Detta är en studie för att lära dig mer om hur kombinationen av studiemedicinerna Sigvotatug Vedotin Plus Pembrolizumab fungerar på personer med icke-småcellig lungcancer med höga nivåer av PD-L1.
22 september 2026 uppdaterad av: Pfizer
AN OPEN-LABEL, RANDOMIZED, CONTROLLED PHASE 3 STUDY OF SIGVOTATUG VEDOTIN IN COMBINATION WITH PEMBROLIZUMAB COMPARED WITH PEMBROLIZUMAB MONOTHERAPY AS FIRST-LINE TREATMENT IN PARTICIPANTS WITH PD-L1 HIGH (≥50% OF TUMOR CELLS EXPRESSING PD-L1), LOCALLY ADVANCED, UNRESECTABLE, OR METASTATIC NON-SMALL CELL LUNG CANCER
The purpose of the study is to compare how the new combination treatment (Sigvotatug Vedotin plus pembrolizumab) works compared to pembrolizumab alone in patients with non-small cell lung cancer (NSCLC) with high levels of PD-L1. This is a protein that acts as a kind of "brake" to keep the body's immune responses under control.
The study is seeking for participants who:
- Are confirmed to have NSCLC (Stage 3 or 4).
- Have PD-L1 levels in more than 50% of the cancer cells.
All participants in this study will receive pembrolizumab at the study clinic once every 6 weeks as an intravenous (IV) infusion (give directly into a vein). In addition, half of the participants will also receive Sigvotatug Vedotin once every 2 weeks as an IV infusion in addition to receiving pembrolizumab.
Participants may receive pembrolizumab for up to about two years. Those participants taking Sigvotatug Vedotin can continue until their NSCLC is no longer responding. The study team will monitorsee how each participant is doing with the study treatment during regular visits at the clinic.
Studieöversikt
Status
Rekrytering
Betingelser
Intervention / Behandling
Studietyp
Interventionell
Inskrivning (Beräknad)
714
Fas
- Fas 3
Kontakter och platser
Det här avsnittet innehåller kontaktuppgifter för dem som genomför studien och information om var denna studie genomförs.
Studiekontakt
- Namn: Pfizer CT.gov Call Center
- Telefonnummer: 1-800-718-1021
- E-post: ClinicalTrials.gov_Inquiries@pfizer.com
Studieorter
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Buenos Aires, Argentina, 1426
- Rekrytering
- Centro Oncologico Korben
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Buenos Aires, Argentina, C1122AAL
- Rekrytering
- Instituto Argentino de Diagnóstico y Tratamiento (IADT)
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Córdoba, Argentina, 5016
- Rekrytering
- Hospital Privado Universitario de Córdoba
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Córdoba, Argentina, 5000
- Rekrytering
- Sanatorio Privado de la Cañada
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Córdoba, Argentina, X5008AAC
- Rekrytering
- Centro Medico Privado CEMAIC
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Córdoba, Argentina, 5000
- Har inte rekryterat ännu
- Centro Urológico Profesor Bengió
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San Juan, Argentina, 5400
- Rekrytering
- Instituto San Marcos
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Buenos Aires
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Berazategui, Buenos Aires, Argentina, B1884BBF
- Rekrytering
- Centro de Oncología e Investigación de Buenos Aires
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Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina, C1426ABP
- Rekrytering
- Fundación Respirar
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Florida, Buenos Aires, Argentina, B1602DQD
- Rekrytering
- Centro Medico de Enfermedades Respiratorias -CEMER
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Mar del Plata, Buenos Aires, Argentina, B7600FZD
- Rekrytering
- Investigaciones Oncológicas C. Colón S.A
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Pergamino, Buenos Aires, Argentina, B2700CPM
- Har inte rekryterat ännu
- Centro de Investigación Pergamino
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Cdad. Autónoma de Buenos Aires
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Buenos Aires, Cdad. Autónoma de Buenos Aires, Argentina, C 1113
- Rekrytering
- Centro de Investigaciones Medicas y Desarrollo LC
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Jujuy Province
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San Salvador de Jujuy, Jujuy Province, Argentina, 4600
- Rekrytering
- Fundacion Ars Medica
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Río Negro Province
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Cipolletti, Río Negro Province, Argentina, 8324
- Rekrytering
- Fundacion Medica de Rio Negro y Neuquen
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Santa Fe Province
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Rosario, Santa Fe Province, Argentina, 2000
- Rekrytering
- Fundacion Estudios Clinicos
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Rosario, Santa Fe Province, Argentina, S2000DSV
- Rekrytering
- Sanatorio Parque
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Rosario, Santa Fe Province, Argentina, S2002KDS
- Rekrytering
- Hospital Provincial del Centenario
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Rosario, Santa Fe Province, Argentina, S2000CVB
- Rekrytering
- Sanatorio Británico
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New South Wales
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Coffs Harbour, New South Wales, Australien, 2450
- Rekrytering
- Coffs Harbour Health Campus
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North Ryde, New South Wales, Australien, 2109
- Rekrytering
- Macquarie University
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Sydney, New South Wales, Australien, 2560
- Rekrytering
- Campbelltown Hospital
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Queensland
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Birtinya, Queensland, Australien, 4575
- Rekrytering
- Sunshine Coast University Hospital
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Douglas, Queensland, Australien, 4814
- Rekrytering
- Townsville University Hospital
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Gympie, Queensland, Australien, 4570
- Rekrytering
- Gympie Hospital
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Nambour, Queensland, Australien, 4560
- Rekrytering
- Nambour General Hospital
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Woolloongabba, Queensland, Australien, 4102
- Rekrytering
- Princess Alexandra Hospital
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Western Australia
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Perth, Western Australia, Australien, 6009
- Rekrytering
- Sir Charles Gairdner Hospital
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-
-
-
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Brasschaat, Belgien, 2930
- Rekrytering
- Algemeen Ziekenhuis klina
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Liège, Belgien, 4000
- Rekrytering
- Centre Hospitalier Universitaire de Liège - Domaine Universitaire du Sart Tilman
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Antwerpen
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Mechelen, Antwerpen, Belgien, 2800
- Rekrytering
- AZ Sint-Maarten
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Bruxelles-capitale, Région de
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Brussels, Bruxelles-capitale, Région de, Belgien, 1090
- Rekrytering
- UZ Brussel
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Hainaut
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Charleroi, Hainaut, Belgien, 6060
- Rekrytering
- Grand Hôpital de Charleroi
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-
-
-
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Jaú, Brasilien, 17210-080
- Har inte rekryterat ännu
- Fundação Doutor Amaral Carvalho
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Rio de Janeiro, Brasilien, 22281-100
- Rekrytering
- Instituto D'Or de Pesquisa e Ensino
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Rio de Janeiro, Brasilien, 22031-011
- Rekrytering
- Instituto D'Or de Pesquisa e Ensino
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Rio de Janeiro, Brasilien, 22271-110
- Rekrytering
- Instituto D'Or de Pesquisa e Ensino
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Rio de Janeiro, Brasilien, 22451-040
- Rekrytering
- Instituto D'Or de Pesquisa e Ensino
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São Paulo, Brasilien, 01246-000
- Har inte rekryterat ännu
- Icesp - Instituto Do Câncer Do Estado de São Paulo
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Ceará
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Fortaleza, Ceará, Brasilien, 60430235
