Este es un estudio para conocer cómo funciona la combinación de los medicamentos del estudio Sigvotatug Vedotin más pembrolizumab en personas con cáncer de pulmón de células no pequeñas con niveles altos de PD-L1.
22 de septiembre de 2026 actualizado por: Pfizer
AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
- Are confirmed to have NSCLC (Stage 3 or 4).
- Have PD-L1 levels in more than 50% of the cancer cells.
All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab.
Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.
Descripción general del estudio
Estado
Reclutamiento
Condiciones
Intervención / Tratamiento
Tipo de estudio
Intervencionista
Inscripción (Estimado)
714
Fase
- Fase 3
Contactos y Ubicaciones
Esta sección proporciona los datos de contacto de quienes realizan el estudio e información sobre dónde se lleva a cabo este estudio.
Estudio Contacto
- Nombre: Pfizer CT.gov Call Center
- Número de teléfono: 1-800-718-1021
- Correo electrónico: ClinicalTrials.gov_Inquiries@pfizer.com
Ubicaciones de estudio
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Bad Berka, Alemania, 99437
- Reclutamiento
- Zentralklinik Bad Berka GmbH
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Berlin, Alemania, 10117
- Reclutamiento
- Charité - Universitätsmedizin Berlin
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Berlin, Alemania, 13353
- Reclutamiento
- Charité Campus Virchow-Klinikum
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Berlin, Alemania, 13353
- Reclutamiento
- Labor Berlin
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Berlin, Alemania, 13509
- Reclutamiento
- Vivantes Humboldt Klinikum Apotheke Nord
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Berlin, Alemania, 13585
- Reclutamiento
- Vivantes Hospital Spandau
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Gauting, Alemania, 82131
- Reclutamiento
- Asklepios Klinik Gauting GmbH
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Großhansdorf, Alemania, 22927
- Reclutamiento
- LungenClinic Grosshansdorf
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München, Alemania, 81377
- Reclutamiento
- Radiologie München
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Baden-Wurttemberg
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Ulm, Baden-Wurttemberg, Alemania, 89081
- Reclutamiento
- Universitaetsklinikum Ulm
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Bavaria
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Gröbenzell, Bavaria, Alemania, 82194
- Reclutamiento
- Johannes Apotheke Gröbenzell
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Traunstein, Bavaria, Alemania, 83278
- Reclutamiento
- Klinikum Traunstein
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Hesse
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Giessen, Hesse, Alemania, 35392
- Reclutamiento
- UKGM Gießen/Marburg
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Kassel, Hesse, Alemania, 34125
- Reclutamiento
- Klinikum Kassel
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Rhineland-Palatinate
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Koblenz, Rhineland-Palatinate, Alemania, 56068
- Reclutamiento
- InVO Institut für Versorgungsforschung in der Onkologie
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Saxony
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Chemnitz, Saxony, Alemania, 09116
- Reclutamiento
- Klinikum Chemnitz - Flemmingstraße
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Chemnitz, Saxony, Alemania, 09113
- Reclutamiento
- Klinikum Chemnitz gGmbH
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Saxony-Anhalt
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Halle, Saxony-Anhalt, Alemania, 06120
- Reclutamiento
- Krankenhaus Martha-Maria Halle-Dölau
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Schleswig-Holstein
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Lübeck, Schleswig-Holstein, Alemania, 23538
- Reclutamiento
- Universitätsklinikum Schleswig-Holstein
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Oldenburg in Holstein, Schleswig-Holstein, Alemania, 23758
- Reclutamiento
- ohO Research GmbH
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Riyadh, Arabia Saudita, 11211
- Aún no reclutando
- King Faisal Specialist Hospital and Research Center
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Riyadh Region
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Riyadh, Riyadh Region, Arabia Saudita, 11472
- Aún no reclutando
- King Saud University Medical City
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Buenos Aires, Argentina, 1426
- Reclutamiento
- Centro Oncologico Korben
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Buenos Aires, Argentina, C1122AAL
- Reclutamiento
- Instituto Argentino de Diagnóstico y Tratamiento (IADT)
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Córdoba, Argentina, 5016
- Reclutamiento
- Hospital Privado Universitario de Córdoba
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Córdoba, Argentina, 5000
- Reclutamiento
- Sanatorio Privado de la Cañada
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Córdoba, Argentina, X5008AAC
- Reclutamiento
- Centro Medico Privado CEMAIC
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Córdoba, Argentina, 5000
- Aún no reclutando
- Centro Urológico Profesor Bengió
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San Juan, Argentina, 5400
- Reclutamiento
- Instituto San Marcos
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Buenos Aires
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Berazategui, Buenos Aires, Argentina, B1884BBF
- Reclutamiento
- Centro de Oncología e Investigación de Buenos Aires
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Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ABP
- Reclutamiento
- Fundación Respirar
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Florida, Buenos Aires, Argentina, B1602DQD
- Reclutamiento
- Centro Medico de Enfermedades Respiratorias -CEMER
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Mar del Plata, Buenos Aires, Argentina, B7600FZD
- Reclutamiento
- Investigaciones Oncológicas C. Colón S.A
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Pergamino, Buenos Aires, Argentina, B2700CPM
- Aún no reclutando
- Centro de Investigación Pergamino
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Cdad. Autónoma de Buenos Aires
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Buenos Aires, Cdad. Autónoma de Buenos Aires, Argentina, C 1113
- Reclutamiento
- Centro de Investigaciones Medicas y Desarrollo LC
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Jujuy Province
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San Salvador de Jujuy, Jujuy Province, Argentina, 4600
- Reclutamiento
- Fundacion Ars Medica
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Río Negro Province
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Cipolletti, Río Negro Province, Argentina, 8324
- Reclutamiento
- Fundacion Medica de Rio Negro y Neuquen
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Santa Fe Province
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Rosario, Santa Fe Province, Argentina, 2000
- Reclutamiento
- Fundacion Estudios Clinicos
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Rosario, Santa Fe Province, Argentina, S2000DSV
- Reclutamiento
- Sanatorio Parque
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Rosario, Santa Fe Province, Argentina, S2002KDS
- Reclutamiento
- Hospital Provincial del Centenario
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Rosario, Santa Fe Province, Argentina, S2000CVB
- Reclutamiento
- Sanatorio Británico
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New South Wales
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Coffs Harbour, New South Wales, Australia, 2450
- Reclutamiento
- Coffs Harbour Health Campus
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North Ryde, New South Wales, Australia, 2109
- Reclutamiento
- Macquarie University
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Sydney, New South Wales, Australia, 2560
- Reclutamiento
- Campbelltown Hospital
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Queensland
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Birtinya, Queensland, Australia, 4575
- Reclutamiento
- Sunshine Coast University Hospital
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Douglas, Queensland, Australia, 4814
- Reclutamiento
- Townsville University Hospital
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Gympie, Queensland, Australia, 4570
- Reclutamiento
- Gympie Hospital
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Nambour, Queensland, Australia, 4560
- Reclutamiento
- Nambour General Hospital
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Woolloongabba, Queensland, Australia, 4102
- Reclutamiento
- Princess Alexandra Hospital
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Western Australia
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Perth, Western Australia, Australia, 6009
- Reclutamiento
- Sir Charles Gairdner Hospital
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-
-
-
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Graz, Austria, 8036
- Reclutamiento
- Medizinische Universität Graz
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Vienna, Austria, 1090
- Reclutamiento
- Medizinische Universität Wien
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Vienna, Austria, 1210
- Reclutamiento
- Klinik Floridsdorf
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Upper Austria
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Linz, Upper Austria, Austria, 4020
- Reclutamiento
- Ordensklinikum Linz GmbH Elisabethinen
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-
-
-
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Jaú, Brasil, 17210-080
- Aún no reclutando
- Fundação Doutor Amaral Carvalho
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Rio de Janeiro, Brasil, 22281-100
- Reclutamiento
- Instituto D'Or de Pesquisa e Ensino
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Rio de Janeiro, Brasil, 22031-011
- Reclutamiento
- Instituto D'Or de Pesquisa e Ensino
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Rio de Janeiro, Brasil, 22271-110
