这项研究旨在了解研究药物 Sigvotatug Vedotin 与 Pembrolizumab 的组合如何在 PD-L1 水平高的非小细胞肺癌患者中发挥作用。
2026年9月22日 更新者：Pfizer
AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
- Are confirmed to have NSCLC (Stage 3 or 4).
- Have PD-L1 levels in more than 50% of the cancer cells.
All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab.
Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.
研究概览
研究类型
介入性
注册 (估计的)
714
阶段
- 第三阶段
联系人和位置
本节提供了进行研究的人员的详细联系信息，以及有关进行该研究的地点的信息。
学习联系方式
- 姓名：Pfizer CT.gov Call Center
- 电话号码：1-800-718-1021
- 邮箱：ClinicalTrials.gov_Inquiries@pfizer.com
学习地点
-
-
Anhui
-
Hefei、Anhui、中国、230031
- 招聘中
- Anhui Provincial Cancer Hospital
-
-
Beijing Municipality
-
Beijing、Beijing Municipality、中国、101149
- 招聘中
- Beijing Chest Hospital,Capital Medical University
-
Beijing、Beijing Municipality、中国、100142
- 招聘中
- Beijing Cancer hospital
-
-
Fujian
-
Fuzhou、Fujian、中国、350014
- 招聘中
- Fujian Cancer Hospital
-
-
Guangdong
-
Guangzhou、Guangdong、中国、510515
- 招聘中
- Nanfang Hospital of Southern Medical University
-
Huizhou、Guangdong、中国、516001
- 招聘中
- Huizhou Central People's Hospital
-
-
Guangxi
-
Nanning、Guangxi、中国
- 招聘中
- Guangxi Medical University Affiliated Tumor Hospital
-
-
Heilongjiang
-
Harbin、Heilongjiang、中国、150081
- 招聘中
- Harbin Medical University Cancer Hospital
-
-
Henan
-
Luoyang、Henan、中国、471003
- 招聘中
- The First Affiliated Hospital of Henan University of Science &Technology
-
Zhengzhou、Henan、中国、450008
- 招聘中
- Henan Cancer Hospital
-
-
Hubei
-
Wuhan、Hubei、中国、430079
- 招聘中
- Hubei Cancer Hospital
-
Wuhan、Hubei、中国、430048
- 招聘中
- Wuhan Union Hospital Cancer Center
-
-
Hunan
-
Changsha、Hunan、中国、410013
- 招聘中
- Hunan Cancer Hospital
-
-
Jiangsu
-
Changzhou、Jiangsu、中国、213003
- 招聘中
- The First People's Hospital of Changzhou
-
Nanjing、Jiangsu、中国、210029
- 招聘中
- Jiangsu Province Hospital
-
Xuzhou、Jiangsu、中国、221006
- 招聘中
- The Affiliated Hospital of Xuzhou Medical College
-
-
Jiangxi
-
Nanchang、Jiangxi、中国、330209
- 招聘中
- The First Affiliated Hospital of Nanchang University
-
-
Jilin
-
Changchun、Jilin、中国、130000
- 招聘中
- Jilin Province Tumor Hospital
-
-
Shaanxi
-
Xi'an、Shaanxi、中国、710061
- 招聘中
- The First Affiliated Hospital of Xi'an Jiaotong University
-
-
Shandong
-
Jinan、Shandong、中国、250117
- 招聘中
- Shandong Cancer Hospital
-
Jinan、Shandong、中国、250013
- 招聘中
- Jinan Central Hospital
-
Linyi、Shandong、中国、276001
- 招聘中
- LinYi Cancer Hospital
-
-
Shanghai Municipality
-
Shanghai、Shanghai Municipality、中国、200032
- 招聘中
- Fudan University Shanghai Cancer Center
-
Shanghai、Shanghai Municipality、中国、200030
- 招聘中
- Shanghai Chest Hospital
-
-
Sichuan
-
Chengdu、Sichuan、中国、610041
- 招聘中
- West China Hospital, Sichuan University
-
Chengdu、Sichuan、中国、610041
- 招聘中
- Sichuan Cancer hospital
-
-
Tianjin Municipality
-
Tianjin、Tianjin Municipality、中国、300052
- 招聘中
- Tianjin Medical University General Hospital
-
-
Yunnan
-
Kunming、Yunnan、中国、650118
- 招聘中
- Yunnan Province Cancer Hospital
-
-
Zhejiang
-
Hangzhou、Zhejiang、中国、310016
- 招聘中
- Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
-
Taizhou、Zhejiang、中国、317000
- 招聘中
- Taizhou Hospital of Zhejiang Province
-
Wenzhou、Zhejiang、中国、325000
- 招聘中
- The First Affiliated Hospital of Wenzhou Medical University
-
-
-
-
-
Petah Tikva、以色列、4941492
- 招聘中
- Clalit Health Services through Rabin Medical Center
-
-
Jerusalem
-
Jerusalem、Jerusalem、以色列、9013102
- 招聘中
- Shaare Zedek Medical Center
-
-
-
-
-
Burgas、保加利亚、8000
- 招聘中
- Complex Oncology Center - Burgas
-
Plovdiv、保加利亚、4000
- 尚未招聘
- Medical Center Futuremeds
-
Sofia、保加利亚、1407
- 招聘中
- Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
-
Sofia、保加利亚、1330
- 招聘中
- MHAT for Women's Health Nadezhda
-
Sofia、保加利亚、1756
- 招聘中
- University Specialized Hospital for Active Treatment of Oncology EAD
-
-
Pazardzhik
-
Panagyurishte、Pazardzhik、保加利亚、4500
- 招聘中
- MBAL Uni Hospital
-
-
-
-
British Columbia
-
Abbotsford British Columbia、British Columbia、加拿大、V2S 0C2
- 招聘中
- BC Cancer Abbotsford
-
-
Quebec
-
Montreal、Quebec、加拿大、H1T 2M4
- 招聘中
- CIUSSS de l'Est-de-l'Île-de-Montréal
-
Saint-Jérôme、Quebec、加拿大、J7Y 0L1
- 招聘中
- Centre de Services Ambulatoire de St-Jerome
-
Saint-Jérôme、Quebec、加拿大、J7Z 2V4
- 招聘中
- Unité de Recherche Clinique du CISSS des Laurentides
-
-
-
-
-
Székesfehérvár、匈牙利、8000
- 尚未招聘
- Fejér Vármegyei Szent György Egyetemi Oktató Kórház
-
Tatabánya、匈牙利、2800
- 尚未招聘
- Komárom-Esztergom Vármegyei Szent Borbála Kórház
-
-
Bekes County
-
Gyula、Bekes County、匈牙利、5700
- 招聘中
- Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház
-
-
Veszprém megye
-
Farkasgyepű、Veszprém megye、匈牙利、8582
- 尚未招聘
- Farkasgyepui Tudogyogyintezet
-
-
-
-
Karnataka
-
Bengaluru、Karnataka、印度、560069
- 招聘中
- Spandana Oncology Centre (SOC)