- Rekrytering
- Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
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Fortaleza, Ceará, Brasilien, 60336232
- Rekrytering
- Crio - Centro Regional Integrado de Oncologia
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Espírito Santo
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Vitória, Espírito Santo, Brasilien, 29043-260
- Rekrytering
- Afecc Associacao Feminina Educacao Combate Cancer
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Estado de Bahia
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Salvador, Estado de Bahia, Brasilien, 41950- 640
- Rekrytering
- Clinica Amo - Rio Vermelho
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Salvador, Estado de Bahia, Brasilien, 41253-190
- Rekrytering
- Instituto D'Or de Pesquisa e Ensino - Hospital São Rafael
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Federal District
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Brasília, Federal District, Brasilien, 70390-150
- Har inte rekryterat ännu
- Onco-Vida - Instituto Especializado De Oncologia
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Paraná
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Curitiba, Paraná, Brasilien, 81520-060
- Rekrytering
- Hospital Erasto Gaertner
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Pernambuco
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Recife, Pernambuco, Brasilien, 52010-902
- Rekrytering
- Real Hospital de Beneficência Portuguesa de Pernambuco
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Piauí
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Teresina, Piauí, Brasilien, 64049-200
- Rekrytering
- Vencer Centro de Pesquisa LTDA
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Rio Grande do Norte
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Natal, Rio Grande do Norte, Brasilien, 59062-000
- Rekrytering
- Liga Norte Riograndense Contra o Câncer
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Rio Grande do Sul
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Ijuí, Rio Grande do Sul, Brasilien, 98700-000
- Rekrytering
- ONCOSITE - Centro de Pesquisa Clinica em Oncologia
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Porto Alegre, Rio Grande do Sul, Brasilien, 90560032
- Har inte rekryterat ännu
- Hospital Moinhos de Vento
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Porto Alegre, Rio Grande do Sul, Brasilien, 90610-000
- Rekrytering
- Hospital São Lucas da PUCRS
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Santa Catarina
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Lages, Santa Catarina, Brasilien, 88501-001
- Rekrytering
- ANIMI - Unidade de Tratamento Oncologico
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São Paulo
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Barretos, São Paulo, Brasilien, 14784400
- Rekrytering
- Fundação Pio XII - Hospital de Câncer de Barretos
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Bragança Paulista, São Paulo, Brasilien, 12916-542
- Rekrytering
- Hospital Universitário São Francisco na Providência de Deus
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Ribeirão Preto, São Paulo, Brasilien, 14051-140
- Rekrytering
- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP)
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Santo André, São Paulo, Brasilien, 09060-650
- Rekrytering
- Faculdade de Medicina do ABC
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São José do Rio Preto, São Paulo, Brasilien, 15090000
- Rekrytering
- Fundação Faculdade Regional de Medicina de São José do Rio Preto
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São Paulo, São Paulo, Brasilien, 01327-001
- Rekrytering
- Hospital Alemao Oswaldo Cruz
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Burgas, Bulgarien, 8000
- Rekrytering
- Complex Oncology Center - Burgas
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Plovdiv, Bulgarien, 4000
- Har inte rekryterat ännu
- Medical Center Futuremeds
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Sofia, Bulgarien, 1407
- Rekrytering
- Acibadem City Clinic University Multiprofile Hospital for Active Treatment Tokuda EAD
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Sofia, Bulgarien, 1330
- Rekrytering
- MHAT for Women's Health Nadezhda
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Sofia, Bulgarien, 1756
- Rekrytering
- University Specialized Hospital for Active Treatment of Oncology EAD
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Pazardzhik
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Panagyurishte, Pazardzhik, Bulgarien, 4500
- Rekrytering
- MBAL Uni Hospital
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Los Ríos Region
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Valdivia, Los Ríos Region, Chile, 5090000
- Rekrytering
- Clínica Alemana Valdivia
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Valdivia, Los Ríos Region, Chile, 5690000
- Rekrytering
- Oncocentro Valdivia
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Santiago Metropolitan
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La Florida, Santiago Metropolitan, Chile, 8241479
- Rekrytering
- Iceg Clinic
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Providencia, Santiago Metropolitan, Chile, 7500966
- Rekrytering
- Fundacion Arturo Lopez Perez
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Providencia, Santiago Metropolitan, Chile, 7501010
- Rekrytering
- Profar
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Providencia, Santiago Metropolitan, Chile, 7500836
- Rekrytering
- FALP
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Providencia, Santiago Metropolitan, Chile, 750000
- Rekrytering
- Fundación Arturo Lopéz Pérez
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Santiago, Santiago Metropolitan, Chile, 8241479
- Rekrytering
- Clínica Vespucio
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Santiago, Santiago Metropolitan, Chile, 8380455
- Rekrytering
- Instituto Nacional del Cancer
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Santiago, Santiago Metropolitan, Chile, 8380456
- Rekrytering
- Sociedad Oncovida SA
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Santiago, RM
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Providencia, Santiago, RM, Chile, 7500921
- Rekrytering
- FALP
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Valparaiso
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Viña del Mar, Valparaiso, Chile, 2520598
- Rekrytering
- Oncocentro Apys
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-
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Marseille, Frankrike, 13915
- Rekrytering
- Assistance Publique Hôpitaux de Marseille - Hôpital Nord
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Nice, Frankrike, 06189
- Rekrytering
- Centre Antoine Lacassagne
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Paris, Frankrike, 75248
- Rekrytering
- Institut Curie
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Paris, Frankrike, 75014
- Rekrytering
- Hopitaux Universitaires Paris Centre-Hopital Cochin
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Aquitaine
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Pessac, Aquitaine, Frankrike, 33604
- Rekrytering
- CHU Bordeaux Haut-Leveque
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Brittany Region
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Quimper, Brittany Region, Frankrike, 1757 - 29107
- Rekrytering
- Centre Hospitalier de Cornouaille Quimper - Concarneau
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Haute-garonne
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Toulouse, Haute-garonne, Frankrike, 31059
- Rekrytering
- CHU de Toulouse - Hopital Larrey
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Ille-et-vilaine
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Rennes, Ille-et-vilaine, Frankrike, 35033
- Rekrytering
- Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
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Languedoc-roussillon
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Montpellier, Languedoc-roussillon, Frankrike, 34070
- Rekrytering
- Centre de Cancérologie du Grand Montpellier
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Loire-atlantique
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Saint-Herblain, Loire-atlantique, Frankrike, 44805
- Rekrytering
- Institut de Cancérologie de l'Ouest
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Saint-Herblain, Loire-atlantique, Frankrike, 44800