- Reclutamiento
- Instituto D'Or de Pesquisa e Ensino
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Rio de Janeiro, Brasil, 22451-040
- Reclutamiento
- Instituto D'Or de Pesquisa e Ensino
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São Paulo, Brasil, 01246-000
- Aún no reclutando
- Icesp - Instituto Do Câncer Do Estado de São Paulo
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Ceará
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Fortaleza, Ceará, Brasil, 60430235
- Reclutamiento
- Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
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Fortaleza, Ceará, Brasil, 60336232
- Reclutamiento
- Crio - Centro Regional Integrado de Oncologia
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Espírito Santo
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Vitória, Espírito Santo, Brasil, 29043-260
- Reclutamiento
- Afecc Associacao Feminina Educacao Combate Cancer
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Estado de Bahia
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Salvador, Estado de Bahia, Brasil, 41950- 640
- Reclutamiento
- Clinica Amo - Rio Vermelho
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Salvador, Estado de Bahia, Brasil, 41253-190
- Reclutamiento
- Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael
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Federal District
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Brasília, Federal District, Brasil, 70390-150
- Aún no reclutando
- Onco-Vida - Instituto Especializado De Oncologia
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Paraná
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Curitiba, Paraná, Brasil, 81520-060
- Reclutamiento
- Hospital Erasto Gaertner
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Pernambuco
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Recife, Pernambuco, Brasil, 52010-902
- Reclutamiento
- Real Hospital de Beneficência Portuguesa de Pernambuco
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Piauí
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Teresina, Piauí, Brasil, 64049-200
- Reclutamiento
- Vencer Centro de Pesquisa LTDA
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Rio Grande do Norte
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Natal, Rio Grande do Norte, Brasil, 59062-000
- Reclutamiento
- Liga Norte Riograndense Contra o Câncer
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Rio Grande do Sul
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Ijuí, Rio Grande do Sul, Brasil, 98700-000
- Reclutamiento
- ONCOSITE - Centro de Pesquisa Clinica em Oncologia
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Porto Alegre, Rio Grande do Sul, Brasil, 90560032
- Aún no reclutando
- Hospital Moinhos de Vento
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Porto Alegre, Rio Grande do Sul, Brasil, 90610-000
- Reclutamiento
- Hospital São Lucas da PUCRS
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Santa Catarina
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Lages, Santa Catarina, Brasil, 88501-001
- Reclutamiento
- ANIMI - Unidade de Tratamento Oncologico
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São Paulo
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Barretos, São Paulo, Brasil, 14784400
- Reclutamiento
- Fundação Pio XII - Hospital de Câncer de Barretos
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Bragança Paulista, São Paulo, Brasil, 12916-542
- Reclutamiento
- Hospital Universitário São Francisco na Providência de Deus
-
Ribeirão Preto, São Paulo, Brasil, 14051-140
- Reclutamiento
- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
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Santo André, São Paulo, Brasil, 09060-650
- Reclutamiento
- Faculdade de Medicina do ABC
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São José do Rio Preto, São Paulo, Brasil, 15090000
- Reclutamiento
- Fundação Faculdade Regional de Medicina de São José do Rio Preto
-
São Paulo, São Paulo, Brasil, 01327-001
- Reclutamiento
- Hospital Alemao Oswaldo Cruz
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-
-
-
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Burgas, Bulgaria, 8000
- Reclutamiento
- Complex Oncology Center - Burgas
-
Plovdiv, Bulgaria, 4000
- Aún no reclutando
- Medical Center Futuremeds
-
Sofia, Bulgaria, 1407
- Reclutamiento
- Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
-
Sofia, Bulgaria, 1330
- Reclutamiento
- MHAT for Women's Health Nadezhda
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Sofia, Bulgaria, 1756
- Reclutamiento
- University Specialized Hospital for Active Treatment of Oncology EAD
-
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Pazardzhik
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Panagyurishte, Pazardzhik, Bulgaria, 4500
- Reclutamiento
- MBAL Uni Hospital
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-
-
-
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Brasschaat, Bélgica, 2930
- Reclutamiento
- Algemeen Ziekenhuis klina
-
Liège, Bélgica, 4000
- Reclutamiento
- Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
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Antwerpen
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Mechelen, Antwerpen, Bélgica, 2800
- Reclutamiento
- AZ Sint-Maarten
-
-
Bruxelles-capitale, Région de
-
Brussels, Bruxelles-capitale, Région de, Bélgica, 1090
- Reclutamiento
- UZ Brussel
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Hainaut
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Charleroi, Hainaut, Bélgica, 6060
- Reclutamiento
- Grand Hôpital de Charleroi
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-
-
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British Columbia
-
Abbotsford British Columbia, British Columbia, Canadá, V2S 0C2
- Reclutamiento
- BC Cancer Abbotsford
-
-
Quebec
-
Montreal, Quebec, Canadá, H1T 2M4
- Reclutamiento
- CIUSSS de l'Est-de-l'Île-de-Montréal
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Saint-Jérôme, Quebec, Canadá, J7Y 0L1
- Reclutamiento
- Centre de Services Ambulatoire de St-Jerome
-
Saint-Jérôme, Quebec, Canadá, J7Z 2V4
- Reclutamiento
- Unité de Recherche Clinique du CISSS des Laurentides
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-
-
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Liberec1, Chequia, 460 01
- Reclutamiento
- Krajska nemocnice Liberec, a.s.
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Nový Jičín, Chequia, 741 01
- Reclutamiento
- Nemocnice AGEL Novy Jicin a.s.
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Olomouc, Chequia, 779 00
- Reclutamiento
- Fakultni nemocnice Olomouc
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Prague, Chequia, 150 00
- Reclutamiento
- Fakultni Nemocnice Motol a Homolka
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Praha 4
-
Prague, Praha 4, Chequia, 140 59
- Reclutamiento
- Fakultni Thomayerova nemocnice
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-
-
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Los Ríos Region
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Valdivia, Los Ríos Region, Chile, 5090000
- Reclutamiento
- Clínica Alemana Valdivia
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Valdivia, Los Ríos Region, Chile, 5690000
- Reclutamiento
- Oncocentro Valdivia
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Santiago Metropolitan
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La Florida, Santiago Metropolitan, Chile, 8241479
- Reclutamiento
- Iceg Clinic
-
Providencia, Santiago Metropolitan, Chile, 7500966
- Reclutamiento
- Fundacion Arturo Lopez Perez
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Providencia, Santiago Metropolitan, Chile, 7501010
- Reclutamiento
- Profar
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Providencia, Santiago Metropolitan, Chile, 7500836
- Reclutamiento
- FALP
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Providencia, Santiago Metropolitan, Chile, 750000
- Reclutamiento
- Fundación Arturo Lopéz Pérez
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Santiago, Santiago Metropolitan, Chile, 8241479
- Reclutamiento
- Clínica Vespucio
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Santiago, Santiago Metropolitan, Chile, 8380455
- Reclutamiento
- Instituto Nacional del Cancer
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Santiago, Santiago Metropolitan, Chile, 8380456
- Reclutamiento
- Sociedad Oncovida SA
-
-
Santiago, RM
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Providencia, Santiago, RM, Chile, 7500921
- Reclutamiento
- FALP
-
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Valparaiso
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Viña del Mar, Valparaiso, Chile, 2520598
- Reclutamiento
- Oncocentro Apys
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-
-
-
Jeonranamdo
-
Hwasun-gun, Jeonranamdo, Corea del Sur, 58128
- Reclutamiento
- Chonnam National University Hwasun Hospital
-
-
Kyǒnggi-do
-
Seongnam, Kyǒnggi-do, Corea del Sur, 13620
- Reclutamiento
- Seoul National University Bundang Hospital
-
Suwon, Kyǒnggi-do, Corea del Sur, 16499
- Reclutamiento
- Ajou University Hospital
-
Suwon, Kyǒnggi-do, Corea del Sur, 16247
- Reclutamiento
- The Catholic University Of Korea St. Vincent's Hospital
-
-
Pusan-kwangyǒkshi
-
Busan, Pusan-kwangyǒkshi, Corea del Sur, 49241
- Reclutamiento
- Pusan National University Hospital
-
Haeundae-gu, Pusan-kwangyǒkshi, Corea del Sur, 48108
- Reclutamiento
- Inje University Haeundae Paik Hospital
-
-
Seoul-teukbyeolsi [seoul]
-
Seoul, Seoul-teukbyeolsi [seoul], Corea del Sur, 03722
- Reclutamiento
- Severance Hospital, Yonsei University Health System
-
Seoul, Seoul-teukbyeolsi [seoul], Corea del Sur, 07061
- Reclutamiento
- Boramae Medical Center
-
Seoul, Seoul-teukbyeolsi [seoul], Corea del Sur, 08308
- Reclutamiento
- Korea University Guro Hospital
-
-
Taegu-kwangyǒkshi
-
Deagu, Taegu-kwangyǒkshi, Corea del Sur, 41404
- Reclutamiento
- Kyungpook National University Chilgok Hospital
-
-
-
-
-
Nové Zámky, Eslovaquia, 94034
- Reclutamiento
- Fakultna nemocnica s poliklinikou Nove Zamky
-
Poprad, Eslovaquia, 058 01
- Reclutamiento
- POKO Poprad s.r.o.