-
-
Maharashtra
-
Mumbai、Maharashtra、印度、400012
- 招聘中
- Tata Memorial Hospital
-
Pune、Maharashtra、印度、411004
- 招聘中
- Sahyadri Super Speciality Hospital
-
Thane、Maharashtra、印度、401107
- 招聘中
- Bhakti Vedanta Hospital and Research Institute
-
-
National Capital Territory of Delhi
-
New Delhi、National Capital Territory of Delhi、印度、110088
- 招聘中
- Fortis Hospital
-
New Delhi、National Capital Territory of Delhi、印度、110005
- 招聘中
- Dr B. L. Kapur Memorial Hospital
-
New Delhi、National Capital Territory of Delhi、印度、110075
- 招聘中
- Venkateshwar Hospital
-
-
Telangana
-
Hyderabad、Telangana、印度、500032
- 尚未招聘
- AIG Hospitals
-
-
-
-
-
Kaohsiung City、台湾、807
- 尚未招聘
- Kaohsiung Medical University Chung-Ho Memorial Hospital
-
Kaohsiung City、台湾、833401
- 招聘中
- Chang Gung Memorial Hospital at Kaohsiung
-
Taichung、台湾、407
- 尚未招聘
- Taichung Veterans General Hospital
-
Tainan、台湾、704
- 招聘中
- National Cheng Kung University Hospital
-
Taipei、台湾、11217
- 招聘中
- Taipei Veterans General Hospital
-
Taipei、台湾、10002
- 尚未招聘
- National Taiwan University Hospital
-
-
Tainan
-
Tainan、Tainan、台湾、73657
- 尚未招聘
- Chi Mei Hospital - Liouying Branch
-
-
Taipei
-
Taipei City、Taipei、台湾、106
- 尚未招聘
- National Taiwan University Cancer Center (NTUCC)
-
-
-
-
-
Adana、土耳其（türkiye）、01140
- 招聘中
- Adana Medical Park Seyhan Hastanesi
-
Ankara、土耳其（türkiye）、06680
- 招聘中
- Liv Hospital Ankara
-
Ankara、土耳其（türkiye）、06520
- 招聘中
- Memorial Ankara Hastanesi
-
Ankara、土耳其（türkiye）、06230
- 招聘中
- Hacettepe Universite Hastaneleri
-
Ankara、土耳其（türkiye）、06560
- 招聘中
- Gazi University Health Research and Application Center Gazi Hospital
-
Ankara、土耳其（türkiye）、06010
- 招聘中
- Gulhane Egitim Arastirma Hastanesi
-
Ankara、土耳其（türkiye）、06800
- 招聘中
- Ankara Bilkent Şehir Hastanesi
-
Antalya、土耳其（türkiye）、07100
- 招聘中
- Antalya Egitim ve Arastırma Hastanesi
-
Diyarbakır、土耳其（türkiye）、21200
- 招聘中
- Dicle Üniversitesi
-
İstanbul - Fatih、土耳其（türkiye）、34098
- 招聘中
- Istanbul Universitesi Cerrahpasa
-
-
Turkey
-
Ankara、Turkey、土耳其（türkiye）、06230
- 招聘中
- Ankara University Health Practice and Research Hospitals
-
-
İ̇stanbul
-
Istanbul、İ̇stanbul、土耳其（türkiye）、34722
- 招聘中
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
-
Istanbul、İ̇stanbul、土耳其（türkiye）、34214
- 招聘中
- Medipol Mega Universite Hastanesi
-
Istanbul、İ̇stanbul、土耳其（türkiye）、34295
- 招聘中
- İ.A.Ü VM Medical Park Florya Hastanesi
-
-
İ̇zmir
-
Izmir、İ̇zmir、土耳其（türkiye）、35100
- 招聘中
- Ege Universitesi Hastanesi
-
Izmir、İ̇zmir、土耳其（türkiye）、35110
- 招聘中
- İzmir Suat Seren Chest Disease Training & Research Hospital
-
-
-
-
-
Mexico City、墨西哥、14080
- 尚未招聘
- Instituto Nacional de Cancerologia
-
Puebla City、墨西哥、72530
- 招聘中
- Clinica Integral Internacional de Oncología
-
-
Jalisco
-
Guadalajara、Jalisco、墨西哥、44340
- 招聘中
- Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
-
-
Veracruz
-
Veracruz de Ignacio de LA Llave、Veracruz、墨西哥、91900
- 尚未招聘
- Instituto Veracruzano en Investigación Clínica S.C.
-
-
-
-
-
Graz、奥地利、8036
- 招聘中
- Medizinische Universität Graz
-
Vienna、奥地利、1090
- 招聘中
- Medizinische Universität Wien
-
Vienna、奥地利、1210
- 招聘中
- Klinik Floridsdorf
-
-
Upper Austria
-
Linz、Upper Austria、奥地利、4020
- 招聘中
- Ordensklinikum Linz GmbH Elisabethinen
-
-
-
-
-
Jaú、巴西、17210-080
- 尚未招聘
- Fundação Doutor Amaral Carvalho
-
Rio de Janeiro、巴西、22281-100
- 招聘中
- Instituto D'Or de Pesquisa e Ensino
-
Rio de Janeiro、巴西、22031-011
- 招聘中
- Instituto D'Or de Pesquisa e Ensino
-
Rio de Janeiro、巴西、22271-110
- 招聘中
- Instituto D'Or de Pesquisa e Ensino
-
Rio de Janeiro、巴西、22451-040
- 招聘中
- Instituto D'Or de Pesquisa e Ensino
-
São Paulo、巴西、01246-000
- 尚未招聘
- Icesp - Instituto Do Câncer Do Estado de São Paulo
-
-
Ceará
-
Fortaleza、Ceará、巴西、60430235
- 招聘中
- Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
-
Fortaleza、Ceará、巴西、60336232
- 招聘中
- Crio - Centro Regional Integrado de Oncologia
-
-
Espírito Santo
-
Vitória、Espírito Santo、巴西、29043-260
- 招聘中
- Afecc Associacao Feminina Educacao Combate Cancer
-
-
Estado de Bahia
-
Salvador、Estado de Bahia、巴西、41950- 640
- 招聘中
- Clinica Amo - Rio Vermelho
-
Salvador、Estado de Bahia、巴西、41253-190
- 招聘中
- Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael
-
-
Federal District
-
Brasília、Federal District、巴西、70390-150
- 尚未招聘
- Onco-Vida - Instituto Especializado De Oncologia
-
-
Paraná
-
Curitiba、Paraná、巴西、81520-060
- 招聘中
- Hospital Erasto Gaertner
-
-
Pernambuco
-
Recife、Pernambuco、巴西、52010-902
- 招聘中
- Real Hospital de Beneficência Portuguesa de Pernambuco
-
-
Piauí
-
Teresina、Piauí、巴西、64049-200
- 招聘中
- Vencer Centro de Pesquisa LTDA
-
-
Rio Grande do Norte
-
Natal、Rio Grande do Norte、巴西、59062-000
- 招聘中
- Liga Norte Riograndense Contra o Câncer
-
-
Rio Grande do Sul