- Rekrytering
- Hôpital Nord Guillaume-et-René-Laennec / CHU de Nantes
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PAYS de Loire
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Cholet, PAYS de Loire, Frankrike, 49300
- Rekrytering
- Centre Hospitalier de Cholet
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Provence-Alpes-Côte d'Azur Region
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Toulon, Provence-Alpes-Côte d'Azur Region, Frankrike, 83056
- Rekrytering
- Centre Hospitalier intercommunal de Toulon La Seyne sur Hospital Sainte-Musse health establishment
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Val-de-marne
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Créteil, Val-de-marne, Frankrike, 94010
- Rekrytering
- Centre Hospitalier Intercommunal de Créteil
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California
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Fullerton, California, Förenta staterna, 92835
- Rekrytering
- Providence Medical Foundation
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Fullerton, California, Förenta staterna, 92835
- Rekrytering
- Providence St. Jude Medical Center
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Fullerton, California, Förenta staterna, 92835
- Rekrytering
- Providence St. Jude Medical Center Virginia K. Crosson Cancer Center and Infusion Center
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Fullerton, California, Förenta staterna, 92835
- Rekrytering
- St. Jude Heritage Medical Group - Fullerton Plaza Multi-Specialty Clinic (Pulmonary Function Test)
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Colorado
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Golden, Colorado, Förenta staterna, 80401
- Rekrytering
- Intermountain Health Cancer Center Lutheran Hospital
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Grand Junction, Colorado, Förenta staterna, 81501
- Rekrytering
- Cancer Centers of Colorado St. Mary's Regional Hospital
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Grand Junction, Colorado, Förenta staterna, 81505
- Rekrytering
- Intermountain Health
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Grand Junction, Colorado, Förenta staterna, 81501
- Rekrytering
- Intermountain Health St. Mary's Regional Hospital
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Wheat Ridge, Colorado, Förenta staterna, 80401
- Rekrytering
- Intermountain Health Lutheran Hospital
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-
District of Columbia
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Washington D.C., District of Columbia, Förenta staterna, 20422
- Rekrytering
- Washington DC Veterans Affairs Medical Center
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Florida
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Orange City, Florida, Förenta staterna, 32763
- Rekrytering
- Mid Florida Hematology and Oncology Center
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Plantation, Florida, Förenta staterna, 33322
- Rekrytering
- BRCR Global
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Illinois
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Elmhurst, Illinois, Förenta staterna, 60126
- Rekrytering
- Endeavor Health
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Hinsdale, Illinois, Förenta staterna, 60521
- Rekrytering
- Hope and Healing Cancer Services
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Libertyville, Illinois, Förenta staterna, 60048
- Rekrytering
- Advocate Medical Group - Libertyville Oncology
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Naperville, Illinois, Förenta staterna, 60540
- Rekrytering
- Endeavor Health
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New Lenox, Illinois, Förenta staterna, 60451
- Rekrytering
- Hope and Healing Cancer Services
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Oak Lawn, Illinois, Förenta staterna, 60453
- Rekrytering
- Advocate Christ Medical Center
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Park Ridge, Illinois, Förenta staterna, 60068
- Rekrytering
- Advocate Lutheran General Hospital
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Kansas
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Overland Park, Kansas, Förenta staterna, 66213
- Rekrytering
- Saint Luke's South Hospital
-
-
Maine
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Portland, Maine, Förenta staterna, 04102
- Rekrytering
- Maine Medical Center
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Scarborough, Maine, Förenta staterna, 04074
- Rekrytering
- MaineHealth Cancer Care and Blood Disorders Scarborough
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South Portland, Maine, Förenta staterna, 04106
- Rekrytering
- MaineHealth Cancer Care and IV Therapy - South Portland
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Massachusetts
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Fairhaven, Massachusetts, Förenta staterna, 02719
- Rekrytering
- Southcoast Centers for Cancer Care
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Fall River, Massachusetts, Förenta staterna, 02720
- Rekrytering
- Southcoast Centers for Cancer Care
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-
Michigan
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Grand Rapids, Michigan, Förenta staterna, 49503
- Rekrytering
- Corewell Health
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Grand Rapids, Michigan, Förenta staterna, 49503
- Rekrytering
- Corewell Health - Butterworth Hospital
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Grand Rapids, Michigan, Förenta staterna, 49503
- Rekrytering
- Corewell Health - Lemmen Holton Cancer Pavilion
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Grand Rapids, Michigan, Förenta staterna, 49503
- Rekrytering
- Corewell Health - Research Specimen Processing Area
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Grand Rapids, Michigan, Förenta staterna, 49503
- Rekrytering
- Corewell Health Investigational Drug Services
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Minnesota
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Burnsville, Minnesota, Förenta staterna, 55337
- Rekrytering
- Minnesota Oncology Hematology, PA
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Coon Rapids, Minnesota, Förenta staterna, 55433
- Rekrytering
- Minnesota Oncology Hematology PA
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Edina, Minnesota, Förenta staterna, 55435
- Rekrytering
- M Health Fairview Cancer Clinic-Edina
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Edina, Minnesota, Förenta staterna, 55435
- Rekrytering
- Minnesota Oncology Hematology PA
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Maple Grove, Minnesota, Förenta staterna, 55369
- Rekrytering
- Minnesota Oncology Hematology PA
-
Maplewood, Minnesota, Förenta staterna, 55109
- Rekrytering
- M Health Fairview St. John's Hospital
-
Maplewood, Minnesota, Förenta staterna, 55109
- Rekrytering
- Minnesota Oncology Hematology PA
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Minneapolis, Minnesota, Förenta staterna, 55415
- Rekrytering
- Hennepin County Medical Center
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Robbinsdale, Minnesota, Förenta staterna, 55422
- Rekrytering
- North Memorial Health Cancer Center
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Saint Louis Park, Minnesota, Förenta staterna, 55426
- Rekrytering
- Park Nicollet Frauenshuh Cancer Center
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Saint Louis Park, Minnesota, Förenta staterna, 55426
- Rekrytering
- Metro Minnesota Community Oncology Research Consortium (MMCORC)
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Saint Paul, Minnesota, Förenta staterna, 55101
- Rekrytering
- Regions Hospital
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Woodbury, Minnesota, Förenta staterna, 55125
- Rekrytering
- Minnesota Oncology Hematology, P.A. Cornerstone Medical Specialty Center
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-
Mississippi
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Jackson, Mississippi, Förenta staterna, 39202
- Rekrytering
- Jackson Oncology Associates, PLLC
-
Jackson, Mississippi, Förenta staterna, 39216
- Rekrytering
- Jackson Oncology Associates, PLLC
-
-
Missouri
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Kansas City, Missouri, Förenta staterna, 64111
- Rekrytering
- Saint Luke's Hospital of Kansas City
-
Lee's Summit, Missouri, Förenta staterna, 64086
- Rekrytering
- Saint Luke's East Hospital
-
-
Montana