-
-
Bratislava Region
-
Bratislava, Bratislava Region, Eslovaquia, 821 01
- Reclutamiento
- Univerzitná nemocnica Bratislava - Nemocnica Ružinov
-
-
Košice Region
-
Košice, Košice Region, Eslovaquia, 040 01
- Reclutamiento
- Vychodoslovensky Onkologicky Ustav a.s.
-
-
Nitra Region
-
Komárno, Nitra Region, Eslovaquia, 945 05
- Reclutamiento
- Nemocnica AGEL Komarno
-
-
Trnava Region
-
Trnava, Trnava Region, Eslovaquia, 917 02
- Reclutamiento
- Fakultna nemocnica Trnava
-
-
-
-
-
Barcelona, España, 08035
- Reclutamiento
- Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR")
-
Barcelona, España, 08035
- Reclutamiento
- Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO"
-
Las Palmas de Gran Canaria, España, 35016
- Reclutamiento
- Complejo Hospitalario Universitario Insular Materno-Infantil
-
Madrid, España, 28040
- Reclutamiento
- Hospital Universitario Fundación Jiménez Díaz
-
Madrid, España, 28003
- Reclutamiento
- FutureMeds - Madrid
-
Madrid, España, 28007
- Reclutamiento
- Hospital General Universitario Gregorio Marañon
-
Málaga, España, 29004
- Reclutamiento
- Hospital Quirón Málaga
-
Seville, España, 41013
- Reclutamiento
- Hospital Universitario Virgen Del Rocio
-
-
A Coruña [LA Coruña]
-
A Coruña, A Coruña [LA Coruña], España, 15006
- Reclutamiento
- CHUAC-Complejo Hospitalario Universitario A Coruña
-
-
Alicante
-
Elche, Alicante, España, 03203
- Reclutamiento
- Hospital General Universitario de Elche
-
-
Barcelona [barcelona]
-
Barcelona, Barcelona [barcelona], España, 08028
- Reclutamiento
- Hospital Universitari Dexeus
-
-
Barcelona/spain
-
Barcelona, Barcelona/spain, España, 08035
- Reclutamiento
- Hospital Universitari Vall D Hebron
-
-
Catalunya [cataluña]
-
Barcelona, Catalunya [cataluña], España, 08041
- Reclutamiento
- Hospital de la Santa Creu i Sant Pau
-
L'Hospitalet de Llobregat, Catalunya [cataluña], España, 08908
- Reclutamiento
- Institut Català d'Oncologia - L'Hospitalet
-
-
Cádiz
-
Jerez de la Frontera, Cádiz, España, 11407
- Reclutamiento
- Hospital Jerez de la Frontera
-
-
Illes Balears [islas Baleares]
-
Palma, Illes Balears [islas Baleares], España, 07198
- Reclutamiento
- Hospital Son Llàtzer
-
-
Madrid, Comunidad de
-
Madrid, Madrid, Comunidad de, España, 28041
- Reclutamiento
- Hospital Universitario 12 de Octubre
-
-
Valenciana, Comunitat
-
Valencia, Valenciana, Comunitat, España, 46010
- Reclutamiento
- Hospital Clinico de Valencia
-
-
-
-
California
-
Fullerton, California, Estados Unidos, 92835
- Reclutamiento
- Providence Medical Foundation
-
Fullerton, California, Estados Unidos, 92835
- Reclutamiento
- Providence St. Jude Medical Center
-
Fullerton, California, Estados Unidos, 92835
- Reclutamiento
- Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center
-
Fullerton, California, Estados Unidos, 92835
- Reclutamiento
- St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)
-
-
Colorado
-
Golden, Colorado, Estados Unidos, 80401
- Reclutamiento
- Intermountain Health Cancer Center Lutheran Hospital
-
Grand Junction, Colorado, Estados Unidos, 81501
- Reclutamiento
- Cancer Centers of Colorado St. Mary's Regional Hospital
-
Grand Junction, Colorado, Estados Unidos, 81505
- Reclutamiento
- Intermountain Health
-
Grand Junction, Colorado, Estados Unidos, 81501
- Reclutamiento
- Intermountain Health St. Mary's Regional Hospital
-
Wheat Ridge, Colorado, Estados Unidos, 80401
- Reclutamiento
- Intermountain Health Lutheran Hospital
-
-
District of Columbia
-
Washington D.C., District of Columbia, Estados Unidos, 20422
- Reclutamiento
- Washington DC Veterans Affairs Medical Center
-
-
Florida
-
Orange City, Florida, Estados Unidos, 32763
- Reclutamiento
- Mid Florida Hematology and Oncology Center
-
Plantation, Florida, Estados Unidos, 33322
- Reclutamiento
- BRCR Global
-
-
Illinois
-
Elmhurst, Illinois, Estados Unidos, 60126
- Reclutamiento
- Endeavor Health
-
Hinsdale, Illinois, Estados Unidos, 60521
- Reclutamiento
- Hope and Healing Cancer Services
-
Libertyville, Illinois, Estados Unidos, 60048
- Reclutamiento
- Advocate Medical Group - Libertyville Oncology
-
Naperville, Illinois, Estados Unidos, 60540
- Reclutamiento
- Endeavor Health
-
New Lenox, Illinois, Estados Unidos, 60451
- Reclutamiento
- Hope and Healing Cancer Services
-
Oak Lawn, Illinois, Estados Unidos, 60453
- Reclutamiento
- Advocate Christ Medical Center
-
Park Ridge, Illinois, Estados Unidos, 60068
- Reclutamiento
- Advocate Lutheran General Hospital
-
-
Kansas
-
Overland Park, Kansas, Estados Unidos, 66213
- Reclutamiento
- Saint Luke's South Hospital
-
-
Maine
-
Portland, Maine, Estados Unidos, 04102
- Reclutamiento
- Maine Medical Center
-
Scarborough, Maine, Estados Unidos, 04074
- Reclutamiento
- MaineHealth Cancer Care and Blood Disorders Scarborough
-
South Portland, Maine, Estados Unidos, 04106
- Reclutamiento
- MaineHealth Cancer Care and IV Therapy - South Portland
-
-
Massachusetts
-
Fairhaven, Massachusetts, Estados Unidos, 02719
- Reclutamiento
- Southcoast Centers for Cancer Care
-
Fall River, Massachusetts, Estados Unidos, 02720
- Reclutamiento
- Southcoast Centers for Cancer Care
-
-
Michigan
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Reclutamiento
- Corewell Health
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Reclutamiento
- Corewell Health - Butterworth Hospital
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Reclutamiento
- Corewell Health - Lemmen Holton Cancer Pavilion
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Reclutamiento
- Corewell Health - Research Specimen Processing Area
-
Grand Rapids, Michigan, Estados Unidos, 49503
- Reclutamiento
- Corewell Health Investigational Drug Services
-
-
Minnesota
-
Burnsville, Minnesota, Estados Unidos, 55337
- Reclutamiento
- Minnesota Oncology Hematology, PA
-
Coon Rapids, Minnesota, Estados Unidos, 55433
- Reclutamiento
- Minnesota Oncology Hematology PA
-
Edina, Minnesota, Estados Unidos, 55435
- Reclutamiento
- M Health Fairview Cancer Clinic-Edina
-
Edina, Minnesota, Estados Unidos, 55435
- Reclutamiento
- Minnesota Oncology Hematology PA
-
Maple Grove, Minnesota, Estados Unidos, 55369
- Reclutamiento
- Minnesota Oncology Hematology PA
-
Maplewood, Minnesota, Estados Unidos, 55109
- Reclutamiento
- M Health Fairview St. John's Hospital
-
Maplewood, Minnesota, Estados Unidos, 55109