-
Ijuí、Rio Grande do Sul、巴西、98700-000
- 招聘中
- ONCOSITE - Centro de Pesquisa Clinica em Oncologia
-
Porto Alegre、Rio Grande do Sul、巴西、90560032
- 尚未招聘
- Hospital Moinhos de Vento
-
Porto Alegre、Rio Grande do Sul、巴西、90610-000
- 招聘中
- Hospital São Lucas da PUCRS
-
-
Santa Catarina
-
Lages、Santa Catarina、巴西、88501-001
- 招聘中
- ANIMI - Unidade de Tratamento Oncologico
-
-
São Paulo
-
Barretos、São Paulo、巴西、14784400
- 招聘中
- Fundação Pio XII - Hospital de Câncer de Barretos
-
Bragança Paulista、São Paulo、巴西、12916-542
- 招聘中
- Hospital Universitário São Francisco na Providência de Deus
-
Ribeirão Preto、São Paulo、巴西、14051-140
- 招聘中
- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
-
Santo André、São Paulo、巴西、09060-650
- 招聘中
- Faculdade de Medicina do ABC
-
São José do Rio Preto、São Paulo、巴西、15090000
- 招聘中
- Fundação Faculdade Regional de Medicina de São José do Rio Preto
-
São Paulo、São Paulo、巴西、01327-001
- 招聘中
- Hospital Alemao Oswaldo Cruz
-
-
-
-
-
Athens、希腊、115 26
- 招聘中
- Errikos Dunant Hospital Center
-
Larissa、希腊、41110
- 招聘中
- University General Hospital of Larissa, Urology Department
-
Thessaloniki、希腊、552 36
- 招聘中
- Agios Loukas Clinic
-
-
Attikí
-
Athens、Attikí、希腊、115 27
- 招聘中
- Thoracic General Hospital of Athens "I Sotiria"
-
Athens、Attikí、希腊、155 62
- 招聘中
- Metropolitan General Hospital
-
Athens、Attikí、希腊、185 47
- 招聘中
- Metropolitan Hospital
-
Marousi、Attikí、希腊、151 23
- 招聘中
- Hygeia Hospital
-
-
Thessaloníki
-
Thessaloniki、Thessaloníki、希腊、570 01
- 招聘中
- European Interbalkan Medical Center
-
-
-
-
-
Bad Berka、德国、99437
- 招聘中
- Zentralklinik Bad Berka GmbH
-
Berlin、德国、10117
- 招聘中
- Charité - Universitätsmedizin Berlin
-
Berlin、德国、13353
- 招聘中
- Charité Campus Virchow-Klinikum
-
Berlin、德国、13353
- 招聘中
- Labor Berlin
-
Berlin、德国、13509
- 招聘中
- Vivantes Humboldt Klinikum Apotheke Nord
-
Berlin、德国、13585
- 招聘中
- Vivantes Hospital Spandau
-
Gauting、德国、82131
- 招聘中
- Asklepios Klinik Gauting GmbH
-
Großhansdorf、德国、22927
- 招聘中
- LungenClinic Grosshansdorf
-
München、德国、81377
- 招聘中
- Radiologie München
-
-
Baden-Wurttemberg
-
Ulm、Baden-Wurttemberg、德国、89081
- 招聘中
- Universitaetsklinikum Ulm
-
-
Bavaria
-
Gröbenzell、Bavaria、德国、82194
- 招聘中
- Johannes Apotheke Gröbenzell
-
Traunstein、Bavaria、德国、83278
- 招聘中
- Klinikum Traunstein
-
-
Hesse
-
Giessen、Hesse、德国、35392
- 招聘中
- UKGM Gießen/Marburg
-
Kassel、Hesse、德国、34125
- 招聘中
- Klinikum Kassel
-
-
Rhineland-Palatinate
-
Koblenz、Rhineland-Palatinate、德国、56068
- 招聘中
- InVO Institut für Versorgungsforschung in der Onkologie
-
-
Saxony
-
Chemnitz、Saxony、德国、09116
- 招聘中
- Klinikum Chemnitz - Flemmingstraße
-
Chemnitz、Saxony、德国、09113
- 招聘中
- Klinikum Chemnitz gGmbH
-
-
Saxony-Anhalt
-
Halle、Saxony-Anhalt、德国、06120
- 招聘中
- Krankenhaus Martha-Maria Halle-Dölau
-
-
Schleswig-Holstein
-
Lübeck、Schleswig-Holstein、德国、23538
- 招聘中
- Universitätsklinikum Schleswig-Holstein
-
Oldenburg in Holstein、Schleswig-Holstein、德国、23758
- 招聘中
- ohO Research GmbH
-
-
-
-
-
Avellino、意大利、83100
- 招聘中
- Azienda Ospedaliera San Giuseppe Moscati
-
Milan、意大利、20132
- 招聘中
- Ospedale San Raffaele
-
Milan、意大利、20141
- 招聘中
- Istituto Europeo di Oncologia IRCCS
-
Padova、意大利、35128
- 招聘中
- Istituto Oncologico Veneto IRCCS
-
-
Campania
-
Naples、Campania、意大利、80131
- 招聘中
- Istituto Nazionale Tumori IRCCS Fondazione Pascale
-
-
Catania
-
Misterbianco、Catania、意大利、95045
- 招聘中
- Humanitas Istituto Clinico Catanese
-
-
Emilia-Romagna
-
Meldola、Emilia-Romagna、意大利、47014
- 招聘中
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
-
-
Pesaro AND Urbino
-
Pesaro (PU)、Pesaro AND Urbino、意大利、61121
- 招聘中
- Azienda Sanitaria Territoriale Pesaro e Urbino (AST PU)
-
-
Piedmont
-
Orbassano、Piedmont、意大利、10043
- 招聘中
- Azienda Ospedaliero-Universitaria San Luigi Gonzaga
-
-
ROMA
-
Rome、ROMA、意大利、00186
- 招聘中
- Ospedale Isola Tiberina - Gemelli Isola
-
-
ROME
-
Roma、ROME、意大利、00144
- 招聘中
- IRCCS Istituto Nazionale dei Tumori Regina Elena
-
-
Sicily
-
Catania、Sicily、意大利、95123
- 招聘中
- Policlinico "G. Rodolico"
-
-
-
-
-
Liberec1、捷克语、460 01
- 招聘中
- Krajska nemocnice Liberec, a.s.
-
Nový Jičín、捷克语、741 01
- 招聘中
- Nemocnice AGEL Novy Jicin a.s.
-
Olomouc、捷克语、779 00
- 招聘中
- Fakultni nemocnice Olomouc
-
Prague、捷克语、150 00
- 招聘中
- Fakultni Nemocnice Motol a Homolka
-
-
Praha 4
-
Prague、Praha 4、捷克语、140 59
- 招聘中
- Fakultni Thomayerova nemocnice
-
-
-
-
-
Nové Zámky、斯洛伐克、94034
- 招聘中
- Fakultna nemocnica s poliklinikou Nove Zamky
-
Poprad、斯洛伐克、058 01
- 招聘中
- POKO Poprad s.r.o.
-
-
Bratislava Region
-
Bratislava、Bratislava Region、斯洛伐克、821 01
- 招聘中
- Univerzitná nemocnica Bratislava - Nemocnica Ružinov
-
-
Košice Region
-
Košice、Košice Region、斯洛伐克、040 01
- 招聘中
- Vychodoslovensky Onkologicky Ustav a.s.