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Billings, Montana, Förenta staterna, 59101
- Rekrytering
- SCL Health - Montana
-
Billings, Montana, Förenta staterna, 59102
- Rekrytering
- SCL Health - Montana
-
-
Nebraska
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Fremont, Nebraska, Förenta staterna, 68025
- Rekrytering
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Fremont
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Grand Island, Nebraska, Förenta staterna, 68803
- Rekrytering
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Grand Island
-
Grand Island, Nebraska, Förenta staterna, 68803
- Rekrytering
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Regional
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Kearney, Nebraska, Förenta staterna, 68845
- Rekrytering
- Kearney Cancer Center
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Lincoln, Nebraska, Förenta staterna, 68516
- Rekrytering
- Cancer Partners of Nebraska
-
Omaha, Nebraska, Förenta staterna, 68130
- Rekrytering
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists
-
Omaha, Nebraska, Förenta staterna, 68114
- Rekrytering
- Oncology Hematology West P.C. dba Nebraska Cancer Specialists - Methodist
-
Omaha, Nebraska, Förenta staterna, 68124
- Rekrytering
- Oncology Hematology West, PC dba Nebraska Cancer Specialists - Bergan
-
-
New York
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Nyack, New York, Förenta staterna, 10960
- Rekrytering
- Hematology Oncology Associates of Rockland
-
-
North Carolina
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Greenville, North Carolina, Förenta staterna, 27834
- Rekrytering
- Brody School of Medicine at East Carolina University
-
Greenville, North Carolina, Förenta staterna, 27834
- Rekrytering
- ECU Health Medical Center
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Wilson, North Carolina, Förenta staterna, 27893
- Rekrytering
- Carolina Cancer Research Center
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-
Ohio
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Avon, Ohio, Förenta staterna, 44011
- Rekrytering
- University Hospitals Seidman Cancer Center at UH Avon Health Center
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Canton, Ohio, Förenta staterna, 44718
- Avslutad
- Gabrail Cancer Center Research
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Cleveland, Ohio, Förenta staterna, 44106
- Rekrytering
- University Hospitals Cleveland Medical Center
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Mentor, Ohio, Förenta staterna, 44060
- Rekrytering
- University Hospitals Seidman Cancer Center at UH Mentor Health Center
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Orange, Ohio, Förenta staterna, 44122
- Rekrytering
- UH Minoff Health Center at Chagrin Highlands
-
-
Texas
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Conroe, Texas, Förenta staterna, 77384
- Rekrytering
- The University of Texas, MD Anderson Cancer Center - Woodlands
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El Paso, Texas, Förenta staterna, 79915
- Rekrytering
- Renovatio Clinical - El Paso
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Houston, Texas, Förenta staterna, 77030
- Rekrytering
- University of Texas MD Anderson Cancer Center
-
Houston, Texas, Förenta staterna, 77030
- Rekrytering
- The University of Texas MD Anderson Cancer Center Investigational Pharmacy Services
-
Houston, Texas, Förenta staterna, 77030
- Rekrytering
- The University of Texas MD Anderson Cancer Center Diagnostic Imaging
-
Houston, Texas, Förenta staterna, 77030
- Rekrytering
- The University of Texas, MD Anderson Cancer Center- Interventional Radiology
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Houston, Texas, Förenta staterna, 77054
- Rekrytering
- The University of Texas MD Anderson Cancer Center Clinical Research Imaging
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Houston, Texas, Förenta staterna, 77079
- Rekrytering
- The University of Texas, MD Anderson Cancer Center - West Houston
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Kingwood, Texas, Förenta staterna, 77339
- Rekrytering
- Community Clinical Trials
-
League City, Texas, Förenta staterna, 77573
- Rekrytering
- The University of Texas, MD Anderson Cancer Center - League City
-
Sugar Land, Texas, Förenta staterna, 77478
- Rekrytering
- The University of Texas, MD Anderson Cancer Center - Sugar Land
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The Woodlands, Texas, Förenta staterna, 77380
- Rekrytering
- Renovatio Clinical
-
The Woodlands, Texas, Förenta staterna, 77381
- Rekrytering
- Woodlands Radiology
-
-
Washington
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Olympia, Washington, Förenta staterna, 98502
- Rekrytering
- American Oncology Network Vista Oncology Division-West office
-
Olympia, Washington, Förenta staterna, 98506
- Rekrytering
- American Oncology Network Vista Oncology Division-East office
-
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Wisconsin
-
Grafton, Wisconsin, Förenta staterna, 53024
- Rekrytering
- Aurora Cancer Care-Grafton
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Green Bay, Wisconsin, Förenta staterna, 54311
- Rekrytering
- Aurora BayCare Medical Center
-
Milwaukee, Wisconsin, Förenta staterna, 53215
- Rekrytering
- Aurora St. Luke's Medical Center
-
-
-
-
-
Athens, Grekland, 115 26
- Rekrytering
- Errikos Dunant Hospital Center
-
Larissa, Grekland, 41110
- Rekrytering
- University General Hospital of Larissa, Urology Department
-
Thessaloniki, Grekland, 552 36
- Rekrytering
- Agios Loukas Clinic
-
-
Attikí
-
Athens, Attikí, Grekland, 115 27
- Rekrytering
- Thoracic General Hospital of Athens "I Sotiria"
-
Athens, Attikí, Grekland, 155 62
- Rekrytering
- Metropolitan General Hospital
-
Athens, Attikí, Grekland, 185 47
- Rekrytering
- Metropolitan Hospital
-
Marousi, Attikí, Grekland, 151 23
- Rekrytering
- Hygeia Hospital
-
-
Thessaloníki
-
Thessaloniki, Thessaloníki, Grekland, 570 01
- Rekrytering
- European Interbalkan Medical Center
-
-
-
-
Karnataka
-
Bengaluru, Karnataka, Indien, 560069
- Rekrytering
- Spandana Oncology Centre (SOC)
-
-
Maharashtra
-
Mumbai, Maharashtra, Indien, 400012
- Rekrytering
- Tata Memorial Hospital
-
Pune, Maharashtra, Indien, 411004
- Rekrytering
- Sahyadri Super Speciality Hospital
-
Thane, Maharashtra, Indien, 401107
- Rekrytering
- Bhakti Vedanta Hospital and Research Institute
-
-
National Capital Territory of Delhi
-
New Delhi, National Capital Territory of Delhi, Indien, 110088
- Rekrytering
- Fortis Hospital
-
New Delhi, National Capital Territory of Delhi, Indien, 110005
- Rekrytering
- Dr B. L. Kapur Memorial Hospital
-
New Delhi, National Capital Territory of Delhi, Indien, 110075
- Rekrytering
- Venkateshwar Hospital
-
-
Telangana
-
Hyderabad, Telangana, Indien, 500032
- Har inte rekryterat ännu
- AIG Hospitals
-
-
-
-
-
Petah Tikva, Israel, 4941492
- Rekrytering
- Clalit Health Services through Rabin Medical Center
-
-
Jerusalem
-
Jerusalem, Jerusalem, Israel, 9013102
- Rekrytering
- Shaare Zedek Medical Center
-
-
-
-
-
Avellino, Italien, 83100
- Rekrytering
- Azienda Ospedaliera San Giuseppe Moscati
-
Milan, Italien, 20132
- Rekrytering
- Ospedale San Raffaele
-
Milan, Italien, 20141
- Rekrytering
- Istituto Europeo di Oncologia IRCCS
-
Padova, Italien, 35128
- Rekrytering
- Istituto Oncologico Veneto IRCCS
-
-
Campania
-
Naples, Campania, Italien, 80131
- Rekrytering
- Istituto Nazionale Tumori IRCCS Fondazione Pascale
-
-
Catania
-
Misterbianco, Catania, Italien, 95045
- Rekrytering
- Humanitas Istituto Clinico Catanese
-
-
Emilia-Romagna
-
Meldola, Emilia-Romagna, Italien, 47014
- Rekrytering
- IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori"
-
-
Pesaro AND Urbino
-
Pesaro (PU), Pesaro AND Urbino, Italien, 61121
- Rekrytering
- Azienda Sanitaria Territoriale Pesaro e Urbino (AST PU)
-
-
Piedmont
-
Orbassano, Piedmont, Italien, 10043
- Rekrytering
- Azienda Ospedaliero-Universitaria San Luigi Gonzaga
-
-
ROMA
-
Rome, ROMA, Italien, 00186
- Rekrytering
- Ospedale Isola Tiberina - Gemelli Isola
-
-
ROME
-
Roma, ROME, Italien, 00144
- Rekrytering
- IRCCS Istituto Nazionale dei Tumori Regina Elena
-
-
Sicily
-
Catania, Sicily, Italien, 95123
- Rekrytering
- Policlinico "G. Rodolico"
-
-
-
-
-
Fukuoka, Japan, 810-8563
- Rekrytering
- National Hospital Organization Kyushu Medical Center
-
Fukuoka, Japan, 811-1395
- Rekrytering
- National Hospital Organization Kyushu Cancer Center
-
Kyoto, Japan, 612-8555
- Rekrytering
- National Hospital Organization Kyoto Medical Center
-
Okayama, Japan, 701-1154