- Reclutamiento
- Minnesota Oncology Hematology PA
-
Minneapolis, Minnesota, Estados Unidos, 55415
- Reclutamiento
- Hennepin County Medical Center
-
Robbinsdale, Minnesota, Estados Unidos, 55422
- Reclutamiento
- North Memorial Health Cancer Center
-
Saint Louis Park, Minnesota, Estados Unidos, 55426
- Reclutamiento
- Park Nicollet Frauenshuh Cancer Center
-
Saint Louis Park, Minnesota, Estados Unidos, 55426
- Reclutamiento
- Metro Minnesota Community Oncology Research Consortium (MMCORC)
-
Saint Paul, Minnesota, Estados Unidos, 55101
- Reclutamiento
- Regions Hospital
-
Woodbury, Minnesota, Estados Unidos, 55125
- Reclutamiento
- Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center
-
-
Mississippi
-
Jackson, Mississippi, Estados Unidos, 39202
- Reclutamiento
- Jackson Oncology Associates, PLLC
-
Jackson, Mississippi, Estados Unidos, 39216
- Reclutamiento
- Jackson Oncology Associates, PLLC
-
-
Missouri
-
Kansas City, Missouri, Estados Unidos, 64111
- Reclutamiento
- Saint Luke's Hospital of Kansas City
-
Lee's Summit, Missouri, Estados Unidos, 64086
- Reclutamiento
- Saint Luke's East Hospital
-
-
Montana
-
Billings, Montana, Estados Unidos, 59101
- Reclutamiento
- SCL Health - Montana
-
Billings, Montana, Estados Unidos, 59102
- Reclutamiento
- SCL Health - Montana
-
-
Nebraska
-
Fremont, Nebraska, Estados Unidos, 68025
- Reclutamiento
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont
-
Grand Island, Nebraska, Estados Unidos, 68803
- Reclutamiento
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
-
Grand Island, Nebraska, Estados Unidos, 68803
- Reclutamiento
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional
-
Kearney, Nebraska, Estados Unidos, 68845
- Reclutamiento
- Kearney Cancer Center
-
Lincoln, Nebraska, Estados Unidos, 68516
- Reclutamiento
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Estados Unidos, 68130
- Reclutamiento
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists
-
Omaha, Nebraska, Estados Unidos, 68114
- Reclutamiento
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist
-
Omaha, Nebraska, Estados Unidos, 68124
- Reclutamiento
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan
-
-
New York
-
Nyack, New York, Estados Unidos, 10960
- Reclutamiento
- Hematology Oncology Associates of Rockland
-
-
North Carolina
-
Greenville, North Carolina, Estados Unidos, 27834
- Reclutamiento
- Brody School of Medicine at East Carolina University
-
Greenville, North Carolina, Estados Unidos, 27834
- Reclutamiento
- ECU Health Medical Center
-
Wilson, North Carolina, Estados Unidos, 27893
- Reclutamiento
- Carolina Cancer Research Center
-
-
Ohio
-
Avon, Ohio, Estados Unidos, 44011
- Reclutamiento
- University Hospitals Seidman Cancer Center at UH Avon Health Center
-
Canton, Ohio, Estados Unidos, 44718
- Terminado
- Gabrail Cancer Center Research
-
Cleveland, Ohio, Estados Unidos, 44106
- Reclutamiento
- University Hospitals Cleveland Medical Center
-
Mentor, Ohio, Estados Unidos, 44060
- Reclutamiento
- University Hospitals Seidman Cancer Center at UH Mentor Health Center
-
Orange, Ohio, Estados Unidos, 44122
- Reclutamiento
- UH Minoff Health Center at Chagrin Highlands
-
-
Texas
-
Conroe, Texas, Estados Unidos, 77384
- Reclutamiento
- The University of Texas, MD Anderson Cancer Center - Woodlands
-
El Paso, Texas, Estados Unidos, 79915
- Reclutamiento
- Renovatio Clinical - El Paso
-
Houston, Texas, Estados Unidos, 77030
- Reclutamiento
- University of Texas MD Anderson Cancer Center
-
Houston, Texas, Estados Unidos, 77030
- Reclutamiento
- The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
-
Houston, Texas, Estados Unidos, 77030
- Reclutamiento
- The University of Texas MD Anderson Cancer Center Diagnostic Imaging
-
Houston, Texas, Estados Unidos, 77030
- Reclutamiento
- The University of Texas, MD Anderson Cancer Center- Interventional Radiology
-
Houston, Texas, Estados Unidos, 77054
- Reclutamiento
- The University of Texas MD Anderson Cancer Center Clinical Research Imaging
-
Houston, Texas, Estados Unidos, 77079
- Reclutamiento
- The University of Texas, MD Anderson Cancer Center - West Houston
-
Kingwood, Texas, Estados Unidos, 77339
- Reclutamiento
- Community Clinical Trials
-
League City, Texas, Estados Unidos, 77573
- Reclutamiento
- The University of Texas, MD Anderson Cancer Center - League City
-
Sugar Land, Texas, Estados Unidos, 77478
- Reclutamiento
- The University of Texas, MD Anderson Cancer Center - Sugar Land
-
The Woodlands, Texas, Estados Unidos, 77380
- Reclutamiento
- Renovatio Clinical
-
The Woodlands, Texas, Estados Unidos, 77381
- Reclutamiento
- Woodlands Radiology
-
-
Washington
-
Olympia, Washington, Estados Unidos, 98502
- Reclutamiento
- American Oncology Network Vista Oncology Division-West office
-
Olympia, Washington, Estados Unidos, 98506
- Reclutamiento
- American Oncology Network Vista Oncology Division-East office
-
-
Wisconsin
-
Grafton, Wisconsin, Estados Unidos, 53024
- Reclutamiento
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Estados Unidos, 54311
- Reclutamiento
- Aurora BayCare Medical Center
-
Milwaukee, Wisconsin, Estados Unidos, 53215
- Reclutamiento
- Aurora St. Luke's Medical Center
-
-
-
-
-
Marseille, Francia, 13915
- Reclutamiento
- Assistance Publique Hôpitaux de Marseille - Hôpital Nord
-
Nice, Francia, 06189
- Reclutamiento
- Centre Antoine Lacassagne
-
Paris, Francia, 75248
- Reclutamiento
- Institut Curie
-
Paris, Francia, 75014
- Reclutamiento
- Hopitaux Universitaires Paris Centre-Hopital Cochin
-
-
Aquitaine
-
Pessac, Aquitaine, Francia, 33604
- Reclutamiento
- CHU Bordeaux Haut-Leveque
-
-
Brittany Region
-
Quimper, Brittany Region, Francia, 1757 - 29107
- Reclutamiento
- Centre Hospitalier de Cornouaille Quimper - Concarneau
-
-
Haute-garonne
-
Toulouse, Haute-garonne, Francia, 31059
- Reclutamiento
- CHU de Toulouse - Hopital Larrey
-
-
Ille-et-vilaine
-
Rennes, Ille-et-vilaine, Francia, 35033
- Reclutamiento
- Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
-
-
Languedoc-roussillon
-
Montpellier, Languedoc-roussillon, Francia, 34070
- Reclutamiento
- Centre de Cancérologie du Grand Montpellier
-
-
Loire-atlantique
-
Saint-Herblain, Loire-atlantique, Francia, 44805
- Reclutamiento
- Institut de Cancérologie de l'Ouest
-