-
-
Nitra Region
-
Komárno、Nitra Region、斯洛伐克、945 05
- 招聘中
- Nemocnica AGEL Komarno
-
-
Trnava Region
-
Trnava、Trnava Region、斯洛伐克、917 02
- 招聘中
- Fakultna nemocnica Trnava
-
-
-
-
-
Fukuoka、日本、810-8563
- 招聘中
- National Hospital Organization Kyushu Medical Center
-
Fukuoka、日本、811-1395
- 招聘中
- National Hospital Organization Kyushu Cancer Center
-
Kyoto、日本、612-8555
- 招聘中
- National Hospital Organization Kyoto Medical Center
-
Okayama、日本、701-1154
- 招聘中
- National Hospital Organization Okayama Medical Center
-
Osaka、日本、541-8567
- 招聘中
- Osaka International Cancer Institute
-
-
Ehime
-
Tōon、Ehime、日本、791-0295
- 尚未招聘
- Ehime University Hospital
-
-
Fukuoka
-
Kurume、Fukuoka、日本、830-0011
- 招聘中
- Kurume University Hospital
-
-
Gunma
-
Otashi、Gunma、日本、373-8550
- 招聘中
- Gunma Prefectural Cancer Center
-
-
Hokkaido
-
Asahikawa、Hokkaido、日本、0708644
- 招聘中
- National Hospital Organization Asahikawa Medical Center
-
-
Hyōgo
-
Kobe、Hyōgo、日本、650-0047
- 招聘中
- Kobe City Medical Center General Hospital
-
-
Kanagawa
-
Yokohama、Kanagawa、日本、2418515
- 尚未招聘
- Kanagawa cancer center
-
-
Mie-ken
-
Tsu、Mie-ken、日本、514-1101
- 招聘中
- Mie Chuo Medical Center
-
-
Miyagi
-
Sendai、Miyagi、日本、9810914
- 招聘中
- Sendai Kousei Hospital
-
-
Osaka
-
Sakai、Osaka、日本、591-8555
- 招聘中
- NHO Kinki Chuo Chest Medical Center
-
Suita、Osaka、日本、565-0871
- 招聘中
- The University of Osaka Hospital
-
-
Tokyo
-
Bunkyo-ku、Tokyo、日本、113-8603
- 尚未招聘
- Nippon Medical School Hospital
-
Chuo-ku、Tokyo、日本、104-0045
- 招聘中
- National Cancer Center Hospital
-
Koto、Tokyo、日本、135-8550
- 招聘中
- The Cancer Institute Hospital of JFCR
-
Meguro-Ku、Tokyo、日本、152-8902
- 招聘中
- National Hospital Organization Tokyo Medical Center
-
-
Yamagata
-
Yamagata、Yamagata、日本、990-9585
- 招聘中
- Yamagata University Hospital
-
-
-
-
Los Ríos Region
-
Valdivia、Los Ríos Region、智利、5090000
- 招聘中
- Clínica Alemana Valdivia
-
Valdivia、Los Ríos Region、智利、5690000
- 招聘中
- Oncocentro Valdivia
-
-
Santiago Metropolitan
-
La Florida、Santiago Metropolitan、智利、8241479
- 招聘中
- Iceg Clinic
-
Providencia、Santiago Metropolitan、智利、7500966
- 招聘中
- Fundacion Arturo Lopez Perez
-
Providencia、Santiago Metropolitan、智利、7501010
- 招聘中
- Profar
-
Providencia、Santiago Metropolitan、智利、7500836
- 招聘中
- FALP
-
Providencia、Santiago Metropolitan、智利、750000
- 招聘中
- Fundación Arturo Lopéz Pérez
-
Santiago、Santiago Metropolitan、智利、8241479
- 招聘中
- Clínica Vespucio
-
Santiago、Santiago Metropolitan、智利、8380455
- 招聘中
- Instituto Nacional del Cancer
-
Santiago、Santiago Metropolitan、智利、8380456
- 招聘中
- Sociedad Oncovida SA
-
-
Santiago, RM
-
Providencia、Santiago, RM、智利、7500921
- 招聘中
- FALP
-
-
Valparaiso
-
Viña del Mar、Valparaiso、智利、2520598
- 招聘中
- Oncocentro Apys
-
-
-
-
-
Brasschaat、比利时、2930
- 招聘中
- Algemeen Ziekenhuis klina
-
Liège、比利时、4000
- 招聘中
- Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
-
-
Antwerpen
-
Mechelen、Antwerpen、比利时、2800
- 招聘中
- AZ Sint-Maarten
-
-
Bruxelles-capitale, Région de
-
Brussels、Bruxelles-capitale, Région de、比利时、1090
- 招聘中
- UZ Brussel
-
-
Hainaut
-
Charleroi、Hainaut、比利时、6060
- 招聘中
- Grand Hôpital de Charleroi
-
-
-
-
-
Riyadh、沙特阿拉伯、11211
- 尚未招聘
- King Faisal Specialist Hospital and Research Center
-
-
Riyadh Region
-
Riyadh、Riyadh Region、沙特阿拉伯、11472
- 尚未招聘
- King Saud University Medical City
-
-
-
-
-
Marseille、法国、13915
- 招聘中
- Assistance Publique Hôpitaux de Marseille - Hôpital Nord
-
Nice、法国、06189
- 招聘中
- Centre Antoine Lacassagne
-
Paris、法国、75248
- 招聘中
- Institut Curie
-
Paris、法国、75014
- 招聘中
- Hopitaux Universitaires Paris Centre-Hopital Cochin
-
-
Aquitaine
-
Pessac、Aquitaine、法国、33604
- 招聘中
- CHU Bordeaux Haut-Leveque
-
-
Brittany Region
-
Quimper、Brittany Region、法国、1757 - 29107
- 招聘中
- Centre Hospitalier de Cornouaille Quimper - Concarneau
-
-
Haute-garonne
-
Toulouse、Haute-garonne、法国、31059
- 招聘中
- CHU de Toulouse - Hopital Larrey
-
-
Ille-et-vilaine
-
Rennes、Ille-et-vilaine、法国、35033
- 招聘中
- Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
-
-
Languedoc-roussillon
-
Montpellier、Languedoc-roussillon、法国、34070
- 招聘中
- Centre de Cancérologie du Grand Montpellier
-
-
Loire-atlantique
-
Saint-Herblain、Loire-atlantique、法国、44805
- 招聘中
- Institut de Cancérologie de l'Ouest
-
Saint-Herblain、Loire-atlantique、法国、44800
- 招聘中
- Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
-
-
PAYS de Loire
-
Cholet、PAYS de Loire、法国、49300
- 招聘中
- Centre Hospitalier de Cholet
-
-
Provence-Alpes-Côte d'Azur Region
-
Toulon、Provence-Alpes-Côte d'Azur Region、法国、83056
- 招聘中
- Centre Hospitalier intercommunal de Toulon La Seyne sur Hospital Sainte-Musse health establishment
-
-
Val-de-marne
-
Créteil、Val-de-marne、法国、94010
- 招聘中
- Centre Hospitalier Intercommunal de Créteil
-
-
-
-
-
Gdansk、波兰、80-214
- 招聘中
- Uniwersyteckie Centrum Kliniczne
-
Gliwice、波兰、44-102
- 招聘中
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
-
Poznan、波兰、60-569
- 招聘中
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
-
-
Greater Poland Voivodeship
-
Poznan、Greater Poland Voivodeship、波兰、60-693
- 招聘中
- Med-Polonia Sp. z o. o.