- Rekrytering
- National Hospital Organization Okayama Medical Center
-
Osaka, Japan, 541-8567
- Rekrytering
- Osaka International Cancer Institute
-
-
Ehime
-
Tōon, Ehime, Japan, 791-0295
- Har inte rekryterat ännu
- Ehime University Hospital
-
-
Fukuoka
-
Kurume, Fukuoka, Japan, 830-0011
- Rekrytering
- Kurume University Hospital
-
-
Gunma
-
Otashi, Gunma, Japan, 373-8550
- Rekrytering
- Gunma Prefectural Cancer Center
-
-
Hokkaido
-
Asahikawa, Hokkaido, Japan, 0708644
- Rekrytering
- National Hospital Organization Asahikawa Medical Center
-
-
Hyōgo
-
Kobe, Hyōgo, Japan, 650-0047
- Rekrytering
- Kobe City Medical Center General Hospital
-
-
Kanagawa
-
Yokohama, Kanagawa, Japan, 2418515
- Har inte rekryterat ännu
- Kanagawa cancer center
-
-
Mie-ken
-
Tsu, Mie-ken, Japan, 514-1101
- Rekrytering
- Mie Chuo Medical Center
-
-
Miyagi
-
Sendai, Miyagi, Japan, 9810914
- Rekrytering
- Sendai Kousei Hospital
-
-
Osaka
-
Sakai, Osaka, Japan, 591-8555
- Rekrytering
- NHO Kinki Chuo Chest Medical Center
-
Suita, Osaka, Japan, 565-0871
- Rekrytering
- The University of Osaka Hospital
-
-
Tokyo
-
Bunkyo-ku, Tokyo, Japan, 113-8603
- Har inte rekryterat ännu
- Nippon Medical School Hospital
-
Chuo-ku, Tokyo, Japan, 104-0045
- Rekrytering
- National Cancer Center Hospital
-
Koto, Tokyo, Japan, 135-8550
- Rekrytering
- The Cancer Institute Hospital of JFCR
-
Meguro-Ku, Tokyo, Japan, 152-8902
- Rekrytering
- National Hospital Organization Tokyo Medical Center
-
-
Yamagata
-
Yamagata, Yamagata, Japan, 990-9585
- Rekrytering
- Yamagata University Hospital
-
-
-
-
British Columbia
-
Abbotsford British Columbia, British Columbia, Kanada, V2S 0C2
- Rekrytering
- BC Cancer Abbotsford
-
-
Quebec
-
Montreal, Quebec, Kanada, H1T 2M4
- Rekrytering
- CIUSSS de l'Est-de-l'Île-de-Montréal
-
Saint-Jérôme, Quebec, Kanada, J7Y 0L1
- Rekrytering
- Centre de Services Ambulatoire de St-Jerome
-
Saint-Jérôme, Quebec, Kanada, J7Z 2V4
- Rekrytering
- Unité de Recherche Clinique du CISSS des Laurentides
-
-
-
-
Anhui
-
Hefei, Anhui, Kina, 230031
- Rekrytering
- Anhui Provincial Cancer Hospital
-
-
Beijing Municipality
-
Beijing, Beijing Municipality, Kina, 101149
- Rekrytering
- Beijing Chest Hospital,Capital Medical University
-
Beijing, Beijing Municipality, Kina, 100142
- Rekrytering
- Beijing Cancer hospital
-
-
Fujian
-
Fuzhou, Fujian, Kina, 350014
- Rekrytering
- Fujian Cancer Hospital
-
-
Guangdong
-
Guangzhou, Guangdong, Kina, 510515
- Rekrytering
- Nanfang Hospital of Southern Medical University
-
Huizhou, Guangdong, Kina, 516001
- Rekrytering
- Huizhou Central People's Hospital
-
-
Guangxi
-
Nanning, Guangxi, Kina
- Rekrytering
- Guangxi Medical University Affiliated Tumor Hospital
-
-
Heilongjiang
-
Harbin, Heilongjiang, Kina, 150081
- Rekrytering
- Harbin Medical University Cancer Hospital
-
-
Henan
-
Luoyang, Henan, Kina, 471003
- Rekrytering
- The First Affiliated Hospital of Henan University of Science &Technology
-
Zhengzhou, Henan, Kina, 450008
- Rekrytering
- Henan Cancer Hospital
-
-
Hubei
-
Wuhan, Hubei, Kina, 430079
- Rekrytering
- Hubei Cancer Hospital
-
Wuhan, Hubei, Kina, 430048
- Rekrytering
- Wuhan Union Hospital Cancer Center
-
-
Hunan
-
Changsha, Hunan, Kina, 410013
- Rekrytering
- Hunan Cancer Hospital
-
-
Jiangsu
-
Changzhou, Jiangsu, Kina, 213003
- Rekrytering
- The First People's Hospital of Changzhou
-
Nanjing, Jiangsu, Kina, 210029
- Rekrytering
- Jiangsu Province Hospital
-
Xuzhou, Jiangsu, Kina, 221006
- Rekrytering
- The Affiliated Hospital of Xuzhou Medical College
-
-
Jiangxi
-
Nanchang, Jiangxi, Kina, 330209
- Rekrytering
- The First Affiliated Hospital of Nanchang University
-
-
Jilin
-
Changchun, Jilin, Kina, 130000
- Rekrytering
- Jilin Province Tumor Hospital
-
-
Shaanxi
-
Xi'an, Shaanxi, Kina, 710061
- Rekrytering
- The First Affiliated Hospital of Xi'an Jiaotong University
-
-
Shandong
-
Jinan, Shandong, Kina, 250117
- Rekrytering
- Shandong Cancer Hospital
-
Jinan, Shandong, Kina, 250013
- Rekrytering
- Jinan Central Hospital
-
Linyi, Shandong, Kina, 276001
- Rekrytering
- LinYi Cancer Hospital
-
-
Shanghai Municipality
-
Shanghai, Shanghai Municipality, Kina, 200032
- Rekrytering
- Fudan University Shanghai Cancer Center
-
Shanghai, Shanghai Municipality, Kina, 200030
- Rekrytering
- Shanghai Chest Hospital
-
-
Sichuan
-
Chengdu, Sichuan, Kina, 610041
- Rekrytering
- West China Hospital, Sichuan University
-
Chengdu, Sichuan, Kina, 610041
- Rekrytering
- Sichuan Cancer hospital
-
-
Tianjin Municipality
-
Tianjin, Tianjin Municipality, Kina, 300052
- Rekrytering
- Tianjin Medical University General Hospital
-
-
Yunnan
-
Kunming, Yunnan, Kina, 650118
- Rekrytering
- Yunnan Province Cancer Hospital
-
-
Zhejiang
-
Hangzhou, Zhejiang, Kina, 310016
- Rekrytering
- Sir Run Run Shaw Hospital of Zhejiang University School of Medicine
-
Taizhou, Zhejiang, Kina, 317000
- Rekrytering
- Taizhou Hospital of Zhejiang Province
-
Wenzhou, Zhejiang, Kina, 325000
- Rekrytering
- The First Affiliated Hospital of Wenzhou Medical University
-
-
-
-
-
Mexico City, Mexiko, 14080
- Har inte rekryterat ännu
- Instituto Nacional de Cancerologia
-
Puebla City, Mexiko, 72530
- Rekrytering
- Clinica Integral Internacional de Oncología
-
-
Jalisco
-
Guadalajara, Jalisco, Mexiko, 44340
- Rekrytering
- Centro de Investigación Clínica y Medicina Traslacional (CIMeT)
-
-
Veracruz
-
Veracruz de Ignacio de LA Llave, Veracruz, Mexiko, 91900
- Har inte rekryterat ännu
- Instituto Veracruzano en Investigación Clínica S.C.
-
-
-
-
-
Utrecht, Nederländerna, 3543 AZ
- Rekrytering
- St. Antonius Ziekenhuis, locatie Utrecht
-
-
Gelderland
-
Harderwijk, Gelderland, Nederländerna, 3844 DG
- Rekrytering
- Ziekenhuis St. Jansdal
-
-
North Brabant
-
Breda, North Brabant, Nederländerna, 4818 CK
- Har inte rekryterat ännu
- Amphia Ziekenhuis, locatie Breda Molengracht
-
-
Overijssel
-
Zwolle, Overijssel, Nederländerna, 8025 AB
- Rekrytering
- Isala, locatie Zwolle
-
-
Provincie Friesland
-
Leeuwarden, Provincie Friesland, Nederländerna, 8934 AD
- Har inte rekryterat ännu
- Frisius Medisch Centrum
-
-
-
-
-
Gdansk, Polen, 80-214
- Rekrytering
- Uniwersyteckie Centrum Kliniczne
-
Gliwice, Polen, 44-102
- Rekrytering
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy Instytut Badawczy
-
Poznan, Polen, 60-569
- Rekrytering
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii im. Eugenii i Janusza Zeylandow
-
-
Greater Poland Voivodeship
-
Poznan, Greater Poland Voivodeship, Polen, 60-693
- Rekrytering
- Med-Polonia Sp. z o. o.
-
-
Lublin Voivodeship
-
Lublin, Lublin Voivodeship, Polen, 20-609
- Rekrytering
- Instytut Genetyki i Immunologii GENIM
-
-
Masovian Voivodeship
-
Warsaw, Masovian Voivodeship, Polen, 02-781
- Rekrytering
- Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie
-
-
Łódź Voivodeship
-
Lodz, Łódź Voivodeship, Polen, 90-302
- Rekrytering
- Instytut MSF Sp zoo
-
-
-
-
Bucharest
-
Bucharest, Bucharest, Rumänien, 013812
- Rekrytering
- SC Memorial Healthcare International SRL
-
Bucharest, Bucharest, Rumänien, 022338
- Rekrytering
- Institutul Oncologic Bucuresti "Prof. Dr. Alexandru Trestioreanu"
-
Bucharest, Bucharest, Rumänien, 077190
- Har inte rekryterat ännu
- Sc Mnt Healthcare Europe Srl
-
-
Cluj
-
Cluj-Napoca, Cluj, Rumänien, 400641
- Rekrytering
- SC Medisprof SRL
-
Florești, Cluj, Rumänien, 407280
- Rekrytering
- SC Radiotherapy Center Cluj SRL
-
-
Constanța County
-
Ovidiu, Constanța County, Rumänien, 905900
- Rekrytering
- Ovidius Clinical Hospital OCH
-
-
Dolj
-
Craiova, Dolj, Rumänien, 200542
- Har inte rekryterat ännu
- Centrul de Oncologie "Sfântul Nectarie"
-
Craiova, Dolj, Rumänien, 200385
- Rekrytering
- SC Oncolab SRL
-
-
Timiș County
-
Timișoara, Timiș County, Rumänien, 300166
- Har inte rekryterat ännu
- S C Oncocenter Oncologie Clinica S R L
-
-
-
-
-
Riyadh, Saudiarabien, 11211
- Har inte rekryterat ännu
- King Faisal Specialist Hospital and Research Center
-
-
Riyadh Region
-
Riyadh, Riyadh Region, Saudiarabien, 11472
- Har inte rekryterat ännu
- King Saud University Medical City
-
-
-
-
-
Zurich, Schweiz, 8091
- Rekrytering
- UniversitätsSpital Zürich
-
-
Canton of Bern
-
Bern, Canton of Bern, Schweiz, 3010
- Rekrytering
- Inselspital Bern
-
-
-
-
-
Nové Zámky, Slovakien, 94034
- Rekrytering
- Fakultna nemocnica s poliklinikou Nove Zamky
-
Poprad, Slovakien, 058 01
- Rekrytering
- POKO Poprad s.r.o.
-
-
Bratislava Region
-
Bratislava, Bratislava Region, Slovakien, 821 01
- Rekrytering
- Univerzitná nemocnica Bratislava - Nemocnica Ružinov
-
-
Košice Region
-
Košice, Košice Region, Slovakien, 040 01
- Rekrytering
- Vychodoslovensky Onkologicky Ustav a.s.