Saint-Herblain, Loire-atlantique, Francia, 44800
- Reclutamiento
- Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
-
-
PAYS de Loire
-
Cholet, PAYS de Loire, Francia, 49300
- Reclutamiento
- Centre Hospitalier de Cholet
-
-
Provence-Alpes-Côte d'Azur Region
-
Toulon, Provence-Alpes-Côte d'Azur Region, Francia, 83056
- Reclutamiento
- Centre Hospitalier intercommunal de Toulon La Seyne sur Hospital Sainte-Musse health establishment
-
-
Val-de-marne
-
Créteil, Val-de-marne, Francia, 94010
- Reclutamiento
- Centre Hospitalier Intercommunal de Créteil
-
-
-
-
-
Athens, Grecia, 115 26
- Reclutamiento
- Errikos Dunant Hospital Center
-
Larissa, Grecia, 41110
- Reclutamiento
- University General Hospital of Larissa, Urology Department
-
Thessaloniki, Grecia, 552 36
- Reclutamiento
- Agios Loukas Clinic
-
-
Attikí
-
Athens, Attikí, Grecia, 115 27
- Reclutamiento
- Thoracic General Hospital of Athens "I Sotiria"
-
Athens, Attikí, Grecia, 155 62
- Reclutamiento
- Metropolitan General Hospital
-
Athens, Attikí, Grecia, 185 47
- Reclutamiento
- Metropolitan Hospital
-
Marousi, Attikí, Grecia, 151 23
- Reclutamiento
- Hygeia Hospital
-
-
Thessaloníki
-
Thessaloniki, Thessaloníki, Grecia, 570 01
- Reclutamiento
- European Interbalkan Medical Center
-
-
-
-
-
Székesfehérvár, Hungría, 8000
- Aún no reclutando
- Fejér Vármegyei Szent György Egyetemi Oktató Kórház
-
Tatabánya, Hungría, 2800
- Aún no reclutando
- Komárom-Esztergom Vármegyei Szent Borbála Kórház
-
-
Bekes County
-
Gyula, Bekes County, Hungría, 5700
- Reclutamiento
- Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház
-
-
Veszprém megye
-
Farkasgyepű, Veszprém megye, Hungría, 8582
- Aún no reclutando
- Farkasgyepui Tudogyogyintezet
-
-
-
-
Karnataka
-
Bengaluru, Karnataka, India, 560069
- Reclutamiento
- Spandana Oncology Centre (SOC)
-
-
Maharashtra
-
Mumbai, Maharashtra, India, 400012
- Reclutamiento
- Tata Memorial Hospital
-
Pune, Maharashtra, India, 411004
- Reclutamiento
- Sahyadri Super Speciality Hospital
-
Thane, Maharashtra, India, 401107
- Reclutamiento
- Bhakti Vedanta Hospital and Research Institute
-
-
National Capital Territory of Delhi
-
New Delhi, National Capital Territory of Delhi, India, 110088
- Reclutamiento
- Fortis Hospital
-
New Delhi, National Capital Territory of Delhi, India, 110005
- Reclutamiento
- Dr B. L. Kapur Memorial Hospital
-
New Delhi, National Capital Territory of Delhi, India, 110075
- Reclutamiento
- Venkateshwar Hospital
-
-
Telangana
-
Hyderabad, Telangana, India, 500032
- Aún no reclutando
- AIG Hospitals
-
-
-
-
-
Petah Tikva, Israel, 4941492
- Reclutamiento
- Clalit Health Services through Rabin Medical Center
-
-
Jerusalem
-
Jerusalem, Jerusalem, Israel, 9013102
- Reclutamiento
- Shaare Zedek Medical Center
-
-
-
-
-
Avellino, Italia, 83100
- Reclutamiento
- Azienda Ospedaliera San Giuseppe Moscati
-
Milan, Italia, 20132
- Reclutamiento
- Ospedale San Raffaele
-
Milan, Italia, 20141
- Reclutamiento
- Istituto Europeo di Oncologia IRCCS
-
Padova, Italia, 35128
- Reclutamiento
- Istituto Oncologico Veneto IRCCS
-
-
Campania
-
Naples, Campania, Italia, 80131
- Reclutamiento
- Istituto Nazionale Tumori IRCCS Fondazione Pascale
-
-
Catania
-
Misterbianco, Catania, Italia, 95045
- Reclutamiento
- Humanitas Istituto Clinico Catanese
-
-
Emilia-Romagna
-
Meldola, Emilia-Romagna, Italia, 47014
- Reclutamiento
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
-
-
Pesaro AND Urbino
-
Pesaro (PU), Pesaro AND Urbino, Italia, 61121
- Reclutamiento
- Azienda Sanitaria Territoriale Pesaro e Urbino (AST PU)
-
-
Piedmont
-
Orbassano, Piedmont, Italia, 10043
- Reclutamiento
- Azienda Ospedaliero-Universitaria San Luigi Gonzaga
-
-
ROMA
-
Rome, ROMA, Italia, 00186
- Reclutamiento
- Ospedale Isola Tiberina - Gemelli Isola
-
-
ROME
-
Roma, ROME, Italia, 00144
- Reclutamiento
- IRCCS Istituto Nazionale dei Tumori Regina Elena
-
-
Sicily
-
Catania, Sicily, Italia, 95123
- Reclutamiento
- Policlinico "G. Rodolico"
-
-
-
-
-
Fukuoka, Japón, 810-8563
- Reclutamiento
- National Hospital Organization Kyushu Medical Center
-
Fukuoka, Japón, 811-1395
- Reclutamiento
- National Hospital Organization Kyushu Cancer Center
-
Kyoto, Japón, 612-8555
- Reclutamiento
- National Hospital Organization Kyoto Medical Center
-
Okayama, Japón, 701-1154
- Reclutamiento
- National Hospital Organization Okayama Medical Center
-
Osaka, Japón, 541-8567
- Reclutamiento
- Osaka International Cancer Institute
-
-
Ehime
-
Tōon, Ehime, Japón, 791-0295
- Aún no reclutando
- Ehime University Hospital
-
-
Fukuoka
-
Kurume, Fukuoka, Japón, 830-0011
- Reclutamiento
- Kurume University Hospital
-
-
Gunma
-
Otashi, Gunma, Japón, 373-8550
- Reclutamiento
- Gunma Prefectural Cancer Center
-
-
Hokkaido
-
Asahikawa, Hokkaido, Japón, 0708644
- Reclutamiento
- National Hospital Organization Asahikawa Medical Center
-
-
Hyōgo
-
Kobe, Hyōgo, Japón, 650-0047
- Reclutamiento
- Kobe City Medical Center General Hospital
-
-
Kanagawa
-
Yokohama, Kanagawa, Japón, 2418515
- Aún no reclutando
- Kanagawa cancer center
-
-
Mie-ken
-
Tsu, Mie-ken, Japón, 514-1101
- Reclutamiento
- Mie Chuo Medical Center
-
-
Miyagi
-
Sendai, Miyagi, Japón, 9810914
- Reclutamiento
- Sendai Kousei Hospital
-
-
Osaka
-
Sakai, Osaka, Japón, 591-8555
- Reclutamiento
- NHO Kinki Chuo Chest Medical Center
-
Suita, Osaka, Japón, 565-0871
- Reclutamiento
- The University of Osaka Hospital
-
-
Tokyo
-
Bunkyo-ku, Tokyo, Japón, 113-8603
- Aún no reclutando
- Nippon Medical School Hospital
-
Chuo-ku, Tokyo, Japón, 104-0045
- Reclutamiento
- National Cancer Center Hospital
-
Koto, Tokyo, Japón, 135-8550
- Reclutamiento
- The Cancer Institute Hospital of JFCR
-
Meguro-Ku, Tokyo, Japón, 152-8902
- Reclutamiento
- National Hospital Organization Tokyo Medical Center
-
-
Yamagata
-
Yamagata, Yamagata, Japón, 990-9585
- Reclutamiento
- Yamagata University Hospital
-
-
-
-
-
Mexico City, México, 14080
- Aún no reclutando
- Instituto Nacional de Cancerologia
-
Puebla City, México, 72530
- Reclutamiento
- Clinica Integral Internacional de Oncología
-
-
Jalisco
-
Guadalajara, Jalisco, México, 44340
- Reclutamiento
- Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
-
-
Veracruz
-
Veracruz de Ignacio de LA Llave, Veracruz, México, 91900
- Aún no reclutando
- Instituto Veracruzano en Investigación Clínica S.C.