-
-
Lublin Voivodeship
-
Lublin、Lublin Voivodeship、波兰、20-609
- 招聘中
- Instytut Genetyki i Immunologii GENIM
-
-
Masovian Voivodeship
-
Warsaw、Masovian Voivodeship、波兰、02-781
- 招聘中
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
-
-
Łódź Voivodeship
-
Lodz、Łódź Voivodeship、波兰、90-302
- 招聘中
- Instytut MSF Sp zoo
-
-
-
-
New South Wales
-
Coffs Harbour、New South Wales、澳大利亚、2450
- 招聘中
- Coffs Harbour Health Campus
-
North Ryde、New South Wales、澳大利亚、2109
- 招聘中
- Macquarie University
-
Sydney、New South Wales、澳大利亚、2560
- 招聘中
- Campbelltown Hospital
-
-
Queensland
-
Birtinya、Queensland、澳大利亚、4575
- 招聘中
- Sunshine Coast University Hospital
-
Douglas、Queensland、澳大利亚、4814
- 招聘中
- Townsville University Hospital
-
Gympie、Queensland、澳大利亚、4570
- 招聘中
- Gympie Hospital
-
Nambour、Queensland、澳大利亚、4560
- 招聘中
- Nambour General Hospital
-
Woolloongabba、Queensland、澳大利亚、4102
- 招聘中
- Princess Alexandra Hospital
-
-
Western Australia
-
Perth、Western Australia、澳大利亚、6009
- 招聘中
- Sir Charles Gairdner Hospital
-
-
-
-
-
Zurich、瑞士、8091
- 招聘中
- UniversitätsSpital Zürich
-
-
Canton of Bern
-
Bern、Canton of Bern、瑞士、3010
- 招聘中
- Inselspital Bern
-
-
-
-
Bucharest
-
Bucharest、Bucharest、罗马尼亚、013812
- 招聘中
- SC Memorial Healthcare International SRL
-
Bucharest、Bucharest、罗马尼亚、022338
- 招聘中
- Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
-
Bucharest、Bucharest、罗马尼亚、077190
- 尚未招聘
- Sc Mnt Healthcare Europe Srl
-
-
Cluj
-
Cluj-Napoca、Cluj、罗马尼亚、400641
- 招聘中
- SC Medisprof SRL
-
Florești、Cluj、罗马尼亚、407280
- 招聘中
- SC Radiotherapy Center Cluj SRL
-
-
Constanța County
-
Ovidiu、Constanța County、罗马尼亚、905900
- 招聘中
- Ovidius Clinical Hospital OCH
-
-
Dolj
-
Craiova、Dolj、罗马尼亚、200542
- 尚未招聘
- Centrul de Oncologie "Sfântul Nectarie"
-
Craiova、Dolj、罗马尼亚、200385
- 招聘中
- SC Oncolab SRL
-
-
Timiș County
-
Timișoara、Timiș County、罗马尼亚、300166
- 尚未招聘
- S C Oncocenter Oncologie Clinica S R L
-
-
-
-
California
-
Fullerton、California、美国、92835
- 招聘中
- Providence Medical Foundation
-
Fullerton、California、美国、92835
- 招聘中
- Providence St. Jude Medical Center
-
Fullerton、California、美国、92835
- 招聘中
- Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center
-
Fullerton、California、美国、92835
- 招聘中
- St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)
-
-
Colorado
-
Golden、Colorado、美国、80401
- 招聘中
- Intermountain Health Cancer Center Lutheran Hospital
-
Grand Junction、Colorado、美国、81501
- 招聘中
- Cancer Centers of Colorado St. Mary's Regional Hospital
-
Grand Junction、Colorado、美国、81505
- 招聘中
- Intermountain Health
-
Grand Junction、Colorado、美国、81501
- 招聘中
- Intermountain Health St. Mary's Regional Hospital
-
Wheat Ridge、Colorado、美国、80401
- 招聘中
- Intermountain Health Lutheran Hospital
-
-
District of Columbia
-
Washington D.C.、District of Columbia、美国、20422
- 招聘中
- Washington DC Veterans Affairs Medical Center
-
-
Florida
-
Orange City、Florida、美国、32763
- 招聘中
- Mid Florida Hematology and Oncology Center
-
Plantation、Florida、美国、33322
- 招聘中
- BRCR Global
-
-
Illinois
-
Elmhurst、Illinois、美国、60126
- 招聘中
- Endeavor Health
-
Hinsdale、Illinois、美国、60521
- 招聘中
- Hope and Healing Cancer Services
-
Libertyville、Illinois、美国、60048
- 招聘中
- Advocate Medical Group - Libertyville Oncology
-
Naperville、Illinois、美国、60540
- 招聘中
- Endeavor Health
-
New Lenox、Illinois、美国、60451
- 招聘中
- Hope and Healing Cancer Services
-
Oak Lawn、Illinois、美国、60453
- 招聘中
- Advocate Christ Medical Center
-
Park Ridge、Illinois、美国、60068
- 招聘中
- Advocate Lutheran General Hospital
-
-
Kansas
-
Overland Park、Kansas、美国、66213
- 招聘中
- Saint Luke's South Hospital
-
-
Maine
-
Portland、Maine、美国、04102
- 招聘中
- Maine Medical Center
-
Scarborough、Maine、美国、04074
- 招聘中
- MaineHealth Cancer Care and Blood Disorders Scarborough
-
South Portland、Maine、美国、04106
- 招聘中
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Massachusetts
-
Fairhaven、Massachusetts、美国、02719
- 招聘中
- Southcoast Centers for Cancer Care
-
Fall River、Massachusetts、美国、02720
- 招聘中
- Southcoast Centers for Cancer Care
-
-
Michigan
-
Grand Rapids、Michigan、美国、49503
- 招聘中
- Corewell Health
-
Grand Rapids、Michigan、美国、49503
- 招聘中
- Corewell Health - Butterworth Hospital
-
Grand Rapids、Michigan、美国、49503
- 招聘中
- Corewell Health - Lemmen Holton Cancer Pavilion
-
Grand Rapids、Michigan、美国、49503
- 招聘中
- Corewell Health - Research Specimen Processing Area
-
Grand Rapids、Michigan、美国、49503
- 招聘中
- Corewell Health Investigational Drug Services
-
-
Minnesota
-
Burnsville、Minnesota、美国、55337
- 招聘中
- Minnesota Oncology Hematology, PA
-
Coon Rapids、Minnesota、美国、55433
- 招聘中
- Minnesota Oncology Hematology PA
-
Edina、Minnesota、美国、55435
- 招聘中
- M Health Fairview Cancer Clinic-Edina
-
Edina、Minnesota、美国、55435
- 招聘中
- Minnesota Oncology Hematology PA
-
Maple Grove、Minnesota、美国、55369
- 招聘中
- Minnesota Oncology Hematology PA
-
Maplewood、Minnesota、美国、55109
- 招聘中
- M Health Fairview St. John's Hospital
-
Maplewood、Minnesota、美国、55109
- 招聘中
- Minnesota Oncology Hematology PA
-
