaikki
Kuvaus
Inclusion Criteria:
-
Participants must meet the following criteria:
- Have pathologically confirmed Stage IIIB or IIIC NSCLC and not be a candidate for surgical resection or definitive chemoradiation, or Stage IV NSCLC per the AJCC Staging Manual (Version 8.0) and the UICC Staging System (Eighth edition).
- Participants with known AGAs including EGFR, ALK, ROS1, NTRK, BRAF, RET, and MET, for which there are approved and available first-line therapies per local SOC are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology.
- Participants with large cell neuroendocrine carcinoma are excluded.
- Must be an appropriate candidate for treatment with pembrolizumab monotherapy per local guidelines.
-
Tumor has PD-L1 expression in ≥50% of tumor cells (TPS ≥50%) as determined by local testing.
-
Measurable disease based on RECIST v1.1 per investigator.
-
Resolution of acute effects of any prior therapy to either baseline severity or NCI CTCAE Grade 1 or less (except for AEs not constituting a safety risk in the investigator's judgment), unless otherwise excluded.
Exclusion Criteria:
-
Life expectancy of <3 months in the opinion of the investigator.
-
Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.
-
Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.
-
Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab.
-
Participants with any of the following respiratory conditions:
- Evidence of noninfectious or drug-induced ILD or pneumonitis
- Known DLCO (adjusted for hemoglobin) <50% predicted.
- Grade ≥3 pulmonary disease unrelated to underlying malignancy
-
Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Up to 5 clinically asymptomatic brain metastases of longest diameter <1.0 cm are permitted without definitive surgery and/or radiotherapy.
-
Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery (excluding peripherally inserted central catheter placement and implantable central venous port placement) within 3 days prior to first dose of study intervention.
-
Receipt of a live vaccine within 30 days prior to first dose of study intervention.
-
Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0.
-
Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.
-
Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for >2 weeks, or required treatment with systemic immunosuppressive therapy.
-
History of autoimmune disease that has required systemic treatment in the past 2 years
-
Participants with prior solid organ or bone marrow transplantation.
-
Currently receiving a high-dose steroid (>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant.
-
Prior and concomitant therapy:
-
Any prior treatment with MMAE-derived drugs or IB6 targeting agents.
-
Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.
- (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose.
- Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose.
-
Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received. This includes both curative and palliative radiotherapy.
-
Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy.
-
Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor
-
-
History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV.
-
Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months
Opintosuunnitelma
Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
- Ensisijainen käyttötarkoitus: Hoito
- Jako: Satunnaistettu
- Inventiomalli: Rinnakkaistehtävä
- Naamiointi: Yksittäinen
Aseet ja interventiot
Osallistujaryhmä / Arm |
Interventio / Hoito |
|---|---|
|
Kokeellinen: Sigvotatug Vedotin with Pembrolizumab
Participants will receive Sigvotatug Vedotin, administered as an IV infusion and pembrolizumab, administered as an IV infusion. |
MMAE-Antibody Drug Conjugate targeting Integrin Beta-6 Anti-PD-(L)1 |
|
Active Comparator: Pembrolizumab Monotherapy
Participants will receive pembrolizumab, administered as an IV infusion. |
Anti-PD-(L)1 |
Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
|---|---|---|
|
Overall Survival
Aikaikkuna: Baseline to date of death from any cause (Approximately 2 years).
|
Overall survival defined as the duration from enrollment to death. |
Baseline to date of death from any cause (Approximately 2 years).
|
|
Progression Free Survival (PFS) assessed by blinded independent central review (BICR)
Aikaikkuna: From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first. |
From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Toissijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
|---|---|---|
|
Progression Free Survival as assessed by Investigator
Aikaikkuna: From Baseline to date of first progression or death (Approximately 4 years).
|
Progression Free Survival (PFS) is defined as the time from the date of first dose of study interventions to the date of first documentation of PD or death due to any cause, whichever occurs first. |
From Baseline to date of first progression or death (Approximately 4 years).
|
|
Objective Response Rate as assessed by BICR
Aikaikkuna: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Objective Response Rate as assessed by Investigator
Aikaikkuna: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Defined as the proportion of participants who achieve a best response of complete response (CR) or partial response (PR) using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria as assessed by Investigator. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Duration of Response as assessed by BICR
Aikaikkuna: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Duration of Response as assessed by Investigator
Aikaikkuna: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Defined time from the initial response (CR or PR) until documented tumor progression or death from any cause and based on Investigator assessment. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Number of participants with adverse events (AEs)
Aikaikkuna: From Baseline to end of treatment (up to 4 years).
|
Counts of participants who had treatment-emergent adverse events (TEAEs), defined as newly occurring or worsening after first dose. Relatedness to [study drug] was assessed by the investigator (Yes/No). Participants with multiple occurrences of an AE within a category were counted once within the category. |
From Baseline to end of treatment (up to 4 years).