-
-
-
-
-
Utrecht, Países Bajos, 3543 AZ
- Reclutamiento
- St. Antonius Ziekenhuis, locatie Utrecht
-
-
Gelderland
-
Harderwijk, Gelderland, Países Bajos, 3844 DG
- Reclutamiento
- Ziekenhuis St. Jansdal
-
-
North Brabant
-
Breda, North Brabant, Países Bajos, 4818 CK
- Aún no reclutando
- Amphia Ziekenhuis, locatie Breda Molengracht
-
-
Overijssel
-
Zwolle, Overijssel, Países Bajos, 8025 AB
- Reclutamiento
- Isala, locatie Zwolle
-
-
Provincie Friesland
-
Leeuwarden, Provincie Friesland, Países Bajos, 8934 AD
- Aún no reclutando
- Frisius Medisch Centrum
-
-
-
-
-
Gdansk, Polonia, 80-214
- Reclutamiento
- Uniwersyteckie Centrum Kliniczne
-
Gliwice, Polonia, 44-102
- Reclutamiento
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
-
Poznan, Polonia, 60-569
- Reclutamiento
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
-
-
Greater Poland Voivodeship
-
Poznan, Greater Poland Voivodeship, Polonia, 60-693
- Reclutamiento
- Med-Polonia Sp. z o. o.
-
-
Lublin Voivodeship
-
Lublin, Lublin Voivodeship, Polonia, 20-609
- Reclutamiento
- Instytut Genetyki i Immunologii GENIM
-
-
Masovian Voivodeship
-
Warsaw, Masovian Voivodeship, Polonia, 02-781
- Reclutamiento
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
-
-
Łódź Voivodeship
-
Lodz, Łódź Voivodeship, Polonia, 90-302
- Reclutamiento
- Instytut MSF Sp zoo
-
-
-
-
Anhui
-
Hefei, Anhui, Porcelana, 230031
- Reclutamiento
- Anhui Provincial Cancer Hospital
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, Porcelana, 101149
- Reclutamiento
- Beijing Chest Hospital,Capital Medical University
-
Beijing, Beijing Municipality, Porcelana, 100142
- Reclutamiento
- Beijing Cancer hospital
-
-
Fujian
-
Fuzhou, Fujian, Porcelana, 350014
- Reclutamiento
- Fujian Cancer Hospital
-
-
Guangdong
-
Guangzhou, Guangdong, Porcelana, 510515
- Reclutamiento
- Nanfang Hospital of Southern Medical University
-
Huizhou, Guangdong, Porcelana, 516001
- Reclutamiento
- Huizhou Central People's Hospital
-
-
Guangxi
-
Nanning, Guangxi, Porcelana
- Reclutamiento
- Guangxi Medical University Affiliated Tumor Hospital
-
-
Heilongjiang
-
Harbin, Heilongjiang, Porcelana, 150081
- Reclutamiento
- Harbin Medical University Cancer Hospital
-
-
Henan
-
Luoyang, Henan, Porcelana, 471003
- Reclutamiento
- The First Affiliated Hospital of Henan University of Science &Technology
-
Zhengzhou, Henan, Porcelana, 450008
- Reclutamiento
- Henan Cancer Hospital
-
-
Hubei
-
Wuhan, Hubei, Porcelana, 430079
- Reclutamiento
- Hubei Cancer Hospital
-
Wuhan, Hubei, Porcelana, 430048
- Reclutamiento
- Wuhan Union Hospital Cancer Center
-
-
Hunan
-
Changsha, Hunan, Porcelana, 410013
- Reclutamiento
- Hunan Cancer Hospital
-
-
Jiangsu
-
Changzhou, Jiangsu, Porcelana, 213003
- Reclutamiento
- The First People's Hospital of Changzhou
-
Nanjing, Jiangsu, Porcelana, 210029
- Reclutamiento
- Jiangsu Province Hospital
-
Xuzhou, Jiangsu, Porcelana, 221006
- Reclutamiento
- The Affiliated Hospital of Xuzhou Medical College
-
-
Jiangxi
-
Nanchang, Jiangxi, Porcelana, 330209
- Reclutamiento
- The First Affiliated Hospital of Nanchang University
-
-
Jilin
-
Changchun, Jilin, Porcelana, 130000
- Reclutamiento
- Jilin Province Tumor Hospital
-
-
Shaanxi
-
Xi'an, Shaanxi, Porcelana, 710061
- Reclutamiento
- The First Affiliated Hospital of Xi'an Jiaotong University
-
-
Shandong
-
Jinan, Shandong, Porcelana, 250117
- Reclutamiento
- Shandong Cancer Hospital
-
Jinan, Shandong, Porcelana, 250013
- Reclutamiento
- Jinan Central Hospital
-
Linyi, Shandong, Porcelana, 276001
- Reclutamiento
- LinYi Cancer Hospital
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, Porcelana, 200032
- Reclutamiento
- Fudan University Shanghai Cancer Center
-
Shanghai, Shanghai Municipality, Porcelana, 200030
- Reclutamiento
- Shanghai Chest Hospital
-
-
Sichuan
-
Chengdu, Sichuan, Porcelana, 610041
- Reclutamiento
- West China Hospital, Sichuan University
-
Chengdu, Sichuan, Porcelana, 610041
- Reclutamiento
- Sichuan Cancer hospital
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, Porcelana, 300052
- Reclutamiento
- Tianjin Medical University General Hospital
-
-
Yunnan
-
Kunming, Yunnan, Porcelana, 650118
- Reclutamiento
- Yunnan Province Cancer Hospital
-
-
Zhejiang
-
Hangzhou, Zhejiang, Porcelana, 310016
- Reclutamiento
- Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
-
Taizhou, Zhejiang, Porcelana, 317000
- Reclutamiento
- Taizhou Hospital of Zhejiang Province
-
Wenzhou, Zhejiang, Porcelana, 325000
- Reclutamiento
- The First Affiliated Hospital of Wenzhou Medical University
-
-
-
-
-
Manchester, Reino Unido, M20 4BX
- Reclutamiento
- The Christie NHS Foundation Trust
-
Reading, Reino Unido, RG1 5AN
- Aún no reclutando
- Royal Berkshire Hospital
-
-
Carnwall
-
Truro, Carnwall, Reino Unido, TR1 3LJ
- Reclutamiento
- Royal Cornwall Hospitals NHS Trust
-
-
England
-
Sheffield, England, Reino Unido, S10 2SJ
- Aún no reclutando
- Weston Park Hospital
-
-
Hampshire
-
Southampton, Hampshire, Reino Unido, SO16 6YD
- Reclutamiento
- University Hospital Southampton NHS Foundation Trust
-
-
Hillingdon
-
Northwood, Hillingdon, Reino Unido, HA6 2RN
- Aún no reclutando
- Mount Vernon Hospital
-
-
London, CITY of
-
London, London, CITY of, Reino Unido, EC1A 7BE
- Reclutamiento
- St Bartholomew's Hospital
-
-
Somerset
-
Taunton, Somerset, Reino Unido, TA1 5DA
- Aún no reclutando
- Musgrove Park Hospital
