High-intensity interval training and health-related quality of life in de novo heart transplant recipients - results from a randomized controlled trial

Katrine Rolid, Arne K Andreassen, Marianne Yardley, Einar Gude, Elisabeth Bjørkelund, Anne R Authen, Ingelin Grov, Kjell I Pettersen, Christian H Dall, Kristjan Karason, Kaspar Broch, Lars Gullestad, Kari Nytrøen, Katrine Rolid, Arne K Andreassen, Marianne Yardley, Einar Gude, Elisabeth Bjørkelund, Anne R Authen, Ingelin Grov, Kjell I Pettersen, Christian H Dall, Kristjan Karason, Kaspar Broch, Lars Gullestad, Kari Nytrøen

Abstract

Background: Studies on the effect of high-intensity interval training (HIT) compared with moderate intensity continuous training (MICT) on health-related quality of life (HRQoL) after heart transplantation (HTx) is scarce. No available studies among de novo HTx recipients exists. This study aimed to investigate the effect of HIT vs. MICT on HRQoL in de novo recipients.

Methods: The HITTS study randomized eighty-one de novo HTx recipients to receive either HIT or MICT (1:1). The HIT intervention were performed with 2-4 interval bouts with an intensity of 85-95% of maximal effort. The MICT group exercised at an intensity of 60-80% of their maximal effort with a duration of 25 min. HRQoL was assessed by the Short Form-36 version 2 (SF-36v2) and the Hospital Anxiety and Depression Scale, mean 11 weeks after surgery and after a nine months' intervention. The participants recorded their subjective effect of the interventions on their general health and well-being on a numeric visual analogue scale. Clinical examinations and physical tests were performed. Differences between groups were investigated with independent Student t-tests and with Mann-Whitney U tests where appropriate. Within-group differences were analyzed with Paired-Sample t-tests and Wilcoxon Signed Rank tests. Correlations between SF-36 scores and VO2peak were examined with Pearson's correlations.

Results: Seventy-eight participants completed the intervention. Both exercise modes were associated with improved exercise capacity on the physical function scores of HRQoL. Mental health scores remained unchanged. No differences in the change in HRQoL between the groups occurred except for Role Emotional subscale with a larger increase in the HIT arm. Better self-reported physical function was associated with higher VO2peak and muscle strength.

Conclusion: HIT and MICT resulted in similar mean changes in HRQoL the first year after HTx. Both groups experienced significant improvements in the physical SF-36v2.

Trial registration: ClinicalTrials.gov number: NCT01796379 Registered 18 February 2013.

Keywords: Exercise; Health-related quality of life; Heart transplantation; High-intensity interval training; Moderate intensity continuous training; Muscle strength,self-reported physical function; Oxygen consumption.

Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Patient recruitment and follow-up
Fig. 2
Fig. 2
Design of the study
Fig. 3
Fig. 3
Correlation between self-reported physical function and VO2peak in the high-intensity training (HIT) group and the moderate intensity continuous training (MICT) group mean 11 weeks after heart transplantation (HTx)
Fig. 4
Fig. 4
Correlation between self-reported physical function and VO2peak in the high-intensity training (HIT) group and the moderate intensity continuous training (MICT) group 1 year after heart transplantation (HTx)

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Source: PubMed

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