-
-
Nitra Region
-
Komárno, Nitra Region, Slovakien, 945 05
- Rekrytering
- Nemocnica AGEL Komarno
-
-
Trnava Region
-
Trnava, Trnava Region, Slovakien, 917 02
- Rekrytering
- Fakultna nemocnica Trnava
-
-
-
-
-
Barcelona, Spanien, 08035
- Rekrytering
- Fundació Hospital Universitari Vall d'Hebron - Institut de Recerca (hereinafter, "VHIR")
-
Barcelona, Spanien, 08035
- Rekrytering
- Fundación Privada Instituto de Investigación Oncológica de Vall Hebron (hereinafter, "VHIO"
-
Las Palmas de Gran Canaria, Spanien, 35016
- Rekrytering
- Complejo Hospitalario Universitario Insular Materno-Infantil
-
Madrid, Spanien, 28040
- Rekrytering
- Hospital Universitario Fundación Jiménez Díaz
-
Madrid, Spanien, 28003
- Rekrytering
- FutureMeds - Madrid
-
Madrid, Spanien, 28007
- Rekrytering
- Hospital General Universitario Gregorio Marañon
-
Málaga, Spanien, 29004
- Rekrytering
- Hospital Quirón Málaga
-
Seville, Spanien, 41013
- Rekrytering
- Hospital Universitario Virgen Del Rocio
-
-
A Coruña [LA Coruña]
-
A Coruña, A Coruña [LA Coruña], Spanien, 15006
- Rekrytering
- CHUAC-Complejo Hospitalario Universitario A Coruña
-
-
Alicante
-
Elche, Alicante, Spanien, 03203
- Rekrytering
- Hospital General Universitario de Elche
-
-
Barcelona [barcelona]
-
Barcelona, Barcelona [barcelona], Spanien, 08028
- Rekrytering
- Hospital Universitari Dexeus
-
-
Barcelona/spain
-
Barcelona, Barcelona/spain, Spanien, 08035
- Rekrytering
- Hospital Universitari Vall D Hebron
-
-
Catalunya [cataluña]
-
Barcelona, Catalunya [cataluña], Spanien, 08041
- Rekrytering
- Hospital de la Santa Creu i Sant Pau
-
L'Hospitalet de Llobregat, Catalunya [cataluña], Spanien, 08908
- Rekrytering
- Institut Català d'Oncologia - L'Hospitalet
-
-
Cádiz
-
Jerez de la Frontera, Cádiz, Spanien, 11407
- Rekrytering
- Hospital Jerez de la Frontera
-
-
Illes Balears [islas Baleares]
-
Palma, Illes Balears [islas Baleares], Spanien, 07198
- Rekrytering
- Hospital Son Llàtzer
-
-
Madrid, Comunidad de
-
Madrid, Madrid, Comunidad de, Spanien, 28041
- Rekrytering
- Hospital Universitario 12 de Octubre
-
-
Valenciana, Comunitat
-
Valencia, Valenciana, Comunitat, Spanien, 46010
- Rekrytering
- Hospital Clinico de Valencia
-
-
-
-
-
Manchester, Storbritannien, M20 4BX
- Rekrytering
- The Christie NHS Foundation Trust
-
Reading, Storbritannien, RG1 5AN
- Har inte rekryterat ännu
- Royal Berkshire Hospital
-
-
Carnwall
-
Truro, Carnwall, Storbritannien, TR1 3LJ
- Rekrytering
- Royal Cornwall Hospitals NHS Trust
-
-
England
-
Sheffield, England, Storbritannien, S10 2SJ
- Har inte rekryterat ännu
- Weston Park Hospital
-
-
Hampshire
-
Southampton, Hampshire, Storbritannien, SO16 6YD
- Rekrytering
- University Hospital Southampton NHS Foundation Trust
-
-
Hillingdon
-
Northwood, Hillingdon, Storbritannien, HA6 2RN
- Har inte rekryterat ännu
- Mount Vernon Hospital
-
-
London, CITY of
-
London, London, CITY of, Storbritannien, EC1A 7BE
- Rekrytering
- St Bartholomew's Hospital
-
-
Somerset
-
Taunton, Somerset, Storbritannien, TA1 5DA
- Har inte rekryterat ännu
- Musgrove Park Hospital
-
-
Suffolk
-
Ipswich, Suffolk, Storbritannien, IP4 5PD
- Har inte rekryterat ännu
- Ipswich Hospital
-
-
-
-
Jeonranamdo
-
Hwasun-gun, Jeonranamdo, Sydkorea, 58128
- Rekrytering
- Chonnam National University Hwasun Hospital
-
-
Kyǒnggi-do
-
Seongnam, Kyǒnggi-do, Sydkorea, 13620
- Rekrytering
- Seoul National University Bundang Hospital
-
Suwon, Kyǒnggi-do, Sydkorea, 16499
- Rekrytering
- Ajou University Hospital
-
Suwon, Kyǒnggi-do, Sydkorea, 16247
- Rekrytering
- The Catholic University Of Korea St. Vincent's Hospital
-
-
Pusan-kwangyǒkshi
-
Busan, Pusan-kwangyǒkshi, Sydkorea, 49241
- Rekrytering
- Pusan National University Hospital
-
Haeundae-gu, Pusan-kwangyǒkshi, Sydkorea, 48108
- Rekrytering
- Inje University Haeundae Paik Hospital
-
-
Seoul-teukbyeolsi [seoul]
-
Seoul, Seoul-teukbyeolsi [seoul], Sydkorea, 03722
- Rekrytering
- Severance Hospital, Yonsei University Health System
-
Seoul, Seoul-teukbyeolsi [seoul], Sydkorea, 07061
- Rekrytering
- Boramae Medical Center
-
Seoul, Seoul-teukbyeolsi [seoul], Sydkorea, 08308
- Rekrytering
- Korea University Guro Hospital
-
-
Taegu-kwangyǒkshi
-
Deagu, Taegu-kwangyǒkshi, Sydkorea, 41404
- Rekrytering
- Kyungpook National University Chilgok Hospital
-
-
-
-
-
Kaohsiung City, Taiwan, 807
- Har inte rekryterat ännu
- Kaohsiung Medical University Chung-Ho Memorial Hospital
-
Kaohsiung City, Taiwan, 833401
- Rekrytering
- Chang Gung Memorial Hospital at Kaohsiung
-
Taichung, Taiwan, 407
- Har inte rekryterat ännu
- Taichung Veterans General Hospital
-
Tainan, Taiwan, 704
- Rekrytering
- National Cheng Kung University Hospital
-
Taipei, Taiwan, 11217
- Rekrytering
- Taipei Veterans General Hospital
-
Taipei, Taiwan, 10002
- Har inte rekryterat ännu
- National Taiwan University Hospital
-
-
Tainan
-
Tainan, Tainan, Taiwan, 73657
- Har inte rekryterat ännu
- Chi Mei Hospital - Liouying Branch
-
-
Taipei
-
Taipei City, Taipei, Taiwan, 106
- Har inte rekryterat ännu
- National Taiwan University Cancer Center (NTUCC)
-
-
-
-
-
Liberec1, Tjeckien, 460 01
- Rekrytering
- Krajska nemocnice Liberec, a.s.
-
Nový Jičín, Tjeckien, 741 01
- Rekrytering
- Nemocnice AGEL Novy Jicin a.s.