-
-
Suffolk
-
Ipswich, Suffolk, Reino Unido, IP4 5PD
- Aún no reclutando
- Ipswich Hospital
-
-
-
-
Bucharest
-
Bucharest, Bucharest, Rumania, 013812
- Reclutamiento
- SC Memorial Healthcare International SRL
-
Bucharest, Bucharest, Rumania, 022338
- Reclutamiento
- Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
-
Bucharest, Bucharest, Rumania, 077190
- Aún no reclutando
- Sc Mnt Healthcare Europe Srl
-
-
Cluj
-
Cluj-Napoca, Cluj, Rumania, 400641
- Reclutamiento
- SC Medisprof SRL
-
Florești, Cluj, Rumania, 407280
- Reclutamiento
- SC Radiotherapy Center Cluj SRL
-
-
Constanța County
-
Ovidiu, Constanța County, Rumania, 905900
- Reclutamiento
- Ovidius Clinical Hospital OCH
-
-
Dolj
-
Craiova, Dolj, Rumania, 200542
- Aún no reclutando
- Centrul de Oncologie "Sfântul Nectarie"
-
Craiova, Dolj, Rumania, 200385
- Reclutamiento
- SC Oncolab SRL
-
-
Timiș County
-
Timișoara, Timiș County, Rumania, 300166
- Aún no reclutando
- S C Oncocenter Oncologie Clinica S R L
-
-
-
-
-
Zurich, Suiza, 8091
- Reclutamiento
- UniversitätsSpital Zürich
-
-
Canton of Bern
-
Bern, Canton of Bern, Suiza, 3010
- Reclutamiento
- Inselspital Bern
-
-
-
-
-
Kaohsiung City, Taiwán, 807
- Aún no reclutando
- Kaohsiung Medical University Chung-Ho Memorial Hospital
-
Kaohsiung City, Taiwán, 833401
- Reclutamiento
- Chang Gung Memorial Hospital at Kaohsiung
-
Taichung, Taiwán, 407
- Aún no reclutando
- Taichung Veterans General Hospital
-
Tainan, Taiwán, 704
- Reclutamiento
- National Cheng Kung University Hospital
-
Taipei, Taiwán, 11217
- Reclutamiento
- Taipei Veterans General Hospital
-
Taipei, Taiwán, 10002
- Aún no reclutando
- National Taiwan University Hospital
-
-
Tainan
-
Tainan, Tainan, Taiwán, 73657
- Aún no reclutando
- Chi Mei Hospital - Liouying Branch
-
-
Taipei
-
Taipei City, Taipei, Taiwán, 106
- Aún no reclutando
- National Taiwan University Cancer Center (NTUCC)
-
-
-
-
-
Adana, Turquía (Türkiye), 01140
- Reclutamiento
- Adana Medical Park Seyhan Hastanesi
-
Ankara, Turquía (Türkiye), 06680
- Reclutamiento
- Liv Hospital Ankara
-
Ankara, Turquía (Türkiye), 06520
- Reclutamiento
- Memorial Ankara Hastanesi
-
Ankara, Turquía (Türkiye), 06230
- Reclutamiento
- Hacettepe Universite Hastaneleri
-
Ankara, Turquía (Türkiye), 06560
- Reclutamiento
- Gazi University Health Research and Application Center Gazi Hospital
-
Ankara, Turquía (Türkiye), 06010
- Reclutamiento
- Gulhane Egitim Arastirma Hastanesi
-
Ankara, Turquía (Türkiye), 06800
- Reclutamiento
- Ankara Bilkent Şehir Hastanesi
-
Antalya, Turquía (Türkiye), 07100
- Reclutamiento
- Antalya Egitim ve Arastırma Hastanesi
-
Diyarbakır, Turquía (Türkiye), 21200
- Reclutamiento
- Dicle Üniversitesi
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İstanbul - Fatih, Turquía (Türkiye), 34098
- Reclutamiento
- Istanbul Universitesi Cerrahpasa
-
-
Turkey
-
Ankara, Turkey, Turquía (Türkiye), 06230
- Reclutamiento
- Ankara University Health Practice and Research Hospitals
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İ̇stanbul
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Istanbul, İ̇stanbul, Turquía (Türkiye), 34722
- Reclutamiento
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
-
Istanbul, İ̇stanbul, Turquía (Türkiye), 34214
- Reclutamiento
- Medipol Mega Universite Hastanesi
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Istanbul, İ̇stanbul, Turquía (Türkiye), 34295
- Reclutamiento
- İ.A.Ü VM Medical Park Florya Hastanesi
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İ̇zmir
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Izmir, İ̇zmir, Turquía (Türkiye), 35100
- Reclutamiento
- Ege Universitesi Hastanesi
-
Izmir, İ̇zmir, Turquía (Türkiye), 35110
- Reclutamiento
- İzmir Suat Seren Chest Disease Training & Research Hospital
-
-
Criterios de participación
Los investigadores buscan personas que se ajusten a una determinada descripción, denominada criterio de elegibilidad. Algunos ejemplos de estos criterios son el estado de salud general de una persona o tratamientos previos.
Criterio de elegibilidad
Edades elegibles para estudiar
18 años y mayores (Adulto, Adulto Mayor)
Acepta Voluntarios Saludables
No
Géneros elegibles para el estudio
Todos
Descripción
Inclusion Criteria:
-
Participants must meet the following criteria:
- Have pathologically confirmed Stage IIIB or IIIC NSCLC and not be a candidate for surgical resection or definitive chemoradiation, or Stage IV NSCLC per the AJCC Staging Manual (Version 8.0) and the UICC Staging System (Eighth edition).
- Participants with known AGAs including EGFR, ALK, ROS1, NTRK, BRAF, RET, and MET, for which there are approved and available first-line therapies per local SOC are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology.
- Participants with large cell neuroendocrine carcinoma are excluded.
- Must be an appropriate candidate for treatment with pembrolizumab monotherapy per local guidelines.
-
Tumor has PD-L1 expression in ≥50% of tumor cells (TPS ≥50%) as determined by local testing.
-
Measurable disease based on RECIST v1.1 per investigator.
-
Resolution of acute effects of any prior therapy to either baseline severity or NCI CTCAE Grade 1 or less (except for AEs not constituting a safety risk in the investigator's judgment), unless otherwise excluded.
Exclusion Criteria:
-
Life expectancy of <3 months in the opinion of the investigator.