Minneapolis、Minnesota、美国、55415
- 招聘中
- Hennepin County Medical Center
-
Robbinsdale、Minnesota、美国、55422
- 招聘中
- North Memorial Health Cancer Center
-
Saint Louis Park、Minnesota、美国、55426
- 招聘中
- Park Nicollet Frauenshuh Cancer Center
-
Saint Louis Park、Minnesota、美国、55426
- 招聘中
- Metro Minnesota Community Oncology Research Consortium (MMCORC)
-
Saint Paul、Minnesota、美国、55101
- 招聘中
- Regions Hospital
-
Woodbury、Minnesota、美国、55125
- 招聘中
- Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center
-
-
Mississippi
-
Jackson、Mississippi、美国、39202
- 招聘中
- Jackson Oncology Associates, PLLC
-
Jackson、Mississippi、美国、39216
- 招聘中
- Jackson Oncology Associates, PLLC
-
-
Missouri
-
Kansas City、Missouri、美国、64111
- 招聘中
- Saint Luke's Hospital of Kansas City
-
Lee's Summit、Missouri、美国、64086
- 招聘中
- Saint Luke's East Hospital
-
-
Montana
-
Billings、Montana、美国、59101
- 招聘中
- SCL Health - Montana
-
Billings、Montana、美国、59102
- 招聘中
- SCL Health - Montana
-
-
Nebraska
-
Fremont、Nebraska、美国、68025
- 招聘中
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont
-
Grand Island、Nebraska、美国、68803
- 招聘中
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
-
Grand Island、Nebraska、美国、68803
- 招聘中
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional
-
Kearney、Nebraska、美国、68845
- 招聘中
- Kearney Cancer Center
-
Lincoln、Nebraska、美国、68516
- 招聘中
- Cancer Partners of Nebraska
-
Omaha、Nebraska、美国、68130
- 招聘中
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists
-
Omaha、Nebraska、美国、68114
- 招聘中
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist
-
Omaha、Nebraska、美国、68124
- 招聘中
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan
-
-
New York
-
Nyack、New York、美国、10960
- 招聘中
- Hematology Oncology Associates of Rockland
-
-
North Carolina
-
Greenville、North Carolina、美国、27834
- 招聘中
- Brody School of Medicine at East Carolina University
-
Greenville、North Carolina、美国、27834
- 招聘中
- ECU Health Medical Center
-
Wilson、North Carolina、美国、27893
- 招聘中
- Carolina Cancer Research Center
-
-
Ohio
-
Avon、Ohio、美国、44011
- 招聘中
- University Hospitals Seidman Cancer Center at UH Avon Health Center
-
Canton、Ohio、美国、44718
- 终止
- Gabrail Cancer Center Research
-
Cleveland、Ohio、美国、44106
- 招聘中
- University Hospitals Cleveland Medical Center
-
Mentor、Ohio、美国、44060
- 招聘中
- University Hospitals Seidman Cancer Center at UH Mentor Health Center
-
Orange、Ohio、美国、44122
- 招聘中
- UH Minoff Health Center at Chagrin Highlands
-
-
Texas
-
Conroe、Texas、美国、77384
- 招聘中
- The University of Texas, MD Anderson Cancer Center - Woodlands
-
El Paso、Texas、美国、79915
- 招聘中
- Renovatio Clinical - El Paso
-
Houston、Texas、美国、77030
- 招聘中
- University of Texas MD Anderson Cancer Center
-
Houston、Texas、美国、77030
- 招聘中
- The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
-
Houston、Texas、美国、77030
- 招聘中
- The University of Texas MD Anderson Cancer Center Diagnostic Imaging
-
Houston、Texas、美国、77030
- 招聘中
- The University of Texas, MD Anderson Cancer Center- Interventional Radiology
-
Houston、Texas、美国、77054
- 招聘中
- The University of Texas MD Anderson Cancer Center Clinical Research Imaging
-
Houston、Texas、美国、77079
- 招聘中
- The University of Texas, MD Anderson Cancer Center - West Houston
-
Kingwood、Texas、美国、77339
- 招聘中
- Community Clinical Trials
-
League City、Texas、美国、77573
- 招聘中
- The University of Texas, MD Anderson Cancer Center - League City
-
Sugar Land、Texas、美国、77478
- 招聘中
- The University of Texas, MD Anderson Cancer Center - Sugar Land
-
The Woodlands、Texas、美国、77380
- 招聘中
- Renovatio Clinical
-
The Woodlands、Texas、美国、77381
- 招聘中
- Woodlands Radiology
-
-
Washington
-
Olympia、Washington、美国、98502
- 招聘中
- American Oncology Network Vista Oncology Division-West office
-
Olympia、Washington、美国、98506
- 招聘中
- American Oncology Network Vista Oncology Division-East office
-
-
Wisconsin
-
Grafton、Wisconsin、美国、53024
- 招聘中
- Aurora Cancer Care-Grafton
-
Green Bay、Wisconsin、美国、54311
- 招聘中
- Aurora BayCare Medical Center
-
Milwaukee、Wisconsin、美国、53215
- 招聘中
- Aurora St. Luke's Medical Center
-
-
-
-
-
Manchester、英国、M20 4BX
- 招聘中
- The Christie NHS Foundation Trust
-
Reading、英国、RG1 5AN
- 尚未招聘
- Royal Berkshire Hospital
-
-
Carnwall
-
Truro、Carnwall、英国、TR1 3LJ
- 招聘中
- Royal Cornwall Hospitals NHS Trust
-
-
England
-
Sheffield、England、英国、S10 2SJ
- 尚未招聘
- Weston Park Hospital
-
-
Hampshire
-
Southampton、Hampshire、英国、SO16 6YD
- 招聘中
- University Hospital Southampton NHS Foundation Trust
-
-
Hillingdon
-
Northwood、Hillingdon、英国、HA6 2RN
- 尚未招聘
- Mount Vernon Hospital
-
-
London, CITY of
-
London、London, CITY of、英国、EC1A 7BE
- 招聘中
- St Bartholomew's Hospital
-
-
Somerset
-
Taunton、Somerset、英国、TA1 5DA
- 尚未招聘
- Musgrove Park Hospital
-
-
Suffolk
-
Ipswich、Suffolk、英国、IP4 5PD
- 尚未招聘
- Ipswich Hospital
-
-
-
-
-
Utrecht、荷兰、3543 AZ
- 招聘中
- St. Antonius Ziekenhuis, locatie Utrecht
-
-
Gelderland
-
Harderwijk、Gelderland、荷兰、3844 DG
- 招聘中
- Ziekenhuis St. Jansdal
-
-
North Brabant
-
Breda、North Brabant、荷兰、4818 CK