-
Olomouc, Tjeckien, 779 00
- Rekrytering
- Fakultni nemocnice Olomouc
-
Prague, Tjeckien, 150 00
- Rekrytering
- Fakultni Nemocnice Motol a Homolka
-
-
Praha 4
-
Prague, Praha 4, Tjeckien, 140 59
- Rekrytering
- Fakultni Thomayerova nemocnice
-
-
-
-
-
Adana, Turkiet (Türkiye), 01140
- Rekrytering
- Adana Medical Park Seyhan Hastanesi
-
Ankara, Turkiet (Türkiye), 06680
- Rekrytering
- Liv Hospital Ankara
-
Ankara, Turkiet (Türkiye), 06520
- Rekrytering
- Memorial Ankara Hastanesi
-
Ankara, Turkiet (Türkiye), 06230
- Rekrytering
- Hacettepe Universite Hastaneleri
-
Ankara, Turkiet (Türkiye), 06560
- Rekrytering
- Gazi University Health Research and Application Center Gazi Hospital
-
Ankara, Turkiet (Türkiye), 06010
- Rekrytering
- Gulhane Egitim Arastirma Hastanesi
-
Ankara, Turkiet (Türkiye), 06800
- Rekrytering
- Ankara Bilkent Şehir Hastanesi
-
Antalya, Turkiet (Türkiye), 07100
- Rekrytering
- Antalya Egitim ve Arastırma Hastanesi
-
Diyarbakır, Turkiet (Türkiye), 21200
- Rekrytering
- Dicle Üniversitesi
-
İstanbul - Fatih, Turkiet (Türkiye), 34098
- Rekrytering
- Istanbul Universitesi Cerrahpasa
-
-
Turkey
-
Ankara, Turkey, Turkiet (Türkiye), 06230
- Rekrytering
- Ankara University Health Practice and Research Hospitals
-
-
İ̇stanbul
-
Istanbul, İ̇stanbul, Turkiet (Türkiye), 34722
- Rekrytering
- TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
-
Istanbul, İ̇stanbul, Turkiet (Türkiye), 34214
- Rekrytering
- Medipol Mega Universite Hastanesi
-
Istanbul, İ̇stanbul, Turkiet (Türkiye), 34295
- Rekrytering
- İ.A.Ü VM Medical Park Florya Hastanesi
-
-
İ̇zmir
-
Izmir, İ̇zmir, Turkiet (Türkiye), 35100
- Rekrytering
- Ege Universitesi Hastanesi
-
Izmir, İ̇zmir, Turkiet (Türkiye), 35110
- Rekrytering
- İzmir Suat Seren Chest Disease Training & Research Hospital
-
-
-
-
-
Bad Berka, Tyskland, 99437
- Rekrytering
- Zentralklinik Bad Berka GmbH
-
Berlin, Tyskland, 10117
- Rekrytering
- Charité - Universitätsmedizin Berlin
-
Berlin, Tyskland, 13353
- Rekrytering
- Charité Campus Virchow-Klinikum
-
Berlin, Tyskland, 13353
- Rekrytering
- Labor Berlin
-
Berlin, Tyskland, 13509
- Rekrytering
- Vivantes Humboldt Klinikum Apotheke Nord
-
Berlin, Tyskland, 13585
- Rekrytering
- Vivantes Hospital Spandau
-
Gauting, Tyskland, 82131
- Rekrytering
- Asklepios Klinik Gauting GmbH
-
Großhansdorf, Tyskland, 22927
- Rekrytering
- LungenClinic Grosshansdorf
-
München, Tyskland, 81377
- Rekrytering
- Radiologie München
-
-
Baden-Wurttemberg
-
Ulm, Baden-Wurttemberg, Tyskland, 89081
- Rekrytering
- Universitaetsklinikum Ulm
-
-
Bavaria
-
Gröbenzell, Bavaria, Tyskland, 82194
- Rekrytering
- Johannes Apotheke Gröbenzell
-
Traunstein, Bavaria, Tyskland, 83278
- Rekrytering
- Klinikum Traunstein
-
-
Hesse
-
Giessen, Hesse, Tyskland, 35392
- Rekrytering
- UKGM Gießen/Marburg
-
Kassel, Hesse, Tyskland, 34125
- Rekrytering
- Klinikum Kassel
-
-
Rhineland-Palatinate
-
Koblenz, Rhineland-Palatinate, Tyskland, 56068
- Rekrytering
- InVO Institut für Versorgungsforschung in der Onkologie
-
-
Saxony
-
Chemnitz, Saxony, Tyskland, 09116
- Rekrytering
- Klinikum Chemnitz - Flemmingstraße
-
Chemnitz, Saxony, Tyskland, 09113
- Rekrytering
- Klinikum Chemnitz gGmbH
-
-
Saxony-Anhalt
-
Halle, Saxony-Anhalt, Tyskland, 06120
- Rekrytering
- Krankenhaus Martha-Maria Halle-Dölau
-
-
Schleswig-Holstein
-
Lübeck, Schleswig-Holstein, Tyskland, 23538
- Rekrytering
- Universitätsklinikum Schleswig-Holstein
-
Oldenburg in Holstein, Schleswig-Holstein, Tyskland, 23758
- Rekrytering
- ohO Research GmbH
-
-
-
-
-
Székesfehérvár, Ungern, 8000
- Har inte rekryterat ännu
- Fejér Vármegyei Szent György Egyetemi Oktató Kórház
-
Tatabánya, Ungern, 2800
- Har inte rekryterat ännu
- Komárom-Esztergom Vármegyei Szent Borbála Kórház
-
-
Bekes County
-
Gyula, Bekes County, Ungern, 5700
- Rekrytering
- Békés Vármegyei Központi Kórház Pándy Kálmán Tagkórház
-
-
Veszprém megye
-
Farkasgyepű, Veszprém megye, Ungern, 8582
- Har inte rekryterat ännu
- Farkasgyepui Tudogyogyintezet
-
-
-
-
-
Graz, Österrike, 8036
- Rekrytering
- Medizinische Universität Graz
-
Vienna, Österrike, 1090
- Rekrytering
- Medizinische Universität Wien
-
Vienna, Österrike, 1210
- Rekrytering
- Klinik Floridsdorf
-
-
Upper Austria
-
Linz, Upper Austria, Österrike, 4020
- Rekrytering
- Ordensklinikum Linz GmbH Elisabethinen
-
-
Deltagandekriterier
Forskare letar efter personer som passar en viss beskrivning, så kallade behörighetskriterier. Några exempel på dessa kriterier är en persons allmänna hälsotillstånd eller tidigare behandlingar.
Urvalskriterier
Åldrar som är berättigade till studier
18 år och äldre (Vuxen, Äldre vuxen)
Tar emot friska volontärer
Nej
Kön som är behöriga för studier
Allt
Beskrivning
Inclusion Criteria:
-
Participants must meet the following criteria:
- Have pathologically confirmed Stage IIIB or IIIC NSCLC and not be a candidate for surgical resection or definitive chemoradiation, or Stage IV NSCLC per the AJCC Staging Manual (Version 8.0) and the UICC Staging System (Eighth edition).
- Participants with known AGAs including EGFR, ALK, ROS1, NTRK, BRAF, RET, and MET, for which there are approved and available first-line therapies per local SOC are ineligible. Documented negative results for EGFR, ALK, and ROS1 AGAs are required for participants with non-squamous histology.
- Participants with large cell neuroendocrine carcinoma are excluded.
- Must be an appropriate candidate for treatment with pembrolizumab monotherapy per local guidelines.
-
Tumor has PD-L1 expression in ≥50% of tumor cells (TPS ≥50%) as determined by local testing.
-
Measurable disease based on RECIST v1.1 per investigator.
-
Resolution of acute effects of any prior therapy to either baseline severity or NCI CTCAE Grade 1 or less (except for AEs not constituting a safety risk in the investigator's judgment), unless otherwise excluded.
Exclusion Criteria:
-
Life expectancy of <3 months in the opinion of the investigator.
-
Any medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or make the participant inappropriate for the study.
-
Participants with any history of another malignancy within 3 years before the first dose of study intervention, or any evidence of residual disease from a previously diagnosed malignancy.
-
Known or suspected hypersensitivity, intolerance, or contraindication to any excipient contained in the drug formulation of sigvotatug vedotin or pembrolizumab.
-
Participants with any of the following respiratory conditions:
- Evidence of noninfectious or drug-induced ILD or pneumonitis
- Known DLCO (adjusted for hemoglobin) <50% predicted.
- Grade ≥3 pulmonary disease unrelated to underlying malignancy
-
Known active CNS lesions are excluded. Participants with definitively treated brain metastases (surgery and/or radiotherapy) may be eligible. Up to 5 clinically asymptomatic brain metastases of longest diameter <1.0 cm are permitted without definitive surgery and/or radiotherapy.
-
Major surgery (defined as a surgery requiring inpatient hospitalization of at least 48 hours) within 21 days or minor surgery (excluding peripherally inserted central catheter placement and implantable central venous port placement) within 3 days prior to first dose of study intervention.
-
Receipt of a live vaccine within 30 days prior to first dose of study intervention.
-
Pre-existing peripheral neuropathy Grade ≥2 per NCI CTCAE v5.0.
-
Uncontrolled diabetes mellitus, defined as HbA1c ≥8.0% or HbA1c between 7.0% and 8.0% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.
-
Prior immune-related AE that led to anti-PD-(L)1 treatment discontinuation, required a high-dose steroid taper (≥0.5 mg/kg prednisone or equivalent per day) for >2 weeks, or required treatment with systemic immunosuppressive therapy.
-
History of autoimmune disease that has required systemic treatment in the past 2 years
-
Participants with prior solid organ or bone marrow transplantation.
-
Currently receiving a high-dose steroid (>10 mg prednisone or equivalent per day) or other immune suppressant or has a condition requiring a chronic high-dose steroid or immune suppressant.
-
Prior and concomitant therapy:
-
Any prior treatment with MMAE-derived drugs or IB6 targeting agents.
-
Prior systemic therapy, including anti-PD-(L)1 therapy, for locally advanced, unresectable, or metastatic NSCLC.