|
|
Pharmacokinetics (PK) of antibody-conjugated monomethyl auristatin E (ac-MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
Aikaikkuna: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of ac-MMAE in plasma: Plasma predose concentration (Cpredose)
Aikaikkuna: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of unconjugated monomethyl auristatin E (MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
Aikaikkuna: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of MMAE in plasma: Plasma predose concentration (Cpredose)
Aikaikkuna: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Number of participants with antidrug antibodies (ADAs)
Aikaikkuna: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the immunogenicity of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Time to response (TTR) using RECIST v1.1 as assessed by BICR
Aikaikkuna: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by BICR. |
The time from the date of randomization to the date of first documentation of objective response.
|
|
TTR using RECIST v1.1 as assessed by investigator
Aikaikkuna: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by investigator assessment. |
The time from the date of randomization to the date of first documentation of objective response.
|
Yhteistyökumppanit ja tutkijat
Täältä löydät tähän tutkimukseen osallistuvat ihmiset ja organisaatiot.
Sponsori
Tutkijat
- Opintojohtaja: Pfizer CT.gov Call Center, Pfizer
Julkaisuja ja hyödyllisiä linkkejä
Tutkimusta koskevien tietojen syöttämisestä vastaava henkilö toimittaa nämä julkaisut vapaaehtoisesti. Nämä voivat koskea mitä tahansa tutkimukseen liittyvää.
Hyödyllisiä linkkejä
Opintojen ennätyspäivät
Nämä päivämäärät seuraavat ClinicalTrials.gov-sivustolle lähetettyjen tutkimustietueiden ja yhteenvetojen edistymistä. National Library of Medicine (NLM) tarkistaa tutkimustiedot ja raportoidut tulokset varmistaakseen, että ne täyttävät tietyt laadunvalvontastandardit, ennen kuin ne julkaistaan julkisella verkkosivustolla.
Opi tärkeimmät päivämäärät
Opiskelun aloitus (Todellinen)
Keskiviikko 23. heinäkuuta 2025
Ensisijainen valmistuminen (Arvioitu)
Tiistai 5. syyskuuta 2028
Opintojen valmistuminen (Arvioitu)
Torstai 1. maaliskuuta 2029
Opintoihin ilmoittautumispäivät
Ensimmäinen lähetetty
Torstai 26. joulukuuta 2024
Ensimmäinen toimitettu, joka täytti QC-kriteerit
Torstai 26. joulukuuta 2024
Ensimmäinen Lähetetty (Todellinen)
Perjantai 3. tammikuuta 2025
Tutkimustietojen päivitykset
Viimeisin päivitys julkaistu (Todellinen)
Perjantai 25. syyskuuta 2026
Viimeisin lähetetty päivitys, joka täytti QC-kriteerit
Tiistai 22. syyskuuta 2026
Viimeksi vahvistettu
Tiistai 1. syyskuuta 2026
Lisää tietoa
Tähän tutkimukseen liittyvät termit
Muita asiaankuuluvia MeSH-ehtoja
- Neoplasmat sivustoittain
- Neoplasmat
- Hengityselinten sairaudet
- Neoplasmat histologisen tyypin mukaan
- Keuhkosairaudet
- Kasvaimet, rauhas- ja epiteelikasvaimet
- Hengitysteiden kasvaimet
- Rintakehän kasvaimet
- Syöpä, bronkogeeninen
- Keuhkoputkien kasvaimet
- Karsinooma
- Keuhkojen kasvaimet
- Karsinooma, ei-pienisoluinen keuhko
- pembrolitsumabi
Muut tutkimustunnusnumerot
- C5751003
- 2024-517968-36-00 (Rekisterin tunniste: CTIS (EU))
Yksittäisten osallistujien tietojen suunnitelma (IPD)
Aiotko jakaa yksittäisten osallistujien tietoja (IPD)?
JOO
IPD-suunnitelman kuvaus
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
Lääke- ja laitetiedot, tutkimusasiakirjat
Tutkii yhdysvaltalaista FDA sääntelemää lääkevalmistetta
Joo
Tutkii yhdysvaltalaista FDA sääntelemää laitetuotetta
Ei
Yhdysvalloissa valmistettu ja sieltä viety tuote
Joo
Nämä tiedot haettiin suoraan verkkosivustolta clinicaltrials.gov ilman muutoksia. Jos sinulla on pyyntöjä muuttaa, poistaa tai päivittää tutkimustietojasi, ota yhteyttä register@clinicaltrials.gov. Heti kun muutos on otettu käyttöön osoitteessa clinicaltrials.gov, se päivitetään automaattisesti myös verkkosivustollemme .