- 尚未招聘
- Amphia Ziekenhuis, locatie Breda Molengracht
-
-
Overijssel
-
Zwolle、Overijssel、荷兰、8025 AB
- 招聘中
- Isala, locatie Zwolle
-
-
Provincie Friesland
-
Leeuwarden、Provincie Friesland、荷兰、8934 AD
- 尚未招聘
- Frisius Medisch Centrum
-
-
-
-
-
Barcelona、西班牙、08035
- 招聘中
- Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR")
-
Barcelona、西班牙、08035
- 招聘中
- Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO"
-
Las Palmas de Gran Canaria、西班牙、35016
- 招聘中
- Complejo Hospitalario Universitario Insular Materno-Infantil
-
Madrid、西班牙、28040
- 招聘中
- Hospital Universitario Fundación Jiménez Díaz
-
Madrid、西班牙、28003
- 招聘中
- FutureMeds - Madrid
-
Madrid、西班牙、28007
- 招聘中
- Hospital General Universitario Gregorio Marañon
-
Málaga、西班牙、29004
- 招聘中
- Hospital Quirón Málaga
-
Seville、西班牙、41013
- 招聘中
- Hospital Universitario Virgen Del Rocio
-
-
A Coruña [LA Coruña]
-
A Coruña、A Coruña [LA Coruña]、西班牙、15006
- 招聘中
- CHUAC-Complejo Hospitalario Universitario A Coruña
-
-
Alicante
-
Elche、Alicante、西班牙、03203
- 招聘中
- Hospital General Universitario de Elche
-
-
Barcelona [barcelona]
-
Barcelona、Barcelona [barcelona]、西班牙、08028
- 招聘中
- Hospital Universitari Dexeus
-
-
Barcelona/spain
-
Barcelona、Barcelona/spain、西班牙、08035
- 招聘中
- Hospital Universitari Vall D Hebron
-
-
Catalunya [cataluña]
-
Barcelona、Catalunya [cataluña]、西班牙、08041
- 招聘中
- Hospital de la Santa Creu i Sant Pau
-
L'Hospitalet de Llobregat、Catalunya [cataluña]、西班牙、08908
- 招聘中
- Institut Català d'Oncologia - L'Hospitalet
-
-
Cádiz
-
Jerez de la Frontera、Cádiz、西班牙、11407
- 招聘中
- Hospital Jerez de la Frontera
-
-
Illes Balears [islas Baleares]
-
Palma、Illes Balears [islas Baleares]、西班牙、07198
- 招聘中
- Hospital Son Llàtzer
-
-
Madrid, Comunidad de
-
Madrid、Madrid, Comunidad de、西班牙、28041
- 招聘中
- Hospital Universitario 12 de Octubre
-
-
Valenciana, Comunitat
-
Valencia、Valenciana, Comunitat、西班牙、46010
- 招聘中
- Hospital Clinico de Valencia
-
-
-
-
-
Buenos Aires、阿根廷、1426
- 招聘中
- Centro Oncologico Korben
-
Buenos Aires、阿根廷、C1122AAL
- 招聘中
- Instituto Argentino de Diagnóstico y Tratamiento (IADT)
-
Córdoba、阿根廷、5016
- 招聘中
- Hospital Privado Universitario de Córdoba
-
Córdoba、阿根廷、5000
- 招聘中
- Sanatorio Privado de la Cañada
-
Córdoba、阿根廷、X5008AAC
- 招聘中
- Centro Medico Privado CEMAIC
-
Córdoba、阿根廷、5000
- 尚未招聘
- Centro Urológico Profesor Bengió
-
San Juan、阿根廷、5400
- 招聘中
- Instituto San Marcos
-
-
Buenos Aires
-
Berazategui、Buenos Aires、阿根廷、B1884BBF
- 招聘中
- Centro de Oncología e Investigación de Buenos Aires
-
Ciudad Autónoma de Buenos Aires、Buenos Aires、阿根廷、C1426ABP
- 招聘中
- Fundación Respirar
-
Florida、Buenos Aires、阿根廷、B1602DQD
- 招聘中
- Centro Medico de Enfermedades Respiratorias -CEMER
-
Mar del Plata、Buenos Aires、阿根廷、B7600FZD
- 招聘中
- Investigaciones Oncológicas C. Colón S.A
-
Pergamino、Buenos Aires、阿根廷、B2700CPM
- 尚未招聘
- Centro de Investigación Pergamino
-
-
Cdad. Autónoma de Buenos Aires
-
Buenos Aires、Cdad. Autónoma de Buenos Aires、阿根廷、C 1113
- 招聘中
- Centro de Investigaciones Medicas y Desarrollo LC
-
-
Jujuy Province
-
San Salvador de Jujuy、Jujuy Province、阿根廷、4600
- 招聘中
- Fundacion Ars Medica
-
-
Río Negro Province
-
Cipolletti、Río Negro Province、阿根廷、8324
- 招聘中
- Fundacion Medica de Rio Negro y Neuquen
-
-
Santa Fe Province
-
Rosario、Santa Fe Province、阿根廷、2000
- 招聘中
- Fundacion Estudios Clinicos
-
Rosario、Santa Fe Province、阿根廷、S2000DSV
- 招聘中
- Sanatorio Parque
-
Rosario、Santa Fe Province、阿根廷、S2002KDS
- 招聘中
- Hospital Provincial del Centenario
-
Rosario、Santa Fe Province、阿根廷、S2000CVB
- 招聘中
- Sanatorio Británico
-
-
-
-
Jeonranamdo
-
Hwasun-gun、Jeonranamdo、韩国、58128
- 招聘中
- Chonnam National University Hwasun Hospital
-
-
Kyǒnggi-do
-
Seongnam、Kyǒnggi-do、韩国、13620
- 招聘中
- Seoul National University Bundang Hospital
-
Suwon、Kyǒnggi-do、韩国、16499
- 招聘中
- Ajou University Hospital
-
Suwon、Kyǒnggi-do、韩国、16247
- 招聘中
- The Catholic University Of Korea St. Vincent's Hospital
-
-
Pusan-kwangyǒkshi
-
Busan、Pusan-kwangyǒkshi、韩国、49241
- 招聘中
- Pusan National University Hospital
-
Haeundae-gu、Pusan-kwangyǒkshi、韩国、48108
- 招聘中
- Inje University Haeundae Paik Hospital
-
-
Seoul-teukbyeolsi [seoul]
-
Seoul、Seoul-teukbyeolsi [seoul]、韩国、03722
- 招聘中
- Severance Hospital, Yonsei University Health System
-
Seoul、Seoul-teukbyeolsi [seoul]、韩国、07061
- 招聘中
- Boramae Medical Center
-
Seoul、Seoul-teukbyeolsi [seoul]、韩国、08308
- 招聘中
- Korea University Guro Hospital
-
-
Taegu-kwangyǒkshi
-
Deagu、Taegu-kwangyǒkshi、韩国、41404
- 招聘中
- Kyungpook National University Chilgok Hospital
-
-
参与标准
研究人员寻找符合特定描述的人，称为资格标准。这些标准的一些例子是一个人的一般健康状况或先前的治疗。
资格标准
适合学习的年龄
18年 及以上 (成人、年长者)
接受健康志愿者
不
有资格学习的性别
全部
描述
Inclusion Criteria:
-
Participants must meet the following criteria:
- Have pathologically confirmed Stage IIIB or IIIC NSCLC and not be a candidate for surgical resection or definitive chemoradiation, or Stage IV NSCLC per the AJCC Staging Manual (Version 8.0) and the UICC Staging System (Eighth edition).