- (Neo)adjuvant anti-PD-(L)1 is allowed if recurrence or progression occurred ≥9 months after the last dose.
- Other (neo)adjuvant or definitive therapy is allowed if recurrence or progression occurred ≥6 months after the last dose.
-
Prior radiotherapy to the lung within 6 months of first dose of study intervention, referencing the last date radiotherapy was received. This includes both curative and palliative radiotherapy.
-
Chemotherapy, biologics, and/or other antitumor treatment with immunotherapy not specifically prohibited that is completed less than 4 weeks prior to first dose of study intervention, or 2 weeks for palliative radiotherapy.
-
Any prior therapy with an immune-oncology agent directed to a stimulatory or co-inhibitory T-cell receptor
-
-
History of or current ongoing infection, including participants positive for active HIV, HBV, or HCV.
-
Severe uncontrolled cardiac or cerebrovascular condition within the previous 6 months
Studieplan
Det här avsnittet ger detaljer om studieplanen, inklusive hur studien är utformad och vad studien mäter.
Hur är studien utformad?
Designdetaljer
- Primärt syfte: Behandling
- Tilldelning: Randomiserad
- Interventionsmodell: Parallellt uppdrag
- Maskning: Enda
Vapen och interventioner
Deltagargrupp / Arm |
Intervention / Behandling |
|---|---|
|
Experimentell: Sigvotatug Vedotin with Pembrolizumab
Participants will receive Sigvotatug Vedotin, administered as an IV infusion and pembrolizumab, administered as an IV infusion. |
MMAE-Antibody Drug Conjugate targeting Integrin Beta-6 Anti-PD-(L)1 |
|
Aktiv komparator: Pembrolizumab Monotherapy
Participants will receive pembrolizumab, administered as an IV infusion. |
Anti-PD-(L)1 |
Vad mäter studien?
Primära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Overall Survival
Tidsram: Baseline to date of death from any cause (Approximately 2 years).
|
Overall survival defined as the duration from enrollment to death. |
Baseline to date of death from any cause (Approximately 2 years).
|
|
Progression Free Survival (PFS) assessed by blinded independent central review (BICR)
Tidsram: From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Progression-free survival is defined as the time interval from the date of randomization to the date of first documented tumor progression determined by blinded independent central review (BICR) assessment as per Response Evaluation Criteria in Solid Tumors (RECIST 1.1) or death due to any cause, whichever come first. |
From Baseline to to date of first documentation of progression OR death (Approximately 2 years).
|
Sekundära resultatmått
Resultatmått |
Åtgärdsbeskrivning |
Tidsram |
|---|---|---|
|
Progression Free Survival as assessed by Investigator
Tidsram: From Baseline to date of first progression or death (Approximately 4 years).
|
Progression Free Survival (PFS) is defined as the time from the date of first dose of study interventions to the date of first documentation of PD or death due to any cause, whichever occurs first. |
From Baseline to date of first progression or death (Approximately 4 years).
|
|
Objective Response Rate as assessed by BICR
Tidsram: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Objective response rate is defined as the proportion of participants who have a confirmed CR or PR, as best overall response assessed by BICR as per RECIST 1.1, from the date of randomization to the date of disease progression, death due to any cause, whichever occurs first. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Objective Response Rate as assessed by Investigator
Tidsram: From Baseline to to the date of progression OR death (approximately to 4 years).
|
Defined as the proportion of participants who achieve a best response of complete response (CR) or partial response (PR) using the Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST v1.1) criteria as assessed by Investigator. |
From Baseline to to the date of progression OR death (approximately to 4 years).
|
|
Duration of Response as assessed by BICR
Tidsram: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Duration of response is defined as the time from first documented evidence of CR or PR until progressive disease (PD) as determined by BICR assessment as per RECIST 1.1 or death due to any cause, whichever occurs first. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Duration of Response as assessed by Investigator
Tidsram: From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
Defined time from the initial response (CR or PR) until documented tumor progression or death from any cause and based on Investigator assessment. |
From the date of the first objective response to the date of disease progression or death (approximately to 4 years).
|
|
Number of participants with adverse events (AEs)
Tidsram: From Baseline to end of treatment (up to 4 years).
|
Counts of participants who had treatment-emergent adverse events (TEAEs), defined as newly occurring or worsening after first dose. Relatedness to [study drug] was assessed by the investigator (Yes/No). Participants with multiple occurrences of an AE within a category were counted once within the category. |
From Baseline to end of treatment (up to 4 years).
|
|
Pharmacokinetics (PK) of antibody-conjugated monomethyl auristatin E (ac-MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
Tidsram: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of ac-MMAE in plasma: Plasma predose concentration (Cpredose)
Tidsram: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of unconjugated monomethyl auristatin E (MMAE) in plasma: Plasma concentration at end of infusion (CEOI)
Tidsram: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
PK of MMAE in plasma: Plasma predose concentration (Cpredose)
Tidsram: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the pharmacokinetics (PK) of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Number of participants with antidrug antibodies (ADAs)
Tidsram: Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
To characterize the immunogenicity of sigvotatug vedotin when administered in combination with pembrolizumab. |
Cycle 1 (up to Day 29), Cycle 3 Day 1, Cycle 4 Day 1, Cycle 5 Day 29, Cycle 8 Day 15, Cycle 11 Day 1, Cycle 14 Day 1, and Cycle 18 Day 1.
|
|
Time to response (TTR) using RECIST v1.1 as assessed by BICR
Tidsram: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by BICR. |
The time from the date of randomization to the date of first documentation of objective response.
|
|
TTR using RECIST v1.1 as assessed by investigator
Tidsram: The time from the date of randomization to the date of first documentation of objective response.
|
Defined as the time from the date of randomization to the date of first documentation of objective response (CR or PR that is subsequently confirmed) per RECIST v1.1 by investigator assessment. |
The time from the date of randomization to the date of first documentation of objective response.
|
Samarbetspartners och utredare
Det är här du hittar personer och organisationer som är involverade i denna studie.
Sponsor
Utredare
- Studierektor: Pfizer CT.gov Call Center, Pfizer
Publikationer och användbara länkar
Den som ansvarar för att lägga in information om studien tillhandahåller frivilligt dessa publikationer. Dessa kan handla om allt som har med studien att göra.
Studieavstämningsdatum
Dessa datum spårar framstegen för inlämningar av studieposter och sammanfattande resultat till ClinicalTrials.gov. Studieposter och rapporterade resultat granskas av National Library of Medicine (NLM) för att säkerställa att de uppfyller specifika kvalitetskontrollstandarder innan de publiceras på den offentliga webbplatsen.
Studera stora datum
Studiestart (Faktisk)
23 juli 2025
Primärt slutförande (Beräknad)
5 september 2028
Avslutad studie (Beräknad)
1 mars 2029
Studieregistreringsdatum
Först inskickad
26 december 2024
Först inskickad som uppfyllde QC-kriterierna
26 december 2024
Första postat (Faktisk)
3 januari 2025
Uppdateringar av studier
Senaste uppdatering publicerad (Faktisk)
25 september 2026
Senaste inskickade uppdateringen som uppfyllde QC-kriterierna
22 september 2026
Senast verifierad
1 september 2026
Mer information
Termer relaterade till denna studie
Ytterligare relevanta MeSH-villkor
Andra studie-ID-nummer
- C5751003
- 2024-517968-36-00 (Registeridentifierare: CTIS (EU))
Plan för individuella deltagardata (IPD)
Planerar du att dela individuella deltagardata (IPD)?
JA
IPD-planbeskrivning
Pfizer will provide access to individual de-identified participant data and related study documents (e.g. protocol, Statistical Analysis Plan (SAP), Clinical Study Report (CSR)) upon request from qualified researchers, and subject to certain criteria, conditions, and exceptions. Further details on Pfizer's data sharing criteria and process for requesting access can be found at: https://www.pfizer.com/science/clinical_trials/trial_data_and_results/data_requests.
Läkemedels- och apparatinformation, studiedokument
Studerar en amerikansk FDA-reglerad läkemedelsprodukt
Ja
Studerar en amerikansk FDA-reglerad produktprodukt
Nej
produkt tillverkad i och exporterad från U.S.A.
Ja
Denna information hämtades direkt från webbplatsen clinicaltrials.gov utan några ändringar. Om du har några önskemål om att ändra, ta bort eller uppdatera dina studieuppgifter, vänligen kontakta register@clinicaltrials.gov. Så snart en ändring har implementerats på clinicaltrials.gov, kommer denna att uppdateras automatiskt även på vår webbplats .