-
Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.
-
Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.
-
Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab.
-
Participants with any of the following respiratory conditions:
- Evidence of noninfectious or drug-induced ILD or pneumonitis
- Known DLCO (adjusted for hemoglobin) <50% predicted.
- Grade ≥3 pulmonary disease unrelated to underlying malignancy
-
Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Up to 5 clinically asymptomatic brain metastases of longest diameter <1.0 cm are permitted without definitive surgery and/or radiotherapy.
-
Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery (excluding peripherally inserted central catheter placement and implantable central venous port placement) within 3 days prior to first dose of study intervention.
-
Receipt of a live vaccine within 30 days prior to first dose of study intervention.
-
Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0.
-
Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.
-
Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for >2 weeks, or required treatment with systemic immunosuppressive therapy.
-
History of autoimmune disease that has required systemic treatment in the past 2 years
-
Participants with prior solid organ or bone marrow transplantation.
-
Currently receiving a high-dose steroid (>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant.
-
Prior and concomitant therapy:
-
Any prior treatment with MMAE-derived drugs or IB6 targeting agents.
-
Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.
- (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose.
- Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose.
-
Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received. This includes both curative and palliative radiotherapy.
-
Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy.
-
Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor
-
-
History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV.
-
Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months
Plan de estudios
Esta sección proporciona detalles del plan de estudio, incluido cómo está diseñado el estudio y qué mide el estudio.
¿Cómo está diseñado el estudio?
Detalles de diseño
- Propósito principal: Tratamiento
- Asignación: Aleatorizado
- Modelo Intervencionista: Asignación paralela
- Enmascaramiento: Único
Armas e Intervenciones
Grupo de participantes/brazo |
Intervención / Tratamiento |
|---|---|
|
Experimental: Sigvotatug Vedotin with Pembrolizumab
Participants will receive Sigvotatug Vedotin, administered as an IV infusion and pembrolizumab, administered as an IV infusion. |
MMAE-Antibody Drug Conjugate targeting Integrin Beta-6 Anti-PD-(L)1 |
|
Comparador activo: Pembrolizumab Monotherapy
Participants will receive pembrolizumab, administered as an IV infusion. |
Anti-PD-(L)1 |
¿Qué mide el estudio?
Medidas de resultado primarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Overall Survival
Periodo de tiempo: Baseline to date of death from any cause (Approximately 2 years).
|
Overall survival defined as the duration from enrollment to death. |
Baseline to date of death from any cause (Approximately 2 years).
|
|
Progression Free Survival (PFS) assessed by blinded independent central review (BICR)
Periodo de tiempo: From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first. |
From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Medidas de resultado secundarias
Medida de resultado |
Medida Descripción |
Periodo de tiempo |
|---|---|---|
|
Progression Free Survival as assessed by Investigator
Periodo de tiempo: From Baseline to date of first progression or death (Approximately 4 years).
|
Progression Free Survival (PFS) is defined as the time from the date of first dose of study interventions to the date of first documentation of PD or death due to any cause, whichever occurs first. |
From Baseline to date of first progression or death (Approximately 4 years).
|
|
Objective Response Rate as assessed by BICR
Periodo de tiempo: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Objective Response Rate as assessed by Investigator
Periodo de tiempo: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Defined as the proportion of participants who achieve a best response of complete response (CR) or partial response (PR) using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria as assessed by Investigator. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Duration of Response as assessed by BICR
Periodo de tiempo: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Duration of Response as assessed by Investigator
Periodo de tiempo: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Defined time from the initial response (CR or PR) until documented tumor progression or death from any cause and based on Investigator assessment. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Number of participants with adverse events (AEs)
Periodo de tiempo: From Baseline to end of treatment (up to 4 years).
|
Counts of participants who had treatment-emergent adverse events (TEAEs), defined as newly occurring or worsening after first dose. Relatedness to [study drug] was assessed by the investigator (Yes/No). Participants with multiple occurrences of an AE within a category were counted once within the category. |
From Baseline to end of treatment (up to 4 years).
|
|
Pharmacokinetics (PK) of antibody-conjugated monomethyl auristatin E (ac-MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
Periodo de tiempo: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of ac-MMAE in plasma: Plasma predose concentration (Cpredose)
Periodo de tiempo: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of unconjugated monomethyl auristatin E (MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
Periodo de tiempo: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of MMAE in plasma: Plasma predose concentration (Cpredose)
Periodo de tiempo: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Number of participants with antidrug antibodies (ADAs)
Periodo de tiempo: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the immunogenicity of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Time to response (TTR) using RECIST v1.1 as assessed by BICR
Periodo de tiempo: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by BICR. |
The time from the date of randomization to the date of first documentation of objective response.
|
|
TTR using RECIST v1.1 as assessed by investigator
Periodo de tiempo: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by investigator assessment. |
The time from the date of randomization to the date of first documentation of objective response.
|
Colaboradores e Investigadores
Aquí es donde encontrará personas y organizaciones involucradas en este estudio.
Patrocinador
Investigadores
- Director de estudio: Pfizer CT.gov Call Center, Pfizer
Publicaciones y enlaces útiles
La persona responsable de ingresar información sobre el estudio proporciona voluntariamente estas publicaciones. Estos pueden ser sobre cualquier cosa relacionada con el estudio.
Fechas de registro del estudio
Estas fechas rastrean el progreso del registro del estudio y los envíos de resultados resumidos a ClinicalTrials.gov. Los registros del estudio y los resultados informados son revisados por la Biblioteca Nacional de Medicina (NLM) para asegurarse de que cumplan con los estándares de control de calidad específicos antes de publicarlos en el sitio web público.
Fechas importantes del estudio
Inicio del estudio (Actual)
23 de julio de 2025
Finalización primaria (Estimado)
5 de septiembre de 2028
Finalización del estudio (Estimado)
1 de marzo de 2029
Fechas de registro del estudio
Enviado por primera vez
26 de diciembre de 2024
Primero enviado que cumplió con los criterios de control de calidad
26 de diciembre de 2024
Publicado por primera vez (Actual)
3 de enero de 2025
Actualizaciones de registros de estudio
Última actualización publicada (Actual)
25 de septiembre de 2026
Última actualización enviada que cumplió con los criterios de control de calidad
22 de septiembre de 2026
Última verificación
1 de septiembre de 2026
Más información
Términos relacionados con este estudio
Palabras clave
Términos MeSH relevantes adicionales
- Neoplasias por sitio
- Neoplasias
- Enfermedades de las vías respiratorias
- Neoplasias por tipo histológico
- Enfermedades pulmonares
- Neoplasias Glandulares y Epiteliales
- Neoplasias de las vías respiratorias
- Neoplasias torácicas
- Carcinoma Broncogénico
- Neoplasias Bronquiales
- Carcinoma
- Neoplasias Pulmonares
- Carcinoma de pulmón de células no pequeñas
- pembrolizumab
Otros números de identificación del estudio
- C5751003
- 2024-517968-36-00 (Identificador de registro: CTIS (EU))
Plan de datos de participantes individuales (IPD)
¿Planea compartir datos de participantes individuales (IPD)?
SÍ
Descripción del plan IPD
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
Información sobre medicamentos y dispositivos, documentos del estudio
Estudia un producto farmacéutico regulado por la FDA de EE. UU.
Sí
Estudia un producto de dispositivo regulado por la FDA de EE. UU.
No
producto fabricado y exportado desde los EE. UU.
Sí
Esta información se obtuvo directamente del sitio web clinicaltrials.gov sin cambios. Si tiene alguna solicitud para cambiar, eliminar o actualizar los detalles de su estudio, comuníquese con register@clinicaltrials.gov. Tan pronto como se implemente un cambio en clinicaltrials.gov, también se actualizará automáticamente en nuestro sitio web. .