- Participants with known AGAs including EGFR, ALK, ROS1, NTRK, BRAF, RET, and MET, for which there are approved and available first-line therapies per local SOC are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology.
- Participants with large cell neuroendocrine carcinoma are excluded.
- Must be an appropriate candidate for treatment with pembrolizumab monotherapy per local guidelines.
-
Tumor has PD-L1 expression in ≥50% of tumor cells (TPS ≥50%) as determined by local testing.
-
Measurable disease based on RECIST v1.1 per investigator.
-
Resolution of acute effects of any prior therapy to either baseline severity or NCI CTCAE Grade 1 or less (except for AEs not constituting a safety risk in the investigator's judgment), unless otherwise excluded.
Exclusion Criteria:
-
Life expectancy of <3 months in the opinion of the investigator.
-
Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.
-
Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.
-
Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab.
-
Participants with any of the following respiratory conditions:
- Evidence of noninfectious or drug-induced ILD or pneumonitis
- Known DLCO (adjusted for hemoglobin) <50% predicted.
- Grade ≥3 pulmonary disease unrelated to underlying malignancy
-
Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Up to 5 clinically asymptomatic brain metastases of longest diameter <1.0 cm are permitted without definitive surgery and/or radiotherapy.
-
Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery (excluding peripherally inserted central catheter placement and implantable central venous port placement) within 3 days prior to first dose of study intervention.
-
Receipt of a live vaccine within 30 days prior to first dose of study intervention.
-
Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0.
-
Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.
-
Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for >2 weeks, or required treatment with systemic immunosuppressive therapy.
-
History of autoimmune disease that has required systemic treatment in the past 2 years
-
Participants with prior solid organ or bone marrow transplantation.
-
Currently receiving a high-dose steroid (>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant.
-
Prior and concomitant therapy:
-
Any prior treatment with MMAE-derived drugs or IB6 targeting agents.
-
Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.
- (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose.
- Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose.
-
Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received. This includes both curative and palliative radiotherapy.
-
Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy.
-
Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor
-
-
History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV.
-
Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months
学习计划
本节提供研究计划的详细信息，包括研究的设计方式和研究的衡量标准。
研究是如何设计的？
设计细节
- 主要用途：治疗
- 分配：随机化
- 介入模型：并行分配
- 屏蔽：单身的
武器和干预
参与者组/臂 |
干预/治疗 |
|---|---|
|
实验性的：Sigvotatug Vedotin with Pembrolizumab
Participants will receive Sigvotatug Vedotin, administered as an IV infusion and pembrolizumab, administered as an IV infusion. |
MMAE-Antibody Drug Conjugate targeting Integrin Beta-6 Anti-PD-(L)1 |
|
有源比较器：Pembrolizumab Monotherapy
Participants will receive pembrolizumab, administered as an IV infusion. |
Anti-PD-(L)1 |
研究衡量的是什么？
主要结果指标
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Overall Survival
大体时间：Baseline to date of death from any cause (Approximately 2 years).
|
Overall survival defined as the duration from enrollment to death. |
Baseline to date of death from any cause (Approximately 2 years).
|
|
Progression Free Survival (PFS) assessed by blinded independent central review (BICR)
大体时间：From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first. |
From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
次要结果测量
结果测量 |
措施说明 |
大体时间 |
|---|---|---|
|
Progression Free Survival as assessed by Investigator
大体时间：From Baseline to date of first progression or death (Approximately 4 years).
|
Progression Free Survival (PFS) is defined as the time from the date of first dose of study interventions to the date of first documentation of PD or death due to any cause, whichever occurs first. |
From Baseline to date of first progression or death (Approximately 4 years).
|
|
Objective Response Rate as assessed by BICR
大体时间：From Baseline to to the date of progression OR death (approximately to 4 years).
|
Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Objective Response Rate as assessed by Investigator
大体时间：From Baseline to to the date of progression OR death (approximately to 4 years).
|
Defined as the proportion of participants who achieve a best response of complete response (CR) or partial response (PR) using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria as assessed by Investigator. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Duration of Response as assessed by BICR
大体时间：From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Duration of Response as assessed by Investigator
大体时间：From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Defined time from the initial response (CR or PR) until documented tumor progression or death from any cause and based on Investigator assessment. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Number of participants with adverse events (AEs)
大体时间：From Baseline to end of treatment (up to 4 years).
|
Counts of participants who had treatment-emergent adverse events (TEAEs), defined as newly occurring or worsening after first dose. Relatedness to [study drug] was assessed by the investigator (Yes/No). Participants with multiple occurrences of an AE within a category were counted once within the category. |
From Baseline to end of treatment (up to 4 years).
|
|
Pharmacokinetics (PK) of antibody-conjugated monomethyl auristatin E (ac-MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
大体时间：Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of ac-MMAE in plasma: Plasma predose concentration (Cpredose)
大体时间：Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of unconjugated monomethyl auristatin E (MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
大体时间：Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of MMAE in plasma: Plasma predose concentration (Cpredose)
大体时间：Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Number of participants with antidrug antibodies (ADAs)
大体时间：Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the immunogenicity of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Time to response (TTR) using RECIST v1.1 as assessed by BICR
大体时间：The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by BICR. |
The time from the date of randomization to the date of first documentation of objective response.
|
|
TTR using RECIST v1.1 as assessed by investigator
大体时间：The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by investigator assessment. |
The time from the date of randomization to the date of first documentation of objective response.
|
合作者和调查者
在这里您可以找到参与这项研究的人员和组织。
赞助
调查人员
- 研究主任：Pfizer CT.gov Call Center、Pfizer
出版物和有用的链接
负责输入研究信息的人员自愿提供这些出版物。这些可能与研究有关。
研究记录日期
这些日期跟踪向 ClinicalTrials.gov 提交研究记录和摘要结果的进度。研究记录和报告的结果由国家医学图书馆 (NLM) 审查，以确保它们在发布到公共网站之前符合特定的质量控制标准。
研究主要日期
学习开始 (实际的)
2025年7月23日
初级完成 (估计的)
2028年9月5日
研究完成 (估计的)
2029年3月1日
研究注册日期
首次提交
2024年12月26日
首先提交符合 QC 标准的
2024年12月26日
首次发布 (实际的)
2025年1月3日
研究记录更新
最后更新发布 (实际的)
2026年9月25日
上次提交的符合 QC 标准的更新
2026年9月22日
最后验证
2026年9月1日
更多信息
与本研究相关的术语
其他相关的 MeSH 术语
其他研究编号
- C5751003
- 2024-517968-36-00 (注册表标识符：CTIS (EU))
计划个人参与者数据 (IPD)
计划共享个人参与者数据 (IPD)？
是的
IPD 计划说明
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
药物和器械信息、研究文件
研究美国 FDA 监管的药品
是的
研究美国 FDA 监管的设备产品
不
在美国制造并从美国出口的产品
是的
此信息直接从 clinicaltrials.gov 网站检索，没有任何更改。如果您有任何更改、删除或更新研究详细信息的请求，请联系 register@clinicaltrials.gov. clinicaltrials.gov 上实施更改，我们的网站上也会自动更新.